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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 64 Documents
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Search results for , issue "Volume 10 Issue 07: (2018) July 2018" : 64 Documents clear
A Study of Chemical Composition for Muscles in two Species of Marine Teleosts Fishes: Hilsa Shad, Tenualosa Ilisha and Gizarred Shad, Nematolosa Nasus Akeil Jameil Mansour
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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A comparative study was conducted on the chemical composition for muscles in two types of marine teleosts species; Halsa Shad, Tenualosa ilisha (Hamilton, 1822) and gizzard shad, Nematalosa nasus (Bloch, 1795). The study samples were collected from the Faw market in southern Basra - Iraq between November - 2017 and December - 2018. The results showed a difference in the chemical composition for muscles of the studied fish. Moisture content had high averages ranged between 69 - 71% while there were few averages of ash content which ranged between 1.64-1.99 % . Protein content ranged between 15.98 - 18.90 % while fat content ranged between 7.35-12.05% in the studied species. The results showed significant differences (P < 0.05) in the protein, fat and moisture content between the studied species, while the differences were not significant (P > 0.05) when analyzing the results of ash content statistically. Keywords: Hilsa shad, Gizzard shad, Fish muscles, Chemical composition.
Assessment of Health Protective Behaviors among Patient with Thalassemia at the Women's and Children’s Hospital in Al-Muthanna City Radha M. Lefta
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Background: Thalassemia is one of the most common disorders in the world, mostly in the region located around and nearby the Mediterranean Sea. People who are under 30 are most likely to have this disease and that's because of short life expectancy for thalassemia patients, due to life threatening complications and possibly the lack of health protective. Objectives: The study aimed to identify the health Protective behaviors through utilization (Nutrition, Drug, follow up, and Socio-Psychology) domains and to determine correlation between overall health protective behaviors and demographics data. Methodology: The study design a quantitative research by a descriptive study, the sampling it is non-Probability "purposive" sample  was conducted on 70 people with Thalassemia at the Women's and Children’s Hospital in Al-Muthanna City for the period from September 7, 2016 to February 16, 2017. A questionnaire it has used as a tool of data collection to fulfill the study, which consist of three parts, include demographic characteristics, medical history, and the health Protective behaviors. A content validity, which is carried out through 13 panels of experts .A panel of experts determines validity, while reliability use split half. A descriptive and inferential statistics are used to analyze the data. Results: The study indicates that the majority of patients have major thalassemia of the study sample are 60% and most   are male. The study sample are most age 5-10 year within age groups  (37.1%) with limited and average income its mild 54%. The study results indicate for assessment for health behaviors health follow-up and levels of drug use is inadequate. The study results depict that there is a significant between overall health protective behaviors and gender. Conclusions: The Study Sample conclusions have inadequate in health protective drug and follow-up domains due to inability to payment the cost of healthcare services because the majority of the study sample is income mild. Recommendations: To establish educational and awareness campaigns for patients and their patients about Thalassemia and to confirm the role of the nurse in actively participating in the guidance of patients.Keyword: Health Protective Behavior, Thalassemia, Drug use, Health follow-up.
GENTAMICIN MODULATES THE GENE EXPRESSION OF HLA IN METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS BIOFILM Nihad Taha Mohammed Jaddoa; Harith Jabbar Fahad Al-Mathkhury
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Objective: The present work was undertaken to investigate the impact of sub inhibitory concentration of gentamicin on hla gene expression in methicillin resistant Staphylococcus aureus isolates. Methods: The bacterial isolates used in this study represent 33 MRSA strains, previously isolated form patients visiting several hospitals in Baghdad. Gentamicin, vancomycin, and oxacillin MIC were determined using broth dilution method. Microtiter plate method was adopted to investigate the biofilm forming capacity. Alpha hemolysin was detected by culturing MRSA isolates on rabbit blood agar. Furthermore, hla gene was detected in MRSA isolates using conventional PCR technique; while, qRT-PCR method was performed to assay the hla expression in planktonic and biofilm cells in presence and absence of gentamicin. Results: the present results demonstrated that 12 (36.36%) isolates were gentamicin-resistant; whereas, all isolates were resistant to oxacillin and sensitive to vancomycin. Out of 33 MRSA, 3, 23, and 7 isolates formed a weak, moderate, and strong biofilm, respectively. Phenotypically, 30 isolates produced alpha hemolysin on rabbit blood agar plates; nevertheless, hla gene was located in 29 isolates. Of considerable interest, the addition of gentamicin significantly (P < 0.05) reduced the hemolysis activity; while, insignificant fold change (less than two) of hla gene was observed in all tested isolates in the presence of sub MIC of gentamicin (16 µg/ml). Conclusion: gentamicin upregulated the hla gene expression in biofilm cells; hitherto, this increment was isolate specific.
