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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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The Effect of Water of Crystallization on Isomerization of Liposome using Sodium Sulfide Nonahydrate Mohammed Fanokh Al-Owaidi
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The endogenous sulfide radicals (HS·/ S-·) play an important role in the biological system. They have cyto-protective antioxidant and pro-oxidants adverse effect. Sulfide radicals can produce isomerization of fatty acid physiologically and pathologically. In terms of biomimetic model using liposome, these radicals can produce trans fatty acid. The production of thiyl radical via photolysis was reported using sodium sulfide nonahydrate (Na2S.9H2O) 'H2S donor' in a phosphate buffer (PH=5.0). The efficacy of  Na2S.9H2O to produce thiyl radical (HS·/ S-·) was evaluated by GC using POPC vesicle in phosphate buffer (PH=5). It has been noticed that the maximum isomerization rate was up to 35% of trans oleic acid after (30 minutes). The declining in the percent of isomerization on what was previously reported is attributing to the low diffused concentration of the H2S, that is due to the crystallization nature of sodium sulfide nonahydrate as well as the low solubility profile of hydrated sodium sulfide. Furthermore, it also refers to the high affinity of thiyl radicals to make weak isomerizing species such as sulfide dimer (HSSH) and polysulfide (Sn2-) in a heat releasing process. Polysulfides themselves have the ability to scavenge the thiyl radical (HS·/ S-·) and then inhibit the isomerization process (Scheme 1).Keywords: Liposomes, Sodium sulfide nonahydrate, Water of crystallization, Trans oleic acid, Trans fatty acid (TFA), Omega-9, POPC vesicle, Polysulfide, Thiyl radical.
The Effectiveness of A Reproductive Health Active Learning Process Model in Improving Teen's Knowledge and Self-Trust in the First Middle School Teresia Retna P; Wahyuningsih Triana Nugraheni
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Adolescence is a transitional period between childhood and adulthood, which begins at the time of sexual maturity, namely between the ages of 11 or 12 years to 20 years, namely before young adulthood (Soejiningsih, 2004). To be ready to enter adulthood, adolescents begin to get acquainted and deal with various adult problems. Biologically, adolescents already have the ability like adults, but psychologically they have not got the right to use these abilities. The occurrence of psychological changes causes confusion among adolescents. They experience emotional turmoil and mental stress so that they easily deviate from the rules and social norms that apply in society. The design of this study was an experiment with a Posttest Only Control Group Design approach. In the experimental design of this study, there were two groups selected randomly. One group acts as a control group and the other group acts as an experimental group. The population in this study were students of health cadres at SMP Negeri 1 Merak Urak, Tuban Regency in 2019/2020, with a sample size of 36 students. The sample of this research was some students of health cadres at SMP Negeri 1 Merak Urak, Tuban Regency, with a sample size of 33 students. The sampling technique used was simple random sampling. The independent variable of this research is the active learning process of adolescent reproductive health, the dependent variable of this study is the level of knowledge and self-confidence of adolescents. The research instrument used in this study was to use a modified adolescent reproductive health active learning process module and a questionnaire to measure the level of knowledge and self-confidence of adolescents in junior high school. Data analysis was used to determine the effect of the independent variable and the dependent variable with the Manova test, with an error rate of α 0.05. Hypothesis testing shows that the significance value for the treatment and control groups tested by the Pillai Trace, Wilk's Lamda, Hotteling's T and Roy's Largest Root procedures is 0.005
Thermodynamic Study of Reaction of Formation of Cd2 + Cation Complex and 18-Crown-6 Ligand in Two-Component Mixtures of Methanol / Ethyl Acetate, Acetonitrile / Ethyl Acetate, Tetrahydrofuran / Acetonitrile, Methanol / Dimethyl Formamide, Acetonitrile / Methanol And Dimethyl Sulfoxide / Acetonitrile Using Conductometry Method Ali Mohebi
