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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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AGE-STRATIFIED PREVALENCE AND ANTIBIOTIC RESISTANCE PATTERNS OF HELICOBACTER PYLORI INFECTION AMONG PATIENTS UNDERGOING UPPER GASTROINTESTINAL ENDOSCOPY IN A TERTIARY CARE HOSPITAL, INDIA Ahmad, Imtiyaz; Hassan, Syed Belal; Mustaqueem, Syed Fiza; Ahmad, Ausaf
Journal of Global Pharma Technology Volume 16 Issue 04 (2024) April 2024
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Abstract

The infection rate of H. pylori varies significantly between developing and developed nations, with rates approximately four to five times higher in developing countries. Antibiotic misuse has contributed to resistance issues, complicating eradication efforts. Study aimed to assess age-specific H. pylori prevalence and antibiotic resistance among patients undergoing Upper Gastrointestinal Endoscopy at a tertiary care hospital in India. Study included patients aged 14 to 86 presenting with symptoms like dyspepsia and epigastric pain. Demographic data and treatment history were collected, excluding recent antibiotic or proton pump inhibitor users. Statistical analysis was performed using SPSS version 16.0. Results indicated an overall prevalence of 61.1%, with similar rates across genders. Infection rates peaked at 73.7% in patients above 70 years. Positive endoscopic findings correlated significantly with H. pylori infection, underlining the importance of endoscopic evaluations. Notably, symptoms like epigastric pain were linked to H. pylori positivity. The study concluded that H. pylori prevalence is notably high in individuals above 70 years old. Additionally, it shed light on gender-specific prevalence patterns and highlighted metronidazole resistance as the most common, followed by levofloxacin and amoxicillin resistance. Furthermore, the study stressed the importance of endoscopic examinations in diagnosing H. pylori infection. Keywords: Antibiotic Resistance, Dyspepsia, Epigastric pain, H. pylori, Prevalence.
BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF OXACEPROL IN HUMAN PLASMA BY USING UV-VISIBLE SPECTROPHOTOMETER Sri, K. Bhavya; Banu, Shaheen; Sumakanth, Mogili
Journal of Global Pharma Technology Volume 16 Issue 04 (2024) April 2024
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Abstract

Osteoarthritis is commonly treated with oxaceprol. An easy, quick, accurate, and exact technique for estimating oxaceprol is required since 1 billion people worldwide suffer from rheumatoid arthritis each year. Utilizing a UV-visible spectrophotometer, procedures are developed and then validated. Only a few techniques for estimating oxaceprol have been described, but after reviewing the literature, we developed a method with a wide linearity range and low DL and QL values. Methanol: ACN was used as the solvent in the development of this procedure. The chosen wavelength for examination in this approach was discovered to be 215nm. To do the spectrum study, a double beam spectrophotometer with UV and visible light was employed.In the UV spectrophotometer, the absorbance of several series of dilutions was measured at a wavelength of 215 nm. Oxaceprol concentration was plotted on x-axis & absorbance was taken on y-axis to plot Calibration curve. All the validation parameters were validated as per ICHQ2 (R1) guidelines. Keywords: Osteoarthritis, UV-visible spectrophotometer, linearity, calibration curve, methanol.
DYSLIPIDEMIA MANAGEMENT THROUGH THE SIDDHA FORMULATION CAPSULE ARJUN FORTE - A CASE SERIES P, Nirmala Devi.; C. B. S, Bharath Christian; S, Ethel Shiny.; M, Vanitha.
Journal of Global Pharma Technology Volume 16 Issue 05 (2024) May 2024
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Abstract

Siddha medicine is an ancient traditional system of medicine healing 4448 diseases in the southern part of India, especially Tamilnadu, Srilanka and Malaysia. Dyslipidemia is a condition which is associated with several morbid manifestations. Generally, dyslipidemia does not have any obvious symptoms but they are usually discovered at routine investigation. But it is a leading cause of death due to atherosclerosis, myocardial infarction and ischemic stroke. Purpose of the study was to treat dyslipidemia with Arjun forte capsule, Siddha oral medicine. Here we present a case that was success with siddha management. Four female patients came to my outpatient department of Santhigiri Siddha Medical College and Hospital, Trivandrum, Kerala, with complaints of difficulty in breathing, no other chronic illness such as Diabetes mellitus/Hypertension. The Lab primary report revealed high levels of serum cholesterol LDL, and Triglycerides. No treatment has been taken so far regarding this issue. I was given 2month treatment of capsule Arjun Forte as an internal medicine along with diet and lifestyle modifications. Excellent results observed ultimately. The amount of lipids in blood came to normal in a lab report and symptoms of difficulty in breathing at night were completely relieved. So, It could be concluded as efficacy of Arjun Forte excellent in treating dyslipidemia. Keywords: Siddha management, Dyslipidemia, Capsule-arjun forte, Specific diet, Metabolic dysfunction, Lifestyle disorders, Herbo mineral drug.
ANTIHYPERLIPIDEMIC EFFECT OF KOMOOTHIRA SILASATHU PARPAM IN TRITON-INDUCED ANTI DYSLIPIDEMIC RATS P, Revathy; G, Thirunarayanan; P, Suvedha
Journal of Global Pharma Technology Volume 16 Issue 06 (2024) June 2024
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Abstract