Effect of Carrageenan as Edible Coating on Storage of Manilkara Zapota Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Manilkara zapota fruits which belong to the family Sapotaceae have been widely cultivated in Vietnam. Immature fruits are hard, gummy and rich in tannin (astringent), while the ripe fruits are soft and, juicy, with a sweet taste and an attractive orange color, which makes them a wonderful dessert fruit. The pulp is sweet and melting. They are normally consumed fresh. Manilkara zapota is a climacteric fruit that ripens shortly after harvest. Objective of this study focused on the carrageenan edible coating affected to weight loss, protein, total soluble solid, vitamin A and vitamin C Manilkara zapota fruits. Different concentrations of carrageenan (0%, 0.5%, 1.0%, 1.5%, and 2.0%) were examined. Results demonstrated that Manilkara zapota fruits which were coated with 1.5% carrageenan could prolong Manilkara zapota shelf-life until 15 days of preservation. So the use of carrageenan coating was one promising method to improve stability of Manilkara zapota fruits during storage.Keywords: Manilkara zapota, Carrageenan, Coating, Shelf-life, Preservation, Stability.
Evaluation of Lipid Profile and Cytogenetic Disturbance in Hypertensive Patients Tayseer Shamran Al-Deresawi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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In the purpose of studying the differences between normal and hypertensive people, this study was focused on estimating these differences using lipid profile and cytogenetic effects. To initiate this process, sampling of blood from 33 patients and 25 healthy individuals of 3 different age categories was performed in Al-Zahra Teaching Hospital and Al-Karama Hospital in Wasit province, Iraq. These blood samples were subjected to measuring cholesterol, triglycerides (TG), HDL, and LDL. Moreover, blood lymphocytes were employed to visualizing certain cytogenetic disturbance indicators such as mitotic index (MI), nuclear division index (NDI), and Micronucleus (MN). When looked at patient group, the results identified significant (p˂0.05) differences between groups revealing increases in all the tested lipids except decreases in HDL. In case of cytogenetic effects, significant increases (p˂0.05) were seen in the MI, NDI, and MN in all patients at all ages. Here, the results indicate important role of blood hypertension in having specific lipid profile and most importantly the changes in the activity of the cells to increase unwanted proliferation.Keywords: Blood Hypertension, Lipid Profile, Cytogenetic.
The Prevalence of Tooth Wear in the Adult Population TONG MINH SON
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Objective: To evaluate the prevalence of tooth wear in the Vietnam adult population in different age groups, for both genders, in different socioeconomic classes, and for different types of teeth. Methods: A total of 800 patients of either gender, ages 18 – 60 years were placed into group A (acid-directly exposed) and group B (acid-indirectly exposed). We recorded the prevalence and severity of tooth wear (TW). TW was measured clinically by Smith and Knight Index. This study included a dentine hypersensitivy (DH) testing device (Yeaple Probe) in addition to the current visual analog scale (VAS) methods of dentine hypersensitivy testing.  Results: A total of 400 patients of group A, out of which 366 patients were diagnosed with tooth wear giving an overall prevalence of 91.5 %. In group B a total 400 patients were investigated out of which 344 (86.0 %) patients showed signs of tooth wear. From a total of 32247 teeth (400 faces) examined 4677 (14.5 %) showed dentine hypersensitive on tooth surface in group A. In group B total 32460 teeth (400 faces) were investigated out of which 1720 (5.3 %) teeth showed signs of dentine hypersensitive. Conclusion: Tooth wear is the prevalent condition in this population. Further investigations and continuous follow-up of cases may allow the mapping of the relationship of biological factors with the occurrence of tooth wear.Keywords: Tooth wear, Dentine hypersensitive, Visual analog scale.
Difference in Sodium and Potassium Reading by Blood Gas Analyzer and Electrolyte Analyzer at Sanglah Hospital Denpasar, Bali, Indonesia Anak Agung Wiradewi Lestari; I Putu Sidhi Rastu Karyana; I Nyoman Wande
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Introduction: Electrolytes measurement is a standard procedure in medical practice to diagnose diseases or disease-related complication. Recently, there is a various device used to analyze blood electrolytes, but the difference accuracy between devices is a problematic issue for clinicians. Thus, we evaluate the differences of sodium and potassium concentration reading by Blood Gas Analyzer (BGA) and Electrolyte Analyzer at Sanglah Hospital to assess whether the difference could be accepted according to Clinical Laboratories Improvement Amendments (CLIA). Methods: A cross-sectional analytic study was conducted in May 2017 at Clinical Pathology Laboratory of  Sanglah Hospital, Denpasar. 30 subjects were enrolled consecutively during the study period and the blood samples were analyzed by both BGA and electrolyte analyzer. The data were analyzed using paired T-Test, Bland-Altman Plot, and Linear Regression. Result: The mean of sodium and potassium measured by BGA were 133.76 ± 5.68 mmol/L and 3.14 ± 0,86 mmol/L, respectively while electrolyte analyzer was 136,43 ± 6,48 mmol/L and 3,51 ± 0,9 mmol/L, respectively. Mean difference between sodium and potassium were 2.67 mmol/L (P=0,000) and 0.36 mmol/L (P=0,000), respectively. Bland-Altman plot analysis in sodium and potassium showed that the limit of the agreement was at -9.9 to 4.56 mmol/L and -1.28 to 0.56 mmol/L, respectively. Conclusion: There was a significant difference between BGA and electrolyte analyzer reading with BGA has higher acceptance level compared to electrolyte analyzer.Keywords: Natrium, Kalium, Blood Gas Analyzer, Electrolyte Analyzer.
