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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 56 Documents
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Search results for , issue "Volume 12 Issue 09 (2020) Sept. 2020" : 56 Documents clear
Pharmacoeconomic Analysis - The Way to Optimization of Using the Health Budget Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Reforming the drug supply system requires the introduction of modern scientific approaches to quality management of pharmacotherapy, the main principle of which is the individual selection of the drug taking into account its effectiveness and safety. Introduction: To analyze the literature on the need and feasibility of using pharmacoeconomic methods to provide medicines. Materials and methods: The basis for research is the methods of pharmacoeconomics. Results: The analysis of the data of literature sources was carried out and the necessity of using pharmacoeconomic methods in the field of health care was determined. Conclusions: As a result of the review, it was determined that pharmacoeconomic analysis is an effective method that facilitates the adoption of optimal decisions in the field of drug supply. Keywords: Arterial hypertension; Health care, Antihypertensive drugs; Form system.
Effect of Pregelatinization on Suweg Tuber Starch (Amorphophallus Paeonifolius) as Tablet Crusher Dwi Setyawan
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: Disintegrant tablet from starch is more often used to crush the tablet that has been swallowed. However, the material of this starch is tablet crusher which very weak. In contrast to the suweg starch (Amorphophallus paeonifolius) which has undergone pregelatinization where the content of amylose and amylopectin and the water absorption capacity that is high enough so that it can crush the tablet quickly. The aim of this study was to determine the influence of pregelatinization towards elephant foot yam (Amorpophallus paeonifolius) starch as disintegrant against tablet physical quality profile of the Paracetamol tablet. Method: The research was carried out by making suweg natural starch which then it made a suspension in the water with a concentration of 20% and heated to the temperature of 60 ± 5 0C and 70 ± 5 0C within 15 minutes. After the suweg pregelatin starch has been made, then a paracetamol tablet and a qualitative examination also made which includes the determination of the paracetamol infrared spectrum, the examination of moisture content, the testing with iodine, the testing with optical microscopy, X-ray diffraction analysis, the starch thermal analysis with DTA, and the examination of swelling power which then compared to each tablet formula made by the wet granulation method. after that, it was continued with the examination of the granule quality, including the examination of moisture content, the examination of granule particle size and number of fines, the examination of flow velocity and rest angle of the granule. Moreover, it was carried out an evaluation of the paracetamol tablet physical quality in the form of hardness test, friability test, and disintegration time test. The data obtained was further analyzed by One Way ANOVA. Result: Tablet formula with pregelatinization of suweg natural starch can reduce the hardness, increased the tablet disintegration time, and made no difference in friability compared to the formulas containing natural suweg tuber starch and SSG. The result of increased disintegration time was then compared with the result of the swelling power test, but did not indicate a correlation both of them. The different of disintegration was not showed a correlation with values of swelling power. Keywords: Suweg Tuber Starch, Starch Pregelatinization, Pregelatinized Starch Tablet.
Synthesis and Characterization of New Heterocyclic Compounds and Studying the Biological Activity Wisam Khalifa Jassim
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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New series of some of synthesized compounds derived of the compound (2- (5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl-substituted benzalidine .The starting material was prepared by the reaction of 3,5-dinitro benzoic acid with thiosemicarbazide in presence of POCl3. The derivatives of Schiff bases were prepared by reaction of 2-amino -5-(3,5dinitro phenyl) 1, 3, 4-thiadiazole with appropriate aldehydes (m-nitro, p-N, N-dimethylamino, p-bromo, o-hydroxy, p-hydroxy) benzaldehydes. These Schiff base were synthesized in order to prepare more important compounds which are the quinazolines and oxazepins. These compounds were synthesized from the reaction of Schiff bases (2- 6) with o-amino benzoic acid (anthranilic acid) and phthalic anhydride respectively. The structures of the new compounds were characterized by FT-IR, 1H-NMR spectroscopy besides the melting points and other properties. The biological activity (antibacterial activity) in-vitro are investigated for the derivatives at prepared concentration (1*10-3 M) and showed inhibition ability against growth of the two types of pathogenic bacteria: [Staphylococcus aurous.] as gram positive and [Escherichia coli] as gram negative and showed inhibition ability against bacteria. The most of these compounds are effective against both types of bacteria in varying degree, with high activity for quinazolines and oxazepines. Keywords: Quinazolines, Oxazepines, Biological activity of 1, 3, 4-thiadiazole, Schiff base.
