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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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PREVALENCE OF HELICOBACTER PYLORI IN OBESE PATIENT Altaee, Mohammed J.; Mohammed, Bilal; Jasim, Ahmed S.; Abdulkadhm, Hasanin
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Helicobacter pylori is a widely recognized pathogen that exhibits a high prevalence among the global population. The infection caused by H. pylori poses significant health risks due to its association with various gastrointestinal disorders, including gastric ulcers, duodenal ulcers, chronic gastritis, and gastric carcinoma. The regulation of gastric hormones, such as ghrelin and leptin, plays a crucial role in energy homeostasis. Ghrelin, secreted by P/D1 cells in the stomach during periods of hunger, stimulates appetite and promotes food consumption. Conversely, leptin, released by P cells in the stomach and adipocytes after food intake, reduces appetite and fosters a sense of fullness. Individuals infected with H. pylori tend to have lower plasma levels of both ghrelin and leptin compared to those who are not infected. Consequently, the reduced serum leptin levels can delay the sensation of satiety during meals, leading to increased energy intake and a potential development of obesity. Aim: Our study has been proposed and structured to achieve the below objectives: Prevalence of H. pylori associated with overweight. Presence or absence of some clinical signs among patient. Prevalence of infection among age group. Methods: Blood seem were collected from 30 person during the period from February to April 2023 and both gender were participate in this study with age ranging from 20-50 years old.Blood tests were used to measure the antibodies against H pylori. The sample were collected and small amount of it applied in to well In the test line area, anti-human IgG is rendered immobile. Following its addition to the device's specimen well, the specimen reacts with the test's H. pylori antigen-coated particles. This mixture interacts with the immobilized anti-human IgG and migrates chromatographically over the course of the test. A colored line will show up in the test line region, signifying a positive result, if the samples contain H. pylori antibodies. A colored line indicating a negative result won't show up in this area if the specimen is devoid of H. pylori antibodies. To act as a methodical. Result: Our study shows that Middle age group were the highest percentage among other age group (35 %). In another hand the overweight patient suffering from H. pylori infection constitutes about 36.7 %. Keywords: Helicobacter Pylori, Obese Patient, Infection.
AN OVERVIEW ON DOSAGE FORM: SUPPOSITORY Jain, Anvesh; Panwar, Mangal Singh
Journal of Global Pharma Technology Volume 17 Issue 01 (2025) Jan 2025
Publisher : Journal of Global Pharma Technology

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Abstract

In this article we converse about various aspects of suppositories such as their introduction, formulations and therapeutic applications. Suppositories are those type of dosage forms that used to provide medication via the vaginal and rectal routes. Before the invention of suppository, liquid enema was used. Enema’s has a big disadvantage that it leaks out of the cavity where it is inserted. Therefore an alternate method of medication was needed and thus suppository was invented. Suppositories can be described as semi-solid dosage form to provide medications via rectal, vaginal routes where they will melt or dissolve and deliver localized or systemic action. Suppositories are preferred over other dosage form because it comes in different shapes and sizes. Suppositories are one of the very convenient modes for drug delivery. In this article we discuss the fundamental components of suppositories including suppository bases, along with the methods of preparation of suppository. This article also targets to fabricate descriptive information about the advancement of suppositories such as, Bi-layered Suppositories, Hollow Suppositories, Effervescent suppositories, etc. Keywords: Suppositories, Types of Bases, Methods of Preparation, Advancement in suppositories.
BIOLOGICALS AND BIOSIMILAR: ADVANCING HEALTHCARE THROUGH INNOVATION AND ACCESSIBILITY Pal, Pradeep; Chorasiya, Anjali; Jawani, Akanshag; Rathore, Chalsy; Panwar, Mangal Singh
Journal of Global Pharma Technology Volume 17 Issue 02 (2025) Feb. 2025
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Abstract

“Biologics” considered one of the fastest growing sectors of the pharmaceutical industry; “Biologics” have introduced many new treatments for life-threatening and rare diseases. The first generation of bio pharmaceutical products produced using recombinant technologies was launched in the 1980s and is now on the way to patent expiration. As a result, research and generic pharmaceutical companies are seizing the opportunity to develop “generic” substitutes for original biologics, referred to here as biosimilars. However, the process of introducing an innovator's biosimilar product is much more complex than the relatively straightforward process of introducing a generic equivalent of an innovator's product based on a new chemical entity. Biologics are produced by cells in culture or whole organisms, which are inherently more variable than chemical synthesis methods. Therefore, unlike generic drugs, it is not possible to create an identical or identical copy of the innovator product. In this way, biosimilars are "similar but not the same" or in other words biosimilars are "a twin but not a clone" of the original biologic innovator product. The field of biosimilars therefore presents several important challenges, including i) validation of similarity, ii) interchangeability of biosimilar and innovative products, iii) possible need for a unique nomenclature to distinguish different bio pharmaceutical products, iv) regulatory framework, v) business opportunities as well as guidance for assistance to manufacturers in product development, vi) intellectual property rights and vii) public safety. Keywords: Biosimilars, Biological drugs, Innovative product, Pharmacovigilance.
THE ROLE OF ARTIFICIAL INTELLIGENCE IN PHARMACEUTICAL RESEARCH AND INSTITUTIONAL EDUCATION: CURRENT CHALLENGES AND FUTURE PROSPECTS Panwar, M. S; Verma, Vaibhav; Sankala, Milan
Journal of Global Pharma Technology Volume 17 Issue 03 (2025) March 2025
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Abstract

