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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Molecular Detection of some Virulence Genes of Streptococcus agalactiae Isolated from Pregnant Women Lamees A. Abdul-Lateef
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

virulence factors like surface proteins, biofilm, and exotoxins s. All these allow bacteria to adhere to tissues causing pathogenesis and invade the immune system causing serious infection. Materials and Methods: A total of 300 samples, 25 of Strep. Agalactiae were collected in this study. Strep. Agalactiae were isolated from pregnant women by standard bacteriological methods. PCR was conducted to determine the some virulence genes of the isolates by using primers cyle, scpB, and hylB. The PCR amplification products were visualized by electrophoresis on 1% agarose gels for 30min at 70v. The size of the amplicons was determined by comparison to the 100 bp allelic ladder. Results: In this study, 25 isolates of Strep. agalactiae were genotypically characterized by PCR assay. Among isolates studies it was found that cylE gene present in all isolates. Also 100% of isolates have ability to produce scpB gene while only 11(44%) was able to produce hylB.Keywords: Streptococcus agalactiae, cylE, scpB, hylB.
Assessment the Effects of Ciprofloxacin and Gentamicin Alone or in Combination to Induce Hepatic Toxicity in Rats Jawad Kadhim Faris
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The aim of this study was to research the comparative effects of ciprofloxacin (CP)  and gentamicin (GT) alone or in combination on the deleterious effects on liver function  and histopathological architecture in rats for  (10) days administration. Doses of 100 mg/kg were used for each of  CP and GT ,and each of both drugs 50mg/kg were combined to estimate the synergistic effect .Thirty two  rats were divided into four groups , group I :control , (1 ml/kg saline orally) group 2: CP  (100 mg/kg orally)  for (10) consecutive days , group 3:  GT  (100 mg//kg) intraperitoneally (i/p)  for (10) consecutive days, group 4: CP  (50 mg/kg orally) plus GT  (50 mg//kg)  i/p  for (10) consecutive days . Blood and liver collected for biochemical and histopathological examination of the liver. The degree of liver injury was determined by measuring biochemical markers, the serum activity of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Malondialdehyde (MDA) levels, as measures of oxidative stress. The results of this study showed that in the serum of the rats in the test groups were found to be significantly higher (p < 0.01) than control group; this effect was found to vary among the groups. These findings are indicative that combination of CP + GT more injury to hepatocytes than GT and CP respectively .The synergistic effects of combination of CP + GT showed the higher levels of liver enzyme and sever liver injury.  Keywords:  Gentamicin, Ciprofloxacin, Combination Hepatotoxicity.
Study of the Effect of Tramadol on Sperm Standards in Male White Rats Marwah Ahmed Miri
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Tramadol is an opioid analgesic, a pain reliever used by the World Health Organization (WHO) to treat postoperative pain and chronic diseases such as acute liver disease, Fibromyalgia and Arthritis. This study was designed to determine the effect of tramadol in fertility in male white rats. White rats were used as an example of mammalian animals. The study included the use of 45 white adults. Animals were raised in the Animal House of the Faculty of Education for Girls / University of Kufa under standard conditions in terms of temperature, light and nutrition.  The study was conducted to assess the damage to the male reproductive tract of white rats due to daily exposure to tramadol. The groups was given orally distilled water as a control group and the other groups were given two doses of tramadol (100, 200 mg) Kg / kg) orally for 8 weeks. The results in this study showed a significant decrease (P <0.05) in body weight, testosterone, albino, seminal vesicles and prostate glands in the treated groups (100, 200 mg / kg) of tramadol compared to control group. The results of the statistical analysis in the present study showed a significant decrease (P <0.05) in the concentration of sperm in the testis and the epididymal tail and a significant decrease (P <0.05) in the percentage of sperm movement in the testis and epididymis, (P <0.05) in the percentage of non-mutated sperm in the serum groups (100, 200 mg / kg) of tramadol compared to the control group.Keywords: Tramadol, Sperm.
