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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Development of Logic Based Learning Evaluation Instruments Kharisma Kusumaningtyas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Logical models are methods for conveying ideas that describe and share the understanding of the interrelationships among elements to operate a program or change effort. The study aimed to compile the development of a logic-based clinical learning practice instrument. Method: This research used an action research design. Sixteen participants joined the Focus Group Discussion (FGD) consisting of Head of Study Program, Academic Coordinator, Practice Division staffs, and Lecturer Representatives from 4 Midwifery Study Program of a university in Indonesia. The FGD was conducted in 2 stages. The analysis used descriptive and inferential analysis. Result: The results obtained clinical practice learning evaluation instruments based on logic models. The results of the validity test with Pearson's product-moment correlation show r = 0.576 and the value of r for each question > r table, so it can be concluded that instruments valid and reliable.  Discussion: Instrument of clinical practice learning program based on logic models in the Midwifery Department consists of context, input, activity, output, and outcomes. The instrument can assess the process of implementing clinical practice learning.Keywords: Learning, Practice, Logic model, Clinical.
Thiadiazole Cyclic Derivatives from Aldamine Compounds (Preparation, Characterization, Thermal Stability) Athraa Sahib Alrammahi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Seven  heterocyclic  derivatives  were  synthesized  by   using  Azotation  reaction  ,followed  by  coupling  reaction  with  phenol  derivative  , the  resulting   compound  cyclized   with  thiosemicarbazide   to  yield  thiadiazole  derivatives  which  reacted  with  carbonyl  compound ( benzaldehyde) with  drops  of  glacial   acetic  acid  to  produce  imine  compound   followed  by  breaking  of  imine  bond (CH=N) to  react   with  ( succinic  anhydride , chloroaceto chloride  , glycine , ortho mercapto benzoic  acid )  to  yield  cyclic  derivatives  from  Aldamine-thiadiazole  derivatives.  Thiadizole-aldamine  derivatives   were  characterized   by  chemical   techniques  such as (1H NMR , IR  and  Mass-  spectra ,  Thermal  Stability).Keywords: Therm, Technic, Stable.
Evaluation of Trace Lead, Chromium and Cobalt Level in the Urine Samples of Industrial Workers Ahmed Fadhil Khudhair
Journal of Global Pharma Technology .
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Abstract

For clinical reasons, and in order to control minimise the effects on the health of individuals exposed to toxic elements, it is most important to monitor concentrations of trace elements in biological materials. Such an examination was achieved for urine samples of workers with different occupations and of different ages. Concentrations of lead, chromium and cobalt were examined in forty urine samples using the flame atomic absorption spectroscopy (F-AAS) technique. The average concentrations of Co, Cr and Pb were 0.0069 to 0.0484 ppm, 0.1056 to 0.9645 ppm and 0.1188 to 0.5067 ppm, respectively. A low detection limit for Co was registered compared to the Pb and Cr. This study has shown that Cr concentrations in the urine samples of people who work in oil refineries were higher than for people working in other vocations.  Concentrations of trace Co, Cr and Pb in the urine of people aged 30-40 years were larger than the concentration found for individuals in other age groups. The T-test, F-test and ANOVA have been used to examine the accuracy and precision of results and compare them with those published in the literature (literature review results).Keywords: Lead, Chromium, Cobalt, Urine, FAAS. 
Empagliflozin Managed Type 2 Diabetes Mellitus in Insulin induced Hypertension: A case report Raja A; Sadagoban GK; Jemi Rachel Shaji; Renita Castelino; Swathi Swaroopa Borra
Journal of Global Pharma Technology Volume 12 Issue 12 (2020) Dec. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Insulin is an essential hormone and has been the cornerstone in the therapy of Diabetes Mellitus. This case highlights insulin-induced hypertension in a type 2 DM patient, managed adequately with empagliflozin. A 60-year female with Diabetic Nephropathy & Hypothyroidism presented with elevated blood pressure after a week of insulin administration. An elevation in the patient’s blood pressure corresponding to the administration of insulin was observed. De-challenge and re-challenge of insulin with dose adjustment, resulted in sudden spike & decrease of blood pressure, thereby pointing a suspicion towards a relation between insulin and hypertension. Discontinuation of insulin and replacement with oral hypoglycemics has resulted in controlled blood pressure levels.
Dilution Effect on a Mixture Solution of Organic Dyes (Cumarin and Rohdamain) Wajeha Abdle Diam
Journal of Global Pharma Technology .
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Abstract

In this study the spectral properties absorption of laser dyes (C480 & R610) mixture have been studied and has been dissolved in ethanol to prepare (1:1,1:21:3,1:4,1:5) ratio from [Rohdamin610(R610): Cumarin 480(C48)]at ( )concentration at room temperature. by added (18,27,36) mel from ethanol per ratio then study the change in the spectral properties of the mixture at each addition. Found that there was a significant increase in the spectral  line width  by increased  the amount of added ethanol and there is red shift increase with Increasing the amount of ethanol added and Decreased in the intensity.Keywords: Dye laser, Dilution. Absorption spectrum.
Isolation of active compounds from aerial parts of Albizia Procera S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

