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Biocaster : Jurnal Kajian Biologi
Published by Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu
ISSN : 28083598     EISSN : 2808277X     DOI : https://doi.org/10.36312/biocaster
Core Subject : Science, Education, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology
Biocaster : Jurnal Kajian Biologi (B : JKB), focus to bridge the gap between research and practice, providing information, ideas and opinion, in addition to critical examinations of advances in biology research, teaching, and learning. Through the coverage of policy and curriculum developments, the latest results of research into the teaching, learning and assessment of biology are brought to the fore. Biocaster : Jurnal Kajian Biologi (B : JKB), receiving and publishing article in the form of research and review (scientific article) in the field of biology education and utilization of biological research in teaching and learning. Each article must be linked to the theme "21st century skills in biology education" and / or "Efforts to support the achievements of the goals set forth in the Sustainable Development Goals (SDGs) through biology education". All articles are published in English and under go a peer-review process. The scope of Biocaster : Jurnal Kajian Biologi (B : JKB), is focused on biology education research/review both in topics covered as well as disciplinary perspective : 1) Biology teaching and learning materials at all education levels; 2) Pure Research of Biology developed or studied to the sources, materials, or instructional media Biology (using the Research and Development paradigm/R&D); 3) Curriculum of Biology Education at all education levels; 4) Quasi-experiment, Class Action Research (CAR), and Lesson Study in Biology teaching and learning; 5) Other Qualitative Research of Biology Education; 6) Biology Learning Evaluation/Assessment; 7) Teacher Professional Issues/Trends in Biology Education; and 8) Environmental education.
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 52 Documents
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Search results for , issue "Vol. 6 No. 1 (2026): January" : 52 Documents clear
Pemanfaatan CRISPR-Cas9 pada Antibodi Monoklonal untuk Terapi HIV Adhytama S, Ryan Putra; Hala, Yusminah
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.843

Abstract

HIV infection remains a global health challenge with high rates of new infections and low levels of viral suppression, especially in middle-income countries. Antiretroviral therapy (ART) has significantly reduced morbidity and mortality, but has not been able to eliminate latent reservoirs so lifelong therapy remains necessary. In the last decade, monoclonal antibodies, particularly broadly neutralizing antibodies (bNAbs), as well as CRISPR-Cas9 gene-editing technology have emerged as innovative therapeutic approaches with long-term remission potential. bNAbs is able to neutralize a broad spectrum of HIV strains and activate immune effector mechanisms, including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, but cost limitations, viral resistance, and duration of effects limit its use as a substitute for ART. In parallel, CRISPR-Cas9 has demonstrated the ability to target HIV proviruses in the host cell genome and enable the engineering of immune cells to stably produce therapeutic antibodies. Pre-clinical studies show that B-cell engineering with CRISPR-Cas9 can maintain immune memory, perform isotype switching, and somatic hypermutation, thus creating "programmed immunity". The combination approach of bNAbs and CRISPR-Cas9 is considered promising because it is able to neutralize circulating viruses while removing latent proviruses, increasing the potential for functional cure. However, biological risks such as off-target effects, Cas9 immunogenicity, limitations of the delivery system, and the emergence of escape mutants remain challenges. This review shows that the integration of monoclonal antibodies with CRISPR-Cas9 opens up a new paradigm of HIV therapy, with the potential to improve efficacy, duration of protection, and decrease reliance on ART. Further research, including advanced phase clinical trials, is needed to ensure its safety, effectiveness, and feasibility of application in human populations.
Pemetaan Habits of Mind Mahasiswa : Landasan untuk Pengembangan Strategi Pembelajaran Berbasis Inkuiri Masiah, Masiah; Adawiyah, Siti Rabiatul; Jaswandi, Lalu
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.849

