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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Characterization of Biofilm production and quorum sensing phenomenon among antibiotic resistant Acinetobacter baumannii isolated from wound infections in Iraq Rawa Abdul Redha Aziz; Sawsan Sajid Al-Jubori
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Objective(s): Acinetobacter baumannii has emerged as a significant hospital pathogen, quickly becoming resistant to wide range of antimicrobials. It has gained notoriety as a cause of debilitating soft tissue infections in soldiers returning from Iraq and Afghanistan.This study focused on the characterization of biofilm production in Iraqi A. baumannii and its regulation by quorum sensing. Material and Methods: twenty four isolates were collected from Baghdad and Al-Najaf hospitals and re-diagnosed by compact Vitek 2 and genetically using housekeeping gene (recA). Phenotypic detection of biofilm formation was screened by microtiter dish assay, twitching motility assay, and SEM. Quorum sensing phenomenon (QS) was detected using conventional PCR. Results: 100% of isolates formed either strong or weak biofilm by microtiter dish assay. Twitching motility test revealed that 79.2% of isolates were motile. SEM analysis showed 79.2% of isolates made different stages of biofilm started with adhesion step and ending with a mushroom like architecture as highly magnification images showed on glass cover slips. PCR analysis of QS showed that 91.7% of A. baumannii harbored AHL gene encoding N-acyl homoserine lactone hydrolase at amplified size 498bp, while 83.3% of A. baumannii isolates could harbor abaI gene encoding N-acyl homoserine lactone synthase at amplified size 382bp. Conclusion: it could be concluded that A. baumannii isolates were capable to produce biofilm and control it using quorum sensing genes expression. This would raise the concern of dissemination of chronic infections among hospitalized patients in two cities: Baghdad and Al-Najaf.
Chemoprofiling of Active n-Hexane Fraction as Alpha-Glucosidase Inhibitors from Kanunang (Cordia myxa L.) Leaves from Enrekang South Sulawesi Ahmad Najib
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Kanunang (Cordia myxa L.) is a native plant from tropical Asia. This study aims to determine the profile of chemical compounds contained in leaves of Kanunang (Cordia myxa) which can inhibit alpha-glucosidase enzyme. Extraction of Kanunang leaves was done by maceration method using ethanol 96% solvent for 3 days then filtered and thickened with rotary vacuum evaporator. Resulting extract with yield value of 5%. The extract was fractionated using conventional column method with n-hexane: ethyl acetate (10: 0) eluent. The n-hexane fraction was tested using the GC-MS instrument with the following condition; injector temperature 250°C, initial oven temperature 70°C, up to 325°C increasing 10°C/minute. The results obtained was 24 compounds which have alpha-glucosidase enzyme inhibitors activity with maximum abundance at RT 12:43, as 9,12,15-Octadecatrienoic Acid, methyl ester (C19H32O2) compound.Keywords: Cordia myxa L.; Chemical profile; GC-MS; Alpha-glucosidase.
Association between Obesity and Markers of Inflammation, Oxidative Stress and Neuronal Injury in Women with Non-alcoholic Fatty Liver Moushira Zaki
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The present study aimed to investigate the association of Nuclear Factor (NF)-κB, oxidized –low density lipoprotein (o-LDL), total antioxidant capacity (TAC), neuron-specific enolase (NSE) and CD4 in obese women with non-alcoholic fatty liver (NAFLD). A total of 36 NAFLD obese women were enrolled in this study and 36 female control healthy women (aged 30-39) without cognitive impairment were examined. NAFLD patients were diagnosed by magnetic resonance elastography. Anthropometric parameters including body height, weight, waist circumference (WC) and body fat % were measured. Serum NF-Κb, TAC, CD4, o- LDL and NSE   were measured by ELISA.  Also, liver function tests, lipid profile were done. The present results showed marked elevation in serum NF-κB and o-LDL, while significant reduction in TAC and CD4 in obese NFALD than normal control subjects. In conclusion results provide evidence of association between obesity, high levels of oxidative stress, inflammatory markers and brain biomarker in women with NAFLD.
