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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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Isolation and Characterization of New Flavonoids from Fumaria Parviflora Cultivated in Iraq Enas Jawad Kadheem
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The aim of this study was to investigate chemical constituents of aerial parts of Fumaria parviflora since no phytochemical investigation had been done previously in Iraq. Methods: Phytochemical screening of the extracts obtained from this plant indicated the presence of flavonoids, saponins, steroids, phenols, and alkaloids. Results: The different chromatographic and spectroscopic results revealed the presence of new flavonoids isolated from Fumaria parviflora Conclusion: The isolation and purification afforded white crystalline powder which was subjected to chemical and spectral identification by infrared and H1- C 13 nuclear magnetic resonance.
Red Blood Cell Alloimmunization among the Transfusion Recipients at Sanglah General Hospital, Denpasar, Bali: A Preliminary Study Sianny Herawati; Usi Sukorini; Teguh Triyono
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background Red blood cell (RBC) alloimmunization is the formation of alloantibodies among the recipientswhich is related to the frequency of antigen-positive blood transfusion received by the recipient. The difficultyto obtain compatible RBC and a higher risk of hemolytic transfusion reactions due to alloimmunizationbecome a challenge in clinical practice. Objectives: This study aims to analyze the characteristics of RBCalloantibodies in the recipient following transfusion at Sanglah General Hospital, Bali, as a preliminary study.Methods A cross sectional study was conducted among 40 recipients with a history of RBC transfusion atleast 3 times and willing to participate in this study from December 2016 to March 2017 at Sanglah General Hospital. Data were analyzed using SPSS ver. 16 software to determine the prevalence of study. Resultsmost recipients were 46 – 65 years (55%). In addition, most recipients were caused by hematology disorder (57.5%), female (52.5%), and O-Rhesus D positive (52.5%). RBC alloantibodies detected in 5% of recipients,all of them were multiple alloantibodies, such as anti-K antibodies (5%), anti-Kp a (5%), anti-E (2.5%), anti-C w(2.5%), anti-Lu a (2.5%) and anti-M (2.5%). Those alloantibodies only found in 46 – 65 years age group.Conclusion the first preliminary study regarding RBC alloimmunization in Bali was found contributed by anti-K,anti Kp a , anti-E, anti-C w , anti-Lu a , and anti-M. The results suggest that erythrocyte antigen phenotypes can beperformed further, particularly the Kell antigen to prevent alloimmunization. However, future studies withbigger samples are needed to determine the incidence of RBCalloimmunization among transfusion recipients in Bali.Keywords: Alloimmunization, Red blood cells, Transfusion recipients.
Some Physiological and Immunological Response of Rats (Rattus rattus) to Purified Microcrystal-LR Moayed Jassim Yass Al-Amari
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The results of present study showed purification of microcrystal-LR from Anabaena circinalis by preparative high performance liquid  chromatography  and observation of some physiological and immunological response of rats to purified microcrystal-LR , the rats was intraperitoneally inject by purified microcrystal-LR from A. circinalis with dose (3, 6, 9) µg/200 gb.w per day for 30 day, the result shown the physiological parameter such as Urea concentration, cholesterol and melatonin concentration in blood and liver tissue were significantly increased with dose elevation of microcrystal-LR as compared with control group, While the total protein concentration in blood and liver tissue was significantly decreased with increasing dose of toxin. The immunological parameter such as interleukin-6 and interleukin-7 in blood and liver tissue were significantly decreased with increasing dose of microcrystal-LR.Keywords: Purified microcrystal-LR, Physiological, Immunological parameter, Cyan toxins.
Relative Expression of PPARγ and ADIPOQ mRNA as markers of Inhibition Adipogenesis on Mesenchymal Stem Cells after Pulsed Electromagnetic Field (PEMF) Exposure Puji Sari
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

