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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Serum Adiponectin Level as an Indicator for Incidence of Type 2 Diabetes Mellitus and Myocardial Infarction in Iraqi Population Shahlaa Kh. Chabuk
Journal of Global Pharma Technology .
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Abstract

Objective lower level of "adiponectin" were observed to be related with obesity, type 2" diabetes" and "CAD" because of the significance of it in this field this consideration was assigned to the role of  "adiponectin" on rate ofT2DM crosswise over classes of BMI, , baseline  glucose and insulin. We likewise proposed to contemplate the relationship of "adiponectin" with rate of incidence of myocardial infarction (MI) regardless the BMI and other traditional risk factors. Subjects and methods: This case-control think about was completed in patients took care of Marjan teaching hospital in Babylon province in Iraq from September 2016 until January 2017. The contemporary investigation was incorporated 54 patients, among of them. 27patients experiencing T2DM and 27 patients experiencing MI contrasted with 25 healthy volunteers of a similar age and sex. Blood sample was taken for evaluation of "adiponectin", and insulin resistance by Elisa technique. Totally the patients experienced a therapeutic checkup and estimated their BMI.Results: the primary consequences of contemporary examination were revealed a critical reduction in the sera level of "adiponectin" in patients with T2DM paralleled with those of control group(P<0.05) . What’s more, a very noteworthy increment in the sera level of HOMA-IR in patients with T2DM contrasted and those of control group (P<0.01). Additionally present outcomes demonstrated reduction "adiponectin" level significantly (P<0•04) contrast with control group• notwithstanding that present result did not demonstrate any significant correlation between "adiponectin" and BMI in MI patients. Conclusions Present examinations suggested that, "adiponectin" consider as predictor for occurrence of T2DM based on the increase BMI that lead to development of insulin resistance, also contemporary study showed that "adiponectin" was linked with MI incidence with no association presented with BMI, sex, age and other CAD risk factors.
Antioxidant and Antimicrobial Activities of Phenolic Compounds Producing from Local Isolate Aspergillus niger Noor Shukur Ahmed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The aim of the present research was to examine the phenolic contents; antioxidant and antimicrobial activities of alcoholic extract for Aspergillus niger biomass. The Phenolic compounds were extracted from biomass of isolate by Ethel alcohol, and identified BY using the high performance liquid chromatography analysis (HPLC).  The results were compared with the standard phenolic compounds. This study has found that generally, the biomass extract contains gallic acid, rutin and kampferole. However, the phenolic compounds were extracted by different solvents including: ethyl acetate, methanol and ethanol. The highest concentration of phenolic compounds (264.3.µg/ml) was obtained from the ethanolic extract. Ethanolic extract was screened for antimicrobial activity by using the holes diffusion method against five selected pathogenic bacterial strains which include each of Staphylococcus aureus, Bacillus cereus, Pseudomonase, Escherichia coli, and Klebsella pnuemoniae. We found that compared to G- bacteria, the extract shows high antimicrobial activity against G+ bacteria. On the other hand, Antioxidant activity was determined by measuring the reduction power, and 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging activity. Moreover, we found that the antioxidant activity had been maximizing ethanolic biomass extract (106.1, 92) % respectively, while ethyl acetate and methanol extracts (59.5, 10) % and (49.4, 5.5) % respectively.Keywords: Antioxidants, Antimicrobial, DPPH, Reducing power, HPLC, Aspergillus niger.
Emergency Management of Preeclampsia-Eclampsia at Primary Services in Surabaya Endah Suprihatin; Sri Hardi Wuryaningsih
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

To reduce maternal mortality due to the relay referral system, initial doses of Sulfas Magnesium (SM) therapy have been established in primary care before being referred, but in practice, magnesium sulfate drugs are often not available at the primary care level or are not used according to guidelines. This study aims to explore the management of emergency preeclampsia-eclampsia in primary services in Surabaya. This research was conducted in 5 primary health services in Surabaya. The sample in this study was health workers who carried out emergency management of the preeclampsia and were selected by disaproportionate stratified random sampling, which consisted of doctors, midwives, and nurses. Data were analyzed using Partial Least Square (PLS). The results showed that organizational characteristics and individual characteristics significantly affected the management of emergency preeclampsia-eclampsia. The magnitude of the coefficient estimate for the characteristics of the officers for the management of emergency preeclampsia-eclampsia was 0.277669 and for the management of emergency preeclampsia / eclampsia was 0.284305. The coefficient was positive, meaning that the better the characteristics of the organization and health workers, the higher the accuracy of the management of emergency preeclampsia. The results of the study indicated that primary health services in Surabaya need to increase the provision of facilities and infrastructure as well as drugs for emergency management of preeclampsia and eclampsia, for health workers it is advisable to increase knowledge especially about the administration of initial doses of magnesium sulfate in preeclampsia-eclampsia patients before being referred. Keywords: Preeclampsia, Eclampsia, Emergency Management, Primary Health Services
Synthesis, Spectral Studies and Biological Activity of Azo dye Complexes with Some MetalIons Amer J. Jarad
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

