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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 56 Documents
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Search results for , issue "Volume 12 Issue 09 (2020) Sept. 2020" : 56 Documents clear
Effect of Retention of Results on Patient Satisfaction with Orthodontic Treatment Anton Timoshin
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Currently, the number of requests for orthodontic care has increased significantly. This is facilitated by a number of factors -the technical capabilities of orthodontists, which have grown many times due to technological progress and the ability to provide the necessary assistance at almost any age; the need for an aesthetic result, which is formed under the influence of the media. As a result, there are high requirements for both yourself and your appearance, as well as for the orthodontist. Thanks to new technologies, such as cortical support, it became possible to solve the treatment of dental anomalies, which previously could only be cured by surgery. But at the same time, such an important issue as the retention of the results achieved remains open. We studied the objective parameters that changed as a result of orthodontic treatment (teleradiography orthopantomography, analysis of control and diagnostic models), and compared them with the subjective assessment of patients. We have found that the patient's motivation, desire to cooperate with the doctor, a clear understanding of the treatment goals allows you to get a high-quality result and keep it for a long enough period of time. Keywords: dental anomalies, orthodontic treatment, bracket system, period of retention, treatment planning.
Designing Boardgame Media for Child Growth Stimulation Through Children’s Games Nurlailis Saadah; Budi Joko Santosa; Budi Yulianto; Uswatun Khasanah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Introduction: Educating children requires interesting and safe media. Childhood is a period of growth and development of various aspects which include fine motor, gross motoric, language, and social personal. Social interaction can use technology that is not limited to space and time through gadgets. If there is no control over the use of gadgets, children can become addicted to them, indifferent to those around them, and rarely communicate with people around them. To anticipate this, alternative media that are safer than gadgets is game board. Methods: This research method included 2 phases. Phase I was Research & Development model research, Phase II was the implementation of the model using Pre-Experimental Design research that applies non-randomized One-Shot Case Study. Data were collected by using interview, questionnaire and observation. The data was processed using the visual comparison matrix analysis method. An attractive game board must be supported by a good mechanism and visibility. Results: Children can grow and develop well if a healthy lifestyle is implanted like healthy food is. The solution to this problem can be achieved by designing educational board games as a medium for learning and playing. The reason is that board games have rules, goals, problems, players, procedures, etc. It can also train psychomotor, emotional, moral, cognitive, artistic, children’s language aspects with fun. The board game is expected to make children interact well so that all aspects of a child’s development run well. Keywords: Board games, Stimulation, Types of Children's Games
In-Silico Screening of Ranggap Bananas (Musa troglodytarum L) Compound Components against Dipeptidyl Peptidase 4 Receptors as Therapeutic Targets for Type 2 Diabetes Anredera cordifolia Leaves Sub-fraction as Anti-Hyperlipidemia Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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This study aimed to evaluate the anti-hyperlipidemic properties of the sub-fraction of the Binahong (Madeira vine, Anredera cordifolia) extract in male Wistar rats. The rats were given high-fat food every day for 3 months and pure cholesterol on weeks 0, 3, 7, and 11. Furthermore, Ethyl acetate sub-fraction of binahong leaves with 0, 12 mg/kg BW, and 0, 24 mg/kg BW doses were given orally for 3 weeks and observed for lipid profile on day 21. The result showed that sub-fractions of Madeira vine leaves decreased in triglyceride, cholesterol, and low-density lipoprotein (LDL) levels and did not influence the high-density lipoprotein level (HDL). Meanwhile, statin decreased total triglyceride, cholesterol, and the LDL level, and increased the HDL level. It concluded that Madeira vine sub-fraction with 0, 24 mg/kg BW dose presented improved results in the lipoprotein profile. Keywords: Binahong, Madeira vine, Anredera cordifolia, Hyperlipidemia, Ethyl acetate fraction.
A Comparative Study on In-vitro Nitric oxide scavenging activity between Zonegran and Levetiracetram Manish Babbu UG; Karthik V P
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Zonegran and Levetiracetram are two new range of anti-epileptics available in the market. Studies have been made earlier to demonstrate the antioxidant activity of the drugs Zonegran and Levetiracetam. Both have a good antioxidant property but there was not any comparative study for both the drugs. This study is to compare the anti-epileptic drugs Levetiracetam and Zonegran and demonstrate which drug has higher antioxidant property through Nitric Oxide radical scavenging activity.Methods: Nitric oxide scavenging activity was determined according to GriessIllosvoy reaction, with the help of Griess reagent. Ascorbic acid is used as positive control for the study. Conclusion: The study done suggests that both Zonegran and Levetiracetram possess antioxidant properties. At lower doses, Zonegran shows higher antioxidant potential over Levetiracetram and at higher doses, Levetiracetram shows slightly higher antioxidant property.
