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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 10 Documents
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Search results for , issue "Volume 09 Issue 04" : 10 Documents clear
CLINICAL AND DERMOSCOPIC FEATURES OF SKIN CANCER AT SANGLAH GENERAL HOSPITAL, DENPASAR: A CASE SERIES STUDY Made Wardhana; Nila Puspasari; Prima Sanjiwani; Darmaputra Darmaputra
Journal of Global Pharma Technology Volume 09 Issue 04
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Background: Dermoscopy or epiluminescence microscopy (ELM) is a non-invasive clinical examination technique of pigmented skin lesions and early stage skin cancers.Methods: This was a retrospective study of patients with skin cancer at dermatology outpatient clinic of Sanglah Hospital from January 2013 to December 2014. These patients were firstly assessed with unaided eye before underwent a dermoscopic examination. All diagnoses were confirmed with a histopathology examination.Results: There were 22 patients with skin cancer who enrolled in this study. The study participants were redominantly women (59.1%), age over 50 years (72.7%), working outdoor (90.9%), with the predominantly predominant site being on the face (96%). There were 7 patients (31.8%)  with malignant melanoma and the predominant dermoscopic features were: atypical pigment network (71.4%), blue whitish veil (57.1%) and irregular streaks (57.1%). There were 10 patients (45.5%) with basal cell carcinoma, with the predominant dermoscopic feature being the arborizing vessel (60%) and ulceration (70%). There were 5 squamous cell carcinoma patients (22.7%) and the predominant dermoscopic features observed were keratin (80%) and hairpin vessels (100%). The histopathological examination results were in accordance with the description of dermoscopy featuresConclusions: Dermoscopy is a non-invasive tool for diagnosis of early skin cancer prior to performing a biopsy for histopathologic examination.
The Adsorptive Acid Orange 7 using Kenya tea Pulps Ash from Aqueous Environments Hamed Biglari
Journal of Global Pharma Technology Volume 09 Issue 04
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The control of environmental pollutions specially water resource pollutions is one of the main challenges throughout the world. The discharge of industrial wastewater such as textile industries containing toxic dyes like acid orange 7 has added to this concern. In this research, the adsorption of acid orange 7 anionic dye on the raw fine-grained tea waste modified with an acid and calcined has been investigated through the adsorption method. To achieve this purpose, the adsorbents of fine-grained CTC tea waste were studied in three forms of raw, treated with concentrated phosphoric acid, and calcined at 350, 450, and 500 °C for the adsorption of acid orange 7 with 50-500 mg/L concentrations from the aqueous conditions at pH 2-10 and t 0-120 min using 1-10 g/L adsorbents. The results showed that the best removal yield is about 98% at pH 2 and time 120 using 50 mg/L of dye and 10 g/L of adsorbent, and the modifications have a negligible effect on the improvement of the raw fine-grained tea waste adsorption. The most adsorption capacity (41.66 mg of orange 7 dye) was obtained using 1 g of the adsorbent. Also, the results illustrated that the adsorption pattern is in agreement with the Langmuir and Freundlich isotherm models. The adsorption pattern in the Freundlich model (R2 97%) is slightly more than Langmuir model (R2 85%). According to the granulated structure of tea waste (fine-grained tea) in three forms of raw, acidic and calcined, Kenya is an appropriate and low-cost adsorbent in the adsorption of orange 7 dye from the aqueous media.Keywords: Water pollution, Adsorption, Kenya tea waste, Acid orange 7dye
TRICHOMONIASIS AMONG PREGNANT WOMEN IN DENPASAR CITY, BALI, INDONESIA Luh Seri Ani; IGA Sri Darmayani
Journal of Global Pharma Technology Volume 09 Issue 04
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Objective: This study aimed to investigate the incidence of T. vaginalis infection among pregnant women in the city of Denpasar, Bali, Indonesia and the associated factors. Methods: There were 376 pregnant women who participated in this study. Study participants were selected using cluster sampling method. These pregnant women were then interviewed and tested for T. Vaginalis infection (microscopic and culture). Results: Infection of T. vaginalis was found in 7.4% of the pregnant women. The infection is most likely to be found in pregnant women who have a lower education level, middle-class status and a history of STIs. It is also most likely if they never had any vaginal douching before if they have intercourse ≥3 times per week, use sitting toilets and use river water as their main water source. Type of toilet used, the practice of vaginal douching, and condom usage show a significant association with trichomoniasis among pregnant women (p values were 0.001, 0.002 and 0.000 respectively). Conclusion: Early detection of sexually transmitted infections (STIs), especially T. vaginalis infection, should be performed during prenatal care to avoid the negative effects on pregnancy.Keywords - pregnancy, STI, vaginal trichomoniasis
