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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Reality of the Strategic Planning of the Faculties and Departments of Physical Education and Sports Sciences According to the Pfeiffer Model Salam Hantosh Rashed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The objective of current research is to identify to identify the reality of strategic planning in the faculties and departments of physical education and sport sciences according to the model (Pfeiffer) from the point of view of decision-makers. The research sample included as deans of faculties and heads of departments of physical education in Iraq has been a period of study from 04/03/2017 until 30/05/2017 was used descriptive and analytical approach to address statistical data. The researchers recommended that strategic planning contribute to the success of the college or the department and its development through the interest in choosing decision makers to fill sensitive administrative positions. And the adoption of the results of scientific research and studies that dealt with the subject of strategic planning as a key source for the development of the institution, and activates communication and a lot of it between the leaders and workers to build more bridges of trust between them, through meetings and seminars held continuously.Keywords: Strategic planning, Physical education and Pfeiffer model.
The Effect of Special Exercises in the Development of Some Sense of Mobility and its Contribution to the Skillful Performance of Futsal Players Ali Falah Mohamed Hassan
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The game of football is one of the most popular games in the world and this game enjoys great care and attention everywhere, because it is one of the most popular games in the countries of the world and the characteristics and variables of search of perceptions of sense - motor and the proportion of its contribution to the performance of the skills of football halls. The aim of the letter is to: Prepare exercises in the development of some sense of mobility for football players of the halls. The study hypotheses were: There were significant differences in the results of the Pre and Post measurements and for the two groups of research (control, experimental) and for the sake of distance measurements. There were significant differences in the results of the dimension measurements and the two groups of research (control, experimental) and for the benefit of the experimental group. The problem of research in some of the club exercises was observed. There is a lack of attention to the dimensions that directly affect the performance of the skills, including the cognitive requirements, despite their importance. So the researchers wanted to go into the study of this problem a pilot study was the development of special exercises to develop awareness (sense - motor) and then the extent of his contribution to the development of the skillful performance of the players of football halls. The research community consists of players of the fans club for the sports season (2017-2018) and one of the clubs was chosen by lottery (18 players). The most important sensory movements that contribute to the skillful performance of the Futsal Hall were identified through a questionnaire distributed to specialists and obtained special perceptions (Time and place and ball) the highest ratios and then the tests were chosen for the research and modified one of them to suit the subject and after the homogeneity and the experiment was carried out for two times and then conducted Pretests on the members of the research sample and then was given special exercises for the experimental group and adopted the group الظا The course was conducted on the trainer's curriculum and lasted for two months and varied methods of giving exercises to fit the best performance and taking into account the training bases and after the tests were carried out in the same conditions as in the Pretests, the fourth section included the presentation of the results and analyzed and discussed by the researchers put them in the tables and which are illustrative means of what came Results of the study in order to identify the validity and conformity of the objectives of the study and its mandate to analyze the reality of the differences between the Pre and Post tests of the two groups as well as the contribution ratios of perceptions sense of movement and skill performance of the post-test MJ Experimental anguish In order to achieve the objectives of the study researcher used the bag statistical (SPSS) .Thus to reached several conclusions and recommendations of the most important of which there is a positive influence in the development of dynamic perceptions _football players lounges and two sets of research (experimental, control), but to varying degrees. The experimental group, which adopted the exercise exercises, showed a clear superiority over the control group in all the post-tests. Based on these results, the researchers recommended the following: The recommended exercises should be used to develop the level of awareness of the players of the football player’s .And the need for the attention of coaches’ players, including the category of applicants to develop the level of perceptions sense - kinetic to meet the requirements of the skills, planning …Football.Keywords: Special exercises, Mobility, Contribution, Skillful performance and futsal.
Gallic Acid, a Promising Chemopreventive Agent, Antagonizes Breast Cancer: Molecular Mechanisms of Action from Cell Culture Studies Hanaa H Ahmed
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective The present consideration converged on trailing the underlying molecular mechanism of gallic acid in striking the distinctly invasive breast cancer cell line; MDA-MB-231 in vitro. Methods The cytotoxic influence of gallic acid and 5-fluorouracil (5-FU) on MDA-MB-231 cells was stipulated by MTT assay. The expression levels of apoptosis, proliferation, progression, invasion and metastases-related genes were identified by RT-PCR. Results Our data specified that gallic acid and 5-FU displayed modest growth suppression with IC50 values of 251 and 367.171 µM contra MDA-MB-231 cells respectively after 48 h. Otherwise, treatment of MDA-MB-231 cells with gallic acid inspired significant downregulation in the expression level of survivin, STAT3, IL-6, VEGF, Slug, Snail, MMP7 and Notch-4 genes. Whereas, 5-FU instigated significant downregulation in the expression level survivin, STAT3, IL-6 and VEGF genes correlated with significant upregulation in the expression level of Snail and Notch-4 genes. Likewise, 5-FU provoked insignificant upregulation in the expression level of Slug and downregulation in the expression level MMP7 genes. Conclusion The attained data throw light on the distinct mechanism by which gallic acid could engage breast cancer. Gallic acid manifested chemopreventive potentiality against breast cancer aggressiveness through rectifying several dysregulated molecules implicated in cancer cell survival, proliferation, progression, angiogenesis, chemoresistance and metastasis.