Background: Cardiovascular disease (CVD) is known to be associated with hyperlipidemia. The statin medicine class inhibits a stage that limits the production of cholesterol at a certain pace, although all statins have negative effects on the musculoskeletal system. The current interest has led to a hunt for novel lipid-lowering drugs with little to no side effects among traditional sources of siddha. Objective: The primary goal of this study is to assess the siddha formulation Komoothira silasathu parpam (KSP)’s antityperlipidemic capability in triton-induced dyslipidemic rats. Methods: Triton was used for the induction of hyperlipidemia in the experimental animals. The animals were divided into control, disease control and treatment groups. Rats belongs to treatment groups were administered test drug KSP at doses of 250 and 500 mg/kg/p.o. Results: The data of the present investigation clearly emphasise that the body weight, total cholesterol, HDL, LDL, VLDL, and triglyceride levels of the triton group demonstrate a significant increase in comparison with normal control rats. Treatment with the siddha formulation KSP at 250 and 500 mg/kg doses results in a significant decrease in the total lipid profile and body weight of the experimental animals, Furthermore, the KSP treatment causes a Consistent decrease in the internal organ weight (heart and liver) of the animals. Histological examination of the liver sample confirms the existence of inflammatory changes in triton treatment, and treatment with PVC reveals a restorative nature in both the dose level. Conclusion: In conclusion, the data of the present study show that the siddha formulation KSP reveals promising antihyperlipidemic activity in Triton induced dyslipidemic rats. Hence KSP type formulations may be the good drug of choice in the clinical management of hyperlipidemia Keywords: Hyperlipidemia, Siddha, Komoothira silasathu parpam, Lipid profile, Body weight, Histopathology.
EXPLORING AMYLASE ACTIVITY IN BACTERIA ISOLATED FROM CEREAL - INFESTING INSECTS: A MICROBIOLOGICAL APPROACH Thakare, Dattabhushan Karvir; Hamde, V.S.; Narsinge, A.P.; Kadam, Aditya S.; Dixit, Ankita M.
Journal of Global Pharma Technology Volume 16 Issue 07 (2024) July 2024
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Abstract

Amylases are significant industrial enzymes with diverse applications across various industries. This study aimed to isolate and screening of amylase-producing microorganisms from the gut and salivary gland microflora of cereal-spoiling insects. Samples were collected from cereals infested by pests such as the lesser grain borer, Granary weevil, Rice weevil, and Angoumois grain moth in the Beed district. The digestive tracts of the third and fifth instar larvae of Sitophilus granarius were dissected, homogenized, and serially diluted. The dilutions were spread on nutrient and starch agar plates and incubated to isolate gut flora. Bacterial isolates were tested for amylolytic activity using the starch hydrolysis test. Among the isolates, one coded as SG6 demonstrated the highest amylolytic activity with a 3 mm zone of clearance on starch agar plates. Morphological and Gram staining analysis identified the isolate as gram-positive and rod-shaped. The clear zones observed around the colony indicate starch hydrolysis by amylase production. The colony characteristics of isolate SG6 were circular, medium-sized, and white, with smooth edges, raised elevation, no pigmentation, and motile nature. This study confirms the presence of amylase-producing bacteria in the gut microflora of cereal-spoiling insects and highlights the potential of isolating SG6 for industrial applications. Keywords: Amylase production, Cereal-spoiling insects, Gut microflora, Starch hydrolysis, Sitophilus granaries.
ISOLATION OF PHAGES FOR CANDIDA INHIBITION AND INCREASING EFFICIENCY OF ANTIFUNGAL AGENTS WITH THEM Panicker, Suneeta; Patil, Samrudhi; Peshwe, Samrudhi; Kale, Sanika
Journal of Global Pharma Technology Volume 16 Issue 08 (2024) August 2024
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Abstract