Pharmacological Action of Aloe Vera and Linseed Oil on Experimentally Induced Hemorrhoid in Rats Noor D. Aziz
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Objective:-Hemorrhoids is recognized as one of the most common medical conditions in general population. It is clinically characterized by painless rectal bleeding during defecation with or without prolapsing anal tissue. This study designed to investigate the in vivo preclinical effect of aloin from aloe vera and linseed oil on experimentally induced hemorrhoid in rats by croton oil. Materials and Methods:  Twenty five albino rats (150-310 gm.) involved in this study. The animals were separated into five groups (5 animals / each).The first and second groups represent negative and positive control, the third one treated with alovera ointment (10 %), the fourth group was treated with linseed oil and the last one treated with proctoheal® cream as a standard treatment. The latter four groups was induced experimentally with hemorrhoid by applying croton oil via rectoanal region. Twenty-four hours after the induction, animals of the respective groups were treated for 5 days. On the fifth day, 1 hour after the relevant treatment, blood samples were collected by cardiac puncture technique for estimating the complete blood picture and C-reactive protein. Rectum is surgically removed (2 cm) to detect macroscopically lesions, histopathological findings and evaluate rectoanal coefficient (RAC). Results:-The cytoarchitecture of rectoanal portion of the animals treated with linseed oil was near to normal, so the response rate of linseed is higher to other treatment (aloe vera ointment). Conclusion:  linseed oil has a priority for alovera extract (Aloin) as well as has a beneficial effect on edema and inflammatory signs.Keywords: Hemorrhoid, Aloe vera, Linseed oil, Rat, Croton oil.
Effect of Costus Specious Extract on Some Types of Pathogenic Bacteria Hanan Shihab Ahmad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The present study aimed to investigate the effect of different concentrations of cold water extract, hot water extract, and alcohol extract of Costus specious plant with concentrations of 25, 50, 100, 150, 200, 250, 300, 350 micro liters / ml tested on eight pathogenic bacteria Staphylococcus aureus, Proteus Klebsiella Bacillus, Entrobactera, Serratia Pseudomonas aeruginosa Escherichia coli, Was obtained from the laboratories of the hospital of the city of medicine in Baghdad. The method of spread across the cattle. There was an effect on the bacteria at different concentrations in the cold water extract Costus specious where there is no effect of the extract on the bacteria enterobacteria. The results of the measurement of the diameter of the inhibition are clear. There is an effect on the bacteria species with the hot water extract of the Indian variety with different concentrations and the alcoholic extract of the Costus specious plant which had an effect on the bacteria species with different concentrations. The difference in the effect of the extract on the growth of the bacteria depends on the type of bacteria and concentration of the extract The effect of cold water extract at a concentration of 5 g / mL was more effective on Staphylococcus aureus. The effect of the hot water extract at a concentration of 5 g / 3 ml had an effect on Klebsiella and E. coli bacteria. The alcohol extract had the highest effect of 2 g / 5 ml on E. coli and the 5 g / mL alcohol extract was more effective on Serratia and Enterobacteria and no effect on bacteria Klebsiella.
The Effect of Gamma Rays in Some Optical and Physical Properties of the Material (PVA) Dissolved in Distilled Water Saad Khalid Rahi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This research includes a study of some optical properties of (PVA) which is dissolved in distilled water before and after irradiation by (γ-ray) the Radiation was done using Co60 source at the rate of 1.25 Mev and the irradiation process was carried out in the Institute and Hospital Radiation and Nuclear Medicine at dose of (8000 rad) with average radiation (500 rad / min) for (16 min). The study of optical properties had included measurement of absorbance, transmission, index of refraction has been measured for all concentration before and after irradiation, as well as the reflectivity, molar refractivity, and absorption coefficient has been measured. The  results shown that the value of absorbance, index of refraction, are increases as the solution concentration increased before and after irradiation, but the value of  transmission, absorption coefficient and reflectivity are decreased when the solution concentration increased before and after irradiation. All measurements are calculated at a constant temperature approximately to (25oC). The reason for the change at value of properties may be due to cross linking of polymer chains and then increased the average viscosity molecular weight for material (PVA) that used in this research. Keywords:  Health, gamma rays, Distilled water.
