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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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Detection of Candida albicans in Females Urinary Tract Infection by using Microscopical and Cultural Methods of Urine Samples in Kirkuk City - Iraq Burhan A. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background: Candiduria is an infectious condition worldwide distribution as a primary infection of human urogenital tract caused by Candida albicans predominantly. Increasing of urinary tract infections with Candida species has led to antifungal resistant conditions as a common problem of women specifically among pregnant women. This study is an attempt to show the incidence of Candida albicans among women attending gynecology clinical in Kirkuk General Hospital in Kirkuk city, by microscopically technique and urine inoculation into Sabouraud Dextrose Agar. Methods & Materials: In this study, one hundred and seventy-four midstream urine samples from women patients of gynecology clinical in Kirkuk General Hospital were collected. All the subjects were clinically assessed for studying C .albicans infection, and then inoculated on Sabouraud Dextrose Agar. Results: The highest percentage of infection of C. albicans was 38(52.8%) of the positive patients and in relation to the patients pregnancy status, C. albicans infection revealed a prevalence of 36(53.7%) higher than 2(40%) for the non-pregnant patients with abnormal general urine examination in age group 27-36 years respectively. Conclusions: The study revealed that the prevalence of Candidal urinary tract infections (UTIs) among the younger reproductive age of the pregnant women was higher than that of non-pregnant women and the Candida albicans was the most common Candida species causative agent of the urinary tract Candidiasis.  Keywords: C. albicans, Microscopical, Culture Methods, UTI.            
Clinical Correlates of the Severity of Diabetic Foot Ulcers Rahadyan Magetsari; Meirizal Hasan; Yossie Atyandhari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

OBJECTIVE Severe diabetic foot ulcer leads to amputation and is associated with higher risk of mortality. The purpose of this study is to identify clinical correlates of severe diabetic foot ulcers. METHODS The design of the study was cross-sectional survey of medical records on patients treated in Sardjito Hospital from 1 January to 31 July, 2014. Severe foot ulcer was measured as grade 4 and 5 according to Wagner classification. ABI (Ankle Brachial Index) to estimate blood flow to lower extremities and Semmes-Weinstein test using monofilament to detect neuropathy, classified as positive or negative, were done in all patients. HbA1C, serum sodium and creatinine levels were measured during the latest hospital visit. RESULTS The results of this study showed that 77 (36.5%) among 211 patients had severe foot ulcers (grade 4 and 5, Wagner classification). ABI and Semmes-Weinstein monofilament test failed to predict severity of diabetic foot ulcers. HbA1c increased the odds of severe ulcers while higher serum sodium level and higher diastolic blood pressure protected patients against severe ulcers. CONCLUSION Better glycemic control and caution against excessive reduction of diastolic blood pressure, usually due to anti-hypertension medication, should be recommended to prevent the development of severe foot ulcer. KEYWORDS: diabetic foot ulcers, severity, glycemic control, hypertension, poor circulation, neuropathy
Organizational Culture as a Function of Predicting Administrative Competencies and Decision-making among the Top Leaders in Faculties of Physical Education and Sports Sciences from the Point of Teaching View Jassem Jaber Mohammed
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The importance of this study is that it is concerned with the human resource, which is the secret of the success of any institution, especially the educational institution, which is the leadership of the senior leadership positions that are supposed to give the institution sufficient attention in all aspects, especially cultural ones, which affect the behavior of individuals in decision-making and their competence to work and thus influence On the work of the institution, as defined by the research community, which is represented by the top leaders of the faculties of physical education and sports sciences, and the total vocabulary of (40) single, was chosen from this community in a comprehensive manner.The researchers used the measure of administrative competencies, decision making and organizational culture, which was built by the researcher Talal bin Abdullah Hussein Al-Sharif in 2014. The scale consists of (38) paragraphs distributed as follows:The first dimension (planning): includes (11) paragraph, namely paragraphs: (1 to 11).The second dimension (organization): includes (9) paragraph, namely paragraphs: (12 to 20).The third dimension (communication): includes (9) paragraph,The fourth dimension (calendar): includes (9) paragraph, namely paragraphs: (30 to 38).It is possible to arrive at the following conclusions: The results of the efficiency of the model to predict the organizational culture of the top leaders of the faculties of physical education and sports sciences in management competencies and decision-making.Keywords: Organizational culture, Administrative competencies, Physical education and sports sciences.
