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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Opportunities for the Prevention of Hypertension by Nutrition Correction Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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AbstractIntroduction. There is much evidence of a relationship between salt intake and blood pressure levels. Limiting sodium chloride consumption significantly lowers blood pressure. The purpose of this study was to study the effectiveness of lowering blood pressure while limiting salt intake in men and women with high and normal blood pressure.Materials and methods. An annual study was conducted, a prerequisite of which was the selection of 2 groups: survey and comparison. They were comparable in terms of gender, age, professional composition and number of participants. To carry out a dietary examination required limiting the salt in the cooking to 0,5 g per serving.Results and discussion. After one year of dietary intervention, a significant decrease in systolic (SBP) and diastolic blood pressure (DBP) was found in men and women in the intervention group (p < 0,05) compared to the control group, which showed a natural decrease in blood pressure, a significant decrease in blood pressure was observed during the study period (p < 0,05). In addition, there was a significant decrease in body weight in the intervention group compared with the control group.Conclusions. Reduced salt intake significantly reduced SBP and DBP in men and women with high blood pressure over a longer follow-up compared with the control group.
Epidemiological Characteristics of Acute Leukemia in Child Welfare Hospital in Baghdad Samahir A. Fadel
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Background: Acute leukemia, the most common form of cancer in children, comprises approximately 30% of all children malignancies, with acute lymphocytic leukemia (ALL) being more common than Acute Myeloid Leukemia (AML) by five times. Objectives: To determine different epidemiological variables associated with acute leukemia& to determine the patterns according to socio demographic data. Patients and Methods: A cross- sectional study and the data collection was carried out for a period of four months, from the 2nd /May/2019 to 2nd /September /2019. Result: The study shows that the majority of patients were ALL & the highest percentage of ALL patients was in the age group (5-9) years, males showed higher percentage than females in both type of leukemia, the highest percentage were from Urban.The majority of patient’s parents’ education level was primary; while the highest percentage of fathers’ occupation was Private sectors & the highest percentage of mothers’ occupation were Housewife.The highest percentage of ALL patients were 4th & more Order in family& AML were the 1st child, the highest percentage of patients with Birth space (2-4) years from there brothers.The highest percentage of patients was feed from their mothers (Breast feeding) during their first year & the highest percentage of patients was normal birth weight.Majority of patient’s Parent consanguinity were not related, while the lowest percentage of patient’s Parent consanguinity were far related.There was an important association between  patients’ blood group AB & ALL. Conclusions: The study shows that the majority of patients were ALL & the highest percentage of ALL patients was in the age group (5-9) years, males showed higher percentage than females in both type of leukemia, the highest percentage were from Urban. Recommendations: Ensure good MCH system to monitor and ensure the quality of health care practice & demonstrating cultural competency to promoting more effective child health services.Keywords: Leukemia, Blood, Cancer, Childhood, Iraq.
Synthesis, Characterization, Antibacterial and Antifungal Activity of Some Bis (1, 3, 4-oxadiazole) Polymer Nawar Jamal Abdul Rada
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Pyridine-2, 6-dicarbohydrazide comp (2) was synthesized from ethanolic solution of diethyl pyridine-2, 6-dicarboxylate comp (1) with excess of hydrazine hydrate. Newly five polymers (P1-P5) were synthesized from reaction of pyridine-2, 6-dicarbohydrazide comp (2) with five different di carboxylic acid in the presence of poly phosphoric acid (PPA). The antibacterial activity of the synthesized polymers was screened against some gram positive and gram negative bacteria.  Antifungal activity of these polymers was evaluated in vitro against some yeast like fungi such as albicans (candida albicans). Polymers P3, P4 and P5exhibited highest antibacterial and antifungal against all microorganisms under test.Keywords: Bis 1, 3, 4-oxadiazole, Polymer, Antibacterial, Antifungal.