Synthesis and Characterization of Zinc Sulphide (ZnS) Thin Film Nanoparticle for Optical Properties Abdullah Hasan Jabbar
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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ABSTRACT. In this paper, we studied the synthesis and optical features of non-conventional energy have led us to this work. Neat Zinc sulfide (ZnS) powder was hired for synthesizing ZnS thin films. 0.5 µm thickness thin films of the ZnS was deposited by a thermic volatility system onto oxidized Si substrates at the cool temperature (T cold = –50ºC) and at the temperature (T ambient = 25ºC). An individual substrate possessor with a thermo-electric cooler was used to cool the substrates, these deposited ZnS thin films were subjected to air annealing at temperatures 100 oC, 200 oC and 300 oC for one hour in a furnace. ZnS synthesis by precipitation technique. UV-Vis spectroscopy and (SEM) scanning electron microscopy used for the study of optical features. Optical features of ZnS thin films were perfected by measuring the absorbance of ZnS films on glass substrates in the range of wavelength 200–900 nm by subtracting the glass substrate as a reference. ZnS thin films used for optical applications.
Immunohistochemistry Detection Method of Rejection Reaction of Human Umbilical Cord Derived Mesenchymal Stem Cell on Rat Sciatic Nerve Tissue Ria Margiana; Ahmad Aulia Jusuf; Silvia Werdhy Lestari
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract:Human umbilical cord derived mesenchymal stromal cells (UC-MSCs) that are accessible from cell banks can be actuated to separate into different cell sorts, accordingly making them handy potential hotspots for cell-based treatments. In injured peripheral nerves, Schwann cells (SCs) add to useful recuperation by supporting axonal recovery and myelin remaking. Here, we first exhibit a framework to induce UC-MSCs to separate into cells with SC properties (UC-SCs) by treatment with β-mercaptoethanol took after by retinoic corrosive and an arrangement of particular cytokines. The UC-SCs are morphologically like SCs and express SC markers, including P0, as evaluated by immunocytochemistry and converse interpretation polymerase chain response. Transplantation of UC-SCs into transected sciatic nerves in grown-up rats improved nerve recovery. The viability of UC-SCs for axonal recovery was tantamount to that of legitimate human SCs taking into account histological criteria and useful recuperation. Immunohistochemistry and immunoelectron microscopy additionally showed myelination of recovered axons by UC-SCs. These discoveries demonstrate that cells with SC properties and with the capacity to bolster axonal recovery and reproduce myelin can be effectively actuated from UC-MSCs to advance practical recuperation after peripheral nerve injury. This framework might be pertinent for the advancement of cell-based treatments.
Sequencing of Zona Pellucida 4 (ZP4) Gene in Patients with Polycystic Ovary Syndrome Infected with Toxoplasmosis Hanaa N. Abdullah
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Polycystic ovary syndrome  is an endocrine disorder in women which leads to reproductive and metabolic abnormalities. The zona pellucida 4 gene is a glycoprotein which is a part of the extracellular matrix of an ovum. Twenty blood samples were taken from women with PCOS. Also, 20 blood samples were taken from the infected women, polycystic ovary with toxoplasmosis and healthy women groups. Whole blood samples were used to perform a polymerase chain reaction, while was ELISA used to measure Anti- Toxoplasma IgG antibody levels in the sera of both the studied and control groups. The biochemical test was used to determine the follicle-stimulating hormone, luteinizing hormone, and Testosterone.  There is a highly significant difference regarding the levels of anti- Toxoplasma IgG antibody among PCOS patients who were infected with Toxoplasma gondii (1.5865±.42295), Toxoplssmosis control group (1.4097±.46171) and healthy control (6380±.33308). The hormones levels of PCOS showed a highly significant difference (P<0.01) FSH; (22.260±3.8692) compared with healthy control (8.362±1.1149) and Toxo. Control group LH; (32.080 ±2.7523), compared to Toxo. Control group (9.939±1.3910) and healthy control (9.445±1.8159) and Testosterone; (2.0470±.55663) compared to Toxo. The control group (.6580±.13575) and healthy control (.6365±.12512) respectively. Single nucleotide polymorphism T6235C indicated that T to C conversion was observed at nt 6325 in the ZP4 gene, and this evolution was experiential in one PCOS. This SNP is a synonymous substitution, which occurred in the fifth position of the proline codon, changing the codon ATA to ACA.

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