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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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IN VITRO COMPARISON OF OSTEOGENIC DIFFERENTIATION POTENTIAL BETWEEN BONE MARROW STEM CELLS AND ADIPOSE TISSUE MESENCHYMAL STEM CELLS : A SYSTEMATIC REVIEW Prima Rizky Oktari
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

AbstractIntroduction. Bone tissue engineering (BTE) becomes a promising issue to improve bone defect repair. Stem cells are the first choice in BTE due to the ability of  selfrenewal and multi-lineage differentiation. Adipose tissue (AT) is another alternative source that can be obtained by a less invasive method and in larger quantities than bone marrow. Materials and Method. Literature search was conducted using several search engines, such as Cochrane, Scopus, PubMed, EBSCO, and Google Scholar. Studies were screened for inclusion and exclusion criteria.. This review used all In vitro experimental comparison of Mesenchymal Stem Cells (MSCs) derived from adipose tissue and bone marrow. We compared osteogenic differentiation potential between these MSCs. The group of comparison is divided into two sub groups, first group is the comparison among the animal MSCs, and the second group is the comparison among the human MSCsResult and Discussion. From three invitro study and one animal study that compares osteogenic activity of MSC from adipose and MSC from bone marrow, Most of the study shows the osteoblastic differentiation of ATMSCs as demonstrated by AP staining was less than that of the BMMSCs. The amount of matrix mineralization shown by Von Kossa staining also showed statistical differences between the two MSCs.Conclusion. ATMSC have differentiation potential similar to that of BMMSC, ATMSC may be a better source for tissue repair in the respect of their abundance and accessibility.Keyword: Osteogenic differentiation, Mesenchymal Stem Cells, Adipose Tissue Mesenchymal Stem Cells.
Antidotal Therapeutic Trials of Induced Acute Sulphur Toxicosis in Male Rats Falah Muosa Kadhim Al-Rekabi
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The current study is planned for treatment of sulphur acute poisoning as laboratory animals model in male rat. Method: Primarily, oral LD50 estimated by probit method and derived statistically by two different statistic programs, Microsoft excel and Spss version 25, the estimated LD50 was 4102 and 4060 respectively which exhibited no statistical differences. After that the toxic nonfatal dose 3000 mg/Kg.BW was chosen and administered through gastric gavag as a single dose to 18 male rats divided equally and assigned as, G1injected I.P by solution contain (0.6 % sodium nitrate + 6% sodium thiosulfate) plus 0.1 ml B-complex per each 100 gm BW, G2 also injected I.P by barium chloride 160 mg/kg.BW plus 0.1 ml B-complex/100gm .BW, while the third group didn’t receive any anti-dote and considered control group. Results: The result revealed that both anti-dotes have various efficiency to overcome acute sulphur poisoning in rat, but barium chloride plus B-complex was the more efficient one. Conclusion: Barium chloride plus B-Complex I.P antidote is capable to overcome sulphur acute poisoning in rat, but further studies are recommended in ruminantsKeywords: Treatment, Acute, Toxicity, Sulphur, Rat.
Compare between Two Methods for Green Synthesis of Silver Nanoparticles Neeran Obied Jasim
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