Photocatalytic Degradation of Textile Dye Cristal Violet Wastewater using Zinc Oxide as a Model of Pharmaceutical Threat Reductions Ayad F. Alkaim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The photo catalytic degradation of Cristal Violet   dye (CV) has been investigated under UV irradiation in aqueous suspension of zinc dioxide under a variety of conditions. The degradation was studied by monitoring the change in dye concentration using UV spectroscopic technique. The effects of key operation parameters such as initial dye concentration, catalyst loading, as well as light intensity on the decolonization extents were studied. And found The initial increase in rate of dye degradation with increase in amount of catalyst is due to increase in number of active sites on the surface of photo catalyst  the rate of photo catalytic degradation and photo degradation efficiency increased with increasing is increasing with increasing UV light intensity.Keywords: Photcatalytic; Cristal Violet dye, zinc oxide
Survey Study about the Association between (Epstein Barr Virus) (EBV) Infection and Breast Cancer Attending Al-Sadder Teaching Hospital in Al-Najaf Al-Ashraf during Years 2017 Ali Abdul Razak Al-Saegh
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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This study was conducted in from January to December 2017, located was doing in Al-Sadder Teaching Hospital in Al-Najaf Al-Ashraf, to detect the relationship between the breast cancer and the EBV which causes cancer, total female attending to the Teaching Hospital is 16 cases the average age was between 31-64 years. Clinical symptom and X-ray was examined at first, Biopsy was doing and sent to the Department of Analysis technique Al-kafeel University for Histopathological and immunohistochemical examination. The aim of this study was to determine where there are associated between EBV and female breast cancer, be that breast malignancy risks in patients testing positive for EBV in Al-Najaf governor for the first time.
Correlations of Serum Vitamin D and Thyroid Hormones with Other Biochemical Parameters in Iraqi Pregnant Women with Preeclampsia Disease Namir I.A. Haddad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Objectives: Preeclampsia is disorder of hypertension in the second half of pregnancy. This study aimed to find correlation of preeclampsia with Vitamin D, thyroid hormones and other parameters in Iraqi pregnant women. Methods: Case study of fifty-eight pregnant with preeclampsia (twenty-nine pregnant women with mild preeclampsia, and twenty-nine pregnant with sever preeclampsia) and twenty-nine healthy pregnant in third trimester was included this study. Serum of Vitamin D, TSH, T3, T4 and other biochemical parameters were measured. Results: The results showed significant decrease (P<0.001) in serum T3 and T4 in mild and sever preeclampsia groups compared to healthy group (1.31±0.31ng/ml and 1.32±0.15ng/ml vs.1.53±0.26ng/ml) and (7.65±0.73µg/dl and 7.40±0.85µg/dl vs. 8.953±0.66µg/dl) respectively. Serum TSH showed significant increase (P<0.001) in mild and sever preeclampsia groups in comparison to healthy group (2.76±0.76µIU/ml and 3.81±0.94µIU/ml vs. 2.43±0.64µIU/ml) respectively. Also, significant decrease in serum vitamin D in mild and sever preeclampsia groups in comparison to healthy group (9.152±1.03ng/ml and 8.564±1.67ng/ml vs. 21.992±5.59ng/ml) respectively. Conclusion: Our results found positive correlation between T3 level with age (P=0.033), gravidity (P=0.024) and history of abortion (P=0.002). Positive correlation T4 level with BMI (P=0.021), gravidity (P=0.040), parity (P=0.039), while a negative correlation with family history (P=0.003) was found. Level Vit.D had positive correlation with gravidity (P = 0.044) and parity (P=0.019), although no correlation found between thyroid hormones and Vit.D during the 3rd trimester. Also, levels TSH, T3, T4 and Vitamin D can be used to predict the severity of PE.Keywords: Vitamin D, TSH, T3, T4, Preeclampsia, Mild PE, Sever PE.
Isolation and Dignosis of Penicillium Expansum from the Cosmetics Which Ability to Produce Patulin and using Zinc Oxide Nanoparticles as Antifungal Compound R. A. Sahib
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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 In this study Penicillium expansum was isolated from the cosmetic samples, 50 cosmetic samples which were used such as (eye shadow, face cream, face mask, lipstick and  hand cream). The sabouraud dextrose agar was used to test  the presence of  P. expansum.  Thin layer chromatography (TLC) was appeared yellow spots of patulin toxin with rate of flow (RF) is 76% under UV light exposure.The UV-visible spectroscopy result proved the wavelength of patulin is located with 270 nm and 1.8 absorbance.High performance liquid chromatography (HPLC) results show that retention time of major peak of standard patulin and a filter extract of P. expansum are  located at (15 and  15.1) min, respectively,  which are located  in the same area. Zinc oxide  nanoparticles using as a fungicide to control development growth of P. expansum which proved high efficiency to decrease growth of P. expansum by percentage of (33,50,77) % respectively in the concentration (2,4,6) mmol/L, while 8 mmol/L of ZnO caused complete inhibition growth of P. expansum as compared with the control group which untreated with ZnO NPs. Scanning electron microscopy (SEM) images show that ZnO NPs caused decreased with disrupted of conidia and decreased number of  mycelium.Keywords: Penicillium expansum, Cosmetics, UV-vis, HPLC, SEM, Zinc oxide nanoparticles.

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