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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Inducement of Agarwood Resin Using Various Chemical Formulation of Stem Tissue (Aquilaria malaccensis) Husni Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Agarwood is described as fragrance wood that is usually derived from the trunk of genus Aquilaria which have been infected by a particular disease. The main focus of this research is to study the effectiveness of four chemical inoculants applied into 6 year old karas tree (A. malaccensis) plantations in Slim River, Perak, Malaysia using dripping techniques. The inoculants used were labelled as A, B, C and D. Commercial inoculant, labelled as K, was used for comparison purposes and control labelled as N. After eight months of inoculation, the karas tree were cut down and discoloured tissue samples were collected.  Solvent extraction methods using dichloromethane (DCM) was carried out to obtain the resin crude extract from the plant tissue. Resin crude extract were then analysed using gas chromatography-mass spectrometry (GC-MS). The results showed that all chemicals successfully stimulated agarwood production. Inoculant A produced the highest crude extract recovery (8.63%) compared to inoculants B (7.45%), D (6.55%), C (5.95%), K (1.89%) and N (0.49%). GC-MS analysis revealed that aromatic compounds, sesquiterpenes, monoterpenes, sterols, alkanes and fatty acid methyl ester were identified from DCM extract. As an outcome, inoculant A is the best to be used as stimulant for agarwood due to product highest yield. This finding will hopefully contribute to new types of inoculants production in agarwood industries in Malaysia.Keywords: Agar wood, artificial inoculation, Chemical inducement, Aquilaria malaccensis, Malaysia
Significance of TLC and HPTLC in Phytochemical Screening of Herbal Drugs Anguraj Moulishankar; Prasanna Ganesan; Madhivanan Elumalai; Karthikeyan Lakshmanan
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
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Abstract

Plants provide the most of the pharmacologically active principles like alkaloids, anthraquinones, cardiac glycosides, coumarins, flavonoids, saponins, tannins, essential oils to humans. A large number of the medicinal plants were used by traditional and folk medicinal practitioners for various ailments. The active principles in them are detected by qualitative chemical tests for each category of phytoconstituents. Many chromatographic methods help in separation of the complex mixtures into individual phytoconstituent. Even though Thin Layer Chromatography (TLC) and HPTLC are rapid and easy methods, the selection of stationary phase and solvent system is always a time-consuming process. The general solvent systems for the specific category of secondary metabolites are available in various literatures, but for specific phytoconstituent one should do trial and error method to identify a suitable solvent system. This review article aims to minimize the valuable time of both beginning and experienced researchers by providing well-organized information about TLC and HPTLC in phytochemical screening. Keywords: TLC, HPTLC, Solvent system, Extraction, Phytochemical analysis, Herbal drugs.
Analyze the Relationship between QWL and Organizational Citizenship Behavior Zabol University Naser Khodizaee
Journal of Global Pharma Technology .
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A high quality of work life (QWL) is essential for all organizations to continue to attract and retain employees. Quality of work life is a comprehensive program which is designated to increase employee satisfaction. In today’s society, improving the working life has been one of the main goals of the organization and staff and their working environment. Today, in modern management concept of quality of work life around the world has become a major social issue. While in past decades only on working life in search of new systems to help staff between work life and personal life balance so that they can communicate. Any improvement in the quality of work life programs organizational culture that promotes the growth and excellence in the organization's staff .Organization citizenship behavior also is one important sociological dimension of organizations. The purpose of current study is Analyze the relationship between QWL and organizational citizenship behavior Zabol University. Using table of Morgan the sample volume was estimated 159 people. The SPSS and multiple linear regression and Pearson Tests were used for data analysis and responding to the hypotheses, respectively. Test show that there is meaningful relationship between six dimensions with quality of work life and organizational citizenship behavior.Keywords: quality of work life, organizational citizenship behavior.
Effect of Pumpkin Concentrate on Alloxan Induced Diabetic Rats Ashish Baldi
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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Abstract

Effect of Pumpkin Concentrate on Alloxan Induced Diabetic Rats
The Cognition of Sensory-Motor and Its Correlation to Some of Physical Fitness Elements and Skill Traits for the Player's Epee Mohamed Abdulrahman Mohamed
Journal of Global Pharma Technology .
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Abstract