Emotional Regulation in Autism Spectrum Disorders: A New Proposed Model for Regulating Emotions through Parent Education Mainul Haque
Journal of Global Pharma Technology Volume 9 Issue 07
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Abstract

Autism spectrum disorders (ASD) may affect all spheres of a child’s life. One of the areas of the behavioral spectrum need to be focused is affected. Thus, the study is enthused in impaired emotional regulation (ER) affecting children with ASD. The significance of ER is related to that promoting adaptive behavior in children; indeed, disturbed ER in ASD children leads to emotional and behavioral problems. Commonly children with ASD lack adaptive ER strategies thus they react impulsively and inadequately to emotional stimuli thus it affects their psychological well-being. Though ER in ASD children is intrinsic the nurturing of these children with an understanding of ER can promote better psychological wellbeing. Thus, study objectives to examine a) the impact of ASD on their ER b) the impact of ER on the psychological wellbeing of children with ASD c) To develop awareness among these parents regarding the impact of ER on the psychological wellbeing of their ASD child. d) To propose a new model of parental education about ER and its significance on psychological wellbeing of ASD children. This study takes a base on the keenly examined past evidence on impaired ER in ASD children and its impact on psychological wellbeing. Proposal for aiding ER through parental education has introduced. The conclusion drawn in this study is that the intervention can be more promising with educating parents regarding ER, may help their child to gain maximum from therapeutic intervention. The new proposed model of intervention extends the further scope for research in this regard.Keywords: ASD; Emotional regulation, Parent’s education, Intervention. 
Assessment the Effects of Ciprofloxacin and Gentamicin Alone or in Combination to Induce Hepatic Toxicity in Rats Jawad Kadhim Faris
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The aim of this study was to research the comparative effects of ciprofloxacin (CP)  and gentamicin (GT) alone or in combination on the deleterious effects on liver function  and histopathological architecture in rats for  (10) days administration. Doses of 100 mg/kg were used for each of  CP and GT ,and each of both drugs 50mg/kg were combined to estimate the synergistic effect .Thirty two  rats were divided into four groups , group I :control , (1 ml/kg saline orally) group 2: CP  (100 mg/kg orally)  for (10) consecutive days , group 3:  GT  (100 mg//kg) intraperitoneally (i/p)  for (10) consecutive days, group 4: CP  (50 mg/kg orally) plus GT  (50 mg//kg)  i/p  for (10) consecutive days . Blood and liver collected for biochemical and histopathological examination of the liver. The degree of liver injury was determined by measuring biochemical markers, the serum activity of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Malondialdehyde (MDA) levels, as measures of oxidative stress. The results of this study showed that in the serum of the rats in the test groups were found to be significantly higher (p < 0.01) than control group; this effect was found to vary among the groups. These findings are indicative that combination of CP + GT more injury to hepatocytes than GT and CP respectively .The synergistic effects of combination of CP + GT showed the higher levels of liver enzyme and sever liver injury.  Keywords:  Gentamicin, Ciprofloxacin, Combination Hepatotoxicity.
The Effectiveness of Ranitidine Compared to Omeprazole in Maintaining Gastric Acidity in Head Injury Patients Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Gastric bleeding due to stress-related mucosal damage (SRMD) is a condition that is caused due to erosive gastritis that often occurs in critically ill patients in intensive care. One condition that is known as a risk factor for SRMD is traumatic brain injury. Two common agents used as gastric ulcer prophylaxis are proton pump inhibitor (PPI) and H2 antagonist receptor (H2AR). The goal of this study was to compare the effectiveness of PPI and H2AR administration as prophylaxis of SMRD in patients with TBIs who were treated in the ICU. Patients and Methods: This is a single-blind, randomized, controlled trial with pre and post-test measurements. All subjects were measured for baseline gastric pH before being given gastric ulcer prophylaxis. Gastric pH was measured using a pH-meter. The subjects were divided into two groups: omeprazole group (omeprazole 40 mg every 12 hours) and ranitidine group (received ranitidine 50 mg every 12 hours). The pH levels were measured regularly twice daily for five days.  Results: 56 subjects were involved in this study and divided equally into two groups. For each gastric pH measurement, the pH in both groups did not significantly differ. The optimal gastric pH was achieved in 24 hours after the first administration of gastric ulcer prophylaxis.  Conclusions: The administration of ranitidine or omeprazole is equally effective in maintaining the acidity of gastric acid in TBI patients in ICU. There was no significant difference in the incidence of gastric bleeding in ranitidine and omeprazole groups. Keywords: ICU, Gastric pH, PPI, H2-receptor antagonist.