In Vitro Antibacterial Activity of Essential oil and Ethanolic Extract of Ajowan (Carum Copticum) against some Food-Borne Pathogens Alireza Mohammadzadeh
Journal of Global Pharma Technology Volume 09 Issue 04
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The present study aimed at evaluating the in vitro antibacterial activity of essential oil and ethanolic extract of ajowan (Carum copticum) against some food-borne pathogens.The micro-dilution method was used to study the antibacterial activity of ajowan (Carum copticum) essential oil and ethanolic extracts against some food-borne pathogens (Bacillus cereus, Staphylococcus aureus, Salmonella typhimurium and Escherichia coli ). The ethanolic leaf extract of ajowan against Salmonella typhimurium strain showed the best antibacterial activity, with the lowest minimal inhibitory concentration (MIC) of 50 mg ml-1 and MBC was 100 mg ml-1 for this bacterium and the results of essential oil on all bacteria tested showed that gram-negative bacteria were sensitively. MIC and MBC of essential oil for Salmonella typhimurium were 16 and 32 mg ml-1 respectively and MIC for Escherichia coli was 32 mg ml-1. According to results, the essential oil and ethanolic extract of this plant has antibacterial activity and therefore it could be used as a natural preservative ingredient in food and/or pharmaceutical industries.Keywords: ajowan (Carum copticum), essential oil, ethanolic extract, antibacterial activity 
The Relationship between Sarcoidosis of Intrathoracic Lymph Nodes and Digestive System Diseases: A Comparative Observation A.V. Medvedev
Journal of Global Pharma Technology Volume 09 Issue 04
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Background: The cases of sarcoidosis of intrathoracic lymph nodes often accompanied by various digestive system diseases have not received enough attention in medical publications. Therefore, the objective of this study is to explore the interrelatedness between the development of gastrointestinal disorders and pulmonary pathology. Materials and methods: The study included 79 patients with sarcoidosis of intrathoracic lymph nodes (ITLN), mean age 46.4±0.9, disease duration 6.8±0.4 years. The patients studied were divided into two groups: patients with ITLN sarcoidosis with gastrointestinal (GI) tract diseases, and people with ITLN sarcoidosis with no symptoms of gastrointestinal tract diseases. All patients underwent laboratory and instrumental examination. Results: Diseases of the digestive system were found in 19 patients with ITLN sarcoidosis. Newly diagnosed digestive system diseases were observed in four patients: one patient with duodenal ulcer, three patients with gastroesophageal reflux disease (GERD). Exacerbation of previously diagnosed diseases was recorded in fifteen patients; most often it was exacerbation of chronic gastritis and chronic duodenal ulcer (five cases each), in three patients it was exacerbation of chronic cholecystitis, in two patients exacerbation of chronic pancreatitis and chronic gastric ulcer was detected. Conclusion: The development of gastrointestinal diseases coincides in time with the development of sarcoidosis or occurs under conditions of its treatment. In patients with sarcoidosis who underwent therapy of this disease, gastrointestinal diseases were observed in 55.5% of patients, in patients with recurrent, progressive course of sarcoidosis they were observed 1.4 times more often than in those with steady course of sarcoidosis. Keywords: Sarcoidosis of Intrathoracic Lymph Nodes (ITLN Sarcoidosis) – Gastrointestinal Diseases-Digestive System Pathology.
Isolation and identification of Steroids from Different Parts of Prosopis Cineraria Preeti Khandelwal
Journal of Global Pharma Technology Volume 09 Issue 04
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Prosopis cineraria are a tree of remarkable importance and a rich   source of secondary metabolites. The present study was carried out to investigate   the steroid content   present in the leaves, stem and pods of Prosopis cineraria. The   method of Tomita et al., was used   for isolation of steroids.  The  structure  of  the  isolated  compound  was  established  on  the  basis  of  physical  and  chemical  test   and  spectroscopic  evidences (TLC, IR and  GC- MS). The study concluded   that a single type of steroid Diosgenin was found in all the parts of the selected plant species.Keywords: Prosopis cineraria; Steroids; Diosgenin; Thin Layer Chromatography.
