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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 04." : 74 Documents clear
Efficacy of Edible Coatings on Enhancing the Shelf-Life of Fresh and Frozen Tilapia (Oreochromis niloticus) Fish N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Tilapia (Oreochromis niloticus) is generally processed to fresh and frozen fillets for domestic consumption. Deterioration of fish quality in refrigerator storage has great impact on the nutritious value of fish and the health of consumers. Freezing and cold storage is an efficient method which preserves taste and nutritional value. Glazing is a process used to reduce undesirable drying or dehydration of fish during frozen or cold storage. Objective of the current research studied the feasibility of edible coating in maintaing and preserving the chemical, microbial and sensory attributes of fresh and frozen tilapia fillet. The fresh and frozen tilapia fillets were treated with different formulas (N0: control; N1: 1.5% w/w chitosan and peracetic acid; N2: 1.5% w/w chitosan and gelatin; N3: 1.5% w/w whey protein isolate and ethanol; N4: 1.5% w/w xanthan gum). The chemical quality was based on the analyzed results of ammonia (µNH3/g) and pH; biogenic amines such as putrescine (mg/kg), cadaverine (mg/kg), histamine (mg/kg), spermine (mg/kg), spermidine (mg/kg); lipid oxidation or malondialdehyde value (mg/kg); microorganism such as Total plate count (cfu/g), Enterobacteriaceae (cfu/g), Coliform (cfu/g), E. coli (cfu/g), Staphylococus (cfu/g), Listeria (cfu/g), Salmonella (cfu/g), Vibrio (cfu/g); sensory score. All treated fresh tilapia fillets were tested after 21 days of cool storage (4oC). All treated frozen tilapia fillets were tested after 12 months of cold storage (-18oC). Results revealed that the incorporation of 1.5% w/w chitosan and peracetic acid could inhibit microbial spoilage and lipid oxidation and therefore maintain the freshness of tilapia fillet for 21 days at 4oC and 12 months at -18oC storage. The study indicated that the combination treatment with edible coating could be commercially utilized to maintain the freshness and prolong the shelf‐life of fresh and frozen tilapia fillet effectively.Keywords: Frozen, Tilapia fillet, Chitosan, Peractic acid, Gelatin, Whey protein isolate, Ethanol, Xanthan gum.
The Alteration of SNAIL2 and MMP-9 Protein Expression of JEG-3 Choriocarcinoma Cell by Methanolic Extract of Tamarindus Indica Fruit Candra Rini Hasanah Putri; Sutiman Bambang Sumitro; Setyawati Soeharto; Karyono MIntaroem
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: Tamarindus indica is one of the famous natural plant that has various effects on health. Recent research has begun to examine the effect of Tamarindus indica on cell malignancy. One of the things that happens in cell malignancy is an increasing ability of cell migration, which is characterized by increasing expression of Snail2 and MMP-9. This study was conducted to determine the effect of extract of Tamarindus indica Fruit Extract (TIFE) towards Snail2 and MMP-9 expression in JEG-3 cells.Methods :.TIFE were extracted by using methanol. JEG-3 cells were grown in culture medium treated with TIFE (at 0, 25, 50 and 100 µg/ml). Immunofluorescence staining was carried out, and observed under Confocal Laser Scanning Microscope.Result: Snail2 expression after treatment with TIFE 50 and 100 µg/ml higher than control- (P=0.015 ; P=0.001) whereas at MMP-9 expression there was a biphasic pattern, in which the MMP-9 expression peaked at concentration of 50 µg/ml (P=0.002), then MMP-9 expression decreased at 100 µg/ml concentration. Conclusion : The expression of Snail2 influence MMP-2 expression after treat with TIFE, so it might increase the potential for JEG-3 cell migration Keywords : Methanolic extract, Tamarindus indica, Snail2, MMP-9