ABSTRACTObjective: Obesity has become a major health problem in the world. PEMF is a modality for healing obesity because its ability to inhibit adipogenesis. Adipogenesis involves PPARγ transcription factor which plays a role in activating adipogenic genes, including ADIPOQ. PPARγ is highly expressed in the early stages of adipogenesis and ADIPOQ is highly expressed in the termination phase of adipogenesis. Both of these genes can be used as a marker of adipogenesis. This study aimed to determine the level of PPARγ and ADIPOQ expression in the group of MSCs that were exposed to PEMF and the group of MSCs that were not exposed to PEMF.Methods: The MSCs were exposed with PEMF intensity of Bmax = 2 mT, f = 75 Hz, 10 minutes a day for 14 days. Total RNA was extracted from MSCs from each treatment group on day 0 (calibrator), 2, 4, 7, and 14. PPARγ and ADIPOQ mRNA expressions were analyzed using the qRT-PCR method.Results: The results of the qRT-PCR analysis showed that the expression of PPARγ and ADIPOQ mRNA in the group that exposed to PEMF was lower than the group of MSCs that were not exposed to PEMF (p <0.05).Conclusion: PEMF exposure has an inhibitory effect on adipogenesis of MSCs. PEMF exposure decreased the relative expression of PPARγ and ADIPOQ mRNA.  Keywords: PEMF; Adipogenesis; Mesenchymal stem cells; PPARγ, ADIPOQ.
Physiological and Anatomical Study of Caraway (Carumcarvi L.) Plant Sprayed with Serine and Arginine Amal Ghanim Al-Kazzaz
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The study aimed to estimate the effects of two amino acids serine and arginine on Caraway (Carumcarvi L.) plant in the old green garden of College of Education for Pure Sciences Ibn AL-Haitham, Baghdad University, during the growing season 2016-2017. Complete randomized design (CRD) was used to conduct the experiment at two treatment (15, 30) mg.L-1 for serine and two treatment (20 and 40) mg.L-1 for arginine foliar spraying with three replicates, and control treatment sprayed with distilled water. Vegetative growth parameters of plants were estimated (plant height, dry weight, fertilizer relative efficiency and absolute rate growth), chemical contents as (content of nitrogen, phosphorus and potassium, protein and arginine concentration, and total chlorophyll) were determined, and seeds yield per plant were calculated. Results showed the response of growth parameters increased with the foliar spraying of both amino acids treatment as compared to control and highest interaction between the two factors was found between 30 mg.L-1 serine and 40 mg.L-1 arginine. As the anatomical feature the study appears that the foliar spray by amino acids (arginine and serine) and their interaction between Arginine 20 mg.L-1  and Serine 15 mg.L-1, led to increase of the epidermis thickness of stem and diameter of stem, also the amino acid led to increase the cortex thickness of stem about 80.2 µm and thickness of sclerenchyma layers significantly about 54.5 µm comparison with control treatment 40.7µm when treatment the plant with Arginine 20 mg.L-1  and Serine 30 mg.L-1, so the treatment led to decrease the vascular bundles thickness from the control treatment especially the treatment, consist from mixed with 40 mg.L-1  Arginine and 30 mg.L-1  Serine about  42.7 µm from the control treatment 109.1 µm.Key words: Caraway plant, Physiology, Anatomy, Serine, Arginine.
Effect of Addition of Silver Nanoparticle on Optical Properties of Polymethylacrelate (PMMA) Films Adel H. Omran Alkhayatt
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The aim of this work to a realization the effect of adding silver nanoparticles on the optical properties of Polymethylmethacrylate (PMMA) films were prepared by using casting technique At a temperature (50ᵒC) with thickness (8±1μm).The optical properties by measuring the spectra absorbability and transmission as a function of wavelength (200-800) nm. The results showed that the transmittance decreased with increasing doping because of increased impurity resulted holds attenuation in the intensity of incident light with a clear increase of absorption and a decrease in optical reflectivity.as well as calculated the optical constants (α,k, and εr) of the prepared films and the results showed an increase when increasing rate of doping .the real part of the Dielectric Constant conduct like the refractive index, while the imaginary part conduct like the extinction coefficient, as for optical conductivity its values increases with increasing the rate of the silver nanoparticles as well as identifying the types of electronic transitions and calculating energy gaps It was found there is diminution in energy gap for direct electron transmission reaching values (5.4 - 4.9) eV.Keywords: Polymethylacrelate, Optical Properties, Silver Nanoparticle, Optical Conductivity
A Comparative Assessment Study on Natural Coagulant and Regenerated Coagulant Alok Suman
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Surface water brings impurities in the form of suspended and colloidal solids. Coagulation and flocculation followed by filtration and disinfection process involved in the treatment of surface water. This process generates large quantity of waste generally known as water treatment sludge (WTS). A typical Water Treatment Plant (WTP) produces about 100,000 tons/year of sludge whereas, on a global scale, available literature estimates that at present the daily production of sludge exceeds 10,000 tons (Babatunde and Zhao, 2007). Increase in demand for milk and dairy products, dairy industries in most of the countries of the world, including India will lead to enhanced productivity, as a result increase in wastewater generation and environmental pollution. The objective of the present study is to determine WTS characteristics obtained from WTP and to investigate the reuse of recovered/regenerated coagulant in synthetic dairy effluent and compare with natural coagulant (Moringa Oleifera Seed Powder (MOSP)). The characterization of WTS shows the maximum amount of SiO2   at 67.75% by using Energy-Dispersive X-Ray Fluorescence (ED-XRF). The other oxides also observed by ED-XRF such as Al2O3 (16.76%), Fe2O3 (5.52%) and MgO (3.33%). For the optimum recovery of the coagulant, WTS acidified with the different normality of sulfuric acid. The RC produced similar turbidity removal efficiency (94%) at 25ml/l dose as compared to natural coagulant at 60 ml/l dose. It also has been observed that the removal of TSS, TDS, BOD and COD efficiently by RC. CPCB [3] reported that some of the WTPs are cleaned once in a year and in the lack of sludge disposal management it disposed off on nearby open lands or drain. Proper handling WTS from WTPs in an economical and environmentally friendly manner remains a very important issue. The recovery, recycling and reuse may provide a sustainable solution to the WTS management.Keywords: Water Treatment, Sludge, Recovery of coagulant, MOSP, SEM, ED-XRD, FTIR, and XRD.
Polymorphisms in micro RNA Genes and Humoral Immune Response to Hepatitis B Vaccine in Iraqi Children and Adolescents Qasim Sharhan Al-Mayah
Journal of Global Pharma Technology .
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Abstract

