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I Wayan Sudarsa
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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Carboxy Methyl Cellulose (Cmc) As Edible Coating to Extend Shelf Life of Duku (Lansium Domesticum) During Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Duku fruit (Lansium domesticum Corr.) is a tropical fruit which contains a variety of nutrients especially vitamins and minerals that are health beneficial. It has a sweet sour taste, fresh, a little seed and has a thin skin. Duku fruit contains several phytochemicals that possess high antioxidant activities. Severe pericarp browning, fruit drop, moisture loss, off-flavor and chilling injury are the predominant problems in harvested longkong fruit during handling and storage. The postharvest handling of duku fruit aims to prolong its quality and value, but it is not yet adequately developed. It is necessary to use postharvest techniques for the extension of duku shelf life. Application of carboxy methyl cellulose (CMC) as edible coating could be considered as a useful approach to maintain its product quality during preservation. Ojective of the present study focused on the effect of carboxy methyl cellulose (CMC) coating on some physicochemical, microbial and sensory characteristics of duku during preservation. Optimal results showed that weight loss, pH, total soluble solids, titratable acidity and ascorbic acid; total plate count; sensory characteristics could be maintained at appropriate levels by coating duku with 1.5% carboxy methyl cellulose (CMC). The present study attempted to investigate some of the most significant findings to extend the shelf life of duku fruit.Keywords: Duku, Carboxy methyl cellulose, Coating, Preservation, Physicochemical, Microbial, sensory
Biological Synthesis and Characterization of Silver Nanoparticles Using Bacillus Subtilis Ayad F. Alkaim
Journal of Global Pharma Technology .
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Abstract

Biological synthesis of silver nanoparticles using Bacillus subtilis was examined and reported. The quick reduction of silver (Ag+) ions was checked using UV-visible spectrophotometers and showed formation of silver nanoparticles within 1 hr. Transmission electron microscopy (TEM) investigation presented that the synthesized silver nanoparticle are 39.6 nm and has spherical shape. Additional the XRD analysis approves the Nano crystalline phase of silver with FCC crystal structure.Keywords: Nanoparticles; Silver; Bacillus subtilis.
The Profile of Blindness Aetiology in Children of SLB/A Denpasar Anak Agung Ayu Sukartini Djelantik
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Blindness in children is one global problem that adressed by the World Health Organization (WHO) to achieve VISION 2020 "The Right to Sight". Blindness also occurs in high prevalence in Indonesia, but study evaluating blindness in childres is rarely conducted. Thus, this study aimed to evaluate and compiled the profile of the etiology factors related to blindess in children in Denpasar, Bali. Method: An cross sectional-obervational analitic study were conducted in SLB / A Denpasar in November 2017 and the data were collected prospectively. The samples of this study were all children in SLB/A Denpasar who met the inclusion criteria. All of the data were analyzed using SPSS 17.0 Result: 37 children were enrolled in this study and consist of 23 (62%) men and 14 (38%) women. Most participants were in the range of 12-14 years old (12 [32%]) followed by 17-20 years (11 [30%]), 9-11 years old (7 [19%]), age 15-17 years (5 [14%]) and age 6-8 years (2 [5%]). According to the visual acuity (VA), the most prevalent eye condition was severe visual impairement (<6/12 – 6/18) with 12 children (32.42%) followed by blindness (VA<3/60) in 11 children (29.72%), moderate visual impairement (<6/18 – 6/60) in 11 children (29.72%) and early visual impairement (<6/12 – 6/18) in 3 children (8.11%). In terms of eye disorder, the most prevalent was ptisis bulbi 5 children (13.5%), followed by leucoma cornea in 4 children (10.8%), nystagmus and microcornea in 2 children (5.4%). The cause of blindness in children in SLB / A was papil atrophy (18.9%), ptisis bulbi (13.5%), and leucoma cornea (8.1%). The congenital cataract with nystagmus and microcornea was found in 4 childen (10.8%) while pseudofakia with PCO was found in 3 children (8.1%). Meanwhile, congenital cataract with nystagmus and microcornea was found in 2 children (5.4%). Conclusion: It can be concluded that the cause of blindness in chlidren in SLB / A were papil atrophy, congenital cataract with nystagmus and microcornea.Keywords: Blind, SLB / A, Visual Acuity, Congenital Cataract, Papil Atrophy.
Determinants of Incident Risk of Acute Respiratory Infection in Infants in Populated City Fitriana Kurniasari Solikhah
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: Acute Respiratory Infection (ARI) was a major cause of morbidity and mortality in infants. ARI was always ranked first of the 10 most diseases in Indonesia. To be able to overcome the spread of ARI, it was necessary to know the risk factors for ARI. The purpose of this study was to analyze the relationship of predisposing factors (education, family income, knowledge, and attitudes), supporting factors (use of health care facilities, ventilation, presence of smokers in the house), driving factors (the role of health workers) with the risk of ARI events recurrent pneumonia in infants. Methods: This type of research was descriptive analysis with a cross-sectional approach. Data collection was done by questionnaire. The population was parents of children under five in the working area. This study used purposive sampling, with a sample of 100 respondents. Data analysis was done by univariate, bivariate with chi-square test and odds ratio. Results: The results showed that the incidence of recurrent Non Pneumonia ARI in toddlers had a significant relationship with knowledge (p-value = 0.017; OR = 0.27, attitude (p-value = 0.003; OR = 0.27), use of health care facilities ( p-value = 0.371; OR = 0.58), ventilation (p-value = 0.028; OR = 0.29), smokers in the house (p-value = 0,000; OR = 7.56), the role of health workers (p-value = 0,000; OR = 0.17). Conclusion: Recommendations need further research to develop a model of prevention of recurrent Non-Pneumonia ARI in infants according to the risk factors of the incident found so that it can.Keywords: Acute Respiratory Infection, Infants, Risk factor.
Synthesis and Characterization of New Derivatives of 1,3-Oxazepine via Cycloaddition Reactions [2+5] of Selected Carboxylic Acid Anhydrides with Azomethines Derived from 4,4'-Methylenebis(3-chloroaniline) Ahmed Khames Ramadan
Journal of Global Pharma Technology .
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Abstract