LOW CD8+ T LYMPHOCYTE/TUMOR BUDDING INDEX PREDICT POSITIVE NODAL STATUS IN BREAST CARCINOMA Ni Putu Sriwidyani; I Wayan Juli Sumadi
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
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Abstract

Introduction: Death in breast cancer patients are mostly caused by the presence of distant metastasis and nodal status is the strongest prognostic factor of metastasis. CD8+ T lymphocyte/tumor budding index is a representation of the anti/protumor properties interaction. The purpose of this study is to prove the interaction between tumor cells and tumor microenvironment and its relationship nodal status in breast carcinoma. Methods: A cross sectional analytic study using 45 cases of breast carcinoma which were underwent mastectomy and radical axillary lymph node dissection at Sanglah Hospital Denpasar during 1 January until 31 December 2017 was conducted. Tumor budding was a small group of cells at the edge of tumor invasion which was evaluated at H-E slide. CD8+ T lymphocyte was evaluated on immunohistochemical slide and was calculated on the peritumoral stroma. Results: Using ROC curve, cut-off value was 4.05. Of all cases, 23 cases with low and 22 cases with high CD8+ T lymphocyte/tumor budding index. CD8+ T lymphocyte/tumor budding index had a significant inverse correlation with nodal status (p=0.000), meanwhile LVI has linier correlation with nodal status in breast carcinoma (p=0.006). Conclusion: there was an inverse relationship between CD8+ T lymphocyte/tumor budding index with nodal status in patients with breast carcinoma
Evaluation of Lactobacillus spp. as a Probiotic Agent against Pathogenic Bacteria Suhad Faisal Hatem Al-Mugdadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Objective: The World Health Organization (WHO) and Agriculture Organization of the United Nations (FAO) defined the robotics in this manner: ‘live microorganisms which, when administered in enough amounts, give a health benefit on the host’. One of the significant features of robotic lactobacilli is to make aggressive activity against pathogenic bacteria because of their ability to produce lactic acid and other organic acids that reduce the pH in the human intestine, in addition to bacteria in and H2O2, which consider a unfriendly environment for the development and survival of various pathogenic bacteria. This study aimed to studying the effect of crude supernatant cell free component extracted from Lactobacillus sp. natural isolate from vagina and commercial sheet including Lactobacillus fermentum, Lactobacillus delbruekii as aprobiotic against various pathogenic bacteria isolates which is multidrug resistance. Materials and Methods: The lactic acid bacteria were isolated from two sources including Lactobacillus sp. from healthy vaginal swabs and commercial Lactobacillus fermentum and Lactobacillus delbruekii as a sachets on MRS selective media agar and broth. Cell free supernatant was extracted from Lactobacillus spp. by using autoclave and cooling centrifuge to evaluate it as Robotic in vitro using agar well diffusion method. Result Anti-bacterial activity of  lactobacillus sp. Isolate supernatant free cells  against pathogenic bacteria by using heat (autoclave) showed biological effect on K. pneumonia(28mm) E.coli in urine(20mm), S .aureus in ear(24mm) , S. aureus in vagina(28mm), Candida albiccans in vagaina (6mm), H. influence in sputum(10mm), K. pneumonia sputum(6mm) and Seriesin wound(16mm).No effect of supernatant was shown by using cooling centrifuge. Commercial mixture of Lactobacillus fermentum, Lactobacillus delbruekii supernatant cell free of these strains which obtained by Cooling centrifuge and Autoclave showed variation in diameter inhibition zones but it still less than  diameter of  zones of vaginal lactobacillus sp. Supernatant. Conclusion: The efficiency of fresh curd supernatant of lactobacilli from healthy vagina in addition to the commercially available lactobacilli strains consider, as a good robotic and therapeutics against pathogenic bacteria. In addition this results conclude that effect components (supernatant) obtained by the heating consider better method than cooling.Keywords: Lactobacillus spp, Probiotic, pathogenic bacteria, Antibacterial activity.
Molecular Identification of Entamoeba Histolytica In Amoebiasis Patients Ali Hassan Al-Timimi
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Infection is the third-greatest parasitic disease responsible for death in the world. Amoebic infections result either in a harmless colonization of the intestine, or in an amoebiosis with invasion and damage of the intestine, liver, lung, and brain. These distinct manifestations are due to the existence of Entamoeba Histolytica alone or with Entamoeba Dispar as a complex of two different, but morphologically identical species. One that is a nonpathogenic commensal in the intestine of humans, E. Dispar, and the other that is capable of inducing cell and tissue damage. Due to genomic DNA differences between pathogenic and nonpathogenic of these protozoan infections, we used a polymerase chain reaction (PCR) method that diagnosed and differentiated the two conditions. DNA extraction protocol using non-fixed stool samples.about60 of 65 stool specimens from patients with amoebiosis was characterized. Among them, 45 (75%) were infected only with the nonpathogenic species, E. Dispar, while 15 (25 %) displayed a mixed infection with the pathogenic nonpathogenic species, E. Dispar and E. Histolytica. The PCR protocol showed a specificity of 1.00 and a sensitivity of 0.95. The molecular approach is therefore reliable and applicable in the identification of pathogenic E. Histolytica infection. Present results provided tha importance data for the Iraqi Health Care System and   addressed the emerging problems of amoebic infection in Iraqi.Keywords: Entamoebahistolytiac, Molecular characterization, E. dispar, Stool sample.
