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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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The Impact of Special Exercises for the Development of a Deep Sense of Block Skill Accuracy in Volleyball for Player's Focal Youth Bassem Hassan Ghazi
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The Aim of ResearchPreparation of special exercises to develop the deep sense and the accuracy of block in the volleyball for focal young players.Learn the effect of special exercises in the development of deep sense and the accuracy of the block of the volleyball of focal young players.HypothesisSpecial exercises have a significant effect on the development of the deep sense and the accuracy of block of the volleyball of the focal young players.As for the research methodology, the researcher chose the experimental method as the appropriate method to solve the problem of research in the design of a single group with the pre and posttests.The sample of the research was chosen from the research community represented by the young players (17-19) years for the Kufa and Al Rawdatain 2016-2017 clubs. The number of players was chosen from them. The number of players was 4 players in each team. The total number of players was 8.The Researcher ConcludedAn evolution in the deep sense of the young players for the movement of the parties to the experimental group.Exercises for deep sense and accuracy contributed to increase the accuracy of the wall of the ball of the volleyball players.The various special exercises developed by the researcher contributed to the development of deep sense and accuracy of the wall barrier.The recommendations wereThe need to use special exercises in the development of deep sense and the accuracy of the wall of the block of the volleyball of young players.The need to develop a deep sense and accuracy of the skill of the wall of the young players to defeat the importance.The need to use exercises for the deep sense of other skills.Keywords: Special exercises, Deep sense, Block skill and focal youth.
Nasal Carriage of Methicillin Resistant Staphylococcus Aureus among Medical Personnel of Salah Al-Din Hospitals using Classical Method and PCR Technique Nihad Abdul-Hussain Jafar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objectives: To screen medical personnel of four hospitals at Salah Al-Din governorate for MRSA, and to compare between the classical method and PCR method for detection of Staphylococcus aureus and MRSA. Materials and Methods: A total of 279 nasal swabs were taken from medical personnel of four hospitals in Salah al-Din (Salah Al-Din General Hospital, Tikrit Teaching Hospital, Samarra General Hospital and Baiji General Hospital). Staphylococcus aureus isolates diagnosed by both classical methods based on morphology, coagulase test, DNase test and mannitol salt agar fermentation, and by PCR by detection of femA gene .The isolates diagnosed as MRSA using classical method by its sensitivity to Cefoxitin in disc diffusion method and by detection of mecA gene with PCR. Results: The results showed that out of the 279 swabs taken from the medical staff of four hospitals in Salah al-Din, 88 were isolated as S. aureus (31.5%) using the classical method used in the hospitals of the governorate under study, and 58 (65.9 %) of them were methicillin resistant S. aureus using the Cefoxitin antibiotic method. However, the PCR results showed that only 57 isolates (20.4%) were diagnosed as S. aureus and that the number of isolates of S. aureus that possessed the mecA gene was only 24 isolates (42.1%) from the total isolates. Conclusion: The classical methods used in most Iraqi hospitals are not accurate in diagnosing S. aureus isolates and MRSA isolates, since 31 (35.2 %) isolates of the 88 isolates were misdiagnosed as S. aureus by the classical method. Furthermore, 34 (58.6 %) isolates of S. aureus were misdiagnosed as MRSA by the classical disc diffusion method.Keywords: MSRA, Nasal carriage, Meca.
Increasing of Early High-Risk Pregnancy Detection with Proactive Intervention in Bangkalan District, Madura Indonesi Budi Prasetyo
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Maternal Mortality Rate (MMR) in Indonesia remains high despite various initiatives had been done to decrease. Factors that correlate with it are culture and referral. In this study, a proactive intervention was conducted to improve cultural and referral issues in a rural area. Aim: to explain the improvement of the early detection of high-risk pregnancy after a proactive intervention. Method: This study is an experimental design by implemented proactive intervention complemented antenatal care programs in the primary health care center. Midwifery students were enlisted to conduct a maternal assistance program to raise awareness of the importance of antenatal care visits, childbirth by health workers, and family planning programs. Results: The proactive intervention showed the increasing of early detection of high-risk pregnancy by skilled health personnel (p =
Synthesis and Characterization of SM (III), Ce (III), Ni (II) AND Cu (II) Dinuclear Complexes Derived from Terephthaldehyde Qassim. Ksuadi
Journal of Global Pharma Technology .
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Abstract

