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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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Immune Response Induced by Pure and Physical Detoxified S.aureus hemolysin Loaded on Calcium Phosphate Nanoparticles Mohamad J. Khadum
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Α-hemolysin is one of the virulence factors that cause damage of RBC membranes. In the present study, S. aureus hemolysin was used as a model of toxin. Pathogenic strain of S. aureus, isolated from patient wounds, was used to produce α-hemolysin in tryptic soy broth medium. After 40 hrs of S. aureus growth, the supernatant was precipitated with 75% ammonium sulphate before purification by DEAE- cellulose and sephacryl-S200 chromatography. Detoxification of pure hemolysin by different temperature and two types of UV light had been achieved. Furthermore, calcium phosphate nanoparticles (CAP NPs) was prepared and used, as nanoadjuvant, to carry detoxified hemolysin. Scanning electron microscope (SEM), UV-VIS spectrophotometer, Zeta potential and X-ray diffraction (XRD) were used to characterize CAP and CAP/hemolysin complex. The CAP NPs appeared spherical in shape with diameter average 36-67nm, while, zeta potential of CAP NPs was -34.47 mV.  The XRD patterns revealed the combination of CAP NPs with detoxified hemolysin and lost crystalline structure of CAP. Moreover, the combination was used to induce T-lymphocyte transformation and cytokines secretion in vitro. Lymphocyte proliferation with0.7 µg/ml of detoxified hemolysin increased proliferation 4.5 fold compared to negative control. On the other hand, 1.4 μg/ml of detoxified hemolysin stimulate the cytokines production of IL-1β and IL-6 to 16.4 and 18 pg/ml, respectively.Keywords: Immune response, Detoxification, Hemolysin, Calcium phosphate, Nanoparticles.
Herbal Tea Production from Moringa Oleifera Leaf Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Moringa oleifera is an important medicinal plant in Vietnam. The leaf of Moringa oleifera has shown the presence of some bioactive components which possesses phytochemical activity. It is highly valued as its vast medicinal properties. Moringa oleifera is currently being promoted as a means to combat poverty and malnutrition. The phytochemical and nutritional properties of the dried leaf of Moringa oleifera used as nutraceuticals, dietary supplements, functional foods. The low moisture content of the dried leaf tea is an attribute to a very high shelf life. Long storage of the dried Moringa oleifera leaf tea would not lead to spoilage due to microbial attack and this supports the practice of storage in dry form. Objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to vitamin C (mg/100g), flavonoid (mg/g) and sensory score of the dried Moringa oleifera leaf tea. Results showed that Moringa oleifera leaves should be blanched in hot water 95oC at 4 seconds in the present of CaCl2 2% and then beeing dried by heat pump dryer at 40oC until 6.5% moisture. The final herbal tea could be preserved under vacuum in PET/AL/PE bag at 4oC to maintain flavonoid content for 12 months. Keywords: Moringa oleifera, Herbal tea, Blanching, Drying, Vaccum, Vitamin C, Flavonoid.
Cosmos caudatus Leaf Ethanol Extract Inhibit Growth and Viability through Membrane Permeability and Apoptosis in Candida albicans Agustina Tri Endharti
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: Candidiasis is the most common fungal gynecological disease in humans. Essentially, the use of antifungal such as Fluconazole has reportedly increased resistance to candidiasis by 7%. The flavonoid has been shown to be used as an antifungal in Candida albicans. Cosmos caudatus contains 51% of Quercetin. To prove the influence of the use of flavonoid antifungal of quercetin group on the growth, viability, membrane permeability, and apoptosis of the C. albicans. Methods: The SV-1148 coded C. albicans isolate was obtained from the Microbiology Laboratory of Brawijaya University, Malang, Indonesia. Initially, the isolate was grown in Sabouraud Dextrose Agar (SDA) medium. The samples were divided into negative and positive control groups of fluconazole (60µg/ml) and difference concentrations (5%, 10%, 20%, and 40%) of leaves ethanol extract of C. caudatus. Results:  Concentration of 40% ethanol extract C. caudatus has Minimum Inhibitory Concentration (MIC) of 30%. This result showed that 40% ethanol extract C. caudatus was able to provide the best growth resistance which was characterized by the absence of colonies from C. albicans. The data of Influx Assay Iodide increased membrane permeability of C. albicans to disrupt cell membranes and induce apoptosis. The percentage of apoptosis increased after treatment of 40% ethanol extract C. caudatus in the culture of C. albicans. Conclusion: C. caudatus has antifungal activity and can be used as an herbal drug in C. albicans infection.