Predictors of Quality of Life in Patients with Heart Failure: A Literature Review Ah. Yusuf
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Heart failure (HF) is a chronic disease characterized by reduce heart efficiency affecting patients’ quality of life (QoL). Patients with HF report lower QoL compared with general population and other patients with chronic disease. There are multidimensional factors affecting QoL. Therefore, it is important to identify factors that could be associated with changes in QoL to improve outcomes. The aim of this study was to identify significantly factors related to QoL in patients with HF according to the available literatures. The literatures were searched in appropriate database, using PICO framework, from January 2012 until August 2018. Eighteen relevant articles were found and reviewed. Factors that are significantly related to QoL in patient with HF can be grouped into 5 categories, i.e. physical factors include physical symptoms, physical activity, functional status, duration of HF, and multiple hospitalization; psychosocial factors include depression, optimism, exercise self-efficacy, and living independently; behavioral factors include self-care engagement, water and sodium restriction; spiritual factors include acceptance of illness and existensial well-being; and demographic characteristics include age, sex, education, economic and employment status. This review provides insight on potentially factors affecting QoL. Proper intervention in modifying those factors is expected to improve the quality of life. Keywords: Heart failure, Quality of life, Health-related quality of life, Predictors.
Molecular Docking of The Potential Compound from Cocoa Shells (Theobroma cacao L.) Against Androgen Receptor as Anti-Alopecia Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The determination of the components of the cocoa shells compounds that have anti-alopecia activity have not been reported, so the molecular docking approach is a very effective alternative before further testing is carried out. This study aimed to determine the potential compound components against androgen receptor targets as anti-alopecia drugs. Molecular docking used ChemDraw Ultra 12.0, Chem3D Pro 12.0, Biovia Discovery Studio 2016 Client®, and Autodock Tools 4.2, as well as to determine the pharmacokinetic properties and toxicity of drug ingredients with Pre-ADMET. It was found that that the components of the cocoa peel compound had the potential to act as anti-alopecia drugs, namely chlorogenic acid, epicatechin, and catechins with the value of the free energy binding (ΔG) and the inhibition constant (Ki) respectively (-7.87 kcal/mol; 1.70 µM)> (-6.48 kcal/mol; 17.65 µM)> (-6.36 kcal/mol; 21.91 µM) with the crucial amino acid residue formed was GLN 858. The pharmacokinetics (plasma protein binding) of epicatechin and catechin were excellent compared to chlorogenic acid and minoxidil because it could penetrate the plasma membrane when interacting. While the toxicity test, the components of chlorogenic acid, epicatechin, and catechin compounds were mutagenic, and only chlorogenic acid was carcinogenic. The study concluded chlorogenic acid, epicatechin, and catechin compounds from the cocoa shells were promising candidates for anti-alopecia drugs to be developed further targeting androgen receptors. It was consistent with the molecular docking results, which showed that ΔG and Ki's values were excellent compared to minoxidil. The pre-ADMET results also showed that the epicatechin and catechin compounds components could penetrate the plasma membrane when given topically compared to minoxidil. Keywords: Alopecia, Cocoa shells, Theobroma cacao, Molecular docking, Androgen receptor.
The Risk Factors That Affecting Carpal Tunnel Syndrome (CTS) Agusni Karma; Tri Riana Lestari; Ujang Abdul Muis; Rizki Rohimah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Introduction: Nowadays, interaction between human and mechine is often happened, it can be with computer or laptop, using computer/laptop with mouse in long period without resting the wrist will lead to symptom of Carpal Tunnel Syndrome (CTS). CTS have a significant correlation with improper posture of the hand and the age. This research is to know the relation between age, improper hand position, and work period towards risk of CTS on staffs who work in front of computer/laptop >4 hours a day. Methods: For the method was give some questionnaires, direct observation and Phallen test to each respondent. Results: From 33 of respondents was found 26 staffs who had risk of CTS. In improper hand position and work period factor was found the p-value of 0.000. But in the age factor was found p-value of 0.277. Analysis: In improper hand position and work period factor it caused by wrong position of the hand and pressure median nerve. In the age factor it caused due to staffs often did wrist gymnastic on work hours which is one of the exercises that preventing CTS. Conclusion: There is correlation between improper hand position and work period with risk of CTS. Keywords: Carpal Tunnel Syndrome, Improper Hand Position, Work Period
Characterization of Carotenoid Extract and Bioactivity Membrane of the Seeds of Annato (Bixaorellana) Lia Kusmita
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Bixa Orellana has a typical compound in the form of carotenoids. The types of carotenoids found in these compounds are bixin and norbixin. Both of these compounds have many benefits, one of which is as an antioxidant. Its nature as an antioxidant can also be used as a sunscreen. The purpose of this study was to determine the characteristics of carotenoid pigment in extract of the B.orellana sees membrane. Besides that, it is also to determine its biological activity in the form of antioxidants and sunscreen protectors. The TLC results showed 4 spot of carotenoids in the extract. Spot 1 identified as a bixin compound, because it has the same Rf as the bixin standard. HPLC result showed there were 5 peaks. The peak in tR of 9.046 was identified as norbixin and the peak in tR of 9.819 was identified as bixin. Carotenoid extract on the membrane of the seeds of B. orellana has antioxidant activity 16 times greater than standard bixin. Carotenoid extract at a concentration of 3.10 ppm had an SPF value of 6.27, including the extra protection category, and had a %TE value of 21.71% and Tp of 18.24% in the sunblock category. Keywords: Carotenoid, Antioxidant, Sunscreen, Bixin.
