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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 04." : 74 Documents clear
Extraction of Staphyloxanthin from Staphylococcus aureus and Studying Some Biological Effect of Staphyloxanthin Pigment Fatima Amer Abd Algabar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Objective: This study aimed to extraction and purification of staphyloxanthine and to determine antibacterial effect of purified extract against pathogenic bacteria. Design and methods: To reach this goal from 306 samples of different clinical sources, Staphylococcus (22.8%) had been isolated and examined as S. aureus depending on cultural morphology, biochemical tests and Vitek2 system.  Staphyloxanthin pigment was extracted by using ethyl acetate with ethanol ,as wells the using qualitative and quantitative screening method to detect antibacterial effect of purified extract   then the results were statistically analyzed by SPSS to   perform the data analysis. Results: The results show significant difference in absorption of staphyloxanthin and the extracts; higher absorption of staphyloxanthin was recorded in tube 7 (0.998). Our study proved that purified extract of staphyloxanthin has an anti-bacterial effecting agent, It made inhibition zone against several kinds of gram negative bacteria at concentration (2, 20) mg/ml. This extract produces high inhibition zone (15mm) against Pseudomonas aeruginosa. In conclusion: our finding to confirm the ethyl acetate and ethanol method is very significant for extracting staphyloxanthin pigment. Our results indicate that column chromatography is one of the most important and widely used techniques for separation of pigment (staphylxanthin); also the purified extract of staphyloxanthin was established as anti-bacterial activity against several gram negative bacteria with highly inhibition zone against Pseudomonas aeruginosa. Keywords: Staphyloxanthin, Antibacterial, Purified extract, Well diffusion.       
Aphasia after Spinal Deformity Correction Surgery in Adolescent Idiopathic Scoliosis A Case Report Aji Antoro
Journal of Global Pharma Technology Volume 11 Issue 04.
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AbstractIntroduction. Advancement in operative techniques, better understanding of biomechanics and breakthrough in technology making spinal deformity correction surgery become more feasible and conducted more often. Majority of the neurological complications were related to spinal cord disruption due to technical issues. However, neurological complications that were attributed to a brain pathology, were more likely to be of ischemic origin.Case Illustration. We performed spinal deformity correction surgery on a 20-year old man with adult idiopathic scoliosis classification Lenke 2AN, with Cobb angle of 68°. On the second day, the serum sodium level showed a reduction. MRI examination revealed hyper acute infarct lesion on the posterior lobe of left temporo-parietal aspect. However, DSA examination was unremarkable. On the third postoperative day, his motoric and sensory functions, and sodium level returned to normal state. His cognitive function and communication abilities were able to return to normal gradually.Discussion. Stroke that occurs during spinal deformity correction surgery is reported in 5.8% of operative cases. Prone positioning accompanied by extension of the neck can compress vertebral arteries, causing reduction in vascular flow. Therefore, inappropriate prone positioning on the operating table for a prolonged period may cause cerebral ischemia.Conclusion. This case may serve as a reminder to surgeons and anesthesiologists towards the existence of such complications. Full awareness of the risk, good preoperative assessment, good surgical training, good communication, good teamwork, and good intraoperative and postoperative monitoring will minimize the risk for neurological complications.
The Effect Of Extra Virgin Olive Oil To Increase Endogeneous Antioxidant And PlGF In Preeclampsia Rat Model Yulia Silvani
Journal of Global Pharma Technology Volume 11 Issue 04.