In Vitro Determination of Antioxidant activity, total phenolics, total flavonoids, anti-cholesterol of extracts Saffron (Crocus sativus) Muhammad Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Background: In Indonesia, saffron (Crocus sativus) drinks are now the latest healthy lifestyle trend. Saffron is used as a natural antioxidant, where antioxidants are related to cholesterol inhibition. The antioxidant activity of saffron is closely related to the content of flavonoids and phenolic compounds. This study aimed to determine Saffron 50% ethanol extract's effect on antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC), and anti-cholesterol. Methods: Inhibition of antioxidant activity with 2-diphenyl-1-picrylhydrazyl DPPH, determining TPC using Folin-Ciocalteu and TFC reagent using AlCl3 reagent, and anti-cholesterol with Cholesterol Standard. Results: TFC 19.14 ± 0.9 mg QE / g, TPC 4.8 ± 0.9 mg GAE / g, antioxidant activity with extract IC 50 6939.02, Quercetin 9.57, Rutin 41.70, and decreased the greatest cholesterol occurred at a concentration of 400 ppm with a decrease of 13.22%. Conclusion: The 50% saffron ethanol extract can be an antioxidant and anti-cholesterol in vitro, but it needs further testing in vivo with the same extract.
The Use of Various Polymers with Solid Dispersion Application of Hot Melt Extrusion (HME) Preparing New Delivery Drug System Sofi Nurmay Stiani
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Hot Melt Extrusion (HME) at the beginning appeared widely used in the plastic industry and food industry, but in the last few decades, many researchers have succeeded in applying the HME method as a drug delivery system and determining various dosage forms in the pharmaceutical industry. The challenges that arise in the pharmaceutical are related to the solubility, dissolution rate, and bioavailability of drugs, especially for drugs that have low solubility in water. The low solubility and bioavailability will reduce the pharmacological effect of a drug. Solid dispersion using HME method succeeded in answering this challenge by distributing the drug evenly in the hydrophilic polymer during the extrusion process and changing the crystalline form to the amorphous form while maintaining drug stability. This review will examine the polymers are suitable for the HME method, Mechanism for solid dispersion using HME method, Steps must be taken to prepare solid dispersions using HME and characterization of solid dispersion resulting from HME and determinants of success of solid dispersions Keywords: Polymer, Solid Dispersion, hot-melt extrusion, Mechanism of solid dispersion, Step HME.
The Effectiveness of Reduction of Weight Metal Contents of Pb, and Hg in Water Electro-coagulation Method Ferry Kriswandana
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Background and Aim: Heavy metals in certain levels can reduce the quality of air, water, and soil. Furthermore, causing health problems for plants, animals and humans, when there is accumulation as a result of industrial activity. Until now, the reduction of heavy metal content in liquid waste has been carried out physically, chemically and biologically. Therefore it is deemed necessary to reduce levels of heavy metals in liquid waste by electrocoagulation. The purpose of this study is to study the performance of electrocoaglation as a reducing agent in reducing Pb and Hg levels in water, so that it can provide references and input for the electroplating industry, batik industry, and others. Method and Materials: This research is a true experimental research with a post test only control group design, which is a research design consisting of a control group and an experimental group. The research sample will be examined in the laboratory. The sample used in this study is a preparation that has been made by dissolving Pb and Hg so that it is like waste from the batik industry or electroplating waste or battery factory waste. The variations in this study were the current / voltage (16, 20, and 24) volts and the detention time (30, 40, 50, and 60) minutes. The independent variable is electrocoagulation which is equipped with cathode and anode. This variable will affect changes in the dependent variable. The dependent variable in this study is the quality of the waste after electrocoagulation by observing the parameters of Pb and Hg. Statistical Analysis: Data analysis using the One-way Anova test or One-way Anova. Results: The results of this study indicate that electrocoagulation as a reducing agent at 16 Volts, 20 Volts, and 24 Volts with a contact time of 30 minutes, 40 minutes, 50 minutes and 60 minutes has a significant effect on Pb and Hg reduction with α = 0.05. The most significant reduction in average Pb occurs in processing with a 20 volt electricity voltage and 60 minutes contact time. Meanwhile, the most significant decrease in Hg levels occurs in processing with a 24 volt electricity voltage and contact time for 30 minutes. Discussion and Conclusion: The reduction in Pb and Hg levels using the electrocoagulation method with aluminum electrodes comes from a redox reaction process where the anode (in acidic pH) will form the Al(s) → Al3+ (aq)¬ + 3e and the cathode will form 3H+ (aq) + 3e- → 1,5H2 (g)¬. After the anode and cathode react, there will be a floc formation which functions as a coagulant that will bind Pb. The conclusion of this study is that the most significant decrease in the average Pb level occurs in processing with a power supply of 20 volts and a contact time of 60 minutes. Meanwhile, the most significant decrease in Hg levels occurred in the treatment with 24 volt electricity and the contact time was 30 minutes. Keywords: Electro-coagulation, Voltage, Contact time, Heavy metals.