Molecular Analysis of Genetic Elements Responsible for XDR in Highly Successful Pathogen Acinetobacter Baumannii Isolated from Clinical Samples of Iraqi Patients Rawa Abdul Redha Aziz
Journal of Global Pharma Technology Volume 09 Issue 04
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Objective(s): A. baumannii infections have gained attention due to the high number of infected soldiers serving in Iraq and Afghanistan. Current study focus on the phenotypic and genotypic detection of antibiotic resistant genes among Iraqi A. baumannii isolates to classify them into appropriate antibiotic resistant level.Material and methods: Antibiotic resistant genes were screened among 24 A. baumannii isolates collected from Baghdad and Al- Najaf hospitals using different phenotypic methods. Genotypic detection was done using PCR. Results: All isolates showed positive results to recA gene at 425bp. Antimicrobial susceptibility testing revealed 100% resistance towards Ceftazidime, Amoxicillin-clavulanic acid, Ticarcillin-clavulanic acid, and Cefepime. Also, 50% isolates were resistant to Colistin sulphate, while 66.7% isolates were resistant to tigecycline. The MIC test for polymyxin B revealed that 83.3% isolates were resistant to ˃32µg/ml. Results showed 16.7% of A. baumannii isolates was MDR, 70.8% was XDR, and 12.5% of isolates was PDR. Also, 87.5% of isolates were carbapenemase producers; while 33.3% were ESBLs producers. PCR studies showed among 22 antibiotic resistant genes tested, there was 100% and 70.8% for aac(6)-Ib, ant(4)IIb-, and aac(3)-I, respectively. Also, 13% of the isolates were harbored mexX gene. Results showed 50% had rmtD followed by rmtA and rmtF 45.83%. Some of the isolates encode ParC2 and GyrA2 (75% and 91.67%, respectively). The OXA 23 and OXA 51 were detected among 29.17% and 75%, respectively. Conclusion: Current study found most A. baumannii isolates were MDR, XDR, and even PDR pathogens among wound infected patients in Baghdad and Al-Najaf hospitals.Keywards: ESBLs, Modified Hodge test, carbapenemase, Pan drug resistant (PDR), multiple resistant (MDR), extremely resistant (XDR).
The Effectivity of Porous Hydroxyapatite loaded with Gentamycin on Chronic Tibial Osteomyelitis in Rabbit Models Ismail Dilogo
Journal of Global Pharma Technology Volume 09 Issue 04
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Introduction. Osteomyelitis management with debridement, guttering, and systemic antibiotics often do not give satisfactory results due to the inability of antibiotics to reach the infection site. Another method of antibiotic delivery in the form of beads are deemed ineffective as it requires two separate surgeries. Combination of local antibiotics with absorbable porous hydroxyappetite scaffolding  and antibiotic carriers have not been studied. Methods. We conducted pre-test and post-test control group in a rabbit model of osteomyelitis. Ten rabbits divided in control group and the treatment group (n=5). We injected Staphylococcus aureus in the rabbit tibia, forming the osteomyelitis model, and subsequently performed treatment for osteomyelitis. In the control group, we performed debridement and administered ceftriaxone injection for 4 weeks, whereas in the treatment group, we added the combination of porous hydroxyapatite and gentamicin. Afterwards, we performed clinical assessment, x-ray examination, culture, and histopathology.Results. Radiologically, tibia cortical thickening scores improved in the treatment group compared to the control group (p=0.48) as well as histopathological osteomyelitis evaluation score (p=0,009). Clinically, there were improvements in the swelling scores (n=5) of the treatment group compared to control group, but no significant statistically (p=0.053). In culture, there were no significant difference between the two groups (p=1.00).Conclusion. Combination of porous hydroxyapatite and gentamicin as a local treatment of osteomyelitis of the rabbit tibia osteomyelitis models improved radiological and histopathological scores and also clinically compared to existing standard treatment procedures for chronic osteomyelitis
THE COMPARISON OF THE LEVEL OF EXPOSURE TO THE SKIN SURFACE TEMPERATURE AND WORKER FATIGUE IN THE METAL CASTING INDUSTRY INDUCTION KITCHEN SYSTEM; USING ONE-OPERATOR LADLE-KOWI AND TWO-OPERATOR LADLE-KOWI wahyu SUSIHONO; Wahyu wahyu Susihono
Journal of Global Pharma Technology Volume 09 Issue 04