Abstract

Habits of Mind (HoM) is an important thinking disposition that supports successful learning in higher education, especially in inquiry-based learning. This study aims to map the profile of students' habits of mind as a basis for developing inquiry-based learning strategies. The study used a quantitative descriptive approach involving 60 students in semesters I, III, V, and VII. Data were collected through an online questionnaire containing 16 indicators of habits of mind based on the Costa and Kallick framework, then analyzed using percentage scores based on semester and indicator. The results showed that students' habits of mind achievement was in the good category, with the highest scores in semesters I (81%) and VII (80%), while semesters III and V were in the sufficient category (74%). Indicators with the highest scores included listening with understanding and empathy (90%), striving for accuracy (85%), and persisting (84%), while the lowest scores were found in thinking flexibly (62%), thinking interdependently (69%), and finding humor (71%). These findings indicate that students possess strengths in perseverance, thoroughness, and empathy, but still need to strengthen their thinking flexibility and collaboration. Therefore, structured and collaborative inquiry-based learning is recommended to develop students' habits of mind in a more balanced manner.
Hubungan Rasio Panjang Jari Telunjuk dan Jari Manis (2D:4D) dengan Tinggi Badan Mahasiswa Universitas Jambi Gayatri, Adinda Kinantia; Agustyn, Amanda Rya; Putri, Dea Abyanti; Napitu, Priska Enjelina; Siburian, Jodion; Anggereini, Evita; Saparuddin, Saparuddin; Tentia, Ine
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.856

Abstract

The finger length ratio (2D:4D) is often used as an indirect indicator to estimate the influence of hormones, especially prenatal sex hormones, which are thought to be related to physical variations such as height. This study aims to analyze the relationship between the index finger and ring finger length ratio (2D:4D) and the height of students at the University of Jambi. This study used a quantitative approach with a correlational design. The sample consisted of 37 students at the University of Jambi who were selected using purposive sampling. The inclusion criteria included students who were willing to participate, were in good physical health, and had no growth disorders or abnormalities of the fingers. Measurements were taken directly of the length of the index finger (2D) and ring finger (4D) on the right and left hands using calipers with an accuracy of 0.05 mm, while height was measured using a tape measure. Pearson's correlation analysis was used to determine the relationship between the 2D:4D ratio and height. The results showed that the relationship between height and the 2D:4D ratio on the right hand (r = 0.184; p = 0.276) and left hand (r = 0.233; p = 0.166) was positive but very weak and not statistically significant. These findings indicate that the 2D:4D ratio is not significantly related to the height of students at the University of Jambi.
Teknologi Pengeditan Gen pada Anemia Sel Sabit (Sickle Cell Disease) : CRISPR-Cas9, Base Editing, dan Prime Editing Fadhilah, Nurul; Hartati, Hartati
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.861

Abstract

Sickle Cell Disease (SCD) is a monogenic disease due to a point mutation in the HBB gene that causes chronic hemolytic anemia and vaso-occlusive crisis, while conventional therapy is generally palliative. In the past decade, CRISPR-based gene editing has developed rapidly and given birth to three main platforms, namely CRISPR-Cas9, base editing, and prime editing which opens up opportunities for more curative therapies through fetal hemoglobin (HbF) reactivation or correction of genetic targets. This literature review aims to compare working principles, cutting-edge achievements, advantages, and limitations, as well as the ethical implications and potential integration of biology learning from the three technologies. The method used is a descriptive-comparative literature review of 2015-2025 publications from reputable databases (PubMed, Scopus, ScienceDirect, SpringerLink, and Nature Portfolio) which is selected based on relevance and quality. The results of the synthesis showed that CRISPR-Cas9 has reached the clinical stage through HbF-enhanced autotemcel (exa-cel/Casgevy) exagamglogen therapy and is reported to suppress vasoocclusive crises in most patients. Base editing offers base change without Double-Strand Break (DSB) and shows promising preclinical results, including HbS conversion strategies into antisickling variants (e.g. HbG-Makassar) as well as modulation of HbF regulators. Prime editing provides the ability to "rewrite" sequences without DSBs or separate DNA donors and shows preclinical evidence in hematopoietic stem cells and animal models, but efficiency, complexity of delivery, and long-term safety data remain challenges. This study emphasizes that strengthening ethical governance (safety, informed consent, and access fairness) needs to go hand in hand with innovation. In addition to biomedical relevance, the topic of SCD-gene editing has the potential to be an authentic context for developing students' genomic literacy, ethical reasoning, and critical thinking through the PjBL and SSI approaches.
Adaptasi Sel terhadap Perubahan Lingkungan Osmotik Ekaputra, Paulus Rudirudolof; Sumira, Sumira; Doi, Yohana Fransiska; Ohaq, Emanuel; Wae, Veronika P. Sinta Mbia
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.873

