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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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Impact of Pharmacokinetic Modification of Controlled Release Floating Tablets of Ranolazine B. S. Venkateswaralu
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study outlines a systematic approach for design and development of oral controlled release floating tablet formulation of Ranolazine. Floating tablet Ranolazine have been shown controlled release there by proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate, Eutragit L 100 and HPMC Polymer combination, respectively. Five batches of tablets were prepared by the direct compression method. The physicochemical properties of different formulations, their Buoyancy lag time and total floating time and swelling index were evaluated. It was found that the hardness of the tablets were effects the Buoyancy characteristic of the dosage form. All five formulations possessed good floating properties with total floating time between 8 – 10 hrs. The in vitro release studies indicated that the floating dosage forms containing Eutragit L 100showed slower release. The cumulative % of in vitro drug release of formulation FR1, FR2, FR3, FR4, and FR5 were 49.36%,58.98%,72.22%, 98.88% and 76.89. Drug release to be enhanced by formulation F4 in compared with the marketed product. Accelerated stability study revealed that optimized formulation was stable for one month without any major changes in assay, dissolution profile, floating lag time and other physical properties. Based on best fitting method, optimized formulation was found to follow Higuchi Model release kinetic.
Physiological Study about Rosuvastatin and Lovastatin as Compared with Quercetin in Rats (Rattus norvegicus) Wissam Sajid Hashim
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study was accomplished to compare the role of the flavonoid quercetin with some antihyperlipidemic drugs rosuvastatin and lovastatin on lipid profile and other serum parameters of rats. In this study, five groups of eight male rats each were used. The groups were allocated as: control, cholesterol, rosuvastatin, lovastatin and quercetin groups. The animals of the control group were maintained on standard diet, while other groups were maintained on cholesterol diet 15mg/kg of diet and dosed orally and daily as follow: rosuvastatin 20 mg/kg body weight, lovastatin 15 mg, and quercetin 100 mg respectively. The results revealed that rosuvastatin and lovastatin could lower lipid profile but still significantly higher than control group while quercetin lowers them without significant difference with control. The liver enzymes were elevated by statins and they were normal and without significant difference in case of quercetin comparing with control group at (P≤0.05).Key words: Quercetin, Rosuvastatin, Lovastatin, Lipid, Rats.
Different Molecular Methods to Determine Genetic Diversity in Pseudomonas aeruginosa Clinical Isolates Reem Akram Naji
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

A total of (210) clinical specimens were collected from patients suffering from different infections such as burns, wounds, ear infections, diabetic foot, and urinary infections, cultured on differential media. All clinical specimens were cultured on different media. The results indicated that 22 (10 %) of the isolates were belong to P. aeruginosa. It was found that six isolates (27.27%) were isolated from wounds, five isolates (22.72%) from burns, six isolates (27.27%) from ear infections, two isolate (9%) from urine and three isolates (13.63%) from diabetic foot infections. In this study, used RAPD, BOX, and ERIC-PCR for the detection of phylogenetic diversity of pseudomonas aeruginosa isolated from different samples, In general, 18 isolates characterized using the three molecular techniques had comparable number of bands with some degree of polymorphism. P. aeruginosa isolates from the same source were clustered in to different groups. The three molecular techniques generated 2 main clusters, and the results of dendrogram of these techniques reveals that two isolates number(11,12) were similarity 100% in three methods techniques this suggest that this give the more discrimination power. While the pattern of others recorded some difference in the distribution. Keywords: Genotyping, Phenotyping, Pseudomonas aeruginosa, Molecular detection, RAPD, BOX, ERIC.
Application of Nanoemulsion Technology for Preparation and Evaluation of Intranasal Mucoadhesive Nano- In-situ Gel for Ondansetron Hcl Nidhal K. Maraie
Journal of Global Pharma Technology .
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Abstract