Evaluation and Investigation of the Prevalence of Superficial Mycosis among Primary Schools Pupils in Al-Dewaniyah Governorate, Iraq Sara K. Al-Zubaidi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: The Superficial mycosis infections are the widespread types of mycosis among children primary schools. Objective: To detection and evaluation the extent and prevalence of superficial mycosis infection among primary school pupils in Al-Dewaniyah province. Subjects and methods: The survey included the selection of the pupils were randomly selected based on those with tinea (ringworm) lesions sample of 103 pupils (males 81, females 22) respectively from ten primary schools (six male and four female schools), they clinically diagnosis dermatophytoses, in the Diwaniyah Teaching Hospital, Dermatology unit, during a period from the beginning of December 2018 till the final February 2019. The specimens were collected in sterile plastic Petri dishes or sterile plastic envelopes and consisted of skin scales, hairs, or clippings from fingernails and toenails. The samples of fingernails and toenails were cut or to get mycelial elements. Results: The results of identity and incidence of the dermatophytes and non-dermatophytes isolated were revealed that dermatophytic isolation " Tinea" was 36/103(34%) among patients and this percentage was distributed to various clinical cases of ringworm ''tinea'', Mean age of patients enrolled in the present study was 20.11+10.99 years with a range of 7 to 13 years, According to gender patients were classified into 25 male s (69%) and 11 females (31 %). dermatophytes infections Is a problem in the health system of many developing countries and influences all ages chiefly primary pupils.  Conclusion: The current study prevalence of superficial mycosis among pupils of primary school was significant risk factors assessed such as poor personal hygiene, overcrowding. Consequently, proper health education, personal and environmental sanitation, provision of infrastructure, primary health care and regular clinical studies are recommended for these primary school pupils.Keywords: Dermatophytes, Primary school pupils, Mycelia, Superficial mycosis.
Preparation and Characterization of Bacterial Cellulose and its Composites with Nano Silver Particles of Bioactive Elements Alaa Abdulnabi Ahmed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Bacterial cellulose has unique physical and mechanical structural properties. Which qualifies it for use in many industrial, medical and other applications? It is more effective in putting out wounds or burns as it used as a catch to take advantage of one of its advantages, which is its ability to retain fluids for longer due to its low degree of crystallization. Where a study carried out for the preparation of Nano silver cellulose compound of two methods, namely thermal reduction and Electrical mothed. An FT-IR spectrum analysis was s and to know the interconnection between silver Nano particles with bacterial cellulose. The size of the particles was estimated silver nanoparticles of (34.6-35.0) nm respectively for both methods with the AFM technique and to ensure the occurrence of actual adsorption with UV-Vis, SEM and EDX technology, while the x-ray technology showed the shape of silver Nano particles cube and at a volume rate of (4.49, 10.06) nm respectively for both methods and was studied  Biological efficacy towards the bacteria of wounds and burns where the results of both methods showed a strong effect to inhibit and stop these bacteria, Finally, compare it to both methods in terms of advantages and disadvantages in terms of the purity of the output was the best but the rate of molecular size and biological effectiveness and time of thermal reduction is the best.Keywords: Bacterial cellulose; Silver nanoparticles; Composites; Antibacterial activity.
A REVIEW ON APPROACHES USED TO OVERCOME PROBLEMS ASSOCIATED WITH CONVENTIONAL DOSAGE FORMS OF H2 ANTAGONIST Mahalaxmi Rathnanand
Journal of Global Pharma Technology Volume 10 Issue 04: (2018) April 2018
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Abstract

Gastro intestinal disease conditions includes acid reflux, heartburn, gastroesophageal reflux disease, dyspepsia, nausea and vomiting, peptic ulcer, abdominal pain, belching, swollen mucosal membrane with gastric fluids, the accumulation of gas in the alimentary canal, biliary tract and gallbladder infection. All these disorders are results of distinctive causes. Overlapping mechanism results in excessive acid secretion and diminished mucous defence. H2 antagonists generally most widely used in treatment of above conditions. Proton pump inhibitors shows therapeutic advances due to inhibition of most potent acid secretion. Neuronal stimulation and hormonal stimulation of receptor on basolateral and parietal membrane is modified by gastric HCl secretion. Cimetidine, ranitidine, famotidine, and nizatidine have been used to treat these conditions which act on H2 receptor. They are structural analogues of H2 receptor that causes decrease tonic activation rate of the receptor. H2 antagonists have disadvantages like handling, bitterness, moisture absorption, gastric emptying. This review mainly focuses on methods to improve problems related to H2 antagonists.
A Systematic Review of Iranian Medicinal Plants Effective on Female Infertility Mahnaz Yavangi
Journal of Global Pharma Technology Volume 08 Issue 10: (2016) October 2016
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Abstract

Infertility is one of the common and rising problems of women. To treat female infertility, medicinal plants may be used in addition to chemical drugs and assisted reproductive technology. To conduct this review, the terms Fertility and Pregnancy in combination with Medicinal plants, Herb, and Phyto were used to search for and retrieve relevant publications indexed in international databases ISI and PubMed and domestic databases Iran Medex and ISC. The articles that fulfilled the inclusion criteria were analyzed. In this systematic review article, the medicinal plants that were found to be effective on female infertility indices were reported. These plants, according to this review article, are Nigella sativa, Panax ginseng, Phoenix dactylifera L., salep, Glycyrrhiza glabra, Apium graveolens L., and Foeniculum vulgare Mill. The medicinal plants used by Iranian people have been reported to exert optimal effects on female fertility in animal studies through antioxidant properties, increasing follicogenesis, hormonal compounds, and other effective compounds on hormonal system as well as enhancing sex cells viability. Keywords: Infertili1ty, Female, Medicinal plants, Iran.

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