Number of new derivatives of 1,3-oxazepinewere synthesized by cycloaddition reaction (2+5)  of (NE,N'E)-4,4'-methylenebis (3-chloro-N-(4-halobenzylidene)aniline) with exo-3,6-epoxy-1,2,3,6-tetrahydrophthallic anhydride, tetrachlorophthalic anhydride and citraconic anhydride by refluxing in dry benzene. (NE, N'E)-4,4'-Methylenebis(3-chloro-N-(4-halobenzylidene)anilines)were prepared by thermal condensation of 4,4'-Methylenebis(3-chloroaniline) and p-halobenzaldehydes in absolute ethanol under reflux conditions. The structure of the target compounds were characterized by their spectral data of FT-IR and 1H-NMR.Keywords: Azomethines, Carboxylic Acid Anhydrides, 1, 3-Oxazepine.
A Comparative Anatomical Study among Some Cultivars of Vitisvinifea L. in Iraq Aseel Kadim Al-Anbari
Journal of Global Pharma Technology .
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Abstract

The anatomies of ten cultivars of Vitis in Iraq were studied. leaf  epidermal characters and petiole anatomy, We carried out to the leaf covered with cuticle, Multi cellular spine trichomes are present on abaxial surface on taxa under study, epidermis cells were uniseriate, irregular or polygonal  shaped in both abaxail and adaxial, in abaxial view we can recognize three types of crystals (druses, raphides, and solitary crystals) in all taxa, Hypostomatic leaf  with pentacytic type in most cultivars, but isolated V.v.cv Alajami  and V.v.cv. Behrezi with Anomocytic type. Bifacial leaf with different rate of cortex. There are two vascular bundles small and big, the big vascular bundle divided into three shapes; crescent, U, and Cordate shape. Small bundles isolated according the numbers of bundles were 5-10 bundles. Petioles shape could be separate in the cultivars to Semicircular, Oval and Pear shape.  The epidermis with crystals occur on the epidermal surfaces of all the  cultivars, multicelluertrichomes was founded in the V.v.cv Alajami,  V.v.cv. Behrezi, and,  V.v.cv. Shaida, the  ground tissue which include of several layers of clorenchyma then Varying sizes of parenchyma cells have a huge area of cortex. Vascular bundle in petioles which showed semi complete loop, and separate loop. The data of our study cleary show that epidermal features could be employed to isolated closely related taxa , our finding have been used as veritable taxonomical tool.Keywords:  Vitis, Vitis's cultivars, Comparative anatomy, Iraq's grapevine.
Ergonomic Participatory in Halal Assurance System (HAS) Implementation to Reduce Boredom and Fatigue in Workers in the Sate Bandeng Processing Industry Wahyu Susihono
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Every processing industry that has obtained a halal certificate from LPPOM MUI is obliged to maintain and maintain the implementation of Halal Assurance System (HAS), as well as sixteen halal certified milkfish satay processing industries from LPPOM-MUI Banten Province. However, in general the implementation of HAS-23000 has been carried out, but there are still weaknesses that need to be fixed. This weakness lies in the awareness of meeting the criteria and data updates by the company's internal halal management team. This weakness is due to the fulfillment of HAS that does not concern the human factors that carry out activities in the company. Humans are still considered as a complementary part of the company's business processes, not used as part of the main factors in the implementation of HAS-23000. Ergonomic Participatory Intervention needs to be done to improve employee performance seen from a decrease in work boredom and work fatigue. The subjects in this study were workers in 16 processing industries that were randomly selected; the sample fulfilled the inclusion criteria of the study. The design of this study was experimental research (treatment by subject design). Subjects in 16 processing industries, prior to the ergonomic participatory intervention, the initial observation (group I) was conducted, then the subject became an intervention group (application of ergonomic partitioning) referred to as group II. Result: The results showed that after an intervention in the form of ergonomic participatory implementation in the implementation of Halal Assurance System (HAS) in 16 milkfish satay processing industries, the mean of work boredom in group I was 89.44 ± 4.53 and group II was 65.69 ± 4.69 or decreased 26 , 64%, the average general fatigue in group I was 93.69 ± 10.85 and group II 83.13 ± 12.28 or a change of 11.27%, general fatigue felt by workers in 16 industries there were significant differences after an ergonomic participatory intervention (p <0.05 ), while fatigue in the aspect of activity experienced a change of 5.30%, fatigue in the aspect of motivation experienced a change of 24.38%, fatigue in the physical aspect experienced a change of 12.58%. Fatigue in the aspects of motivation and physical aspects there is a very significant change, but in the fatigue aspect of the activity changes that occur is not significant p> 0.05). Intervention with ergonomic participatory can improve employee performance in halal certified satay milkfish food processing industry, seen from the decrease in the level of boredom and work fatigue (general fatigue, activity fatigue, motivation fatigue and physical aspect fatigue). Decreased boredom also occurs (26.64%), indicating that there has been an increase in employee performance as indicated by an improvement in employee mental perceptions. Improved employee performance shows an improvement in the implementation of the criteria in the Halal Assurance System (HAS).Keywords: HAS-23000, Halal, Participatory ergonomics, Boredom, Fatigue.
The Role of the Mining Company Corporate Social Responsibility and the Issue of the Weda Bay Sea Ecosystem Environmental Health Faisal Faisal; Jamal HI Arsyad; Rusdin Alauddin
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Purpose: This research is aimed to know the management of the Corporate social responsibility carried out by the PT. TEHT in Central Halmahera and also to know how the ideal mining management activity is which is based on environmental management and protection. Method: The method used is the empirical research method using the statute approach and the case approach. Result: The inventarization results of field study are analyzed to obtain the conclusion, then it is analyzed using the integrative and conceptual method of analysis which is courced from the primary and the secondary data. The problem which is analyzed in this research departs from when PT. TEHT disposed ore in the Central Halmahera sea, which directly brings loss to the sea ecosystem of the Weda Bay. This is because the responsibility of a company has direct impact to the social and the environmental activities. It is manifested in the form of behaviors and activities which should be in line with the sustainable development and the social welfare. Also, the legal regulations are integrated with the principle of sustainable environment protection and management. Conclusion: The company should be aware of the social and the environmental health dimensions which become the processing location of the mining materials. The Weda Bay experienced environmental destruction due to mining and it becomes an unhealthy environment.
Study Second Harmonic Generation of KTP Crystal Raad S. Alnaily
Journal of Global Pharma Technology .
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Abstract