In this study, compared  between two biological  methods were used for synthesize  Ag nanoparticles , the first used the extract of the conocarpus and the second used Aspergillus niger .Characterized of these nanoparticles was study by UV–vis spectrum(UV), X-Ray diffraction (XRD), scanning electron microscopy (SEM )analysis .Also antimicrobial activity of synthesis nanoparticles were investigation .Results show, used of plant extract  can be considered as the best formulation for the preparation of silver nanoparticles Because of its small particle size, good stability and purity.Keywords: Ag nanoparticles, Green synthesis, Conocarpus extract, A. Niger.
In Vitro Evaluation and Post-thawing Activation of Najdi, Arabi (Najdi × arabi) Rams Spermatozoa Using Amino Acids and Pentoixfilline Added to Tris Extender Bushra F. Hassan
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This study was done on pooled semen ejaculates of three groups of rams, Arabi, Najdi and their crosses collected by artificial vagina, semen was evaluated before dilution and after thawing from freezing for one month. Dilution of ram’s semen was done by Tris extender as a standard diluents and its semen parameters was evaluated compared with parameter of extenders after addition of glycine and cysteine amino acids. Then all spermatozoa of all diluents were in vitro activated using CO2 incubator for one hour after addition of pentoxiphilline. Also a new seminal diluents was used which is 5% of beet pulp juice of pH 7. Results revealed that dilution with extender having amino acids have significantly better results than Tris standard extender. Also in vitro activation after addition of pentoxifilline gave same results. It is obvious that glycin extender had the better results followed by cysteine extender then Tris standered extender and lastly the extender of beet pulp juice. Keywords: Extender, Rams spermatozoa, Amino acid, Beet pulp.
Diagnosis of Hypothyroidism by Using Some Biomarkers and Immune Markers Nawras.N. Al-alawae
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Thyroid hormones play vital roles in maintaining energy physiological state and regulation energy expenditure. Their physical effects, mediate at multiple target organs, primarily to stimulate cell metabolism and activity. Thyroid illness may be a medical condition that affects the perform of the ductless gland (the endocrine organ found at the front of the neck that produces thyroid hormones).The symptoms of thyroid illness vary reckoning on the sort of Thyriodism. In individuals with gland disease, the thyroid doesn't build enough endocrine to stay the body running usually. Common causes of hypothyroidism, autoimmune disorder, surgical removal of the thyroid, and radiation treatment.  Patients typically have enlargement of the ductless gland (goiter) and either traditional (euthyroid) or gently attenuated (hypothyroid) metabolic state. The T3 , T4 , and thyrotrophic hormone levels is also high in what seems to be a counteractive  mechanism to confirm maintenance of euthyroid and eumetabolic states  The Synapsin one (SYN 1) may be a member within which that job as neural protein, that interface with the living substance surface of conjunction vesicles. Analysis was carried TTR may be a 55kDa homo-tetramer with a compound of dimers quaternary structure that's composed within the liver, plexus choroideus and retinal shade animal tissue for outpouring into the course system, neural structure liquid and also the eye, severally, Analysis was dole out victimisation SPSS version 23The mean variations between T3, T4, TSH, Tg, Anti-Tg, TPO, Anti-TPO, Synapsin one and Transthyretin with management.
IMPLEMENTATION OF MARKER PROTEINS USING STANDARDISED EFFECT Shruti Jain
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