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Background: Preeclampsia is a special disease in pregnancy with oxidative stress as one of its pathogenesis pathways, suspected that it can interfere the process of angiogenesis and negatively impacts the fetus and maternal wellbeing. Objective: This study aimed to determine effect of EVOO as a strong exogenous antioxidant to increase SOD activity and GSH level in accordance with improvement on PlGF level as an angiogenesis factor in preeclampsia rat model. Method: This research consisted of five groups; negative control, positive control (preeclampsia rat model), doses 1, 2, and 3 that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure measurements were carried out at the 12th, 15th, and 19th day of pregnancy. After sacrificed, placentas were collected to determine SOD activity and GSH level either maternal plasma to determine PlGF level. Results: Result of this study showed that there was a reduction of GSH (p=0.02) and PlGF (p=0.233) level between negative and positive control group meanwhile SOD activity seem increased (p=0.049). There were significant differences among positive control and dose 1 in SOD activity (p=0.008), dose 3 in GSH level (p=0.000), both dose 1 (p=0.017) and 2 (p=0.000) in PlGF level. Conclussion: Administration of EVOO increased SOD and GSH in all three doses groups, while there was a decrease in PlGF at dose 3. EVOO had been shown to be a potential antioxidant in preeclampsia through increased SOD activity and GSH level, at once modulate angiogenesis through increased PlGF level.Keywords: Preeclampsia, EVOO, SOD, GSH, PlGF, Antioxidant, Oxidative stress, Angiogenesis
Evaluation and Investigation of the Prevalence of Superficial Mycosis among Primary Schools Pupils in Al-Dewaniyah Governorate, Iraq Sara K. Al-Zubaidi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Background: The Superficial mycosis infections are the widespread types of mycosis among children primary schools. Objective: To detection and evaluation the extent and prevalence of superficial mycosis infection among primary school pupils in Al-Dewaniyah province. Subjects and methods: The survey included the selection of the pupils were randomly selected based on those with tinea (ringworm) lesions sample of 103 pupils (males 81, females 22) respectively from ten primary schools (six male and four female schools), they clinically diagnosis dermatophytoses, in the Diwaniyah Teaching Hospital, Dermatology unit, during a period from the beginning of December 2018 till the final February 2019. The specimens were collected in sterile plastic Petri dishes or sterile plastic envelopes and consisted of skin scales, hairs, or clippings from fingernails and toenails. The samples of fingernails and toenails were cut or to get mycelial elements. Results: The results of identity and incidence of the dermatophytes and non-dermatophytes isolated were revealed that dermatophytic isolation " Tinea" was 36/103(34%) among patients and this percentage was distributed to various clinical cases of ringworm ''tinea'', Mean age of patients enrolled in the present study was 20.11+10.99 years with a range of 7 to 13 years, According to gender patients were classified into 25 male s (69%) and 11 females (31 %). dermatophytes infections Is a problem in the health system of many developing countries and influences all ages chiefly primary pupils.  Conclusion: The current study prevalence of superficial mycosis among pupils of primary school was significant risk factors assessed such as poor personal hygiene, overcrowding. Consequently, proper health education, personal and environmental sanitation, provision of infrastructure, primary health care and regular clinical studies are recommended for these primary school pupils.Keywords: Dermatophytes, Primary school pupils, Mycelia, Superficial mycosis.
The Profile of Blindness Aetiology in Children of SLB/A Denpasar Anak Agung Ayu Sukartini Djelantik
Journal of Global Pharma Technology Volume 11 Issue 04.
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Introduction: Blindness in children is one global problem that adressed by the World Health Organization (WHO) to achieve VISION 2020 "The Right to Sight". Blindness also occurs in high prevalence in Indonesia, but study evaluating blindness in childres is rarely conducted. Thus, this study aimed to evaluate and compiled the profile of the etiology factors related to blindess in children in Denpasar, Bali. Method: An cross sectional-obervational analitic study were conducted in SLB / A Denpasar in November 2017 and the data were collected prospectively. The samples of this study were all children in SLB/A Denpasar who met the inclusion criteria. All of the data were analyzed using SPSS 17.0 Result: 37 children were enrolled in this study and consist of 23 (62%) men and 14 (38%) women. Most participants were in the range of 12-14 years old (12 [32%]) followed by 17-20 years (11 [30%]), 9-11 years old (7 [19%]), age 15-17 years (5 [14%]) and age 6-8 years (2 [5%]). According to the visual acuity (VA), the most prevalent eye condition was severe visual impairement (<6/12 – 6/18) with 12 children (32.42%) followed by blindness (VA<3/60) in 11 children (29.72%), moderate visual impairement (<6/18 – 6/60) in 11 children (29.72%) and early visual impairement (<6/12 – 6/18) in 3 children (8.11%). In terms of eye disorder, the most prevalent was ptisis bulbi 5 children (13.5%), followed by leucoma cornea in 4 children (10.8%), nystagmus and microcornea in 2 children (5.4%). The cause of blindness in children in SLB / A was papil atrophy (18.9%), ptisis bulbi (13.5%), and leucoma cornea (8.1%). The congenital cataract with nystagmus and microcornea was found in 4 childen (10.8%) while pseudofakia with PCO was found in 3 children (8.1%). Meanwhile, congenital cataract with nystagmus and microcornea was found in 2 children (5.4%). Conclusion: It can be concluded that the cause of blindness in chlidren in SLB / A were papil atrophy, congenital cataract with nystagmus and microcornea.Keywords: Blind, SLB / A, Visual Acuity, Congenital Cataract, Papil Atrophy.