2-(2-amino-5-nitro-phenylazo),-phenol was ready by grouping the diazonium salt of 2-aminophenol with 4-nitroaniline.Thegeometry of azo ligand(HL)was resolved on the origin of (C.H.N) analysis,1H and 13CNMR spectra, infrared spectra and UV–vis electronic absorption spectra. Dealing with the azo ligand produced with Rh+3 and La+3ataqueous ethanol for a 1:3 metal: ligand rate, and in perfect ph. The formation for compounds have been described by utilizing flame atomic, absorption,(C.H.N),Analyses, conductivity, infrared spectra and UV–vis spectral procedures. Nature in the produced compounds, have been studied, obey the ratio of mole and continuous, variance, manners, Beer's law, yielded up a concentration, rate (1×10-4- 3×10-4M),. High molar, absorbent, have been observed from compound solutions. At the origin data an octahedral geometry were assigned for the produced complexes. Biological activity of the produced compounds was assayed. In appending, the dyeing carried out of these compounds was practical above cotton fabric. The dyes were light and detergent stability.Keywords: Transition metals, Azo dyes, Complexes, Dyeing, Biological activity.
Investigating Individual Factors and Mental Health with Preference of Delivery Type in Women Referred to Qamar-E-Bani-Hashem Hospital in Khoy in 2014 Soudabeh Niroomand
Journal of Global Pharma Technology .
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Abstract