A new ligands  (H2L1, H2L2) and Theirs Binuclear  complexes with (SmIII ,CeIII, NiII and CuII  ). Both ligands  prepare in two steps, the first step dissolution  of terephthaldehyde in methanol and reacted under refluxe with O- phenylen diamine  to give N1,N1,-(1,4-Phenylenebis (methanylylidene) bis(benzene-1,2-diamine)  which reacted in the second step with  O-Vanillin to give the ligand6,6,-((1E,1,E)-((((1,4-Phenylenebis (methanylylidene)) bis(azanylylidene)) bis(2,1- phenylene) ) bis(azanylylidene  bis(methanylylidene)  bis(2- meth oxyphenol) (H2L1) and reacted with 2-Hydroxy-1- naphthaldehyde to give the ligand  1,1,-((1E)-((((1,4-phenylenebis (methanylylidene)) bis(azanylylidene)) bis (2,1- phenylene)) bis(azanylylidene))bis(methanylylidene)bis(naphthalene-2-ol (H2L2 ).The four complexes manufacture by immediate reaction of the ligands with appropriate metal chloride. The ligands and Theirs  complexes were characterize by spectroscopic methods ,Elemental Analysis (C.H.N),Infrared Spectroscopy (FT-I.R), Nuclear Magnetic Resonance Spectroscopy (1H-NMR),  Mass Spectra , Magnetic sensitivity and Molar conductivity .  The data of these measurements suggest a Sequare planer geometry for (CuII , NiII) ,  Monocapped octahedron for Ce III and Sm III  complexes .Keywords: Binuclear complexes, Terephthaldehyde, Schiff base, Inner-transition metals.
Investigation of the Effects of Human Resource Management (HRM) practices on Corporate Social Responsibility (CSR), A Study in Zabol University of Medical Sciences Mohammad Mostafa Dahmardeh
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

The purpose of the present study is to investigate the effects of human resources management (HRM) practices on corporate social responsibility in Zabol University of Medical Sciences. The independent variable in this study is the practices of human resources management. Human resources management focuses on policies, procedures and systems that affect the behaviour, thoughts and actions of employees. Dependent variable of this study is the organizational performance. The organizational performance is defined as the manner of performing tasks and activities and the results of them. The social responsibility is the mediator variable of this study. Social responsibility is defined as tasks and obligations that the organization must do to protect and help the society in which it works. The hypotheses of this research are based on the impact of the independent variable on the dependent variable with respect to the role of mediator variable. The statistical population of this study is the headquarters of Zabol University of Medical Sciences. The minimum sample size according to Cochran’s formula is estimated to be 102 people that have been selected by simple random sampling. The findings of this study have approved all primary and secondary hypotheses of research and show that the human resources management practices has a significant impact on the organizational performance through social responsibility.Keywords: Human resources management (HRM) practices, Corporate social responsibility (CSR), Organizational performance
Cystatin C, E-glomerular Filtration Rate and Creatinine are Considered as a Marker in Iraqi Patients with Chronic Kidney Disease Mohammed Qasim Waheeb
Journal of Global Pharma Technology .
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Abstract