Artificial intelligence (AI) has emerged as a transformative tool in pharmaceutical research, enhancing drug discovery, development, and optimization. The integration of machine learning (ML) and deep learning (DL) models has expedited the identification of potential drug candidates, personalized medicine, and predictive analytics for clinical trials. However, despite its rapid advancement, AI in the pharmaceutical industry faces challenges such as data quality, regulatory compliance, and ethical considerations. This paper reviews the commonly used AI models in pharmaceutical research, current obstacles, and the future of AI-driven innovations in the field. Keywords: Artificial intelligence, Machine learning, Deep learning, Drug discovery, Pharmaceutical research, Clinical trials, Personalized medicine.
A COMPREHENSIVE REVIEW OF PHARMACEUTICAL VALIDATION AND QUALIFICATION: CONCEPTS, PRACTICES, AND EVOLVING TRENDS Meena, Manish; Jain, Anvesh; Panwar, Mangal S
Journal of Global Pharma Technology Volume 17 Issue 04 (2025) April 2025
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Abstract

Pharmaceutical validation is a critical component of current Good Manufacturing Practices (cGMP), ensuring that processes, systems, and methods consistently produce products that meet predetermined quality standards. This review explores the principles and types of validation with a focus on process validation, equipment qualification, analytical method validation, cleaning validation, and computer system validation. Emphasis is placed on the regulatory frameworks provided by agencies such as the FDA and EMA, as well as the lifecycle approach to validation, which includes process design, qualification, and continued verification. The article also highlights recent advancements such as risk-based validation strategies, the use of automation and digital tools, and the implementation of ICH guidelines. By integrating both foundational knowledge and emerging trends, this review provides a strategic overview valuable for quality assurance professionals, regulatory personnel, and pharmaceutical researchers. Keywords: Pharmaceutical Validation, Process Qualification, cGMP, Risk-Based Validation, Lifecycle Approach.
COMPARARIVE STUDY OF EFFECT OF SUBSTITUENTS PRESENT ON CEPHALOSPORIN RING ON THE ANALYTICAL METHOD AND STATISTICAL PARAMETERS OF VARIOUS GENERATION DRUGS Dilip M. Chafle
Journal of Global Pharma Technology Volume 17 Issue 11 (2025) Nov.2025
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Abstract

Cephalosporin are very important class of antibiotic drugs which frequently prescribed by medical practitioners in modern allopathy for treatment of bacterial infections. In the present study Cefadroxil, Cefalexin, Cefaclor, Cefuroxime, Cefixime, Cefotaxime, Cefepime and Cefpirome drugs of various generation cephalosporin were selected. The spectrophotometric technique was used to study the effect of substituents of cephalosporin ring on the analytical method and statistical parameters of varios generation cephalosporin drugs. In the proposed method Fe (III) is reduced to Fe (II) by reacting with cephalosporin drug and then complexed with 1, 10 Phenanthroline. The reaction conditions for each drug such as maximum wavelength of absorption, time for complexation of reaction, volume of Fe (III) solution, volume of 1, 10 Phenanthroline solution and volume of phosphoric acid are optimized. The other parameters such as Beer’s law limit, molar absorptivity, Sandell’s sensitivity, regression equation and correlation coefficient have been determined. Lastly correlation of the substituent present on cephalosporin rings in various generations and their effect on analytical method and statistical parameters have been evaluated. Keywords: Spectrophotometry, Cephalosporin, Comparative study, Generation, Substituents.
COVID-19 DISEASE 2019: A REVIEW ARTICLE Salil, Salil Sanghvi; Mangal S. Panwar
Journal of Global Pharma Technology Volume 17 Issue 10 (2025) Oct. 2025
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Abstract

Corona viruses are a group of enveloped viruses with no segmented, single-stranded, and positive-sense RNA genomes. Corona viruses belong to the “Coronaviridae family”, which causes various diseases, from the common cold to SARS and MERS. In March 2020 the World Health Organization declared the SARS-Cov-2 virus a global pandemic. We performed a review to describe existing literature about Corona Virus Disease 2019 (COVID-19) history, Symptoms, Epidemiology, Clinical features, Clinical manifestations, Diagnosis, Treatment, Prevention.   Keywords: COVID-19, Symptoms, Epidemiology, Clinical features, Clinical manifestations, Diagnosis, Treatment, Prevention.
AN ANALYTICAL COMPREHENSIVE REVIEW PAPER ON HARNESSING THE POWER OF HERBAL DRUGS IN PHARMACY: FROM ANCIENT ROOTS TO MODERN THERAPEUTICS , Sakshi Sharma; Manan Agrawal; Sapna Vyas; Mangal S Panwar
Journal of Global Pharma Technology Volume 17 Issue 12 (2025) Dec. 2025
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Abstract

Herbal medicines have been central in the establishment and development of pharmacy as one of the oldest and most reliable sources of therapeutic drugs. With their rich biodiversity and wide reservoir of bioactive metabolites, medicinal plants continue to yield new leads for drug discovery and development. In contemporary pharmacy, herbal drugs not only find extensive use as first-line therapies in numerous cultures but also used as complementary medicines in combination with standard drugs. Their array of pharmacological activities—such as anti-inflammatory, antioxidant, antimicrobial, and anticancer properties-emphasizes their therapeutic value. In addition, the herbal drugs have benefits like reduced toxicity, cost-effectiveness, and patient compliance. Still, issues pertaining to standardization, quality control, safety, and scientific proof remain essential areas of attention. The coordination of traditional knowledge and contemporary pharmaceutical research is the key to maintaining the effectiveness, safety, and international acceptability of medicinal plants. Accordingly, herbal medicines remain of extremely important significance in pharmacy, serving to bridge the gap between traditional healing systems and evidence-based practice. Keywords: Herbal drugs, Modern therapeutics, Pharmacy.

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