The game of fencing with the epee passed through a great development in the performance of skill and plan through the increased attention given to it by specialists and interested of trainers and researchers, as well as conducting research and studies that have a major role. In upgrading the game for the better. The importance of this research is evidenced by the linking of skills to some sensory abilities - the movement and the elements of physical fitness and motor skills may help in obtaining factors that contribute to the development of learning and training development of the game of fencing with many aspects of epee, hence, the researcher noted that many of the trainers focus in their training on the elements of fitness and motor skills without taking into account the importance of cognitive abilities - sense of movement and its relationship to these elements and skills played by the player in the stadium. And the relationship between some cognitive abilities of the sense of movement and some elements of fitness and skill qualities of the game of fencing with the epee. The sample of the research was chosen in a deliberate manner, the number of (24) players representing the clubs of Baghdad and the provinces of the game of duel with epee, (4) players for each club and the researcher used the statistical bag for social sciences (SPSS) to address the findings. The most important conclusion was the weakness of the accuracy of the stab, which indicates the weakness of the sense of precision of the weapon (tool) to the legal targets of the competitor. The researcher recommended emphasizing the development of training programs that work on the development and development of flexibility and agility and speed of movement of motorists fencing with epee.Keywords: Cognition, Kinetic sensation, Physical fitness and epee.
Molecular Detection of Some Virulence Genes of Salmonella Typhymurium and Salmonella Enteritidis Isolated from Patients Suffering Watery Diarrhea Lamees A. Abdul-Lateef
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Salmonella enterica virulence factors can be divided into chromosomal, plasmid and bacteriophages encoded virulence factors. Many of the Salmonella virulence factors, such as adhesion, invasion, and toxin genes are clustered in certain areas of the chromosome known as “Salmonella pathogenicity islands” (SPI). A total of 200 clinical stool samples were collected during this study which obtained from patient Suffering from watery diarrhea who a dmintted to three main hospitals of Babylon Governorate: Merjan Medical city, Al-Hillah Surgical Teaching Hospital and Babil Teaching Hospital for Women and Children during a period of three months (from july 2018 to September 2018). Out of 200 specimens 35(17.5%) were detected by culture and vitek2 compact, 24 (12%) of them were confirmed by PCR using target gene, (17) Salmonella typhimurium and (7) Salmonella enteritidis. PCR was conducted to determine the some virulence genes of the isolates by using primers inv A, sdiA and sifA. The PCR amplification products were visualized by electrophoresis on 1% agarose gels for 35min at 70v. The sizes of the amplicons were determined by comparison to the 200 bp allelic ladder. Among isolates studies it was found that invA gene present in 13(54)% isolates of S. enterica ,(9) isolates of S. typhimurium and (4) isolates of S. enteritidis , sdiA gene it was found in all isolates (100)% while sifA gene it was found in all isolates only isolate number 18 not contained this gene 23(96)%.Keywords: Salmonella typhimurium, S. enteritidis, invA, sdiA and sifA.
High Level of Uterine Endocervical Interleukin-8, Matrix Metalloproteinase-8, and Interleukin 1Β as a Risk Factor for Preterm Labor Suwardewa TGA; Suwiyoga K K; Mantik Astawa N; Sutirta Yasa IWP
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

