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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis and Characterization of Graphene Oxide Nanosheets by Electrochemical Exfoliation Method and its Antibiofilm Activity against Pseudomonas aeruginosa Husam N. Abbas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

In this work, the Graphene oxide (GO) nanosheets were synthesized by a electrochemical exfoliation method. The morphological, structure and optical properties were investigated by using Field emission scanning electron microscope (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy, FTIR and UV-VIS spectroscopy. FE-SEM images of GO nanosheets confirmed the presence of layered structure. The crystalline size and number of layers of GO nanosheets were estimated by XRD analysis.  The UV-VIS spectrum of GO nanosheets shows maximum and shoulder absorption peaks. The oxidation of graphene was confirmed via FTIR analysis by the appearance of functional groups of oxygen. Raman analysis showed the formation of peaks D, G and 2D. The antibiofilm activity of different concentrations of GO nansheets against Pseudomonas aeruginosa (P. aeruginosa) as a model of more antibiotics resistant Gram-negative bacteria was investigated. These results confirm that the GO nanosheets material damages the biofilm of P. aeruginosa. Therefore, It can be considered as an anti-bacterial material.Keywords: Graphene Oxide, Nanosheet, Electrochemical Exfoliation, Antibiofilm, Pseudomonas aeruginosa.
Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole - Five Membered Ring)- Ligands Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

A series of oxadiazole- Azo ligands have been synthesized via  many  steps  sequence. Oxadiazole -azo  ligands   were prepared through   reacting  azo–oxadiazole  derivatives  with phenol  heterocyclic  derivatives  diazotized   then  coupled   via   coupling  reaction  followed  by  cyclization  reaction   to  yield   azo- heterocycles   derivatives   which  act   five  membered  ring. The structures of the newly  prepared    Ligands  were  identified   through  more  than   technique  like (1H NMR, IR and Mass spectra) ,(Thermal ,microbial  assay ) for  all  ligands.Keywords: Oxadiazole, Thiosemicarbazide, Thiadiazol, Cyclization, Azo,Imidazole, Oxazole, Thiazole.
Hepatitis B Virus Surface Antigen Subtype in Positive HBsAg Subjects in Mengwi District, Badung, Bali-Indonesia Made Agus Hendrayana
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Indonesia is a country with a high prevalence of hepatitis B virus infection and can develop into chronic hepatitis in the community. Indonesia is a multiethnic country with a vast territory, so it is estimated that the prevalence of each hepatitis B virus subtype varies greatly in different regions. Sequences in the S region gene encoding amino acids can show hepatitis b virus subtypes through exclusive variations in subtype determinants of HBsAg. This hepatitis B virus subtype is epidemiologically important, because it can show differences in geography and ethnicity in its spread. This study aims to analyze the hepatitis B virus subtype in HBsAg positive subjects in Mengwi, Badung, and Bali-Indonesia. The subjects of the study were 75 patients who came to the Mengwi I Badung Primary Health Center. All serum samples were examined for HBsAg by the ELISA method. In HBsAg positive serum samples, hepatitis B virus subtypes are determined. The DNA is extracted from serum samples that are HBsAg positive. Amplification of portions of DNA S gene from serum HBsAg positive was performed by polymerase chain reaction first-round and second-round. The nucleotide sequence of the hepatitis B virus is converted into amino acid sequences and multiple alignments are performed. The hepatitis B virus subtype was determined by amino acid substitution analysis at positions 122, 127, 134, 159, 160 and 177 in the S gene assisted by using a computer program. The subjects with HBsAg positive were obtained from 11 out of 75 samples (14.7%). The results of hepatitis B virus subtype analysis found that almost all samples, 10 of 11 samples (90.9%) had adw2 subtypes, while one sample (9.1%) had adrq + subtype.Keywords: HBsAg, Subtype, HBV, Mengwi.
The Effect of Dewandaru (Eugenia uniflora L.) Fruits Extracts on Testes Heat-induced Rats Ika Widi Astuti
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Spermatogenesis can run optimally if the testes temperature is 2-8o C lower than body temperature. Higher testicular temperature causes oxidative stress, which results in infertility. The purple-red colour of Dewandaru (Eugenia uniflora L.) fruits have very high of flavonoid. The study aimed to examine the effect of Dewandaru (Eugenia uniflora L.) fruit extract on testis in heat-induced rats. Methods: The study was conducted at Integrated Biomedical Laboratory, Faculty of Medicine, Universitas Udayana between March until July 2019. This True experimental with randomised post-test only control group design consisted of a total of 24 rats. These were divided into four groups, with the group I and II was a negative and positive control. Group III and IV were treatment pre and post heat induction. Lipid peroxidation (MDA) level, Bcl-2, serum testosterone, and testis weight were measured. Data were presented as mean, and one-way ANOVA was used as a statistical tool with significant p<0.05. Result: Treatment with Dewandaru (Eugenia uniflora L.) fruit extract before and after heat induction, respectively showed a decrease significantly in the serum lipid peroxidase level, increase in the Bcl-2 expression, testosterone level, and testis weight. There is no significant difference between treatment pre and post heat induction. Conclusion: This study shows that Dewandaru (Eugenia uniflora L.) fruit extract altered the lipid peroxidase level, Bcl-2, testosterone level, and testis weight.Keywords: Bcl-2, Dewandaru fruits extract, Heat induction, MDA, Oxidative stress, Testosterone, Testis weight.
Correlation of IL-10 Gene Polymorphisms and Serum Level with Hepatitis C Virus Infection in Iraq Hassan M. Naif
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Hepatitis C virus (HCV) infection is a major health problem worldwide where130-150 million people are chronically infected with HCV, which progress to cirrhosis or hepatocellular carcinoma. A total of 120 subjects were recruited to assess the correlation between gene polymorphisms (IL-10-1082 and -819) with the susceptibility to HCV infection in Iraqi patients by using allele specific PCR. The serum level of IL-10 was assessed by ELISA. Gene polymorphism results of IL-10-1082A/G (rs1800896) showed significant increase in AA distribution (P=0.0076) and allele A frequency (P=0.049) among the control group while AG distribution were significantly higher in patients (P=0.0082). Although, G allele frequency had but an association (P=0.049), but the homozygous GG mutant genotype had no significant differences between the two groups. While the genotype analysis of the second SNPs of IL-10-819C/T (rs1800872) showed that neither CC nor CT genotypes distribution were associated with HCV infection (0.1627 and 0.2559, respectively) but the TT distribution and allele frequency had a suggestive association in patients (P=0.0483 and 0.0257, respectively). Results of IL-10 serum levels were higher by two-fold in patients than in healthy controls. It appeared that the IL-10-1082 AA genotype had a protective effect against HCV infection but the TT genotype of -819 mutations had a suggestive association with susceptibility to infection with HCV in Iraqi patients. Such correlation may indicate a protective role for IL-10 and could be used as a predictive risk susceptibility biomarker for progressive infection with HCV. Keywords: Hepatitis C virus, IL-10, Polymorphism, Cytokine, Iraq.
Validating and Validate the Persian Version of International Social Survey Programme Reihaneh Mahallati
Journal of Global Pharma Technology .
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Abstract