Effect of Isolate Catechin GMB4 in Expression of GRP78 and Tunel Assay in Rat Cataract Model Nugraha Wahyu Cahyana
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

AbstractThis research is to explore glucose-regulated protein 78 (GRP78) expression and Tunel assay, signs of stress of endoplasmic reticulum (ER) and apoptosis in rat cataract model. Cataract was formed by inducing a subcutaneous injection of 19 µmol/kg sodium selenite to ten-day-old Wistar rats. The neonatal rats were divided into five groups randomly (n=5 in each group): a control group, and four cataract-induction groups, treated with either 0, 50, 100, 200 mg/kg catechin Isolate From GMB4 Clone Green Tea. We performed slit-lamp biomicroscopic analysis, immunohistochemistry for GRP78 and Tunel. Both eyes of all rats in Group 1 did not exhibit cataract formation. In Group 2, one out of five (20%) developed grade 3 cataracts and the remaining four out of five (80%) developed grade 4 cataracts. The grade of cataract formation decreased in groups 3, 4 and 5. The difference in exhibited cataract in the lens of all rats between Group 2 and any eyes of groups 3 or 4 and 5 were significant (P = 0.022, 0,001, 0,001). The mean amount of Tunel cells and GRP78 of group II rats were significantly (P < 0.01) higher than the levels in Group I, Group III, Group IV and Group V. Stress of Endoplasmic reticulum and apoptosis in the lens that increased following cataract formation in rats was suppressed by catechin Isolate From GMB4 Clone Green Tea.
Cystatin C as Marker for Detection of Renal Function Change in Obstructive Uropathy Due to Ureteric Stone Mufeed J. Ewadh
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective: To Detection of Ureteric Stone Using Cystatin C "marker in Compare with serum Creatinine. Methods: Between September 2016 to February 2017 at Al-Hilla Teaching Hospital, Urology Department. The study group consisted of 25 healthy subjects as control with age between (20-66)year and 25 patients of Ureteric Stone with age from (20-62)year, the biochemical measurement including human CST3 (Cystatin C), ELISA kit used in the present study and serum Creatinine test used as biochemical diagnostic assessment. Results: Statistical analysis show significant difference (P<0.005) in the mean age (40.64±11.47), 21-30 years was the most influential of these disease compared with the other age groups. The percentages of males and females in patients group 16(64%) and 9(36%) respectively, while in the control group female were 14(56%), and male 11(44%) respectively. In total twenty five  patients  60% from the total  number  were unilateral and 40%  bilateral ureteric stone, study reveals that there was a significant increase (P. value<0.001) in the Cystatin C marker between study groups the mean value was (2.56 ±0.81) compared to  control group (0.82 ±0.17) with (P. value<0.001). Creatinine level revealed no significant association (p>0.05) between the level in the control and patients. In order to confirm the results of cystatin C levels using ELISA , the characteristic of the teqnique :Sensitivity (92%) , Specificity (96%).The characteristic of colorimetric methods test as compare to clinical diagnosis  in detection of Creatinine :Sensitivity (40%) , Specificity (88%). Conclusion: Cystatin C found to be a more accurate than Creatinine in detection the obstruction due to ureteric stone.Keywords: Creatinine, Stone, Cystatin C, Biochemical study, Urinary Tract.
Compare the Forms of ACE Gene According to Maximum Oxygen Consumption before and After the Lactic Voltage in 1500 Meters Running Players Alia Abdulkhader Safah
Journal of Global Pharma Technology .
