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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 52 Documents
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Search results for , issue "Volume 11 Issue 08 (2019) Aug. 2019" : 52 Documents clear
The Role of Cowmilk’s Colostrum as the Source of Passive Immunity and Growth Factor for Improving the Haematological Status and Titre of Antibody against Hog Cholera in Pre-Weaning Piglets Ida Bagus Komang Ardana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: pre-weaning piglets often suffer from anemia, and infected with the bacteria so as growth slows even death. Aim: The purpose of this study was to determine the effect of cow colostrum administration on hematology profile and anti-body titers as an immunomodulatory effect to prevent germ infection. Methods: Seventy two piglets were divided in 4 groups in this research. Group who were not given bovine colostrum as a control, group who were given cow colostrum dose of 3 ml per animal, groups of piglet given bovine colostrum dose of 6 ml per animal, and a group of bovine colostrum piglet given a dose of 9 ml per animal. At the age of 7 days vaccinated against Hog Cholera and repeated at 14 days. Besides, at the period of 20 days all the piglets to have blood drawn and then accommodated in a vacuum tube which already contains anticoagulant (EDTA) for examination hematological profile is checked with Automated Manual VET ABC Blood Counter, made in Germany. Finally at the age of 30 days all piglet blood drawn and then accommodated in the tube for examination Hog Cholera antibody titer by ELISA. The data were analyzed with statistical test. Result: The results showed bovine colostrum supplementation at a dose of 1-5 days of age piglet 3-9 ml/piglet can raise the profile hematology and Hog cholera antibody titer. Conclusion: Addition of cowmilk’s colostrum in pre-weaning for the first five days of life could improve both the hematological profile and immunomodulatory set.Keywords: Piglet, Bovine colostrum, Hematology.
Efficacy of Drying and Stir-frying to Purple Rice Paddy Herb (Limnophila aromatica) Tea N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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In Vietnam, L. aromatica is easily cultivated in flooded rice fields. This herb has two very distinct flavours of lemon oil and cumin.  It is used in Vietnamese cuisine to add flavour in soup broths, sauces, and other foods. In order to create a new kind of functional herb tea, we have penetrated on various parameters such as drying and stir-frying the total phenolic and total flavonoid content in the dried stir-fried rice paddy herb tea. Our results revealed that drying raw purple rice paddy herb at 55oC to 8.5% moisture content and then stir-frying at 140oC in 6 minutes could produce the good organoleptic property while maintaining the best phenolic and flavonoid content in this functional beverage. These findings provided useful information for manufactures in processing of this herb to preserve potential sources of bioactive components for consumer and public health. Keywords: Rice paddy herb, Tea, Beverage, Drying, Stir-frying, Phenolic, Flavonoid, Organoleptic.
The Relationship between Blood Pressure with P-Selectin in Indonesian Hypertension Patients R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: The involvement of vascular inflammation is shown in the initiation and development of hypertension. P-selectin plays an important role in the inflammatory response through the initiation of leukocyte adhesion in platelets and endothelial cells. The purpose of this research was to determine the relationship between blood pressure and P-selectin in Indonesian hypertensive patients. Methods: The cross-sectional design study was conducted in 56 patients with hypertension, aged 40 to 60 years, blood pressure and serum P-selectin (sP-selectin) concentration measured. sP-selectin was determined by a colorimetric ELISA sandwich. Interpretation of the relationship between blood pressure components and sP-selectin concentration was carried out by statistical analysis. Results: It was found that sP-selectin level did not correlate significantly with systolic blood pressure (r = 0.078; P = 0.568), diastolic blood pressure (r = -0.014; P = 0.921), mean arterial pressure (r = 0.062; P = 0.648), and pulse pressure (r = 0.062; P = 0.648). Conclusion: Our results concluded that the increase in blood pressure components was not significantly associated with an increase in circulating sP-selectin concentration in hypertensive patients. Thus, there was no significant correlation between blood pressure and P-selectin in hypertensive patients. The tendency of positive results indicated an inflammatory involvement in hypertension.Keywords: Blood pressure, P-selectin, hypertension, Vascular inflammation adhesion, ELISA.