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Ladle-kowi is a liquid steel of tool transportation coming from the induction industry. There are two designs of Ladle-kowi such as; Ladle-kowi designed to be operated by one-operator weighing at 15 kg and Ladle-kowi operated by two-operator weighing at 50 kg. Diverse design drafts of Ladle-kowi affect the differences in physical and mental burdens received by every worker. Up to now, the use Ladle-kowi in the metal casting industry of induction system has become a necessity that functioned as a tool for the transport and distribution of liquid steel into the molds. Problems faced by many workers are on the selection of ladle-kowi which will affect the physiological condition of the human body in the form of exposure and fatigue on peripheral skin surface temperature. Human nature has the ability, skill and limitations of laboring which has not been used as a parameter for determining comfortable and safe working conditions. This study aims to determine the level of exposure of the skin surface temperature and the level of fatigue which is then used as the basis of proposals to improve working conditions and serve as the basis of recommendations for a more convenient and safe Ladle-kowi usage. The subjects in this study was workers in the metal casting industry using the facility in the form of Ladle-kowi with one-operator with a capacity of 15 kg filled with molten steel and Two-operator Ladle-Kowi filled with liquid steel capacity of 50 kg. This study belongs to the category of taxonomic research in the form of cross sectional analytic. Subjectsw were randomly selected from all workers in the metal casting industry of induction system. Samples taken were 14 people who have been taken and met the criteria for inclusion and exclusion. The results showed that exposure to the skin surface temperature is lower (0,03OC) than when workers used one-operator ladle-kowi compared with workers using two-operator ladle-kowi. There is a strong positive correlation patterns of exposure time to the degree of exposure to the skin surface temperature. The mean score of fatigue in general when using one-operator ladle-kowi is 97.25 ± 10.75 consisting of activities fatigue by 32.67 ± 4.78, motivational fatigue by 33.50 ± 5.58, and physical fatigue by 31.08 ± 6, 10, while the mean score of fatigue in general when using two-operator ladle-kowi reached 93.58 ± 10.25  consisting of activities fatigue by 29.33 ± 2.00, motivational fatigue by 31.83 ± 6.14, and physical fatigue by 32,42 ± 5.35. Only in aspects of activities fatigue, they experienced the highest fatigue differences of 10.20% (p <0.05) using one-operator ladle-kowi than to using the two-operator ladle-kowi. Conclusion: The use of one-operator ladle-kowi is better when compared with the use two-operator ladle-kowi, seen from the level of exposure of the surface temperature of the skin, but two-operator ladle-kowi is better when compared to using a one-operator ladle-kowi, seen from the average value of general fatigue (down 3.77%). One-operator ladle-kowi needed improvements in the form of a  working re-organization so that workers' fatigue can be lowered, while the to operators ladle-kowi required the addition of a shield mounted on a frame ladle-kowi to reduce the radiated heat of molten steel
Bio-Adsorption of Aniline from Aqueous Solutions using Activated Raw Sludge Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 04
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Aniline is a simple aromatic ring compound with wide application in several industries. Since it is soluble and highly toxic, aniline is threatening to human and environment and can disturb aqueous species life. Aniline also has mutagenic and carcinogenic properties. The aim of the present study was to eliminate aniline from aqueous solutions by the use of activated raw sludge. In this experimental study, the efficiency of activated raw sludge in eliminating aniline along with the impact of other influential variables such as pH (3, 5, 7, 9, 11), contact time (0-120 minutes), adsorbent dose (0.2, 0.4, 0.6, 0.8, 1.5 mg/L) and aniline initial concentration (10-250 mg) was investigated. Adsorption isotherm was assessed using Freundlich and Langmuir isotherms. The results indicated that the maximum efficiency of activated raw sludge in eliminating aniline was 80% which was achieved at the optimum condition of pH 11, contact time of 30 minutes, 0.2 mg/L adsorbent dose and aniline initial concentration of 200 mg/L. In addition, isotherm data showed the most fitness into Langmuir adsorption model (R2 0.990). Therefore, activated raw sludge possesses a high capacity to eliminate aniline from aqueous solutions and chemical industry wastewater.Keywords: Aniline, adsorption, sludge, adsorption, isotherms, Langmuir 

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