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

The reaction of formation of complex between Cd2 + cation and large ring ligand of 18-crown-6 in solvent systems of methanol / ethyl acetate, methanol / dimethyl formamide, methanol / acetonitrile, acetonitrile / ethyl acetate, acetonitrile / tetrahydrofuran, and acetonitrile / dimethyl sulfoxide was studied at different temperatures by conductometry method. The obtained results indicate that the formed complexes have a stoichiometry of 1: 1 [ML]. The values of the complex stability constants, determined by using conductometry data, show that the formed complex stability is affected by the nature and composition of the solvent. In all two-component mixtures of solvents, a nonlinear relationship is observed for variations in stability constant of the complex, formed by the composition of the solvent. This type of behavior is attributed to solvent-solvent interactions in solvent binary mixtures. The values of the thermodynamic parameters (ΔH ° c, ΔS ° c, ΔG ° c) for the complex have been obtained from temperature dependency of the stability constants. These results showed that the reaction thermodynamics of the formation of the complex is affected by the nature and composition of the mixture of solvents. In the studied solvent systems, entropy or enthalpy, and in some cases, both factors were favorable for complex formation.Keywords: Thermodynamics, 18-Crown-6, CD2 + Cation, Non- Aqueous Two-Component Mixture Solvent, Conductometry.
The Analysis of Organizational Learning and role of Knowledge Management Component to Improve its Hamid Tajdar
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

In this study, we have tried to identify those factors among key success factors of knowledge management that their implementation increases the organizational learning of staff. The method of study was so that firstly eight key factors of success of 1. IT 2 human resource 3. Support of top managers 4.Training of staff 5.Motivating staff 6.Sharing 7.Organizational culture 8. Team work, and organizational learning were considered as the dependent variables. Then, the relationship between dependent and independent variables was investigated. The subject of knowledge management in the University of this is a new subject and investigating the success factors can play an important role in organizational learning of its staff. The population of this research is staff of Zabol University that their total number was 400 and a sample size of 190 was selected based on Morgan table. Data were collected by a standard questionnaire with Cronbach's alpha of 0.920, and t-test and SPSS software were used to analyze the collected data. The results show that the key success factors of knowledge management have impact on staff organizational learning. At the end of study, some recommendations have been presented to enhance organizational learning level and successful implementation of knowledge management systems to managers of Zabol.Keywords: Knowledge management, Organizational culture, Success factors, Organizational learning.
Effect of Grape Seeds Ethanolic Extract on Spatial Memory in Mice Ali M. Ghazi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Grape (Vitis vinifera) is a member of vitaceae family. The seeds are rich in polyphenols and phenolic acids that are not only safe to be consumed, but also recognized to produce several and meaningful health benefits. We aimed here to investigate the memory and learning processes (spatial memory) activity of the ethanolic extract of the grape seeds by using Morris Water Maze (MWM) test in laboratory mice. The present study revealed that the administration of ethanolic extract of Vitis vinifera (50 mg/kg, IP for 3 days) showed significant reduction to the escape latency using the MWM especially in the 4th and 5th day of experiment when the results were compared to the control group.  Conclusion: grape seed extract may behave as a memory stimulant that opens doors to use it medically as a supportive therapy in case of impaired memory functions.Keywords: Vitis vinifera, Spatial memory, Morris Water Maze.