In this paper, we tried to investigate to display the performance of the pure single potassium Titanyl Phosphate (KTiOPO3 or KTP) crystal of dimension (6×6×3) mm3 as a distinguished proposal model of second harmonic generation and using CW Nd: YAG laser that has the spectral wavelength 1064nm to generate 532nm. The efficiency of the frequency doubler for Nd: YAG laser by means of this proposed crystal element were satisfied with both arrangements. They was13% one step the nonlinear optical properties as third order, such as the nonlinear refractive index and nonlinear absorption were also measured in this work to indicate on the high nonlinearity optics of this electro-optical material with the infrared and visible wavelengths range.Keywords: - Second harmonic generation, second-order susceptibility χ (2), potassium Titanyl phosphate (KTiOPO3 or KTP), Nonlinear refraction index , Nonlinear absorption coefficient, Third order nonlinear optical susceptibility χ(3).
Technical Aspects Affecting to Jackfruit (Artocarpus Heterophyllus) Beverage Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Jackfruit (Artocarpus heterophyllus) is a tropical climacteric fruit. It is one of the commonly consumed foods in Vietnam. Its fesh in fully ripen stage can be eaten directly as a fruit. Jackfruit contains a wide range of phytonutrients such as carotenoids that can act as antioxidants. The jackfruit fesh is highly perishable and ofen undergoes favour loss, tissue sofening, and cut surface browning. During the jackfruit havesting season, excessive supply of the fruit causes the price of jackfruit decreasing dramatically. This fruit is underutilized in commercial scale processing. Therefore we have our tried to add value to the jackfruit fruit. One method of adding value to fresh jackfruit is processing it into drink. We carried out the investigation of extraction (ratio of water: jackfruit, temperature and time of blanching); juicy mixture; preservation. Our result showed that the jackfruit drink having the best quality when extracting with water: jackfruit pulp ratio (70:30) at 85 oC in 3 minutes. The sample was then cooled to 37°C before the addition of pectinase enzyme at 0.09%. The juice was then incubated in a water bath at 37°C in 30 minutes. After the incubation process, the juice was heated in a water bath at 100°C for 2 minutes to inactivate all enzymes present. The hydrolyzed jackfruit juice will be formulated with sugar 2.5%, citric acid 5%, carrageenan 0.06%. Jackfruit drink shelf-life could be maintained for 12 months.Keywords: Jackfruit, Artocarpus heterophyllus, Beverage, Carrageenan, Pectinase, shelf-life

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