Giant Cell Tumor of the Right Distal Radius Campanacci Iii Treated with Wide Excision and Space Filler Using Prefabricated Polymethyl Methacrylate (Pmma) Bone Cement: A Case Report Magetsari R
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

ABSTRACT Background: Giant cell tumor of bone (GCT) is the most common benign aggressive primary bone tumor (metastatic rate less than 5% of cases). The hallmark appearance of GCT is an expansile lesion which is centrally radiolucent with formation of a thin neocortex at the border of the lesion (epiphysis and metaphysis). Campanacci grade is the classification system for giant cell tumors. Grade I tumors are confined within the cortex, grade II expand to cortex, and grade III perforating cortex with higher incidence of recurrence and transformation into malignancy. Functional outcome of the wrist joint was evaluated using Mayo wrist score (pain intensity, functional status, range of movement, and grip strength).Case Report: A 39 years old male presented lump in his right wrist joint since 6 months ago. The patient complained of decreasing range of motions and palpable mass that increase progressively over time. Slight pain was also felt around the wrist joint. He sought traditional (masseuse) therapy for the last 6 months, but the complaint persisted. He then underwent operation (tumor excision and augmented graft) in our institution. The graft was made from PMMA bone cement and designed identically similar to distal part of the patient’s radius. Histopathologic analysis was consistent with Giant cell tumor. We evaluated patient’s functional outcome using Mayo wrist score, with satisfactory result.Discussion : Most common method of replacing distal part of radius after excision of GCT was grafting using proximal fibula or ceramic prosthesis. There has never been a published clinical trial of using PMMA as a space filler. Nonetheless we used prefabricated PMMA bone cement based graft to mimic the bone in order to prevent the risk of recurrence and to achieve good functional outcome. We took the measurement of the patient’s left radius using X-ray as a model, then fabricate the PMMA bone cement in the Anatomy laboratory according to the model’s measurement. Although it’s not a popular method, but after 6 months of follow up satisfactory functional outcome was achieved (Mayo wrist score) and without sign of recurrence or metastatic.Conclusion: After excision of the GCT, prefabricated PMMA bone cement could be considered as one alternative of space-filling material to achieve good functional outcome.Keywords : Giant cell tumor, Radius, Excision, Bone Cement, Polymethyl Methacrylate, Graft
Synthesis, Spectral and Antibacterial Studies of New 1-(4-Antipyrine azo)-2-hydroxy-3, 6-Disulphonic Acid Sodium Salt with Group IIB Metal ions Alyaa Khider Abba
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

A series of IIB group metal complexes have been synthesized from new azo ligand derived from 4-amino-antipyrine and 2-hydroxy-3, 6-disulphonic acid sodium salt. The structural features have been done on the basis of metal content C.H.N analysis, molar conductance measurement, FT-IR, UV-Vis and HNMR spectral studies. The natures of the prepared complexes were studied according to the Jobs method and Mole ratio method after fixing the optimum condition of pH and concentration. Beers low obeyed over a concentration range (1×10-4 -3×10-4) M .The stability constant of the complexes and Gibbs free energy have been conformed. The antibacterial studies were also studies.Keywords: azo dye, 4-aminoantipyrine, Spectral studies, Antibacterial studies.