A Modern Strategy to Study the Life Cycle of Lesser House Fly and the Biological Control against the Bacterial Pathogens by Using the Larvae on the Bacterial Cultures Hussein JabarJasim
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The current research was performed that the lesser house flies were completed the life cycle on the bacteria cultures, also, This study was used the larvae lesser house fliesas a modern biologic control method against several types of pathogenic bacteria include (E. coli, S.aureus and K. pneumonia).The lesser house flies were attracted and laid the eggs on the bacteria cultures during the period that extended from April to May 2016-2018 (two seasons). The Lesser house fly eggs Samples were collected from different regions in south and central of Iraq, Al-Muthanna province and Baghdad province. On the other side, Different bacterial isolates were used such as E. coli, K. pneumonia and S. aureus. The present study was divided into seven groups. The first group was used an organic substance such as a sliced tomato as a control group inside petri dishes. The second and third groups were included E. coli cultured on Maconkey agar and Nutrient agar respectively. While, the fourth and fifth group were included K pneumonia cultured on Maconkey agar and Nutrient agar respectively. The sixth group was included   S. aureus cultured on Nutrient agar. Finally, the seventh group was contained only Nutrient agar and Mackonkey agar without bacteria. The second  , third , fourth , fifth  and sixth , seven group were distributed in   the mentioned regions   each area was included 10 petri dish from each group  which 60 dish in each region. While the eggs were transferred from the other groups to the control group. The seventh group was used to ensure the attraction of the lesser house flies to the bacteria cultures was not because the culture media itself, the dishes of all groups except the control group were opened   to allow the flies to attract to bacteria growth and enter the petridishes of groups. Morphological examination of larvae in the present study was carried out, after 7 days of hatching the eggs size of all the groups was approximately 2 millimeters.Keywords: A Modern Strategy, Life Cycle, Biological Control, Larvae Lesser House Fly, Bacterial Cultures.
Pharmacodynamics and Hepatoprotective Properties of Drugs Affecting Metabolic Processes in Patients with Drug-Induced Liver Injury on the Background of Specific Antituberculosis Therapy Anna V. Berestova
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective. Data on pharmacodynamics and hepatoprotective properties of taurine, ursodeoxycholic acid and their combinations in the treatment and prevention of drug-induced liver injury on the background of specific anti-TB therapy is presented. In the study course, a retrospective analysis of primary medical documentation of 270 patients was carried out. Materials and Methods. These patients were undergoing antituberculosis therapy in regional clinical tuberculosis hospitals during 2013-2016. Clinical studies were conducted in the regional clinical tuberculosis hospital in 2016-2018. At the clinical stages, 100 patients were examined. Results and Discussion. A retrospective analysis showed that in a real clinical practice, anti-TB therapy is canceled even with a moderate increase of the transaminase level. Temporary cancellation and correction of specific therapy led to a slowed-down x-ray dynamics and an increase in the length of hospital stay. It also helped to reduce clinical manifestations of liver injury and decreased enzyme activity in most patients for 8-14 days, though the transaminases absolute values remained above the reference values. Conclusion. Taurine intake in dose of 1000 mg/day for the pharmacological correction and prevention of drug-induced liver injury showed high drug efficacy both in monotherapy and combination with ursodeoxycholic acid. Taurine shows an immunomodulatory effect in patients with tuberculosis, with increase of CD3, CD4, CD16, immuno-regulatory index and decrease of CD8, the level of cytokines IL-4, IL-6 and TNF-α.Keywords: Drug-induced liver injury, Specific antituberculosis therapy, Pharmacodynamics, Hepatoprotectors, taurine, Ursodeoxycholic acid.
Histo-Chemical Effects of Iraqi-Camel Colostrum Extracts on Some Liver Biomarkers in Albino Rats Zainab Ibrahim Mohammed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study was intended to investigate the histo-chemical effects of Iraqi camel (Camelus dromedaries) colostrum on liver tissues and enzymes of albino rats, Rattus norvegicus. Colostrum was collected at 30ml at post-parturition times of 0, 6, and 12hr. The colostrum was subjected to an extraction procedure to obtain a filtered fluid that contained bioactive substances. These extracted fluids were given to 4 groups/5 rats each. Group1 (0G), Rats were given 0.1ml of 0hr-colostrum extract orally for 1 week. Group2 (6G), Rats were given 0.1ml of 6hr-colostrum extract orally for 1 week. Group3 (12G), Rats were given 0.1ml of 12hr-colostrum extract orally for 1 week. Group4 (control group, CG), Rats were given tap water only. Body and liver weights were measured every week for 4 weeks. Blood samples and liver samples were collected after 30 days to perform assays of measuring serum proteins and liver enzymes. The results indicate richness of colostrum with protein and fat. The results also revealed increases the levels of liver enzymes and changes in the tissues of the livers. These levels increased especially at 30 days of the experiment for the groups that were given camel colostrum extracts. These results indicate important effects of camel colostrum to prepare and protect body against various environmental intruders such as pathogens. Our results generate important information for future work to thoroughly study colostrum extracts on infections in humans and animals.Keywords: Camel, Colostrum, Liver enzymes, Rats. 