Abstract

This study aims to examine the mechanism of cell adaptation to hypertonic conditions through osmoregulation processes in various types of cells and organisms. The method used is a systematic literature review of 30 national and international journal articles sourced from Google Scholar and ScienceDirect databases. Articles were selected based on inclusion criteria that include topic suitability, availability of osmotic experimental data, and relevance to cellular responses. The results of the study indicate that cells adapt through the accumulation of compatible osmolytes such as proline, glycine betaine, and sorbitol to maintain intracellular water and ion balance. This response was observed in various objects, including Rhoeo discolor cells that showed optimal adaptation to 0.26 M sucrose with a decrease in plasmolysis from 85% to 36%, and Inpari rice seeds with an increase in drought tolerance of up to 50% through proline accumulation. Active osmoregulation was also found in frog erythrocytes, Lactobacillus plantarum, tiger prawns (543-610 mOsm/L), and tilapia which recorded an 80% survival rate at graded salinities. In general, increased osmoregulatory capacity significantly reduced cell damage from hypertonic stress, although the magnitude of the response varied among organisms. These findings have important implications for the development of rainfed agriculture, brackish water aquaculture management, and the selection of genotypes resistant to extreme climate change.
Kajian Etnobotani Tradisi Ruwah Rosul : Praktik Ritual Masyarakat Kediri Sebelum Upacara Adat Pernikahan Indraswari, Ratna Afieh; Sholehah, Anisa Putri; Istiqomah, Roisah Maulidatunnisa Al; Achmad, Derryl Jevani; Muhaimin, Fahrul Ghani; Pitaloka, Karin Anindita Widya; Mahanal, Susriyati
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.878

Abstract

This study aims to document and preserve the local knowledge of the people of Duwet Village, Kediri Regency, regarding the use of plants in the Ruwah Rosul tradition, which is carried out before traditional wedding ceremonies. This study uses a qualitative descriptive method with the determination of key informants (traditional leaders) through purposive sampling, followed by snowball sampling of additional informants (people who practice the tradition). Data collection was carried out through interviews, observations, and documentation, which were then validated using triangulation techniques. The data were analyzed descriptively through the stages of data reduction, data presentation, and conclusion drawing. The results of the study found 10 types of plants dominated by shrubs, with flowers being the most widely used part of the plant in each ritual arrangement. Each plant has a philosophical meaning that represents the values of prayer, hope, and harmony in life. Most species have not been evaluated for their conservation status (Not Evaluated), but conservation practices have been carried out by the community through cultivation in their yards. This study provides a new contribution by integrating aspects of ethnobotany, cultural symbolism, and local conservation into a single framework for analyzing the Ruwah Rosul tradition.
Studi Etnobotani Tumbuhan Anti-Penyakit Kulit dalam Sistem Pengobatan Tradisional Masyarakat Desa Jeruk Purut, Pasuruan Laili, Dewi Sofiatul; Refdiana, Heni; Amelia, Najwa Rofisa; Muhaimin, Fahrul Ghani; Pitaloka, Karin Anindita Widya; Mahanal, Susriyati
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.880

Abstract

This study aims to document and preserve local knowledge about the use of medicinal plants for skin diseases used by the community of Jeruk Purut Village, Pasuruan Regency. The research method used is a qualitative descriptive approach. Data were collected through interviews, observations, and documentation. Key informants were determined using purposive sampling, followed by snowball sampling to expand information from additional informants. The data were analyzed descriptively through data reduction, data presentation, and conclusion drawing. The results of the study identified 14 plant species from 11 families used by the community to treat skin diseases, including acne, tinea versicolor, dermatitis, scabies, and ringworm. Leaves are the most widely used part of the plant due to their secondary metabolite content, which is effective as an antibacterial, antifungal, and anti-inflammatory agent. Processing is done traditionally through pounding, boiling, cutting, grating, or heating, and applied by rubbing, sticking, compressing, or drinking. The conservation status of most species is classified as Not Evaluated, indicating limited data and the need for further research as a basis for assessing extinction risk. These findings emphasize the importance of preserving local knowledge and the need for further research to ensure the sustainable use of medicinal plants.
Etnobotani Tumbuhan Ritual dalam Tradisi Tosan Aji Madakaripura : Eksplorasi Pengetahuan Lokal Masyarakat di Singosari, Malang Marella, Fannia Zulfa; Fitriani, Fika; Christina, Vicke Indriani; Muhaimin, Fahrul Ghani; Pitaloka, Karin Anindita Widya; Mahanal, Susriyati
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.881