The aim of this study was to validate and validate the International Social Survey Program me (ISSP) single significant pride. National pride of economy, politics, art, history of a country known to play a role in the daily lives of individuals and determine their attitude Methods: The study population all male and female high school students in regions 1 and 2 in Yazd second academic year 2014-15 number was 14069. This study was a multi-stage random sampling method. The sample size of 525 patients was estimated by Cohen's table. However, after the removal of incomplete questionnaires and remove data threw a total of 474 participants entered the data were analyzed.This questionnaire measures at both national prides. The first, ISSP in the successes especially proud that the people in the 10 areas assessed The second part of the questionnaire, measures of general national pride and includes 5 components that evaluates the patriotism and sense of national superiority. The reliability of national pride in the success and national pride, especially from 0.72 to 0.81 0.33 to 0.70 along been public Results: Confirmatory factor analysis in this study showed that the test of ISSP in the population has two components Basic pride and pride is special. Public national from 0.33 to 0.70 has been along.Keywords: Validating, International social survey program me, Persian version.
A Security Conceptual On Android Platform for Mobile Health Applications Kanaan Jalal Brakas Kaky
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Mobile Health application are readily accessible to the average uses of mobile devices, and despite the potential of mHealth applications to enhance the availability, affordability and effectiveness of delivering healthcare services, that take care of touchy medical data, or as such, have also the strength to carry enormous gambles according to the safety and privacy concerning their users. Developers on applications are commonly unknown, yet users are ignorant over what their data are animal managed and used. The proliferation of mobile phones together with built-in sensors makes large-scale sensing viable at low cost. During cellular sensing, information hourly includes user-sensitive facts certain as much its real-time location. We analyzed 40 downloaded apps beyond the Google Play save and confirmed that of run-on in accordance with health reasons, the outcomes were 100% successful, certain namely blockading traffic, revealing touchy consumer information, and affecting the heartbeat. Toughness Based on the composition comment that advised the need because the supposed protection framework, three-distinct or according to phases are presented, each concerning which is described among a resolve section. First, discussed the layout system about the preceding segment according to increase a protection frame for m Health apps to ensure the safety or privateness concerning sensitive medical data. The 2nd section is mentioned whoever in accordance with acquiring the implementation concerning a prototypic proof-of-concept version over the framework. Finally, the third segment finish mentioned the comparison procedure of terms on usefulness then efficiency for the proposed framework.Keywords: Mobile Heath, Health Effects, Android Security
Synthesis, Characterization and Spectral Studies of Azo Dyes Ligands Complexes with Some Metal Ions and Their Industrial and Bacterial Application Wedian Mansor Obaid
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