Theoretical Justification of Structure and Development of Capsule Technology with Cerebroprotective Activity Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Treatment of brain remains an urgent problem in the health system in Ukraine, due to the wide prevalence of the most common as a result of this disease causes cerebrovascular diseases, including atherosclerosis and hypertension, leading to a narrowing of the blood vessels of the brain and decreased cerebral blood flow. An alternative method of treatment of cerebrovascular diseases (CVD) it is expected pharmacological effect, which is achieved through use in medicines herbal drug that exhibits antyarytmichal, sedative, tranquilizing, antispasmodic, antiseptic hypotensive effects. According to literature data types such therapeutic activity black horehound grass, the grass dead-nettle herb wormwood and compatible whose presence leads to a potentiation of pharmacological action due to the fact that the components of the content biologically active substances (BAS) show a complex impact on different parts of body systems and increase reliability and predictable therapeutic effect. This complex of action reduces the possibility of side effects of display. The aim of this work is the theoretical basis structure and development of technology for rational drug cerebroprotective action in the form of hard gelatin capsules based on dry extracts medical plant material (MPM), namely black horehound grass, herb nettle deaf, sage herb. On the basis of experimental studies, we have proved the composition of masses for encapsulation of drug in the form of hard gelatin capsules number 0. Composition per capsule: a mixture of dry extracts MPM-400 mg; aerosol-50 mg; lactose monohydrate -50 mg. The weight of the contents of the capsule-500 mg. Keywords: Dry extracts, Development composition and technology, Gelatin capsules, Cerebroprotective activity.
Human sperm DNA integrity : A difference of storage temperature and period of freeze-drying process silvia werdhy lestari; ahmad silalahi; hamdani lunardi; agustinus agustinus
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The cryopreserve technique using liquid nitrogen is used to preserve human sperm. Nevertheless, this technique has several disadvantages, such as bacterial/viral contamination and its expensive cost. Freeze-drying process offers more simple and cheaper of sperm storage technique. This study aimed to investigate the effect of storage temperature and period of freeze-dried human sperm on DNA integrity. Human sperm samples of 15 donors were prepared with simple washing techniques. Post-washing samples (T0) were divided into 4 groups with the same volume. The four group of samples carried on the freeze-drying process and stored based on different temperature and period: 4°C for 1 week (T1), room temperature (24-25ºC) for 1 week (T2), 4°C for 3 months (T3), and room temperature for 3 months (T4). Sperm DNA integrity was analyzed before and after the storage period of each group. There was a statistically significant difference of sperm DNA integrity of freezes - dried at 4°C in 1 week versus 3 months (T1 vs T3), at room temperature in 1 week versus 3 months (T2 vs T4) (p
The Role of Lipopolysaccharide and Tight Junction Protein-1 (Zo-1) Levels and Symbiosis of Black Rice Extract in Obese Patients Armanto Makmun
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Excessive fat accumulation, which is commonly known as obesity, causes health problems for the community, such as metabolic disorders. Recent studies have shown that the gut micro biota is involved in the occurrence of metabolic disorders in obesity. The gut micro biota can regulate body weight by influencing metabolic processes, regulating the expression of host genes, increasing the ability to extract and store energy. Intestinal micro biota imbalance and increased plasma lipopolysaccharide (LPS) contribute to inflammation in obesity. The latest safe approach in cases of obesity is to use active ingredients from local foods. In South Sulawesi, Indonesia and also in other Asian countries found black rice as the local product that is very good for health because the high level of bioactive compounds that are important for health such as anthocyanin, proteins, amino acids, and phenolic acids. The ingredients in black rice play a role in modulating the composition of the intestinal micro biota as indicated by the increasing composition of Bifid bacterium and Lactobacillus. The increase in the composition of Bifid bacterium causes improvement in the expression of tight junction proteins in the intestinal epithelium, thereby contributing to prevent the translocation of LPS into the circulation. Apart from its role in modulating the composition of bacteria, it can also function to influence intracellular signaling.

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