Effect of Self Efficacy Training on Diet and Blood Glucose Compliance in Diabetes Type 2 Mellitus Patients Hariyono Hariyono
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Background: Self-efficacy training is an effective way for people with diabetes mellitus to get improved blood glucose compliance and control. The purpose of this study was to analyze the effect of self-efficacy training on diet compliance and blood glucose. Methods: This study used a quasi-experimental pre-post-test with a control group. The population of this study was all Diabetes Mellitus patients in the Public Health Center area with 17 sample respondents for each group. The sampling technique was purposive sampling. The variables of this study were: self-efficacy training, diet compliance, and blood glucose. The way to collect data was by using questionnaires and laboratory examinations. Result:  The results showed that self efficacy training did not affect the adherence of diabetic patients in either the intervention group or the control group with the Wilcoxon test results showing the intervention group (p = 0.863 (p <0.05)), the control group (p = 0.677 (p < 0.05)) and the Mann-Whitney test (p = 0.909 (p> 0.05)). The second result showed that self-efficacy training had an effect on blood glucose in patients with Diabetes Mellitus in the intervention group but did not affect the control group, according to the Wilcoxon test results showed for the intervention group (p = 0.003 (p <0.05), the control group (p = 0.163 (p> 0.05) and the Mann-Whitney test (p = 0.080 (p> 0.05). Discussion: self-efficacy training can improve blood glucose control quite well, but still requires integration with other components related to the pillars of Diabetes Mellitus management. Self-efficacy training is not significant enough to improve the adherence of diabetic patients but with increased knowledge and behavior, it is hoped that they will be able to increase their motivation to support increased self-care abilities, change behavior and carry out activities to maintain glycemic control.Keyword: Self Efficacy Training, Diet Compliance, Blood Glucose, Glycemic Control, Diabetes Mellitus.
Investigating the Genetic Change in BRAF Gene Causing Manifestation of Prostate Cancer in a Sample of Iraqi Patients Jaleel I. Asaad
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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This study included 100 patients suffering prostate cancer, 15 persons with family history of cancer served as positive control, and 30 healthy men served as negative control.  Prostate cancer tissues were collected from surgical room and subjected to DNA extraction for further processing.  Four primers were designed to investigate lethal changes at BRAF location related to this disease. Six pathogenic mutations were found among patients included in this study. These were rs1131692058, rs180177042, rs397507484, rs121913364, rs121913377, rs113488022, and rs1131692058. These represented ingle nucleotide polymorphism except for rs1131692058 which was found a deletion mutation. More data showed that positive control were less specific to associate with BRAF primer suggesting they bear variations susceptible for lethal change that may developed to cancer.
Rapid Determination of Bi (III) and Al (III) in Pharmaceutical Formulations using Organic Reagent Spectrophotometrically Jumana W. Ammar
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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A new trend describes the development and validation of a simple, sensitive and selective spectrophotometric methods for the determination of Bi (III) and Al (III) in pharmaceutical formulations have been conducted. In this paper, 4-(4 acetamidophenylazo) pyrogallol was synthesized as a new organic compound, 4-APAP, by coupling pyrogallol with diazotized p- aminoacetanilide in medium of controlled pH. 4- APAP was characterized by techniques of FT-IR, H-NMR, GC-Mass, TG and DSC thermal analysis methods. Solvatochromic behavior in solvents of various polarities was also investigated.Keywords: Pharmaceutical applications, Pyrogallol, Bi (III), Al (III).
Prospects for the Use of the Herb Chamomile in the Manufacture of Dietary Supplements Аngelina V. Streljaeva
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: Chamomile flowers is a widely studied pharmaceutical raw material, however, pharmaceutical herb chamomile herbal raw material practically has not been studied, but in practice is an interesting and promising item for further study. The objective of the study was carrying out of the analysis of the herb chamomile raw material (two types-fresh and dried). Method: In accordance with the Russian SP (State Pharmacopoeia) procedures, there were produced etheroleum and alcohol extract. Moisture content was determined as for dried raw material: 14.00±0.74%, for fresh raw material: 71.40±2.23%. Quantitative and qualitative composition was assessed by GLC (gas-liquid chromatography, mass detector) and HPLC (high-performance liquid chromatography) methods. Results: As of comparative analysis of etheroleum and alcoholic extract from herb chamomile, it should be pointed out that azulene derivatives were present in etheroleum and in alcoholic extract; however, chamazulene as such was identified just in etheroleum. In alcoholic extract there was no chamazulene. In alcohol extract there were identified vitamins, flavonoids (kaempferol is the important one), phenol compounds, coumarins, organic acids-ferulic acid and its derivatives, peptides and sugars. Conclusion: The herb chamomile is both a promising dietary food supplement, and a pharmaceutical preparation. There are a lot of studies concerning the determination of herbal`s bioactive components. This process is important for quality control of herbs and its products.Keywords: Herb chamomile, Chamazulene, Matricin, Kaemferol, Ferulic acid.