Objective: Developing more effective and promising in situ gel nasal preparation for ondansetron HCl (OND-HCl) using nanoemulsion (NE) technology and study all the parameters that can optimize the final formula. Method: Screening of oils, surfactants and co-surfactants was performed on the basis of OND-HCl solubility and NE area of emulsifier ratio (Smix), respectively. Pseudo-ternary phase diagrams were constructed by aqueous titration method. Twelve NE formulas were prepared by ultrasonic emulsification and characterized for droplet size, zeta potential, polydispersity index, separation, conductivity, TEM, % transmittance, dilution and visual transparency. The best NE formulation was selected and applied to prepare nano-in situ gel (NIG) using poloxamer 407 as thermoreversible polymer, chitosan and HPMC E15 as mucoadhesive polymers.  The six NIG formulas were evaluated for pH, drug content, osmolarity, gelation temperature, mucoadhesive force, viscosity and in vitro drug release.  Results: The mean droplet size, polydispersity index, zeta potential, conductivity and % transmittance for the selected NE formula (F11) were found to be 64.87 nm, 0.544, - 0.146, 210 μS/cm, and 99.08% respectively. The gelation temperatures, pH, drug content, osmolarity and mucoadhesive force for the selected  NIG formula (NIG6) were 33 ºC, 5.8, 99.215%, 106.06 mOsmol/l (0.62%), 7372.21 dyne/cm² respectively. The in vitro drug release study of NIG6 showed 100% after 6h.  Conclusion: The results of this work indicated the possibility of application of NE technology in the formulation of NIG that has good mucoadhesive force to prolong the preparation residence time in the nose.Keywords: Chitosan, Nano-in situ gel, HPMCE15, Nanoemulsion, Ondansetron HCl.
Are Household Water Purification Devices Useful to Improve the Physical Chemical and Microbial Quality of the feed Water? Case Study: Bandar Abbas South of Iran Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 02
Publisher : Journal of Global Pharma Technology

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Abstract

Part of the Bandar Abbas population in southern Iran, in order to access to better water quality than municipal tap water systems, use household water purification devices. The aim of this study was to determine to what extent these devices are effective in improving the quality and the efficiency are desirable for the production of water quality. This cross-sectional study that was conducted in a six-month period time in 2015 in Bandar Abbas. A total of 30 samples of water from various home water purification apparatuses were sampled and tested for hardness, alkalinity, pH, total dissolved solids (TDS) and electrical conductivity (EC), turbidity and MPN was performed on the samples. Statistical analysis was performed using SPSS version 19 and statistical tests ANOVA and Pearson correlation test. The efficiency of the apparatuses to reduce turbidity, hardness, alkalinity, Na, K and Cl, respectively were 45.9, 39, 22.3, 30.6, 34.9 and 53 percent, and in reduce of TDS and EC respectively were 37.5 and 59 percent. The devices ability to change the pH of water was low and negative; (-5.8 percent). In 26.6% of influent samples, microbial contamination was detected, which in all mentioned cases, the microbial contaminated were showed in effluent samples. In general, the use of these devices was not necessarily lead to improved water quality. After working the 12-month period significantly decreased efficiency. The number of treatment stages did not impact in device efficiency improvement.Keywords: Water treatment, Purification devices, Water quality, Chemical quality.
Study the Level of Iron Indices and Oxidative Stress in Patients with Chronic Renal Failure of Diwaniya Territory Hussein M.K. Al-Mohammad
Journal of Global Pharma Technology .
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Abstract