Objectives: Most of the fungal infections are caused by Candida sp. The five prominent species of Candida which are involved in these infections are Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis and Candida dublinienesis. Generally, echinocandin, ketoconazole fluconazole, amphotericin B are recommended to treat Candida infections. But, these infections are often complicated by resistance or refractoriness to current antimicrobial agents. The resistance to azole is most prominent, especially in C. albicans and C. dublinienesis. Therefore, an urgent need exists for new therapeutic strategies based on the identification of new microbial targets and novel antimicrobial agents. One such hypothetical therapeutic strategy may involve the use of mycoviruses that are able to selectively infect fungi. Methods: Candida was isolated from clinical samples. Phages against Pseudomonas were isolates and then checked the antifungal efficiency of these phages by double overlay agar method. Efficiency of these phages with the known antifungal agent (ketoconazole) was determined.Results: The phages of Pseudomonas were found to be effective against the Candida sp. Incorporation of isolated phages into antifungal agent increased its efficiency. These isolated phages can be used in various medicinal products like intimate hygiene, antifungal creams, etc. Conclusion: There are not many reports on bacterial phages against fungus pathogens hence such primitive investigations can aggravate researchers across the global to think innovatively on the similar lines and research to the molecular levels. Keywords: Candidiasis, Biofilm, Morphology switching, Azole resistance, Pseudomonas phages, Antifungal creams.
EVALUATION OF THE ANTIEPILEPTIC EFFECT OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODEL USING MAXIMAL ELECTROSHOCK SEIZURE (MES) Sahoo, Snehalata; Ray, Jassaswi; Prusty, Shaktiketan; Mohanty, R.
Journal of Global Pharma Technology Volume 16 Issue 09 (2024) September 2024
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Epilepsy, a neurological disorder characterized by recurrent seizures, poses significant challenges to affected individuals due to its diverse etiology and limited therapeutic options. This thesis explores the potential therapeutic efficacy of ethanolic extracts derived from Cassia tora leaves in managing epilepsy. Through preclinical investigations, the study aims to elucidate the pharmacological mechanisms underlying the antiepileptic properties of Cassia tora, shedding light on its viability as a complementary or alternative therapy for epilepsy management. Experimental methodologies include in vitro assays to assess neuroprotective effects, in vivo animal models to evaluate seizure severity and frequency, as well as biochemical analyses to elucidate the extract's impact on neurotransmitter systems and oxidative stress pathways. Results from this research endeavor contribute valuable insights into the development of novel therapeutic interventions for epilepsy, potentially enriching the existing armamentarium of antiepileptic drugs and enhancing patient outcomes. Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions worldwide. Current pharmacological treatments often have limitations, prompting exploration into alternative therapies such as herbal extracts. Cassia tora, known for its medicinal properties, is hypothesized to possess antiepileptic effects. This thesis investigates the potential of Cassia tora ethanolic leaf extract in mitigating seizures induced by maximal electroshock (MES) in animal models. Keywords: Cassia tora (C.T), Chrysophanol, Emodin, Anthraquinones, Rat.
RECENT DRUG DISCOVERY STATUS AGAINST PEPTIC ULCER Panda, Girija Shankar; Sahoo, Deeptitapa; Ray, Jassaswi; Mohanty, R.; Nayak, Ritesh Kumar
Journal of Global Pharma Technology Volume 16 Issue 10 (2024) October 2024
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Abstract

Peptic ulcer is a customary disease, it affecting around 5-10% of the general population worldwide, but with notable regional and rectal variants. The two most common etiological causes are the chronic infection with Helicobacter Pylori (HP) and the uses of nonsteroidal anti-inflammatory drugs (NSAIDS). Its diagnosis is based mainly in the endoscopy and the active search of contaminant Helicobacter pylori presence. Peptic ulcers are found to be due to an imbalance between aggressive factors such as hydrochloric acid, pepsin, refluxed bile, leukotrienes, relative oxygen species and defensive factors, which include the function of the mucus, bicarbonate barrier, prostaglandins, mucosal blood flow, cell renewal and migration, non-enzymatic and enzymatic antioxidants and some growth factors. Keywords: Helicobacter Pylori, NSAID, Proton Pump Inhibiter, Leukotriene, Bicarbonate Barrier, Refluxed Bile.
EXPLORING THE ANTI-PARKINSONIAN POTENTIAL OF CASSIA TORA ETHANOLIC LEAVES EXTRACT IN ANIMAL MODELS Mishra, Bandana; Ray, Jassaswi; Prusty, S.K.; Mohanty, Rajashree; Patra, Anup Ku
Journal of Global Pharma Technology Volume 16 Issue 11 (2024) November 2024
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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments resulting from the loss of dopaminergic neurons. Current treatments provide symptomatic relief but do not halt disease progression. In this study, we investigated the potential therapeutic effects of Cassia tora ethanolic leaves extract (CTELE) on PD using animal models. CTELE, known for its rich bioactive compounds, was administered orally to PD-induced animals, and their behavioral responses were assessed using standard motor function tests. Additionally, histopathological examination and biochemical assays were performed to evaluate the neuroprotective mechanisms of CTELE. Our results demonstrate that CTELE treatment ameliorated motor deficits in PD animal models, as evidenced by improved locomotor activity and coordination. Furthermore, histological analysis revealed a preservation of dopaminergic neurons in the substantia nigra pars compacta of CTELE-treated animals compared to untreated controls. Biochemical analysis showed a reduction in oxidative stress markers and an increase in antioxidant enzyme activity in CTELE-treated animals, suggesting its potential neuroprotective effects. These findings suggest that CTELE may hold promise as a natural therapeutic agent for PD and warrant further investigation into its underlying mechanisms of action and clinical efficacy. Keywords: Cassia tora leave, Parkinson’s disease.
PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
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The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.

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