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Abstract

The objective of the study was to identify the forms of ACE gene in mid-distance runners as well as to identify maximum oxygen consumption and the pre-voltage and post-voltage lactation threshold of 1500 meters and to determine the differences between the groups according to the two periods before and after the voltage according to the forms of the ACE gene. The research problem was to identify which alleles of the ACE gene were better in the physiological abilities of the players and included the imposition of research. There were differences in the maximum oxygen consumption and the lactic threshold in the two stages before and after voltage according to the gene shapes of 1500 meters running athletes. The researcher used the descriptive method in the survey method. The sample was randomly selected. They were players of Al-Qadisiyah clubs for the field and field players. The sample consisted of 16 players. The sample divided three groups according to the forms of the gene (II, ID, DD). The researcher concluded that the preferred form is the genetic makeup (II), which gives the physiological potential of players running 1500 meters.Keywords: ACE gene, Maximum oxygen consumption and lactic threshold.
Mycoplasma gallisepticum Infection and Efficacy of Inactivated Poultry Viral Vaccines Marwa Fathy
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Objective: This study was designed to evaluate the effect of Mycoplasma gallisepticum (MG) infection on the antibody titers of viral vaccines in fourteen-day-old specific pathogen-free (SPF) chicks. Methods: Five types of inactivated poultry viral vaccines-Newcastle disease viral vaccine (NDVV), avian influenza viral vaccine (AIVV), infectious bronchitis viral vaccine (IBVV), infectious bursal disease viral vaccine (IBDVV) and Reo-Virus Vaccine were used to vaccinate five hundred chicks. The chicks were divided into twenty groups at the age of 14 days; five groups were infected with MG. At day twenty-one, all the groups were vaccinated (four groups for each vaccine one of them previously infected by MG and one simultaneously infected by MG). At day twenty-seven, five vaccinated non-infected groups were infected. Results: All pre-infected groups showed highest antibody titers against NDV, AIV, IBV, IBDV, and Reo V (7.4 log2, 7.1 log2, 20EU, 20EU, and 17EU, respectively) 28 days post-vaccination. The lowest titer appeared in non-infected vaccinated groups with NDV, AIV, IBV, IBDV, and Reo V (6.5 log2, 6.5 log2, 12EU, 14EU, and 11EU, respectively). Conclusion: This study highlighted the outcome of poultry vaccination with inactivated virus vaccines by using serological immune response especially in the presence or absence of Mycoplasma infection of chicks.Keywords: Mycoplasma gallisepticum, Poultry, Vaccine evaluation, SPF chicks, Serological immune response.
Analysis of Factors Affecting the Participation of Women of Childbearing Age in Visual Inspection with Acetic Acid (VIA) in The Community Health Center of Bangkalan Uswatun Khasanah; Siti Anisak; Nurlailis Saadah; Esyuananik Esyuananik; Anis Nurlaili
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Nurlailis Saadah1, Esyuananik1, Anis Nurlaili1 1Midwifery Department, Poltekkes Kemenkes Surabaya; Jl. Pucang Jajar Tengah 56 Surabaya (yusa_0510@yahoo.com) *Corresponding Author: Uswatun Khasanah Abstract Cervical cancer is a malignant disease that it is possible to cause death. Unfortunately, the community still has a very low awareness to check themselves.More than 70% of sufferers come to the hospital at an advanced stage that is difficult tocure. This study aims to analyze the factors that influence the participation of women of childbearing age in visual inspection using acetic acid in the community health center of Bangkalan. The study was conducted in March-June 2019 with a cross sectional study design. The number of research subjects was 104 women of childbearing age taken by cluster random sampling.The dependent variable included predisposing factors (knowledge, motivation, culture), supporting factors (distance to health facilities and income) and reinforcing factors (midwife counseling). The independent variable included the participation of women in childbearing age in the VIA test. Data analysis was performed using the chi square test and logistic regression with a significance level of α = 5%. The results showed that knowledge had an influence on the participation of women in childbearing age in VIA tests (p value 0.047 0.05).Knowledge is the initial factor of a behavior that is expected to be positively correlated with behavior. In addition, environmental influences (including culture) also shape the behavior. However,not all people are aware and ready to implement behavioral changes. The existence of socio-cultural influences with gender bias, as well as the lack of information and the ability to receive and absorb information can influence the norms and beliefs of the community in utilizing health services including the effort to take part in VIA tests. For this reason, it is necessary to conduct socialization to targets related to VIA inspection through printed and electronic media. In addition, health workers need to improve their skills in counseling based on VIA counseling standards. Keywords: Predisposing Factor, Reinforcing Factor, Enabling Factor, Women of Childbearing Age Participation, VIA Test
A Comparison between the Effects of Nasal Lavage with Hypertonic, Isotonic and Hypotonic Saline Solutions for the Treatment of Chronic Sinusitis Nader Saki
Journal of Global Pharma Technology .