Pattern and Characteristic of Sports Related Injury in Emergency Department Sardjito Hospital Andreas Wahyu Wicaksono
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective. Sport activites have been encouraged to everyone due to its benefits to the physical fitness, improving the endurance, and has psychological good impacts. But, sport activites also carries risk of injury to the body. Sports-related injuries are not an uncommon cause of ED visit. The aim of this study was to identify the pattern and characterize emergency department (ED) visits that result from sports-related injuries across the Sardjito Hospital.Methods. The study took place retrospectively observational study over a period of two years from January 2014 to December 2015 and included people 3 years of age or over. Any patient presenting with an injury attributable to participation in organised sport had their details and phone number noted in the medical record form by the orthopaedic resident. The patient medical record were analysed retrospectively. Demographic trends, pattern and characterstic for each patient were recorded.Results. A total of 133 elligible patients were enrolled to this study, 98 were male with the mean of age was 17.5. The most common type of sport that cause of injury was cycling (22.6%), followed by running (21.8%) and then football (17.3%). The majority of the patient sustained upper extremity injury (75.9%). 108 patients sustained fracture, 15 dislocation, and 10 soft tissue injury. There was statistical differences between type of injury as compared with age group (p = 0,000), the age group of <10 years old, 11-20 years old, 31-40 years old and >40 years old suffered more fracture than dislocation and soft tissue injury. There was statistical differences between type of injury as compared with injured extremity (p = 0.03), the injury mostly affected superior extremity, but there was no statistical difference between type of injury as compared with type of sports, gender and side of injury (left or right) (p > 0.05). Conclussions. Sports can cause musculoskeletal injuries, good preparation must be taken to avoid severe injury. High percentage of upper extremity injury and lower extremity injury, the specific type and location of injuries of each sport should be known by health professionals.Keyword: sport injury, emergency department, age group, gender, location and types of injuries
Evaluation of the Bacterial Contamination of Well Waters and the Effects of Leaf Plant Extract of Melia Azedarach on Such Contamination Saba Riad Khudhaier Al-Taei
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

This work has been conducted to examine bioactivity of certain species of bacteria in well water samples collected from eight wells in Yusufiyah area southern Baghdad and to assess the effects of plant leaf extraction of Melia azedarach on these bacteria. Bacteriological properties such as total plate count cfu/ml, MPN/1.ml, Fecal Coliform, Fecal Streptococci, E. coli and Pseudomonas aeruginosa of well water samples have been evaluated in July and January 2017. Total numbers of bacteria in July was varied from 210 to 6070 CFU / ml while the total numbers of bacteria in January was ranged from 115 to 1300 CFU / ml. The local and international specifications MPN reached the upper limit for the preparation of the total coliform count in a manner most likely CFU / ml> 1600 (MPN) and have a minimum CFU / 900ml in July but in January, it has reached the upper limit of the number of total coliform manner that count the most likely CFU / 100 ml> 1550 (MPN) and minimum CFU / 100 ml 100 hence conclude that 87.5% of water wells in July and January. Well waters indicators fecal coliform bacteria and E. coli and fecal Streptococci contamination. However, the contamination with fecal coliform bacteria was considered as an acceptable because they are not exposed to any type of chlorination before consumption by users. The dried plant leaves of the Melia azedarach were extracted by using methanol alcohol and the bioactivity of this extract was evaluated with isolated bacteria. The results have showed that the effects of the extract depend on bacteria species and the extraction concentration used. However, it was found that the extract had significant bioactivity on bacterial contaminated water and such ability of methanol alcoholic extract may be due to the content of steroidal, phenols and tannins compounds in the examined plant leaves being very effective against microbes.Keywords: Bioactivity,   Melia azedarach, Extraction, Bacterial contamination, Well water.
Effects of Binahong (Anredera Cordifolia) Leaf Ethanol Extracts on Blood Glucose Levels and Pancreas Histopathology in Hyperglycemic Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: The use of binahong leaf has been carried out for medical purposes for centuries. Severalstudies have shown that binahong contain alkaloids, saponins, tannins, glycosides, and terpenes,which can be known to have effects to reduce blood sugar levels. Objective: This study to determinethe effect of binahong leaf ethanol extract in reducing blood glucose and histopathological change inhyperglycemic rats. Method: This study was an experimental study using Wistar rats that weredivided into five groups. The normal group was given with distilled water (P0), the positive controlgroup received glibenclamide (P1), and intervention group was given orally binahong leaf extract ofethanol with a dose of 10mg/kg (P2), 15 mg/kg (P3) and 20 mg/kg (P4). Blood sugar level wasevaluated from the initial day of measurement to two weeks. Pancreas tissue was obtained toevaluate the histopathological change. Results: Mean blood sugar level in each group respectively94.28±6.19 mg/dL, 133.61±47.05 mg/dL, 117.56±26.73 mg/dL, 124.77±37.05 mg/dL, and 136.57±47.55mg/dL. The result of Kruskal-Wallis test was p=0.011. Multiple comparison test showed significantresult between P4 with P0 (p=0.011). Conclusion: Binahong leaf ethanol extract with a dose of 20mg/kg significantly reduce blood glucose level in the hyperglycemic rat.Keywords: Binahong, Anredera cordifolia, Blood glucose, Hyperglycemic rat.