In this paper we have discussed the null hypothesized mean,  standardized effect, true population mean, group sample size,  population S.D., type I error rate (Alpha),  critical value ,and power of different marker proteins (AkT, EGFR, ERK, JNK, MK2, IRS and FKHR) theoretically and validate it with Minitab and Statistica Software. Different plots have been plotted between power and sample size, power and standardized effect, power and type 1 error rate. Later we have plotted a correlation graph for different marker proteins which shows mean, SD, max, min, histogram plot, and scatter plot for each marker protein.
Carboxy Methyl Cellulose (Cmc) As Edible Coating to Extend Shelf Life of Duku (Lansium Domesticum) During Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Duku fruit (Lansium domesticum Corr.) is a tropical fruit which contains a variety of nutrients especially vitamins and minerals that are health beneficial. It has a sweet sour taste, fresh, a little seed and has a thin skin. Duku fruit contains several phytochemicals that possess high antioxidant activities. Severe pericarp browning, fruit drop, moisture loss, off-flavor and chilling injury are the predominant problems in harvested longkong fruit during handling and storage. The postharvest handling of duku fruit aims to prolong its quality and value, but it is not yet adequately developed. It is necessary to use postharvest techniques for the extension of duku shelf life. Application of carboxy methyl cellulose (CMC) as edible coating could be considered as a useful approach to maintain its product quality during preservation. Ojective of the present study focused on the effect of carboxy methyl cellulose (CMC) coating on some physicochemical, microbial and sensory characteristics of duku during preservation. Optimal results showed that weight loss, pH, total soluble solids, titratable acidity and ascorbic acid; total plate count; sensory characteristics could be maintained at appropriate levels by coating duku with 1.5% carboxy methyl cellulose (CMC). The present study attempted to investigate some of the most significant findings to extend the shelf life of duku fruit.Keywords: Duku, Carboxy methyl cellulose, Coating, Preservation, Physicochemical, Microbial, sensory
The Effect of Silver and Titanium Dioxide Nanoparticles on Fungi Isolated from Patients in Babylon City Ali Mahmoud Shaker
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The samples of skin, hair and nail were collected from 50 dermatophytosis patients who are admitting to Marjan Teaching Hospital in Hilla-Babylon province during the period from August 2018 to September 2018. Out of the dermatophytosis patients, there are 32 males and 18 females, the patients age ranges from 15 to >45 years. Potato Dextrose Agar and dermatophyte test medium agar had used for isolation of fungi. For identification of isolated fungi had used microscopic examination after staining the sample with methylene blue. According to the results of this study, the males are 64.3% while females are 35.7% with dermatophytosis patients. The most age groups are between (31-45) years with dermatophytosis recorded (46%). From the result found most cases present in skin 52%. In order to determine the minimum inhibitory concentration of silver nanoparticles, microdilution method was used in 96-well microplates. The concentrations of 1000, 500, 250, 125, 62.5, 31.25, 15.625, 7.81and 3.9 ppm were prepared from silver nanoparticles. From the result was found the IC-50 and IC-90 of SNPs for Trichophyton strains were estimated at 283.78 and 848.76 ppm, respectively. The IC-50 and IC-90 of SNPs for Candida albicans were estimated at 5.77 and 25.99 ppm, respectively. For A. niger, the IC 50 and IC 90 of SNPs were 69.49 and 632.08 ppm, respectively. The IC 50 and IC 90 of SNOs for Mucor were 25.53 and 354.75 ppm, respectively. While In order to determine the minimum inhibitory concentration of titanium dioxide nanoparticles, microdilution method was used in 96-well microplates. The concentrations of 32, 16, 8, 4, 2, 1, 0.5, 0.25and 0.125 mg/ml were prepared from titanium nanoparticles. From the result was found the IC 50 and IC 90 of TiO2 nanoparticles for Trichophyton strain were estimated at 6.89 and 23.63 mg/ml, respectively. The IC 50 and IC 90 of TiO2 nanoparticles for C. albicans were 3.49 and 19.5 mg/ml, respectively. The IC 50 and IC 90 of TiO2 nanoparticles for A. niger were 8.82 and 23.67 mg/ml, respectively. The IC 50 and IC 90 of TiO2 nanoparticles for Mucor were 8.82 and 23.67 mg/ml, respectively.Keywords: Dermatophytes, silver nanoparticles, Titanium dioxide nanoparticles, Minimum Inhibitory Concentration, Aspergillus niger.
Effect of Nutritional Supplementation and Anabolic Androgen with Testosterone on Kidney and Liver Function of Athletes in Baghdad City Firas Salih Abdulhadi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

This research was conducted to explore the impact of hormones and protein supplementabuseon liver and kidney function and some physiological parameters of athletes. Twenty four volunteers were split equally into two groups, group A: athletes who used androgenic hormones for more than six month, group B: athletes who used proteins and group C: eight volunteers male are normal control without use of any hormones or nutritional supplementation. This research studied intake effect on serum urea, creatinine, total protein, aspartate aminotransferase (AST), alkaline aminotransferase (ALT), sodium, potassium and calcium in the three groups. Results showed a significant elevate (P<0.05) in the level of urea, creatinine, AST and ALT for group A and B compared with the control group, but total protein was lower in group A and control group compared with group B. Furthermore, sodium significantly (P<0.05) decreased in group A and group B compared with control group, on the contrary potassium level and the calcium were significantly decreased in control group compared with group A&B.Keywords: Nutritional supplementation, Anabolic Androgen with testosterone, Kidney, Liver.
Biological Synthesis and Characterization of Silver Nanoparticles Using Bacillus Subtilis Ayad F. Alkaim
Journal of Global Pharma Technology .
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Abstract

Biological synthesis of silver nanoparticles using Bacillus subtilis was examined and reported. The quick reduction of silver (Ag+) ions was checked using UV-visible spectrophotometers and showed formation of silver nanoparticles within 1 hr. Transmission electron microscopy (TEM) investigation presented that the synthesized silver nanoparticle are 39.6 nm and has spherical shape. Additional the XRD analysis approves the Nano crystalline phase of silver with FCC crystal structure.Keywords: Nanoparticles; Silver; Bacillus subtilis.

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