Correlation between Body Mass Index and Cartilage Oligomeric Matrix Protein Levels in Woman with Postmenopausal Symptomatic Osteoarthritis IGN Wien Aryana
Journal of Global Pharma Technology Volume 11 Issue 04.
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Background: Measurement of serum cartilage oligomeric matrix protein (sCOMP) concentration is expected to be new approach  for osteoarthritis early detection. Osteoarthritis has been linked to obesity as its risk factor. This study aimed to determine relationship between BMI and sCOMP in woman with symptomatic osteoarthritis. Methods: : A cross-sectional study was done using consecutive sampling. The study population comprised of female patients age 50-70 y.o who had menopause since last 1 year and symptomatic knee arthritis. Osteoarthiris were comfirmed by genu imaging. sCOMP concentration were determined in Clinical Phatology Laboratorium of Sanglah Hospital using ELISA technique. The body mass index was calculated using the standarized formula. Correlation test was used to determine the correlation between body mass indexes with sCOMP level. Results: From total of 68 participants, the mean age was 73.66 (SD 9.356), the mean BMI was 21.97 (SD 4.66), and the mean sCOMP concentration was 7.935 (SD 10.11). Significant correlations (p <0.01) occured for this sample. However, Spearman’s rho was quite low (r = -0.382), indicating only weak correlations. A higher BMI was associated with lower sCOMP concentration. Conclusion: The results prove the relationship between BMI and sCOMP concentration. Further research is needed to reveal causality between both variables.Keywords: Osteoarthitis, Women, BMI, sCOMP concentration.
Congenital Pseudoarthrosis Tibia (CPT) performed Free Vascularized Fibular graft : A case report Muhammad Bayu Wicaksono
Journal of Global Pharma Technology Volume 11 Issue 04.
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AbstractCongenital pseudarthrosis of the tibia (CPT) remains one of the most challenging problems confronting the orthopaedic surgeon. The operative results are frequently less than successful; many cases require several surgical procedures, and a significant number of them ending in amputation. The purpose of this study was to access the surgical results, complications, secondary procedures, and long-term results of free vascularized fibular graft (FVFG). We reported a case of a 5 years old boy complained unable to walk, was diagnosed as Congenital Pseudarthrosis of the left tibia. The patient had been doing several operation procedure, finally performed FVFG. After 5 months follow up, ORIF with intramedullary Kirschner wire provided stability, and acceptable alignment resulted in bony union. However, even achieving union of pseudarthrosis is not enough for the resolution of the disease. This is only half of the problem, the other half is to maintain union. Keywords : Congenital pseudoarthrosis tibia, Free Vascularized Fibular graft
Study the Ascorbic Acid Levels, Lipoprotein Ratio and Hypocholesterolemia Action of Dry Okra Extract on Experimental Model of Locally Male Rabbits Hamzah H. Kzar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Okra (Abelmoschus esculentus) is a flowering plant in the mallow family. Okra is important for its edible green and dry seed pods. The plant is cultivated in tropical, subtropical and warm temperate regions around the world. The geographical source of okra now is very available in Iraq. The rabbit rapidly develops severe hypercholesterolemia and decrease in levels of ascorbic acid and increase in ratio of bad cholesterol to good cholesterol in response to dietary manipulation. The results of this study showed that, there was a significant decrease in serum total cholesterol  and lipoprotein ratio for groups of rabbits that administrated with dry okra aqueous extract with its seeds (0.5g/kg) (DOE+ cholesterol oil-fed) as compared to control group( not administrated) at the end of six week of experiment (398±4.0) vs. (175± 5) (P < 0.05). On the other hand, a significant difference in the level of serum total cholesterol (P<0.05) starts in control group treated with cholesterol-oil fed at the end of six week of experiment as compared to cholesterol+ DOE group  (398±4) vs. (543±4). The aqueous extract of dry okra may be enhancing the conversion of cholesterol to bile acids in the liver by activation of an enzyme α-hydroxylase. DOE may be having inhibition action on HMG-COA synthase that responsible on endogenous synthesis of cholesterol in liver. Keywords: Dry okra extract, Induce cholesterol. Lipoprotein ratio, Ascorbic acid.