Different Parameters Affecting to Rhodomyrtus tomentosa Wine Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Fermentation is a relatively efficient, low energy preservation process which increases the shelf life, and decreases the need for refrigeration or other forms of food preservation technology. It is, therefore, a highly appropriate technique for use in developing countries and remote areas where access to sophisticated equipment is limited. Rhodomyrtus tomentosa plays an important holistic role in the daily lives of several ancient cultures, providing medicinal benefits. There is limited study mentioning to processing of this nutritional fruit. Therefore we explored a wine fermentation from Rhodomyrtus tomentosa by focusing on the effect of different parameters such as pectinase concentration and time of treatment for juice extraction, yeast inculate for wine fermentation, fermentation temperature and secondary fermentation to wine quality. Our results proved that 2.5% pectinase was used for juice extraction in 40 minutes, 2.5% sacchromyces cerevisiae was used for the main fermentation at 29.5oC in 15 days, and 6 weeks of aging in dark bottle at 10.5oC was enough to get a pleasant Rhodomyrtus tomentosa quality. Using Rhodomyrtus tomentosa having medicinal and nutritional value as a substrate for wine production, the health benefits of them can be improved widely.Keywords: Rhodomyrtus tomentosa, Wine, Pectinase, Fermentation, Sacchromyces cerevisiae, Aging.
Post-Spinal Anesthesia Hypotension during Cesarean Delivery, A Review Ghalib J Al-asadi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Maternal hypotension is a common complication after spinal anesthesia for cesarean delivery. Prevention and treatment of post-spinal hypotension (PSH) in cesarean delivery has been frequently investigated. Fluid loading is superior to no-fluid regimen; however, the incidence of PSH is still high with all fluid loading protocols; thus, the use of fluid loading as a sole method for prophylaxis might be not satisfactory for many anesthetists. Phenylephrine is the preferred vasopressor for prevention and management of PSH in most cases. Ephedrine may be more beneficial in patients with bradycardia, patients with uteroplacental insufficiency and pre-eclamptic patients. Norepinephrine infusion was recently investigated as an alternative for prophylaxis of PSH with minimal cardiac side effects. The high incidence of PSH with most of the pharmacological and non-pharmacological methods suggests the need for multimodal protocols for prevention and management of this problem. PSH in cesarean delivery is a common daily situation facing all anesthetists; thus, future research should focus on simple and rapid protocols that can be easily applied by anesthetists with moderate and low experience with minimal need to complex devices or costly drugs.Keyword: Hypotension, Spinal anesthesia, Cesarean delivery.
Using Mathematical Models within the Cosmetological Aid Organization in the Context of Botulinum Toxin Therapy of Upper Face Skin Age-Related Changes Olga Nikolaevna Krasilnikova
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Mathematical modeling is the language of modern science. This paper describes the application of the mathematical evaluation of the clinical efficiency of botulinum toxin therapy of age-related changes in the skin of the upper half of the face on the example of correcting the three zones of the patient. For this purpose, we used the scoring scale; schedules that help the doctor get new information about the effectiveness and quality of the procedure throughout the observation period, and master practical skills of quality examination. Such an approach in cosmetology will make it closer to evidence-based medicine, contributing to the objectification and systematization of the accumulated data.Keywords: Cosmetological care, Botulinum toxin therapy, Evaluation of the efficiency of injection correction of age-related facial skin changes, Quality of medical care, Integral quality factor.

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