Background The consent of the mother on the experience of giving birth has to a large extent with the decision she made about the type of her next delivery. Health-related beliefs or Health Locus of Control(HLC), are referring to the point that to what extent a person's health is under control of internal factors (self) or external factors (effective or influential individuals).  Method 380 patients admitted to the Khoy hospital, gave birth to their childes, were selected randomly in this descriptive study. The participants in this study were asked about their next preferred method of delivery, Social demographic questionnaire were made, and trust in doctors and health-related beliefs questionnaires were completed by the participants. Descriptive statistics (mean, standard deviation) and analytical (Spearman correlation coefficient test and regression) were used for data analysis.  Research findings Mean age of women was in the range of 10/5 ± 24/24. The results showed psychosocial factors in the area of trust between doctor and health-related beliefs, there was no statistically significant relationship with the preferred method of delivery. Also, individual variables such as age, spouse's education, and income prognostic factors were the preferred method of delivery. Conclusion There was no significant relationship between the preferred type of labor and the psychological factors in women. However, with the increase in women's education and their spouses, as well as the type of job and income preferences about method of delivery also changed. By adopting the results of this research can develop strategies to reduce caesarean sections and its complications.Keywords: Method of delivery, Cesarean, Psychological factors.
Determination the Nosiocomial Infections among Burned Patients Admitted at Al-Husseini Teaching Hospital in Holy Karbala Nada Khazal Kadhim Hindi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Burn injuries behold one of the most devastating injuries among people for all age in the worldwide leading to causes premature mortality and with the disability. Materials and Method: An Analytical and Descriptive Study Conducted in order to identify bacterial and associated bacterial types to burn exposure types and with a microbial location among 100 patients who were burned and who arrived at AL-Husseini Hospital Teaching/ Burn Department) were taken by swabs, equipment, nurse, and environment of hospital. Data was collected and analyzed through a descriptive and inferential statistics approach. Results: Most of the bacteria that transmitted to the burned patients were (Staphylococcus aureus) which causes burn nosocomial infections was isolated commonly from hands of nurses and equipment of patients. Patients were exposed significantly to the types of bacterial infection when the value of p detection <0.01. Also, the types of bacterial infection is associated with artificial to a large extent the location of bacteria isolated as the value of p <0.01. Conclusion: The study concluded that Staphylococcus aureus skin more bacteria in the hospital environment and medical staff, which can be infected with the patient, especially a patient who is under fire. Bacterial infections are associated with types of burns. Bacterial infection is also dependent on microbial infection. Confirmed our findings need for careful cleansing of patients and their surroundings.Keywords: Determination, Nosiocomial Infections, Burned Patients.
Killing of Multi-Drug Resistant Staphylococcus Aurous Isolated from Women with Genital Tract Infection with Special Reference to Laser Photosensitization Shaimaa N. Mizil
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Multi-Resistant Staphylococcus aureus(MRSA)were obtained from Al-Yarmook Hospital in Baghdad from women with urinary tract infection (UTI)and genital tract infection(GTI)after susceptibility test for 17 antibiotics we selected the (MRSA)isolates and detect the methicillin resistance gene(mecA),we investigate the best dye for photosensitization among the four dyes (methylin blue MB, crystal violate CV, toluidin blue TB and coomassie brilliant blue-G (CCB) that has the maximum absorption of the wave length of the red laser(635 nm),the most resistant isolate used in  laser photosensitization death time experiment with the selected dye( toluidin blue TB)as the best dye for photosensitization in different power density (12,24,40,60,80 and 100)mW/cm2 with different exposure time ,we found from the results that the percentage of survival cells decreased with the increasing the exposure time to laser light and the time of killing MRSA decrease when the power density increasing. This considers an alternative method to kill MRSA.Keywords: Multi-resistant S. aureus, photosensitization, Laser.
Biological Control of Mosquitoes Cluex pipiens Using Locally Isolate of Bacillus Thuringiensis in Diyala Province Sarmad Qassim Mohammad
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The study included isolating, diagnosing and studying the ability of  Bacillus thuringiensis to kill Culex pipiens larvae, the samples were isolated from different places of agricultural soils in Diyala province. The results of the fermentation medium to grow the B thuringiensis inoculums showed that the best liquid fermentation medium was the barley extract, with 20 gm. A ratio of sucrose per liter mixed with 20 mg of the Amoxicillin antibiotic. The bacterial density in it was 221x106 colony forming unit/ml. Then carry the bacterial suspension on calcium carbonate, preparation three concentrations (1, 2, 3g) of the dry preparation/liter of sterilized water. The results show that the effect of different concentrations of B.thuringiensis on the death rate larvae of Culex pipiens was significant, it was the highest value of dead larvae it was (2.52) at 3 g/L concentrations of B. thuringiensis sand the lowest value of dead larvae it was (0.92) at 1 g/L concentration of B.thuringiensis, at a significant level (0.05).  There were also significant differences between the days, the highest value of dead larvae it was in the fourth day of treatment (2.55) and the lowest value of dead larvae it was on the first day of treatment (0.15) at a significant level (0.05). Twenty-four hours after the initiation of the treatment of larvae Culex pipiens with the bio product of B.thuringiensis, she appeared symptoms of change in behavior, slowed the moving of larvae gradually until completely stopped movement and shrunk, due to the effect of crystalline protein , which decomposes in the middle gut of the larvae and is associated with receptors in the membrane of the gastrointestinal tract, then poison enters the membrane causing the weakness of the epithelial cells and swelling and dissolution causing holes in the membrane  or that the toxins of the bacteria may lead to a disturbance in the nervous system leading to paralysis in the organs responsible for feeding and then the death of larvae from hunger.Keywords: Bacillus thuringiensis, Bioproduct, Mosquitoes, Culex pipiens, Larvae, death.
Antimicrobial Action of Allium sativum and Elettaria Cardamomum against Streptococcus Mutans and Lactococcus Raffinolactis Detachment of Tooth Rot Ashraf Sami Hassan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Twenty specimen from individuals endure tooth rot in various age from Hospitals of the city of Baghdad, segregate analyze of the phenotypic qualities by development of these microorganisms on the way of life media, minute determination and tests biochemical depending on a framework vitek 2 ,where the outcomes demonstrated the microscopic organisms that cause tooth rot is Streptococcus mutans and Lactococcus raffinolactis in equivalent extents, natural adequacy of watery concentrates of Allium sativum and Elettaria cardamomum against the microbes, from the outcomes demonstrate that disengages of Streptococcus mutans was the most touchy to the fluid concentrate comparator with microbes Lactococcus raffinolactis that indicated less impact towards our concentrates under review, On the other hand, the outcomes demonstrated that the fluid concentrate of the Elettaria cardamomum it is best against the development of bacterial species under review contrasted and fluid concentrate of Allium sativum.Keywords: In vitro, Herbal extracts, Antimicrobial activity, Dental pathogens.
Synthesis, Physico-Chemical Characterization, and Cytotoxicity Assay of Mannich Base Derivatives with Heavy Metal Ions on RAW 264.7 Cell Line Mahasin Alias
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Heavy metal complexes of Pd (II), Pt(IV) and Au (III) with new ligands of mannich base S-(1-(benzothiazole-2-ylamino)methyl]-H-benzimidazole-2-yl]4-nitrobenzothioate as (L1), S-(1-((pyra- zine-2-carboxamido)methyl)-1-H-benzoimidaz-ole-2-yl)4-nitrobenzothioate as (L2) & S-(1-Morph- olinomethyl)-1-benzoimidazol-2-yl) 4-nitrobenzothioate as (L3) have been prepared and characterized in solid state, their most probable structure were established through a combination of different spectroscopic and analytical techniques such as: elemental analysis C.H.N.S, flame atomic absorption (A.A), FT-IR, UV–vis spectrophotometry, 1H13CNMR, as well as conductivity and magnetic susceptibility measurements. The ratio of M:L and stability constant was determined by using molar ratio method in solution state. From the spectral studies, an octahedral geometry of PtL1, PtL2, AuL2, PtL3, PdL3 & AuL3 complexes, while PdL1, AuL1 & PdL2 have square planner geometry.  Cytotoxic effect of prepare ligands and their novel complexes were evaluated against RAW 264.7 cell line by using four different concentrations (400, 200, 100 & 50µg/ml) in exposure time 48 hrs. and compared this effect with control positive Cis-Pt.Keywords: Mannich base, Benzimidazole, Analytical techniques, Cytotoxic, Exposure time.

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