Abstract

This study aims to document and preserve the local knowledge of the Singosari community, Malang Regency, East Java in utilizing plants for the Tosan Aji Madakaripura tradition. A qualitative descriptive approach was used in this study, where data were collected through semi-structured interviews, observation, and documentation. Key informants were determined using a purposive sampling technique, then additional informants were selected using snowball sampling. The data obtained were then analyzed descriptively with the stages of data reduction, data presentation, and conclusion drawing. The results showed that there were 25 plant species from 19 families dominated by tree habitus with the most widely used part being the trunk for carving and extracting. Plants used in this tradition have different philosophical meanings that reflect the reasons for their use in the tradition. The conservation status of most plants is included in the category of least concern, meaning that their populations are still stable, and there are conservation efforts by the community through cultivation. The implementation of the Tosan Aji Madakaripura tradition demonstrates that various plant species are not only used practically but also possess philosophical meanings that represent the relationship between humans and nature. This finding emphasizes that traditional plant use must be balanced with conservation-based management to maintain the sustainability of biological resources.
Ketika Purnama Menyentuh Tumbuhan : Kajian Etnobotani dalam Tradisi Padhang Bulan di Candi Jago, Malang Husna, Nur Fadhilla Lailatul; Imaniah, Yukabad Noor; Rafi, Naufal Sulthan; Muhaimin, Fahrul Ghani; Pitaloka, Karin Anindita Widya; Mahanal, Susriyati
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.882

Abstract

This study aims to document and preserve local knowledge about the use of plants in the Padhang Bulan tradition at Candi Jago, Tumpang Village, Malang Regency, East Java, including the types, habits, parts used, methods of use, philosophical meanings, and conservation efforts. The research used a qualitative descriptive approach. Data were obtained through interviews, observations, and documentation. Informants were determined using purposive sampling techniques, followed by snowball sampling. The data were analyzed descriptively through the stages of reduction, presentation, and conclusion drawing. The results showed that there were 21 plant species from 13 families, dominated by the Araceae family, with the majority being herbaceous and tree habitus. The most widely used parts of the plants were fresh flowers and leaves, each of which had philosophical meanings in the context of the ritual. Most of the plants are classified as Least Concern and are obtained through cultivation as a form of local conservation. The novelty of this study lies in the integration of ethnobotanical documentation, philosophical meanings, and plant conservation practices into a single framework of ritual analysis, which confirms the role of Padhang Bulan as a medium for the transmission of local knowledge as well as a strategy for preserving plant diversity based on culture.
Jejak Flora dalam Festival Encek : Kajian Etnobotani Tumbuhan Ritual di Desa Sumbersekar, Malang Ramadhania, Irma Nur; Kholisotun, Charisma Mayang; Sari, Ray Tunjung; Erviana, Rifdah Hanani; Muhaimin, Fahrul Ghani; Pitaloka, Karin Anindita Widya; Mahanal, Susriyati
Biocaster : Jurnal Kajian Biologi Vol. 6 No. 1 (2026): January
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v6i1.886

Abstract

This study aims to document and preserve the local community's knowledge regarding the use of ritual plants in the Encek Festival. This study focuses on identifying the types, habits, parts used, methods of use, philosophical meanings, and conservation efforts of the plants used in the Encek Festival. This study uses a qualitative descriptive approach. Data were collected through interviews, observation, and documentation. This study involved a number of informants who were determined gradually through purposive sampling, followed by snowball sampling until data saturation was reached. The data obtained was then analyzed descriptively with reference to Miles and Huberman's analysis stages, namely data reduction, data presentation, and conclusion drawing. The results of the study show that the Encek Festival utilizes 10 plant species from 8 families, dominated by tree habitus, with flowers as the most widely used part and generally arranged in ritual processions. These plants have philosophical meanings as symbols of spirituality to God. The conservation status of most species is classified as Not Evaluated, while several others are classified as Least Concern, indicating a relatively low risk of extinction. Based on how they are obtained, the plants used come from cultivation and purchase, so their use does not directly put pressure on plant populations. This study confirms that the Encek Festival plays an important role in preserving ethnobotanical knowledge while maintaining the sustainability of local cultural values amid the dynamics of modernization.

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