Oxidative anxiety and level iron files is impacting everything in the movement of endless renal disappointment (CRF) and in the beginning of atherosclerosis. Hemodialysis patients are at particularly high hazard for IRON inadequacy due to blood misfortune related with the dialysis procedure. The point of the present examination was to assess level iron and the variables that may impact the oxidative antioxidative adjust in patients with kidney disappointment. The investigation gather was comprised of 60 patients because of CRF. Additionally 60 subjects constituted a control gathering. We quantified changes in serum superoxide dismutase, and glutathione peroxidase action, and malondialdehyde levels and ferretin, press, transferitin, transferin immersed, EIBS and TIBC in unending renal disappointment patients and contrasted and solid control gatherings. Superoxide dismutase and glutathione peroxidase movement, and malondialdehyde levels were tested with spectrophotometric techniques. Superoxide dismutase action of CRF patients bunch were higher than those of the control gathering (p<0.005). Glutathione peroxidase movement of the CRF quiet gathering were lower than those of control gathering (p<0.005). Malondialdehyde levels in patients were higher than those of the control gathering (p<0.05).Also in the present examination, essentially expanded (p < 0.05) at ferret in, press, transferitin, transferin soaked and critical decline (p < 0.05) EIBS, TIBC. A few investigations of SOD action in ceaseless renal disappointment patients have discovered clashing outcomes. We suggest that the expanded SOD movement could be a defensive system for the cells because of the hyper production of free radicals in interminable renal disappointment. Diminished serum cancer prevention agent action in CRF patients on kidney may add to the expanded oxidative harm and in the improvement of renal entanglements. This examination shows the presence and expanded generation of oxidative anxiety coming about because of hemodialysis and aggravation in cell reinforcement protein framework. Our outcomes underpins that an expansion in oxidative anxiety might be considered as one of the real hazard factors in constant renal disappointment patients.
Study of Linear Optical Properties of Acridine-orange Laser Dye Lazem Hassan Aboud
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this research, the linear optical properties and the effect of concentration of the solution on absorption spectra and fluorescence spectra of the acridine_orange dye. It was prepared three concentrations acridine_orange dye dissolved in ethanol (1*10^-3, 1*10^-4, 1*10^-5) M. It was measured spectroscopic properties of the dye solution and for all concentrations (absorption coefficient, refractive index, and fluorescence life-time and quantum yield of florescence level). The results showed that the linear absorption coefficient and linear- refractive index increase with solution concentration increasing and (life-time of fluorescence increases, quantum yield decreases) with solution concentration increasing.Keywords: Acridine_orange dye, linear optical properties, laser dye.
Morphological and Histological Study of the Pancreas of quail (Coturnixcoturnix) Dhaferah Jaafar A. Al Fatlawi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Study was carried out on  seven pairs of adult quail ((Coturnixcoturnix), The pancreas was excised from the duodenum rapidly after slaughter of the birds, the observations showed that there's no difference of structure features between sex (male and female of quail pancreas. The Pancreas is situated on the right side of abdominal cavity in the area between the ascending and descending duodenal loops, attached with the alimentary tract covered with capsules, the parenchyma of pancreas divided it to lobules by fascicles of connective tissue extended from capsule. The parenchyma of pancreas divided in to two kinds of glands exocrine and endocrine gland, the exocrine composed of serous acini cells and ductal cells, the duct system composed of intercalated duct attached to the centroacinar cells inside the lumen of serous acini, followed by intralobular duct, interlobular duct, and main duct (pancreatic duct) Endocrine gland divided in to two types of islets, the large one Alpha islets, and the small types Beta islets, supplied by rich network of blood vessels. Each ofducts, aggregation of lymphatic tissue and blood vessels can be seen in section of parenchyma. No clear boundaries between the exocrine portion and Islets of Langer hans. In conclusion the Anatomical features and histological structure of quail (Coturnixcoturnix) pancreas was found to be similar to that of other avian speciesKey words: Morphological. Histological. Pancreas, Adult. Quail. Coturnixcoturnix.
In-Vitro the Anti-Protozoal Activity of Onions Extract (Allium Cepa) and Metronidazole in Entamoebagingivalis Which Cultured in Tysgm-9 Medium Raflaa S.H. Hussian
Journal of Global Pharma Technology .
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Abstract

Entamoebagingivalis ( E. gingivalis )is an amoebae that is present in the human oral cavity associated with poor oral hygiene and advanced periodontal disease. The aim of the present study is to confirm antiprotozoal activity of Onions extract and metronidazole in E. gingivalis which cultured in TYSGM-9 medium as well as determinethe frequency of this among patients with periodontitisdisease. The study included 46 sample collected from patient with age (11-20) years, result show infection with this parasite 56.5 %. These samples are cultured in TYSGM-9 media, and then treated with Onions extract (Allium cepa) and metronidazole which show inhibited growth of parasite at 100μg/ml.                                                                                                 Keywords: Entamoebagingivalis, Allium cepa, Metronidazole
Influence of Proteoglycanes on Reactive Changes of Cerebral Neurons under Stress Alexey Rozhentcev
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The article presents research data on the effect of proteoglycans on reactive changes in cerebellum neurocytes under the action of a stressor. We simulated hypobaric hypoxia as a stress factor affecting cerebellar neurons. This is due to the fact that hypoxic conditions are widespread and can occur both in injuries and in various diseases. The histological and histochemical methods were used to determine the effect that proteoglycans have on changes that occur in cerebellum neurocytes under the influence of a stressor. Our comprehensive studies have helped to establish that the introduction of proteoglycans in order to correct the effect of hypobaric hypoxia on cerebellum neurocytes has a positive effect on intracellular production and excretion of high molecular weight compounds. So, in the neurons of the cerebellum of rats of the experimental group, a smooth increase in the processes of physiological regeneration was noted. In addition, destructive changes in neurocytes were less pronounced compared with the control group. The ultrastructural studies of rat cerebellum nerve cells in the control group showed that under the action of hypoxia in the early stages there was an increase in the volume of intracellular structures, and then, with prolonged exposure – a decrease in their volume. This, in turn, has a negative effect on metabolic processes inside the neuron and, as a consequence, the growth of destructive changes. An experimental study showed the effectiveness of the use of proteoglycans for the correction of changes in cerebellum neurocytes under the influence of a simulated stress factor.Keywords: Hypoxia, Cerebellum, Neuron, Proteoglycans, stress factor, Ultra-structure.

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