The purpose of the study is to isolate active compounds from herbal plants that have various effects on living systems. The plants are indispensable sources for both preventive and curative medicinal preparations of various traditional medicine systems practiced worldwide. Albizia species is used to treat anxiety, cancer, depression, insomnia, sore throat and to reduce swelling associated with trauma. Isolation of active constituents and pharmacological screening can assist us to find new therapeutically active drugs. The compound (1) 2,2- dimethylvinyl methyl ketone and  compound (2) 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexene (C30H50) are isolated from hexane and ethyl acetate fraction of albizia procera belonging to the family mimosoideae. The above isolated Compound (1) is an intermediate to synthesis a number of different types of organic compounds and Compound (2) showed potential hepatoprotective effect against drug induced hepatotoxicity. The structure of compound have been established [1] by IR, 1H NMR, 13C NMR and MASS spectrophotometry.
Phenotypic and Genotypic Characterization of Some Virulence Factors among Proteus mirabilis Isolated from Clinical Samples in Al-Najaf Al-Ashraf/ Iraq Ahlam Kadhum Al-Yasseen
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study aimed to investigate the phenotypic and genotypic pattern of some virulence factors in Proteus mirabilis isolates from clinical samples. A total of 110 urine samples were collected from patients with urinary tract infection from both sexes and 100 vaginal swabs were collected of women with vaginal infections during the period from October 2017 to January 2018. The results of primary isolation and identification of bacterial isolates depending on microscopic, culturing on CHROM agar and biochemical test showed that 36.3% of isolates were belong to Proteus while the results of PCR techniques that used to confirmed identification using 16SrRNA revealed that 27.2% of isolates were belong to Proteus mirabilis. Variable results in the ability of bacterial isolates to produce protease and hemolysin have been obtained in which 30% and 100% of bacterial isolates gave positive results respectively. Also the results of PCR technique showed that all isolates (100%) were possess zap A, rsb A and mrp A encoding for the production of protease, protein that regulates  bacterial swarming behavior and mannose resistant pilli (MR /P) respectively by the appearance of amplicons with molecular weight  552, 485 and 366 bp.Keywords:  Genotypic; Proteus mirabilis; Phenotypic; and Clinical Samples.
Synthesis , Characterization , Antimicrobial of Studies New 2,2'-[(1Z,2Z)-ethane-1,2 diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and their transition metal complexes Ibrahim . A Flifel
Journal of Global Pharma Technology .
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Abstract

A new ligand 2,2'-[(1Z,2Z)-ethane-1,2-diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and its Cr(III) , Co(lll) and Ni(ll) complexes were synthesized . The new ligand and its complexes have been characterization on the basis their spectra of 1HNMR, mass, Fourier transform infrared (FTIR) , as well as magnetic susceptibility, elemental analysis[C,H,N] and conductance measurements  . The program of Hyperchem 7.51 has been used up for theoretical accounts using PM3 method [1] to study the electrostatic potential that provided good information about the complexity site. Of the results obtained we can suggested octahedral geometrics for Cr (III) and Co (III) complexes, while tetrahedral geometry for Ni (II) complex .A ligand and its complexes were screened for their antibacterial activity against two kinds of strains Escherichia coli (gram negative bacterial strains) and staphylococcus aureus (gram positive bacteria strains), This research showed excellent results in comparison with Ciprofloxacin as standard drug. Keywords: ligand, complexes, Characterization, Hyperchem, electrostatic potential, antibacterial.     
Technical Parameters Influencing to Cayratia trifolia Fox Grape Wine Making N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Cayratia trifolia is a weak herbaceous climber. Its fruit is fleshy, juicy, dark purple or black. Cayratia trifolia Linn. Is a medicinally important plants and used in the treatment of various diseases. In order to utilize this valuable fruit, objective of this study focused on major technical parameters such as sugar supplementation and yeast ratio in the primary fermentation; different clarifying agents such as gelatin, kaolin, egg white, bentonite  in the secondary fermentation. Results showed that sugar concentration and yeast ratio in the initial must were very important to the ethanol, titratable acidity and aroma in wine. Gelatin was suitable in fining step to control haze turbidity in wine. From this study, consumers had more chance to enjoy a healthy food drink orginated from natural source. Keywords: Cayratia trifolia, Wine, Yeast, Sugar, Gelatin, Ethanol, Acidity, Turbidity.
EFFECT OF SOME CHEMICAL ELICITORS ON SOME SECONDARY METABOLITE INDUCTION OF CORDIA MYXA L. IN VITRO alaa jabbar taha
Journal of Global Pharma Technology .
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Abstract

Cordia myxa a tree belongs to boraginaceae family contained many secondary products like Flavonoids and Alkaloids. So uses as anti - inflammation, and antibacterial .The objective of this research to increase some secondary products from callus extraction by using chemical elicitors, like ZnSo4 and CoCl2 in various concentration, the method of Budhiraja was use to estimate the concentration of secondary products. Results showed that 0.5mg/l from ZnSo4 lead to significant increase compound dihydroxyrobmetin, Rubinin, and Chlorogenic reaching 2.95, 218.44, 60.99, µg/ml respectively. Moreover, had 2.5mg/l of ZnSo4 concentration negative impact on concentration of secondary metabolites, all compound decreased except datiscoside that arrived to highest rates significantly 70.63 µg/ml. While treatment 0.5 mg/l CoCl2 lead to decrease all compounds except hesperdin, which was significantly increase to 71.42 µg/ml, the concluded of this research showed that 0.5mg/l of CoCl2 and 2.5mg/l of Zno4 had negative effect on most  concentration of secondary metabolites. 

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