Antiseptic White Honey Liquid Soap Formulation and its Effectiveness against Nosocomial Infections Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa Multiresisten (PaMR) are the main bacteria that cause nosocomial infections. Prevention of MRSA and PaMR transmission can be done by maintaining a clean body through the use of antiseptic bath soap that is sensitive to this bacterium. This study aimed to carry out a white honey antiseptic liquid soap formula that could be useful for killing MRSA and PaMR bacteria. This research was based on laboratory research on white honey as an antiseptic derived from natural ingredients. Organoleptic examination, pH, viscosity, consistency, antibacterial effectiveness for 56 days of storage, then from the evaluation results of the formula was best done a hedonic test. Statistical calculations with fixed random block complete design models were applied for a conclusion of evaluation tests. The results of the test activity of the liquid shower soap showed that all three formulations had activity against the MRSA and PaMR bacteria. Growth Inhibitory Concentration Minimum preparation of antiseptic liquid bath soap was 12.5% w/v. Antiseptic liquid soap with a concentration of 12.5% had a phenol coefficient of 0.4167 for MRSA bacteria and 0.9 for PaMR bacteria. The comparative test results showed that the best formula (F2) activity was 0.859: 1 against MRSA and 0.7167: 1 against PaMR compared to liquid bath soap in the market. The test results showed that the best liquid bath soap formula based on stability and the lowest GICM value was white honey antiseptic liquid soap with a concentration of 12.5% w/v.Keywords: Antiseptic bath soap, Nosocomial infections, White Honey, Methicillin-Resistant Staphylococcus aureus (MRSA), Multiresistent Pseudomonas aeruginosa (PaMR).
Think Pair Share (TPS) Method Improves Knowledge and Attitude of School-Age Children in Vegetable Consumption Praba Diyan Rachmawati
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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School-age children need vegetable consumption to meet optimal growth and development needs. However, it remains a challenge to ensure the need of adequate quantities of vegetable consumption. The Think Pair Share (TPS) method may offer the solution of this problem. The aim of this study was to analyze the effect of applying health education with a think pair share on the knowledge and attitudes of school-age children in vegetable consumption. This study used a pre-experimental research design. The population in this study was  40 students at a fourth-grade elementary school and employed total sampling technique. The independent variable was health education with a think pair share learning method, while the dependent variables in this study were knowledge and attitudes. Instruments in this study were questionnaires of knowledge and attitudes. The data were analyzed using Wilcoxon Sign Rank Test statistical test  with significance α≤0.05. The results of the statistical tests showed significant effect on knowledge (p=0.000) and attitude (p=0.000) of children in consuming vegetables. Think Pair Share method can increase the knowledge and attitude of children in vegetable consumption. Future studies may consider using this method as a medium of health education to increase vegetable consumption in school-age children.Keywords: Attitude, Knowledge, Think pair share, Vegetable consumption.
Anti-diabetic Activity of Dry Extract of Gymnema Sylvestre Sanna Sboeva
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The purpose of the study was to study the mechanism of antidiabetic action and compare the hypoglycemic effect of taking extracts of different concentrations of gurmar in a laboratory rat population. Studies were conducted in 2018 in a population of 400 laboratory rats based on the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) (Moscow, Russian Federation). 300 animals made up the experimental group, 100 - the control. We used 25, 50, and 75% gurmar extract and diabeton, which were given orally to animals from the experimental group at a dosage of 70 mg to 1100 mg per 1 kg of body weight and 10 mg per 1 kg of body weight, respectively. Tests for glucose digestibility were performed by administering extracts of gurmar after fasting, dosage of 270 mg per 1 kg of body weight. The hypoglycemic effect of gurmar-based drugs activates enzymes associated with the inhibition of absorption of glucose from the intestine, as well as with its breakdown. Studies have established 25% as the most optimal dose of gurmar extract. The dosage in this case is 270 mcg per 1 kg of body weight. The maximum hypoglycemic effect is observed 2 hours after taking the drug. For high concentrations of the drug, a 25–30% lower hypoglycemic activity was recorded. Another drug, taken for comparison-diabeton, is superior in its effect to 25% gurmar extract by 20%. A 30% increase in beta-endocrinocyte nuclei may indicate an increased physiological activity of these cells.Keywords: Gurmar, type 2 diabetes mellitus, Extracts, Diabeton.

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