Immunological Impact of Laser and Activated Carbon Nanoparticles on the Vaccination Efficiency with DTP Vaccine Kaiser N. Madlum
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective(s): This work aimed to investigate the possibility of using laser vaccine adjuvant (LVA) to enhance deeply injected intramuscular vaccination. The second aim was to detect the effect of super activated carbon nanoparticles (SACNP) on the immune response.  Materials and Methods: (DTP) vaccine was used in this study to vaccinate male rats intramuscularly (i.m.), after irradiation with either red (λ=635 nm) or green (λ=532 nm) laser lights. Blood samples were collected 14 days later.  Results: LVA caused dynamic alteration of rat immune response. It caused a significant elevation in the pro-inflammatory cytokines (IL-1β & IL-6) and anti-inflammatory cytokine (IL-4) levels. SACNP showed an attractive effect on immune response especially in the presence of laser light. Conclusion: This paper demonstrates the applicability of LVA for intramuscular vaccination. Red laser and SACNP, which is a new form of nanoparticles, show an attractive effect on immune response.Keywords: DTP, Laser adjuvant, Vaccination, Cytokines, Immune response, Bio stimulation.
An Analytical Study of Iraq's Participation in the Olympic Swimming Championships for the Period 1956-2016 Zahia Sabah Abdulsalam
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The Problem of Research is to answer the Following QuestionsIs there a comprehensive historical study of all of Iraq's participation in the Olympic Games in swimming sport since the founding of the Iraqi Federation in 1956 and until 2016?Is there a study that presented the most important achievements achieved by Iraq in the sport of swimming during the Olympic Games for the period 1956 to 2016?Detecting the reasons that hindered Iraq's access to advanced positions in the Iraqi Olympic Swimming during the participations.Are there any reasons why Iraq did not participate in the sport of swimming in some Olympic Games during the period 1956 to 2016?The Research Objectives toRecognition of Iraq's participation in the sport of Olympic swimming in the Olympic Games since the founding of the Iraqi Federation in 1965 until 2016.Recognize the most important achievements achieved by Iraq in the sport of Olympic swimming in the Olympic Games during the period from 1965 to 2016.Identify the main obstacles that prevented Iraq from participating in some of the Olympic Games in this sport.The researchers discussed the history of the Iraqi swim and the presentation of all the Olympic Games since the emergence of the first session until 2016, whether there was a participation of Iraq in that session or not, and used the historical approach or so-called documentary methodology, benefiting from the analysis and discussion of all Iraq's foreign participation in the courses The research community represents the pioneers, swimmers, trainers and members of the current governing bodies of the Iraqi Central Swimming Federation, who have witnessed all the participations from 1956 to 2016 in the spa. The study sample consisted of (60) persons, (50) persons are the sample of the main experiment, and (10) people were the sample of the pilot experiment.The Researchers Concluded the Following:Most of Iraq's participation in the courses was very modest or weak.Decrease in the number of swimmers participating in modern courses due to economic and administrative reasonsLack of adequate infrastructure for swimmers as well as lack of material resources provided to swimmers by previous and current federations and for various conditions as well.The fluctuation in the previous years and for several reasons.The lack of material resources for holding special training camps prior to participation in the courses and if they are rare, they do not fit in with the number of courses held and participating in them.Keywords: Analytical study and Olympic Swimming.

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