The Effect of Interpersonal on the Use of Traditional Medicine in Hypertension Patients with Health Promotion Model Approach Ronal Surya Aditya
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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ABSTRACT: Hypertension is a disease that requires compliance with drug consumption, but many people are affected by using traditional medicine. Interpersonal influences affect them in the choice of treatment. This study aims to determine the interpersonal influence on traditional drug use in hypertensive patients with a theoretical approach to health promotion models. The subjects of this study were 148 hypertension people in Posyandu, Jenggolo Village, Kepanjen Regency. The design of this research is Cross-Sectional with the sampling technique uses purposive sampling to get a sample of 108 people. Retrieval of data using questionnaire sheets and multiple linear regression statistical tests. The results of the study using multiple linear regression test showed that family support had a B value of 0.111 with sig = 0.036, support of health workers had a value of B 0.156 with sig = 0.028, and peer support had a value of B 0.233 with sig = 0.002. The beta coefficient value on family support is 0.203, health worker support is 0.212, and peer support is 0.297. It can be concluded that the three supporters, namely family, health workers and peers, influence the use of traditional medicine. The most dominant influence in this study was on peer support. The results of this study are expected to provide input for other researchers about providing interventions to peers in patients with hypertension.
Green and Health Constitution of Green Open Space and Its Implementation in Surakarta Absori Absori
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Purpose: to find the essence from 1945 Constitution of the Republic of Indonesia Article 28H Paragraph (1) confirms that the right to obtain a good and healthy environment and good health services is part of human rights. Methods: this reaserch is a normative juridical methods and his research aimed at describing the Green Constitution in government policy regarding green open space and its implementation in Surakarta as an attempt to carry out the development and planning of the city that is environmentally friendly. This research was legal research conducted using a qualitative non-doctrinal approach. The results: showed that the Green Constitution that is friendly and perspective of the environment contained regulations and protections for environmental perspective. Based on data from the Regional Spatial Planning Coordinating Team (called TKPRD) Surakarta has 10% open space and the latest research conducted by the Geographic Information System (2015) of Surakarta has 9.17% green open space. Conclussion: The Municipal Government of Surakarta should provide green open space about what is mandated in Law by 30%.
Emergency Management of Preeclampsia-Eclampsia at Primary Services in Surabaya Endah Suprihatin; Sri Hardi Wuryaningsih
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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To reduce maternal mortality due to the relay referral system, initial doses of Sulfas Magnesium (SM) therapy have been established in primary care before being referred, but in practice, magnesium sulfate drugs are often not available at the primary care level or are not used according to guidelines. This study aims to explore the management of emergency preeclampsia-eclampsia in primary services in Surabaya. This research was conducted in 5 primary health services in Surabaya. The sample in this study was health workers who carried out emergency management of the preeclampsia and were selected by disaproportionate stratified random sampling, which consisted of doctors, midwives, and nurses. Data were analyzed using Partial Least Square (PLS). The results showed that organizational characteristics and individual characteristics significantly affected the management of emergency preeclampsia-eclampsia. The magnitude of the coefficient estimate for the characteristics of the officers for the management of emergency preeclampsia-eclampsia was 0.277669 and for the management of emergency preeclampsia / eclampsia was 0.284305. The coefficient was positive, meaning that the better the characteristics of the organization and health workers, the higher the accuracy of the management of emergency preeclampsia. The results of the study indicated that primary health services in Surabaya need to increase the provision of facilities and infrastructure as well as drugs for emergency management of preeclampsia and eclampsia, for health workers it is advisable to increase knowledge especially about the administration of initial doses of magnesium sulfate in preeclampsia-eclampsia patients before being referred. Keywords: Preeclampsia, Eclampsia, Emergency Management, Primary Health Services

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