The remarkable reduction in the incidence of hepatitis B virus (HBV) is mainly attributed to the vaccination regime. However, some individual variations in immune response to this vaccine do exist which may be actually referred to as genetic factors. This study aimed to evaluate the role of three single nucleotide polymorphisms (SNP) in microRNA genes, that is, miR-146a G>C, miR-149 C>T and miR-196a2 C>T in the humoral response to HBV vaccine. A total of 86 children and adolescents who had completed the vaccination program from Al-Zahraa Health Center during the period between October 2016 to January 2017 were recruited for this study. Serum levels of anti-HBs IgG was measured with enzyme linked immunosorbent assay (ELISA), DNA was extracted from blood sample and specific primers were used for the amplification of gene fragments corresponding to the SNPs. According to the instructions of the ELISA kit, among the investigated 86 subjects, only 58 (67.44%) had good immune response. Direct sequencing was used for genotyping. In recessive model, the frequency of GC+CC genotypes of miR-146a G>C was significantly higher in responders than non-responders (OR = 2.598, 95% CI = 1.008-6.698, P = 0.046), and the minor allele (C allele) was more frequent among responders than non-responders (OR = 2.16, 95%CI = 1.029-4.532, P = 0.039). The wild homozygous genotype (CC) and miR-196a2 C>T was more frequent in responders than non-responders (OR = 2.881, 95% CI = 1.044-7.953, P = 0.041) with significant effect of dominance model in responders against non-responders (OR = 3.143, 95% CI = 1.210-8.161, P = 0.016). Furthermore, the major allele (allele C) was more frequent in responders than non-responders (OR = 2.724, 95% CI = 1.253-5.922, P = 0.013). These data indicate the important role of miR-146a G>C and miR-196a2 C>T in immune response against HBV vaccine.Key words: Mi RNA, Hepatitis B vaccine, Single nucleotide polymorphisms.
Adjusted Permutation Method for Multiple Attribute Decision Making with Pruning Solution Approach Ali Athari Beyragh
Journal of Global Pharma Technology Volume 08 Issue 05
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Abstract

Permutation method is one of the multi-critera decision making techniques which can get the best order of the given alternatives to have the best benefits. This method solves the decision making problem by calculation the benefit of each possible permutation with N Factorial calculations for N alternatives. In this paper, we presented a new method for improving the classical permutation method. It works with pruning the possible permutation sequences of the alternatives to reach the best solution. Our method can solve the problem by less than N(N-1)/2 calculations. It tries to find the best order by comparing the effect of switching the places of two nearby alternatives in the permutation sequences.Keywords: Multi-criteria Decision Making, Adjusted Permutation, Pruning.
Histomorphological Study and Scanning Electron Microscopy of the Duodenum in the Iraqi Black Partridge (Francolinus francolinus) Ola Al-Bhadly
Journal of Global Pharma Technology .
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Abstract

Objective: This project aimed to study the Morphological description and histological structure by using light and scanning electron microscope of duodenum in both male and female Iraqi black partridge (Francolinus francolinus) Methods: To conduct this investigation, 20 healthy Iraqi black partridge were collected from local suppliers. Birds were euthanized, dissected and then specimens were processed for histological and histochemical staining techniques. Results: Morphological study showed the duodenum consists of descending and ascending limbs forming (U) shaped tube called duodenal loop extend from the right side of the dorsal surface of the gizzard. The pancreatic and bile ducts opened in the end of the ascending limb. Male had significantly higher than Female in the mean length and weight of duodenum. Histologically, the wall of the duodenum was consisted of four tunicae mucosa, submucosa, muscularis and serosa. The mucosa had a distinctive feature by the presence of villi had finger shape and the crypts of lieberkuhn which covered by simple columnar epithelium with goblet cells. The goblet cells gave positive reaction with PAS stain. Duodenal villi appeared by SEM very long and finger-like shaped with two organized orientations, primary and secondary villi. No significant differences between sexes in the villi height, crypts depth and the number of goblet cells but significantly difference in the mean thickness of tunica. Conclusion: the results showed that the significant difference in the mean length, weight of duodenum and thickness of tunica between two the sexes may be related to differences in food intake amounts. Goblet cells neutral mucopolysaccharide secretions; in fact, the latter stain is an indicator mucin substance which are very important in digestion and absorption and subsequent body growth of the bird.Keywords: Duodenum, Histomorphology, IRAQI Black Partridge, Scanning electron microscope.

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