The Use of Methanolic Extract of Annona Muricata Linn Leaves as an Effective Anti-Hyperglycemia on Mice Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: Extracts from various morphological parts of soursop leaf (Annona muricata Linn/Annonaceae) are widely used in many parts of the world for the management, control, and treatment of a human diseases, including diabetes mellitus (DM).  This study investigates possible anti-hyperglycemia effects of methanolic extract of Annona muricata Linn in mice experimental paradigms of DM.Materials and Methods: The mice used were divided into three experimental groups. Group A served as ‘control’ animals and received sodium citrate buffer solution in quantities equivalent to the administered volumes of methanolic extract of Annona muricata Linn. Diabetes mellitus was induced in Groups B and C by intraperitoneal injections of streptozotocin (STZ, 80 mg/kg body weight). Group C were additionally treated with methanolic extract of Annona muricata Linn (100 mg/kg body weight, PO) for two weeks.Results: A statistically significant lower blood glucose level was found in Group C compared to Group B in sixth (215.14±78.37 vs 319.57±135.92 mg/dL) and seventh week (158.57±24.23 vs 238.85±51.35 mg/dL) of observation.Conclusion: Daily dose of 100 mg/kg body weight methanolic extract of Annona muricata Linn administration lowers blood glucose compared to those who did not receive in mice.
Genetic Variation of At-Hook Transcription Factor (Akna) Rs3748178 is Associated with the Relapse of Graves’ Disease Dwi Anita Suryandari
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: As many as 30-60% of patients with Graves' disease (GD) have relapsed after antithyroid withdrawal, which may be caused by genetic variation of susceptibility factors. This study aimed to analyze the genetic variation of AT-hook transcription factor AKNA rs3748178 and its association with relapse in Graves' disease patients.Methods: This research was a case-control study examining 60 DNA samples of GD patients, who were equally allocated into relapse and remission groups. Genetic variation was analyzed with PCR-RFLP. Fisher's exact test was used for statistical analysis and a p-value less than 0.05 was considered significant.Results: The proportion of patients who experienced a relapse with homozygote wild type (n= 27, 90%) was significantly higher (p= 0.015) compared to the heterozygote and homozygote mutant (n=3, 10%). Graves’ disease patients with GG genotype were more likely to have a relapse (OR 6.00, 95% CI 1.48–24.3, p= 0.015). The proportion of patients who experienced a relapse with G allotype (95%) was significantly higher (p= 0.004) compared to A allotype (5%). Graves’ disease patients with G allotype were more likely to have a relapse (OR 6.33, 95% CI 1.73–23.2, p= 0.004).Conclusions: Genetic variation of AT-hook transcription factor AKNA rs3748178 is associated with relapse in GD patients.Keywords: Graves’ disease, recurrence, genetic variation
Microwave Vacuum Drying Variables Affecting to Processing of Dried Gomphrena globosa Floral Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Microwave vacuum drying is one of the most energy demanding processes. Water evaporation takes place at lower temperatures under vacuum, and hence the product processing temperature can be significantly lower, offering higher product quality. Gomphrena globosa is one of the traditional medicinal plants widely distributed in Vietnam. It’s considered as a valuable source for pharmaceuticals against various ailments. Gomphrena globosa L. flowers are a promising source of natural antioxidants. Objective of this study focused on the influence of processing parameters such as the microwave power (100, 150, 200, 250, 300 W), system pressure (20, 25, 30, 35, 40 kPa) and drying time (15, 20, 25, 30, 35 min) on shrinkage coefficient, rehydration ratio, color change, total phenolic, flavonoid, betacyanin of dried herbal during the microwave vacuum (MV) drying of Gomphrena globosa. At the end of drying process, we also monitored the stability of dried Gomphrena globosa flower during 12 months of preservation. Our results showed that the optimal drying process should be conducted at microwave power 250 W at 35 kPa within 30 min to get the best quality of dried Gomphrena globosa flower. From this approach, shelf-life of dried Gomphrena globosa flower could be last for 12 months without any deterioration. The low temperature and fast mass transfer conferred by vacuum combined with rapid energy transfer by microwave heating generates very rapid, low temperature drying and thus it has the potential to improve energy efficiency and product quality.Keywords: Gomphrena globosa, microwave vacuum drying, Shrinkage coefficient, Rehydration ratio, Color change, Total phenolic, Flavonoid, Betacyanin.
Antioxidant Potential, Total Phenolic and Flavonoids Content of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: The aim of this work was to estimate the total phenolic and flavonoids content, and to evaluate in-vitro antioxidant activity of ethanolic extract of Cordia obliqua.Methods: The ethanolic extract of Cordia obliqua was examined by Iron chelating activity, Total antioxidant activity, Total phenol and flavonoids with reference standard EDTA (Ethylenediaminetetraacetic acid), Ascorbate and catechol respectively through in vitro models.Results: The antioxidant activities of the extract were positively associated with the total phenolic and flavonoid contents of the ethanolic extract of cordia obliqua.Conclusion: Ethanolic extract of Cordia obliqua. showed strong scavenging activity. These in vitro assays indicate that this plant extract is a better source of natural antioxidants. The presence of antioxidants such as phenolics, flavonoids, tannins and proanthocyanidins in plants may provide protection against a number of diseases including cancer, neurodegeneration and inflammation. 