Synthesis and Identification of Biaryi of Cholic Acid Derivatives via Suzuki-Miyaura Cross-coupling Reaction and Study of Their Biological Activity Abbas Sami Abd
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Cholic acid derivatives(2-6) and (10-15)were Synthesized by treatment of cholic acid 1 with 4-aminoaniline  in the presence of N, N'- Dicyclohexylcarbodiimide (DCC) as coupling reagent and 4-dimethylaminopyridine (DMAP) as catalyst in CH2Cl2-DMF gave compound (2) that reacted with approperate cyanophenyl, 2,3-diflurophenyl, 3,4-dimethoxy phenyl)boronic acid using palladium (0) tetraks - triphenyl phosphine (Pd(0)Ph3P)4) and Na2CO3 as a catalysts in 2ml from DMF and H2O by using microwave Technique afford (10-12)  . The carbohydrazide derivative (5, 6) was prepared from methyl cholate 3 and hydrazine hydrate. The prepared hydrazone was introduced by reaction of the cholic acid with the carbonyl compounds (4-formyl phenyl boronic acid and 4-bromo ace to phenone) in refluxing acidic Et OH. The synthesis of compounds (14-15)  was accomplished from (6) with appropriately functionalized boronic acid derivatives by using Susuki - Miyaura criss-coupling reaction while the compounds(13) synthesized from reaction of (5) with (6) under Susuki - Miyaura criss-coupling reaction too (.some of these compounds show moderate to good  activity against Staphylococcus aureus bacteria and Candida albicans fungal. The reaction was monitored by (TLC) technique. All new Cholic acid derivatives were characterized by melting points, elemental analysis, FT‐ Invra red radiation, 1H, 13C spectroscopy. Antimicrobial activity of these derivatives was also determined.Keywords: Cholic acid, Cholic acid hydrazones ,Bile acids, Susuki -Miyaura cross -coupling reaction, Antimicrobial activity.
Study of the Effect of Tramadol on Sperm Standards in Male White Rats Marwah Ahmed Miri
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Tramadol is an opioid analgesic, a pain reliever used by the World Health Organization (WHO) to treat postoperative pain and chronic diseases such as acute liver disease, Fibromyalgia and Arthritis. This study was designed to determine the effect of tramadol in fertility in male white rats. White rats were used as an example of mammalian animals. The study included the use of 45 white adults. Animals were raised in the Animal House of the Faculty of Education for Girls / University of Kufa under standard conditions in terms of temperature, light and nutrition.  The study was conducted to assess the damage to the male reproductive tract of white rats due to daily exposure to tramadol. The groups was given orally distilled water as a control group and the other groups were given two doses of tramadol (100, 200 mg) Kg / kg) orally for 8 weeks. The results in this study showed a significant decrease (P <0.05) in body weight, testosterone, albino, seminal vesicles and prostate glands in the treated groups (100, 200 mg / kg) of tramadol compared to control group. The results of the statistical analysis in the present study showed a significant decrease (P <0.05) in the concentration of sperm in the testis and the epididymal tail and a significant decrease (P <0.05) in the percentage of sperm movement in the testis and epididymis, (P <0.05) in the percentage of non-mutated sperm in the serum groups (100, 200 mg / kg) of tramadol compared to the control group.Keywords: Tramadol, Sperm.
Efficacy of Carrageenan as Emulsifier and Breadfruit Flour as Substitute Ingredient on Physicochemical, Microbial and Organoleptic Properties of Fermented Ice Cream Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Breadfruit is a nutritious food but not widely utilized in industrial production. Carrageenan has excellent functionality on phase separation and cryoprotection. Ice cream is a delicious and nutritious frozen dairy product widely consumed. It is a complex microcrystalline network of liquid and solid phases. This study focused on the utilization of carrageenan as stabilizer and breadfruit flour as a substitute ingredient on physicochemical, microbial and organoleptic properties of fermented ice cream. Different supplementation ratio of carrageenan (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) and breadfruit: milk (30%:, 70%; 40:60%, 50%:50%, 60%: 40%; 70%: 30%) were demonstrated. The fermentation process was conducted with Lactobacillus sp. starter culture (ratio 0.2%) at loading cell 109 cfu/ml at 37oC in 48 hours. Results revealed that carrageenan (2.0%), breadfruit: milk (60%: 40%) were ideal for production of fermented ice cream. From this investigation, consumers have more chance to consume one kind of functional ice cream from breadfruit starch.Keywords: Breadfruit, Carrageenan, ice cream, Lactobacillus, physicochemical, Microbial, Organoleptic, fermentation.
Evaluation of Surface Soils Contamination by Polycyclic Aromatic Hydrocarbons of Selected Samples in Al-Diwaniya City, Iraq Faiq F. Karam
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The concentrations and spatial distribution of thirteen polycyclic aromatic hydrocarbons from٦ soil have been investigated in four regions locate in Al-Diwaniya city, Iraq. Sechelt extractions is used to extract PAHs compounds from all samples, gas chromatography was used to determine the PAHs concentration in all samples. The total concentrations of thirteen PAHs were ranged from 4.46ng.g-1 in site one to 17.24 ng.g-1 in site three of dry weight. The PAHs compounds those consist of four to six fused aromatic rings represent the majority among other PAHs in soil samples.Keywords: Al-Diwaniyah pollution, Contamination with PAHs, Extraction of PAHs from soil, Soil pollution, PAHs in Iraqi soil.

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