The preterm birth is a birth that takes place on a gestational age between 20–36 weeks and six days. The preterm birth   is the leading cause of neonatal mortality and morbidity. Despite the current treatment procedures, the incidence of preterm birth has not changed in the last two decades. Incomplete understanding of the pathophysiological mechanisms underlying preterm labor is the major obstacle to prevent preterm birth. Recently, endocervical inflammation has been thought as a risk factor of a preterm labor. Several important substances such as endocervical IL-8, MMP-8, and IL-1β, has been considered to play a key role on preterm birth through cervical ripening. With those assumptions, the detection of a higher level of uterine endocervical IL-8, MMP-8, and IL-1β can be used to predict preterm labor. The design of this study is an observational case control study with a case group, which consisted of pregnant women with 20–36 weeks and six days of gestational age who had signs of labor, and the control group consisted of pregnant women with 20–36 weeks and six days of gestational age who had no signs of labor. The material used for this study is cervical mucous, and the enzyme-linked immunosorbent assay method was used to assess the level of IL-8, MMP-8, and IL-1β at laboratory of Veterinary Medicine of Udayana University Denpasar. In this study we used 48 samples, among which 24 were case group, and 24 as a control group. The mean age of the women, gestational age, and parity from both group are (27.04 vs 28.62 years old), (31.8 vs 29.50 weeks), and (0.96 vs 1.29) respectively, which are statistically homogenous (p > 0.05). Each level of interleukin-8, matrix metalloproteinase, and interleukin-1β suggests a risk factor of a preterm labor for: 35 times (OR = 35.00; CI 95% = 6.95–176.39; p = 0.001); 6.6 times (OR = 6.60; CI 95% = 1.25–34.95; p = 0.016), and 8.3 times (OR = 8.3; CI 95% = 2.15–32.3; p = 0.001), orderly. Among these cytokines, one that contributes most through a preterm birth is interleukin-8 (61%), followed by matrix metalloproteinase-8 (27%), and interleukin-1β (12%).Conclusion: Endocervical inflammation with high level of IL-8, MMP-8, and IL-1β is a risk factor for preterm labor. IL -8 gives the most contribution on preterm labor.Keywords: Preterm birth, Endocervical IL-8, MMP-8, and IL-1β.
The Impact of Extraintistinal amobiosis on TP53 Gene in Patients with Hepatocellular Carcinoma Basheer. Abd. Nasralla
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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In this study, 20 serum samples and 8 liver abscess biopsy specimens were taken from 20 hepatocellular carcinoma and E. histolytica infected patients. Laboratory findings of patients with liver abscess showed increased total white blood cell count (WBC), increased C-reactive protein, (AST), (ALT), alkaline phosphatase (ALP), gamma-glutamyl  transpeptidase (GGT) and bilirubin. The result of PCR performed on liver abscess patients was positive for the DNA of E.histolytica infected patients and 8 biopsy liver abscess patients. To detect TP 53 gene in hepatocellular with liver abscess of all 8(100%), mutation occurred in sequences of TP53, and there were changes in several locations on the exons. Nucleotides changes were shown in TP53 gene Exon 147,152,160.203 and 235amplified from tumor liver cancer samples. The mutation occurred on nucleotides TCC, GGT, ACT, CGC and ATC of TP53 gene.Keywords: Extra intestinal amebiasis. TP53 gene, Hepatocellular carcinoma.
Identification and Prioritization of Effective Factors on Increasing the Short-Term E-Learning Systems’ Effectiveness in University Jihad in Khorasan Razavi Abdolali Keshtegar
Journal of Global Pharma Technology .
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Abstract

In the present era, computer and subsequently internet are ones of the main human inventions which led to some great changes in human life that has caused a virtual world and an incentive for universities in order to invest in e-Learning section. But what that makes the importance of discussion clear is making attempt to succeed in using e-learning system and checking these systems’ success rate and unsuccessful attempt for implementing e-learning will cause loss of capital. This research was conducted with the purpose of identifying and ranking the effective elements on increasing the effectiveness of short-term e-learning systems in university Jihad in Khorasan Razavi. Therefore, the components and indicators of e-learning systems’ effectiveness assessment were suggested according to previous studies, then, a questionnaire was provided to the e-Learning learners of the of University Jihad Education Deputy of Mashhad with the aim of identifying the components of measuring the effective factors of e-Learning systems in order to assess the validity and appropriateness of the proposed components and indicators. Collected data of questionnaire was processed by software SPSS and one-sample t-test and Pearson correlation coefficient test have been used to analyze data. Six components were finalized with 26 indicators. The main components respectively include: 1- school characteristic. 2- Information quality.3- Quality of system and infrastructure. 4- Service quality. 5- Support factors. 6- Comprehensive characteristics.Keywords: E-Learning system, E-Learning’s assessment components.
Impact of Pharmacokinetic Parameters Modifications of Tamsulosin Hydrochloride Controlled Release Pellets Palanisamy Vishnu
Journal of Global Pharma Technology Volume 10 Issue 12.
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In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities. There are so many oral delivery systems in that one of the advance techniques is Pellatization. Tamsulosin  controlled  release pellets prepared by pellatization method that the Tamsulosin is coated on inert suger spheres by using non perial seeds as a binder solutions and Hydroxypropylmethylcellose, Ethyl cellose, Eudragit, Triethyl citrate coating agents used for controlled release action. The prepared pellets were evaluated for Moisture content, Acid resistance Assay, and In-vitro drug release study. All the formulation exhibited assay, Moisture content with in the range given in USP. Dissolution studies revealed that formulations containing Eudragit 0.287gms coating agent Hydroxypropylmethylcellose, 0.00312gm of ethyl cellose 0.138gm Showed 100% of drug release, at the 8th hour. The concentration of coating agents Hydroxtpropylmethycellose and Ethyl cellose had an effect on in-vitro drug release had the same drug release profile when compare with US dissolution parameters, and innovator drug release. Thus, the pellets apart from fulfilling all official and other specifications and exhibited higher rate of drug release.

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