The Relationship between Blood Groups and Dermatophytoses of Women in Karbala City Aseel Najah Sabour
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Objective: The current study aims to investigate the relationship between dermatophytoses and blood groups in women. Methods: Thirty women patients with dermatophytoses who visited the hospitals in the holy province of Karbala were diagnosed with the clinical manifestations of them by dermatologists specialists in these hospitals, and blood samples were obtained in the laboratory and the ABO examination for them to know their blood groups and Rh. Results:  Patients are women aged 3 to 90 years. The age group 33-47 years is the highest among the patients, reaching 30%. Most patients (96.67%) were Rh+, while 3.33% were Rh-. People with blood group A are the most likely to develop dermatophytoses with percentage 36.67% of patients, followed by women patients of blood group B with 26.67% , women patients of  blood group O were 20%, while AB blood group women patients were the lowest with 16.66%.The clinical manifestations tinea capitis of dermatophytoses were the most common among the others , and tinea capitis significantly correlated with blood group A, and the rest of the clinical manifestations showed no significant correlation with any of the blood groups. Conclusion: There is a relationship between infection of dermatophytoses and blood groups, specifically between tinea capitis with blood group A. Keywords: Dermatophytosis; Blood groups; Tinea capitis.
Evaluation of Seismic Behaviour in Defensive Tunnels with Oval and Rectangular Cross-Sections in Loose and Dense Soils Peyman Farhadi Yeganeh
Journal of Global Pharma Technology .
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Abstract

Underground spaces are frequently applied in defense areas due to their natural and environmental conditions. Passive defense is a good tool for reducing the possible losses and increasing the efficiency of these structures. By studying the past events, it can be observed that, despite the popular belief, these structures have incurred irreparable damages during the earthquake. To this end, the present paper evaluated the seismic behavior of two specimens of rectangular and oval tunnels applied in passive defense using the plaxis 2D software. These structures were placed under three particular earthquake accelerographs in a dense and loose soil (soil environment of Bandar Abbas), and it was attempted to study the seismic behavior of these tunnels affected by the form of the structure and the soil-structure interaction using this dynamic analysis. The analysis of results showed that the earthquake had a greater impact on rectangular tunnels in loose soil, and the construction of oval tunnels will be more justified in the environment of Bandar Abbas.Keywords: Underground spaces, Passive defense, Earthquake, Soil-structure interaction.
Isolation and Purification of the Z-disc from Vertebrate Myofibrils Samer N. Khalaf
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The Z-disc is located within the I-band between neighboring sarcomeres (the fundamental unit of contraction within the muscle). It is composed of approximately 40 proteins, mostly α-actinin. Recent studies have reported that this part of the sarcomere is an active structure that contributes to the sensing mechanism and signaling pathways that control muscle activity. Several mutations occur in the Z-disc proteins and cause many diseases. In addition, the interactions between these proteins are not understood yet. Thus, many attempts have been made to isolate a well-preserved Z-disc that would help to understand the interactions between its proteins and treatment of different diseases, particularly some cardiac diseases. Different strategies have previously been applied to isolate the Z-disc from insects, for example, but these were harsh conditions that caused damage to the Z-disc. Herein, mild conditions were applied to extract a well-preserved Z-disc from vertebrate myofibrils. Our procedure was primarily based on two steps; homogenisation of myofibrils into A-bands and I-bands after digestion of titin with trypsin, and then depolymerising actin through gelsolin. Phase contrast light microscope, SDS-PAGE analysis and electron microscopy with negative staining were employed for visualization. Myofibrils were prepared successfully in a suitable quality (striated and single myofibrils) and quantity. Titin was cleaved using trypsin and the A-band and I-band were partially separated. Furthermore, our findings showed partially depolymerisation of actin filaments with gelsolin. The mild conditions used were considered a promising start to a successful method for isolation of Z-discs from vertebrates.Keywords: Z-discs, Sarcomere length, Titin, Trypsin, Actin, Gelsolin.