People with diminished glomerular filtration rate (GFR) are at more serious hazard for cardiovascular disease and different comorbidities. Creatinine-based conditions are utilized to estimate GFR, recognize patients with potential kidney disease, and arrange them into various stages since serum creatinine is uncaring to changes in the GFR.The aim of study to assess analytic execution of serum cystatin C e-glomerular filtration rate and creatinine as markers of kidney function in patients. Sixty cases at various stages of renal disability and 30 healthy control groups were tried. serum cystatin C were higher in stage 2 chronic kidney disease (CKD) when contrasted with the control gathering (p<0.05). For stages 3– 5 the median levels of cystatin C and creatinine were observed to be essentially higher than the control group.Keywords CKD, EGFR, Cystatin, Creatinine.
Synthesis and Phase Transition Study of New Mesogence Derived from 1, 4-Phenylenediamine Nisreen H. Karam
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This work include synthesized and characterization the compound [I] by reaction 1,4-phenylenediamine with chloro acetic acid  then this compound  reaction with methanol in present  sulfuric acid to synthesized ester compound [II] after that reaction with hydrazine hydrate to synthesized acide hydrazide [III] and the later compound reaction with substituted acetophenone[IV]n to synthesized substituted acetophenone hydrazones[V-XI]. In addition synthesized4-formylpyrazole derivatives [XII-XVIII] via cyclisation substituted acetophenone hydrazones [V-XI] with Vilsmeier-Haack reagent DMF/POCl3. The compounds characterized by melting points, FTIR, 1HNMR and mass spectroscopy. The mesomorphic behavior studied by using polarized optical microscopy and differential scanning calorimetry. Keywords: Liquid crystals, 4-formylpyrazole, 1, 4-phenylenediamine, Mesomorphic properties.
Potential of Pomelo Fruit (Citrus Maxima) Extract on T47D, WiDr, and HepG2 Cancer Cells Vevi Maritha; Aris Hartono; Mega Arianti Putri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Currently, alternative therapies are needed for breast, colon, and liver cancer patients. Those therapies are therapies that can selectively kill cancer cells without damaging other cells that have high development, such as hair and nails. One of those alternative therapies is the use of plants in cancer therapy. Pomelo has the potential as an anti-cancer agent because it contains phytochemical compounds, one of which is lycopene. Lycopene is a free anti-radical compound found in pomelo (citrus maxima). The lycopene content in pomelo fruit is more than in other parts, such as in leaves and fruit skin. Lycopene works by suppressing the proliferation or multiplication of cells through mutations in the initiation and progression phase of cancer. In cervical cancer patients, cell multiplication occurs quite rapidly, so that with the presence of lycopene, cervical cancer cell growth can be inhibited. Lycopene compounds can minimize the oxidation process and reduce the presence of free radicals in the body. Free radical compounds interact with DNA and reduce physiological functions that can increase cervical cancer cell growth. Lycopene is a compound that can counteract these free radicals and is also able to slow down or even prevent the oxidation process of other molecules and eliminate free radicals in the body that can cause cell damage. Through these two mechanisms, namely suppressing cell multiplication and eliminating free radicals, lycopene can be used as a cancer therapy. The cytotoxic activity test of pomelo fruit extract was carried out using the MTT method on T47D, WiDr, and HepG2 cells. The pomelo fruit was extracted by maceration method using 96% ethanol solvent. Cancer cell cultures were transferred as many as 1x104 cells/well in culture media consisting of FBS, penicillin-sterptomycin, amphoterizin-B, and RPMI 1640 into 96-well plates and incubated in a 5% CO2 incubator overnight. Furthermore, the test samples were given a series of levels and replications were made three times (triplo), and then they were incubated again overnight. On the third day of testing, MTT reagent was added, and after 4 hours, formazan crystals in living cells would be formed. Furthermore, SDS stoper was added to stop the MTT reaction. Then, the absorbance reading was carried out using an elisa reader at a wavelength of 595nm and the determination of the IC50 value was then carried out as well. The results showed that the IC50 value of pomelo extract in T47D 50 cells was 954.34 µg/mL, in WiDr cancer cells was 130.70 µg/mL, and in HepG2 cancer cells was 1,660.257 µg / mL. This shows that pomelo extract has the potential as an anti-cancer agent for breast and colon cancer, but not for liver cancer. This research could contribute to the development of breast and colon cancer drugs.
Synthesis, Structural and Biological Studies of Chromium(III) ,Manganese(II),Cobalt(II),Nickel(II),Copper(II) and Zinc(II) Complexes with Tere Dentate N2O Donor Azo-based Coumarin Ligand MAHMOOD NAJM ALOTHMAN; HIBA YOUSIF ALAZAWI
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

The present work describes the synthesis and characterization and biological studies of new transition metal complexes derived from Azo ligand(LH) of 6-hydroxycoumarine. The new azo LH was synthesized from condensation the diazonum salt chloride of 5-methylmercapto-2-amino-1,3,4-thiadiazole with alkaline solution of 6-hydroxycoumari at 0 C temperature. The octahedral geometry was adopted fpr the prepared complexes in 2:1 mole ratio of L/M up on CHNM analyses and other spectroscopic methods. The ligand LH and metal complexes were confirmed their structures with the help of CHNM analyses, NMR, MS, UV-Visibel spectra and magnetic and molar conductivity measurements. The biological assays of the solutions of LH and it s metal complexes in DMSO solvent were screenec against some positive, negative grams bacteria and some fungal organisms. The observed results from diffusion method revealed that almost metal complexes have higher activity rather than the free solutions ofv LH due to the chelation theory of inhibition zone
Effectiveness of Reconstruction Methods in Compressive Sensing for Biomedical Images Urvashi Ji
Journal of Global Pharma Technology .
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Abstract

For the effectual storage and transmission of signal in telemedicine, compression of medical images is one of the indispensable operations. Acquisition speed is always an issue in medical images like magnetic resonance imaging and computed tomography images. Compressed sensing came up as an inkling that achieves sparse signal with under sampled Nyquist rate. Compressed sensing is always astounding because only few samples can perfectly recover the entire signal is indeed a big achievement. In this paper different performance parameters peak signal to noise ratio, compression ratio, structural similarity in dearer evaluated for medical images by reconstruction algorithms like basic pursuit (l1), least square (l2), or thogonal matching pursuit. From these recovery algorithms, it is pointed thatl1norm minimization is most established convex optimization approach to achieve better quality image. Performance metric speak signal to noise ratio and root mean square error are observed at different measurement samples and it is seen that peak signal to noise ratio increases with increased measurement and root mean square error decreases. Keywords:Compressed Sensing, Sparsity, Compression Ratio, Structural Similarity Index, Root Mean Square Error, Performance Root Mean Square Error Difference.

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