Factors Associated With Interprofessional Collaboration for Handling Stunting In Children Nursalam .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: An estimated in every 4 (25%) infants and toddlers were stunted in Surabaya. With slow progress in stunting reduction in this many regions is not due to insufficient diet alone, it needs interprofessional collaboration (IPC) which will improve the performance of health workers in the management of stunting. The aimed of this study is to understand the knowledge, attitude, self-efficacy, collaboration, communication about interprofessional collaboration to handle children aged < 5 years were stunted. Methods: The research used a cross-sectional study. The population in this study was 128 health workers. Samples were taken by simple random sampling. Independent variables were knowledge, attitude, self-efficacy, collaboration communication. The dependent variable was interprofessional collaboration. The instrument used a questionnaire. Data were analyzed by using correlation and logistic regression with a significance level of p <0.05. Results: The focus of this study is to understand the knowledge, attitude self-efficacy, collaboration communication in interprofessional collaboration as a way to handle stunting aged < 5 years; for self-efficacy p=0,027. A health worker who had good knowledge, attitude self-efficacy, collaboration communication, impacted and improve interprofessional collaboration as a prevention effort against stunting. Conclusion: From this study, we can conclude that the knowledge, attitude, self-efficacy, collaboration communication improve interprofessional collaboration in handling stunting in children under five. The better knowledge, attitude and belief about interprofessional collaboration, the better the implementation of interprofessional collaboration.Keywords: Factor personal, Interprofessional collaboration, Stunting, Children.
Effectiveness of Lactobacillus acidophilus as Probiotic in Cantaloupe (Cucumis Melo) Juice Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Cantaloupe is one of the most consumed fruit crops worldwide specially in Viet Nam due to its pleasant flavour and nutritional value. Cantaloupe is highly perishable, due to its high moisture content.  Lots of cantaloupes rot away in the farmland. The production of freshly cantaloupe juice is a best way to raise the merchandise rate of cantaloupe and to prolong its product shelf-life during consumption. Lactic acid fermentation increases the shelf life of cantaloupe juice and also enhances various beneficial properties, including nutritive value and flavours. Objective of this study focused on the effect of Lactobacillus acidophilus as probiotic in cantaloup (Cucumis Melo) juice production. Different technical parameters such as the initial soluble solid content (8.0, 8.5, 9.0, 9.5, 10.0 oBrix), Lactobacillus acidophilus innoculum size (1.0, 1.5, 2.0, 2.5, 3.0 g/L), fructo-oligosaccharide (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) were examined during fermentation at 37oC in 48 hours. Results showed that the best fermented juice quality would be achieved by the initial soluble solid content 9.5oBrix, Lactobacillus acidophilus innoculum size 2.0 g/L, fructo-oligosaccharide 2.0%.Keywords: Cantaloup, Lactobacillus acidophilus, Probiotic, Juice, Fructo-oligosaccharide, Innoculum.
Antimicrobial Resistance Patterns and Metallobeta-lactamases Producing of Imipenem Resistant Pseudomonas aeruginosa Isolated from Clinical Samples of Iraqi Patients Marwa Lafta Jebur
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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In this study, a total of 160 clinical samples (72 burned skin, 25 wound, 18 sputum, 24 urine and 21 ear samples) were collected from five hospitals in Baghdad during the period December 2017 - April 2018. The samples were cultured on MacConkey agar and blood agar plates to isolate Pseudomonas aeruginosa in order to estimate its prevalence rate, which was 65% (104/160) of the total clinical samples. It was found that 37.5% (39/104) of P. aeruginosa isolates were resistant to imipenem (IRPA). A phenotypic detection of beta-lactamases showed that all IRPA isolates did not produce extended spectrum beta-lactamases, while 89.7% (35/39) of these isolates produced metallo-betalactamases (MBLs). Antibiotic susceptibility test against 11 antibiotics using the disk diffusion method showed that all metallo-betalactamases producing IRPA isolates were sensitive to polymyxin B, while resistance rates were 100% to both cefotaxime and ceftazidime, 94.3% to both netilmicin and amikacin, 91.4% to each of meropenem, gentamicin and tobramycin, 88.6% to cefepime, 82.9% to aztreonam and 77.1% to piperacillin/tazobactam. The resistance of metallo-betalactamase producing IRPA isolates for antibiotics according to MIC values was 100% to both tigecycline and cefazolin, 91.4% to meropenem, 85.7% to tobramycin, 80% to both cefepime and gentamicin, 71.4% to each ceftazidime, amikacin and levofloxacin, and 51.4% to ciprofloxacin.Keywords: Pseudomonas aeruginosa; Metallobeta-lactamases; and Antimicrobial Resistance.

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