Evaluation Causes of Hypertension in Some Cities at East Capital Baghdad by Serum Sodium Level Enamm S. Abdullah
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The studies discuss how the higher serum sodium by high sodium dietary intake effect on management & control of primary hypertension. By take a random 150 patients labeled as primary hypertension with the same medication sources from ministry of health (MOH) in east capital Baghdad. And we neglect the other patients they have other causes that lead to higher blood pressure by measure the serum sodium and questionnaire. The result show there is a higher percent have uncontrolled HTN even take the medications cause of high sodium daily dietary intake reach to 32% in adhamiah, 58% in Al - Saader city, 44% in Al-zaafaraniah.   Keywords: HTN (hypertension), PHCC (primary health care center), serum sodium level.
Measurement of Some Blood Parameters in Smokers of Men in the Province of Al-Muthanna Areej Shakeer Jassum
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The detached of this study is to consider the influence of smoking on some blood parameters and to calculate the negative special influences of cigarette on the biochemical properties of blood in males. This study was lead at Al- Hussein Educational Hospital in AL- Muthanna province."The study excluded (80) blood samples of men, (40) including smokers and (40) non-smokers and were considered a control group."The age of smokers and control group ranged between (20-50) years .The samples of blood were reserved and the hemoglobin concentration, full number of red blood cells, blood volume and full number of white blood cells were calculated. The results presented a significant enhance (p <0.05) in white blood cells, red blood cells, packed cell volume , grand cell and hemoglobin paralleled with control group. The study also displayed non- significant differences in the total of plates, lymph cell and mid cell paralleled with control group. In deduction, our findings displayed that continuous cigarette smoking has severe adverse influences on blood parameters (such as hemoglobin, total renal corpuscle). "These changes may be linked with a greater risk of developing at hero sclerosis, red fera, chronic uncooperative pulmonary disease or heart disease and blood vessels.
An Opinion about the Current Development and Immunity of Zika Vaccines Ibrahim M S Shnawa
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The current available developing zika virus vaccines and virus immunity are being stated.  All the known vaccine classes have been attempted for evolving human zika approved vaccine(s).At the experimental preclinical level both preventive and therapeutic vaccines are known. While on clinical level, neither preventive nor therapeutic zika vaccines are globally approved for public human use   till now. Zika vaccine immunity in mice monkeys and to lesser extent in man has shown to be dependent on the nature of the active immunogen forming the investigational vaccine. Different vaccine design may affect different immune response types. The vaccine immunity in mice and monkeys are rather different from that of man though they are of mammalian lineage. Live attenuated and inactivated whole virus vaccines induced virus neutralizing zika antibody responses .Zika DNA vaccine makes induced cell mediated immunity .mRNA vaccines showed antibody and cell mediated immunity. The  features of  zika infection versus zika vaccine immunity can be summarized as :i- Virus neutralizing antibody responses ,ii-antibody response reduces local and systemic viremia associated with immune protection ,iii- post challenge sterile immunity ,iv- antibody dependent immune enhancement of other related viruses ,v-zika  pathologic autoantibody mediate nervous  immune tissue injuries ,and v-zika specific monoclonal antibodies were found valid for immunotherapy of zika infection based onto passive immune effect of mAb at the experimental level.  Having an in hand global approved zika vaccine will needs   around five to ten years to be attained.Keywords: Antibody, Autoantibody
Effectiveness of Chamomile Tea toward Sleep Quality Amount Autistic Children Nuh Huda
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: Autistic children often experience sleep problems when compared to children in the general population. Difficulty in starting sleep or maintaining sleep occurs in about 10% to 20% of children aged 4-15 years; it can cause other problems such as behaviour disorders, cognitive, and hyperactivity. Consuming chamomile tea before going to sleep is believed to make the body's muscles relax and make the individual sleep faster. This study aims to analyze the effectiveness of chamomile tea on sleep quality in autistic children in Surabaya.  Method: pre-experimental research with one group pre-post-test design. The population of 221 of autistic children with a sample of 66 respondents selected by simple random sampling. The instrument used a questionnaire sheet CSHQ (Children Sleep Habit Questionnaire), the independent variable in this study was the drinking of chamomile tea, the dependent variable was sleep quality, data were analyzed using the Wilcoxon Signed Test (α = 0.05).  Results: after being given chamomile tea once every 2 days for 1 month it was found 54 respondents (81.8%) improved their sleep quality and 12 respondents (18.2%) had a stable sleep quality. Wilcoxon Signed Test results show the effectiveness of chamomile tea on sleep quality for children with autism p=0.0013.  Conclusion: Chamomile tea has an active ingredient apigenin which will bind GABA in the brain to reduce excessive brain activity so that the body becomes calmer and more relaxed. So that chamomile tea can be consumed by children with autism to reduce sleep disorders.Keywords: Autistic children; Chamomile tea; Sleep quality.

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