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Abstract

Background and Objectives Nasal lavage is an adjuvant treatment used for sinonasal diseases like sinusitis. There is no general consensus on the superiority of one of the three common solutions of hypertonic saline, hypotonic saline, and isotonic saline for the treatment of sinusitis’s symptoms. Furthermore, the majority of past studies have focused on two solutions of isotonic saline and hypertonic saline. In addition, no study has been published on the effect of hypotonic saline in the treatment of sinusitis symptoms. More importantly, in Iran no study has been conducted on this area. Due to the high importance of sinusitis disease and spending a lot every year for the treatment of the disease and its complications arising from it for patients and the country’s health system and with regard to the auxiliary use of saline solution is an inexpensive and easy treatment, we decided to conduct this study. Methods & Materials: This clinical trial study was conducted on 185 patients with chronic sinusitis referred to Imam and Apadana Hospitals (Ahvaz, Iran). With a diagnosis of chronic sinusitis by an ear, nose and throat specialist and using the CT scan, the patients have been selected. For collecting the data the necessary symptoms and information on the patients were recorded in a standard information gathering questionnaire. The patients were randomly divided into four groups. The first group received medication the second group medication as well as nasal lavage or hypertonic saline; the third group received medication in addition to nasal lavage or isotonic saline; the fourth group received medication plus nasal lavage or hypotonic saline. Results The results show the nasal lavage has an optimal therapeutic effect on headache symptoms, discharge from the nose and throat, coughing, nasal obstruction, olfactory problems, feeling of fullness in the face and according to all the criteria the isotonic saline has a useful treatment effect and is more effective than the hypertonic saline and has improved the nasal obstruction in about 50% of patients. Conclusion our findings showed better therapeutic features for isotonic saline solution with no serious side effects compared with the use of this solution is of greater priority.Keywords: Nasal lavage, Chronic Sinusitis, Isotonic, Hypotonic, Hypertonic Saline.
Novel Metal Complexes Derived from Selenosemicarbazone Ligand; Synthesis, Spectral Investigation and Biological Activity Talib H. Mawat
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The formation of a novel bidentate Schiff-base seleno-ligand (HL) and its metal complexes are reported. The title ligand (E)-2-((R)-2-((R)-(4-(dimethylamino)phenyl)((3-nitrophenyl)amino)- methyl)cyclohexylidene)hydrazine-1-carboselenoamide (HL) was prepared from the reaction of 2-((4-(dimethylamino) phenyl) ((3-nitrophenyl)amino) methyl) cyclohexan-1one with KSeCN and NH2NH2 in a 1:1:3 mole ratio using a mixture of CHCl3:EtOH (1:3) as a medium. The reaction of the ligand with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions in a 2:1 (L:M) mole ratio resulted in the isolation of new selenosemicarbazone complexes of general formula K2[ML2Cl2] and [M`L2], (M= Mn(II), Co(II) and Ni(II); M`= Cu, Zn and Cd). A range of physico-chemical methods were used to predict the geometry of complexes. These analyses indicated the formation of octahedral, square planar and tetrahedral geometry about (Mn(II), Co(II) and Ni(II)), Cu(II) and (Zn(II), Cd(II)) ions, respectively. The thermal analysis of the ligand and some metal complexes were investigated to check the stability of tested compounds. Biological activity of the ligand (HL) and its metal complexes against Gram negative bacterial strains; E. coli, B. sabtuius and K. Pneumoniae and Gram positive species; St. aureus were studied. The compounds displayed various activity towards tested bacteria. Further, selenosemicarbazone compounds were examined against four fungus species (Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilsis). More, the tested compounds showed activity towards all four fungus species (except Co(II)-complex that showed no activity against Candida tropicalis).Keywords: Selenosemicarbazone ligand; Metal complexes; Structural study; Biological activity.

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