1-[4-(4-Acetyl-2-hydroxy-phenylazo)-phenyl]-ethanone (HL1) and1-[3-Hydroxy-4(4-nitro-phenylazo)-phenyl]-ethanone (HL2) were produced by combination the diazonium salts of amines with 3-hydroxyacetophenone. (C.H.N) analyses, FT-IR, UV-Vis, 1H and 13CNMR spectral are use to identified for the ligands. Complexes for Zn+2,Cd+2 and Hg+2 were prepared as well specified through using atomic absorption of flame, analysis of elements, spectral methods also conductivity quantification. The nature of production complexes were studied continued mole ratio as well continued variance ways, Beer's law followed over condensation scope (1×10-4- 3×10-4)M. High molar absorption for compound solutions have been noticed. Analytical datum showed that in every the complexes offered 1:2 metal-ligand ratios. Depending physicochemical data a tetrahedral geometry were described of the metal chelates. Biological efficacy from compounds has been tested. Other than, dyeing completed of the produced compounds has been workable on fabric of cotton.Keywords: Complexes, azo dyes, microbial activity, dyeing.
Assessment of Mothers' Knowledge upon their Children with Enzyme Deficiency (G6PD) in Pediatric Teaching Hospital at AL-Hilla City/Iraq Abdul Mahdi. A. Hasan
Journal of Global Pharma Technology .
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Abstract

Aims of the study to identify knowledge of mother's toward their children with G6pd. And to find out demographic characteristic of mother's children with G6pd like age level of education. Methodology: 1 .design of the study: descriptive study of mother and child. 2. Setting of the study: the study was carried out of maternal and child Babylon hospital.    3. Time of the study: the study period extended from 20 november2016 to 12 January 2017. Results: Glucose-6-phosphate dehydrogenase (G6PD) regulates production of the reduced form of Nicotinamide adenine dinucleotide phosphate   (NADPH) through the pentose phosphate pathway. G6PD may therefore affect superoxide anion production via vascular NADPH oxidase, which is key in mediating the vascular response to angiotensin II (Ang II). We determined the hypertensive and vascular hypertrophic response to Ang II in G6PD-deficient mice. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy and in Babylon Iraq, is a significant cause of infection- and drug-induced hemolysis and neonatal jaundice. Our goals were to determine the prevalence of G6PD deficiency among Babylon children of different ethnic backgrounds and to identify predictors of G6PD deficiency by analyzing vital signs and hematocrit and by asking screening questions about symptoms of hemolysis. We studied 200 children (100 males and 100 females) aged 1 month to 15 years. We found that the overall prevalence of G6PD deficiency was 15.3% (38.5% in males, 61.5% in females). Mean oxygen saturation, heart rate and hematocrit were not significantly different in G6PD deficient and G6PD sufficient children In conclusion; we determined the prevalence of G6PD deficiency in Nigerian sub-populations. The odds of G6PD deficiency were decreased in Igbo children compared to Yoruba children. There was no association between vital parameters or hematocrit and G6PD deficiency. We found that a history of scleral icterus may increase the odds of G6PD deficiency, but we did not exclude other common causes of icterus such as sickle cell disease or malarial infection. Recommendations Molecular screening for all deficient patient admitted to pediatric hospitals due to hemolytic crises.so establishing and conducting educational awareness programs for G6PD deficiency especially among mother's .and specific clinical follow up program for the deficient children and their families and establishing nationwide program of newborn screening for G6PD deficiency.Keywords: Mother, Knowledge, Effect, Glucose 6 phosphate deficiencies, School age.
Differential Profile of Cytokine TNF-Α, MDA and SOD Level in Sepsis Induced By Cecal Ligation and Puncture Compared with Induced By LPS Dian Samudra
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: The aim of this study is to analyse the differential of TNF-α cytokine profile, MDA, and SOD levels between sepsis-induced in mice by cecal ligation and puncture (CLP) which were then compared with lipopolysaccharide (LPS) injection. Methods: This study made use of experimental animals, 28 mice divided into 4 groups: control (healthy mice), mice model of sepsis due to cecal ligation and puncture (CLP), a group of mice modeled sepsis due to LPS i.p injection of 103 (LPS1) and LPS 105 CFU i.p injection dose (LPS2). Afterward, TNF-α levels were examined using a sandwich enzyme immunoassay technique and calculation of MDA and SOD levels in blood, liver, and kidneys. Results: The results showed that the level of TNF-α cytokines in mice model of sepsis with LPS induction of 105 CFU (LPS2) increased significantly (p <0.05) compared to the sepsis model with CLP (LPS2: 1.11 ng/ml vs 0.34 ng/ml). MDA levels in serums, livers, and kidneys of the experimental animals were also found to increase after LPS induction of 103 and 105 CFU doses. In contrast, SOD levels experienced a significant decrease due to LPS injection of dose 105 CFU in comparison with the CLP sepsis model. Conclusion: This study found that the best sepsis model was the one with LPS induction of 105 CFU doses which was characterized by a high production of TNFα cytokines, excessive MDA levels, and low levels of SOD antioxidant enzymes. By finding the best sepsis model, it can be used for therapeutic needs by targeting the inhibition of TNF-α proinflammatory cytokines and oxidative stress indicators MDA and SOD. Keywords: cecal ligation and puncture (CLP), LPS, MDA, sepsis, SOD, TNF-α

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