Role of Vitamin B12, Folic Acid and Oxidative Damages, in Serum of Patients with Vitiligo Sherief Mahdy Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Background: Vitiligo is a chronic common disease which may cause as a result of oxidative stress which is proposed to implicate in its etiopathogenesis. Vitiligo is an autoimmune disease affecting skin, hair and oral mucosa. This disease is characterized by a loss of melanin. Disturbance of thyroid hormones has been known as a key trigger of this pathology. Objective: The aim of this study is to determine the levels of vitamin B12, folic acid , oxidative stress (lipid peroxidation ;MDA),total antioxidant capacity (TAC), Paraoxanase (PON1)in serum of patients with  vitiligo  compared to matches control group. Materials and subjects:  The study included 42 patients from Egyptian population suffering from generalized vitiligo (29 male patients and 13 female patients; mean age 35.1 years; ranging from 28-45 years and 36 healthy volunteers as control group (22 male patients and 14 female patients; mean age 36.2 years; ranging from 25–47years). Vitiligo patients were recruited from Medical research center of excellence of National Research Centre, Egypt, during interval of 6 months (1 October, 2018 to 31 March , 2019). Vitiligo diagnosis is based on if areas of patient's skin, hair or eyes lose coloring and confirmation is done by using Wood’s lamp. Blood samples were obtained from the patients and controls. PON1, MDA, TAC vitamin B12 (vit.B12) and folic acid biomarkers were analyzed in serum samples of both control and vitiligo patients. Results :  The present results declared  significant elevation of  oxidative stress ; MDA  (+159.26), which is associated with significant decrease in PON(-34.10) ,TAC (-35.89),vitamin B12(-53.41)  and folic acid (-89.23) in vitiligo patients compared to  control group. Conclusion: Oxidative stress and antioxidant balance are strongly implicated in the vitiligo patients .Vitiligo disease should be examined for multifactorial such as homocysteine levels for a possible implication due to the  postulation  in the pathogenesis of vitiligo based on the previous  findings . Moreover, the therapeutic role of supplementation with Vitamin B12/folic acid in vitiligo needs to be studied further.Keywords: Autoimmune disease, Melanin loss, Oxidative stress, Vitiligo, Vit. B12, Folic acid, TAC,PON.
The Association Between Brachial Ankle Pulse Wave Velocity and Left Ventric Mass Index In Patients With Hypertension Budi Susetyo Pikir
Journal of Global Pharma Technology Volume 11 Issue 04.
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Background: Arterial stiffness has been considered as a modest method in detecting the arterial burden that can trigger left ventricular hypertrophy in the heart. Increased left ventricle hypertrophy in hypertension patients is a predictor which has impact in the increase of morbidity and mortality. Objectives: We aimed to investigate the association between brachial ankle pulse wave velocity (BaPWV) and left ventricle mass index (LVMI) in patients with hypertension. Material and Methods: This study was conducted by collecting secondary data of 40 hypertension patients aged >40 years old, suffered from hypertension >1 year and have encountered brachial ankle pulse wave velocity test and echocardiography test. Results: There was a significant positive correlation between brachial ankle pulse wave velocity and left ventricle mass index in hypertension patients with r = 0.493 dan p = 0.001. Also, there was a significant correlation between BaPWV and Relative Wall Thickness with r = 0.404 and p = 0.01. There was a significant difference of LVMI value in males and females with the result of (117.78+22.70 and 100.15+16.82, p = 0.008). In contrast, there was no significant difference in BaPWV value in males and females (1865.63+322.29 and 1811.08+350.28). It was also obtained a significant correlation between age factor and systolic blood pressure with LVMI and BaPWV (r = 0.493, p = 0.001). Conclusions: There was significant positive correlation between BaPWV and LVMI in hypertension patients. The arterial stiffness was an indicator of increased left ventricle mass index in hypertension patients.Keywords: Brachial ankle pulse wave velocity, Left ventricle mass index, Hypertension, Heart.

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