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Ayyub Harly Nurung
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Editor's Address: 3rd Floor Laboratory Faculty of Pharmacy, 2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia
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INDONESIA
Journal Microbiology Science
Published by Universitas Muslim Indonesia
ISSN : 2808392X     EISSN : 28083911     DOI : https://doi.org/10.56711/jms
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
Journal Microbiology Sciences (J. Mic. Sciences) receives writing in the form of research results, scientific studies and brief descriptions relating to Microbiology, such as Molecular and Microbial Epidemiology Clinical Microbiology Medical Microbiology Pharmaceutical Biotechnology and others related to Microbiology Sciencee
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 75 Documents
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Antibacterial Activity of N-Hexan and Ethyl Acetate Fractions of Gaharu (Aquilaria Malaccensis) Leaves against Bacteria that Cause Infection Yahya, Fifi Adelia; Herwin, Herwin; Fitriana, Fitriana
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1139

Abstract

Gaharu (Aquilaria malaccensis) leaves contain alkaloids, terpenoids, flavonoids, saponins, and tannins that can help cure infections. This study aims to determine the antibacterial activity of n-hexane and ethyl acetate fractions of Gaharu leaves against skin infection bacteria such as Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis by Bioautography-TLC. Gaharu leaves symplisia was extracted using the maceration method using ethanol 96% solvent and fractionation with solid-liquid method to obtain n-hexane and ethyl acetate fractions. The result of the screening antibacterial activity of n-hexane and ethyl acetate fractions of Gaharu leaves with concentrations of 0,5% active to 4 bacteria test. The results of antibacterial activity n-hexane and acetaet ethyl fraction by Bioautography-TLC using n-hexane:ethyl acetate (1:4) eluent showed Rf 0.67 and Rf 0,16 value in the n-hexane fraction and an Rf 0.78 value in the ethyl acetate fraction active to 4 bacteria test.  The identification results of the chemical compound of the n-hexane fraction contain flavonoids and tannins (AlCl3 and FeCl3 reagents.), the ethyl acetate fraction contains flavonoids ( AlCl3 reagents).
Antibacterial Properties in Fermentate Extracts of Endophytic Fungus Derived from Marine Algae Caulerpa lentillifera Against Gastrointestinal Pathogenic Bacteria Paliwengi, Andi Sinrang
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1118

Abstract

Endophytic fungi, residing symbiotically within living plant tissues, are a promising source of novel bioactive compounds. These fungi are known to produce secondary metabolites with a wide range of biological activities, including antibacterial properties. This study explored the antibacterial potential of fermented extracts from endophytic fungi isolated from the marine alga Caulerpa lentillifera, a food source consumed by coastal communities and traditionally used for medicinal purposes. Thin-layer chromatography (TLC) bioautography was employed to identify extracts with activity against common gastrointestinal pathogenic bacteria, such as Escherichia coli, Shigella dysenteriae, and Salmonella typhi. Two endophytic fungal isolates displayed promising antibacterial activity against these pathogens. TLC analysis tentatively identified the presence of flavonoids and alkaloids, potentially responsible for the observed effects. This research sheds light on the pharmacological potential of endophytic fungi and their applications in combating bacterial infections.
Antibacterial Activity Test Of Ethanol Extract Of Matoa Leaves (Pometia pinnata) Against Bacteria That Cause Digestive Tract Infections Kamilah, Eva
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1160

Abstract

Matoa Leaves (Pometia Pinnata) Are One Of The Plants That Are Effective As An Antibacterial. This Study Aims To Determine The Antibacterial Activity Of Ethanol Extract Of Matoa (Pometia Pinnata) Leaves Against Several Bacteria That Cause Digestive Tract Infections. This Research Method Was Carried Out Experimentally To Test The Antibacterial Activity Of Matoa (Pometia Pinnata) Leaves Using An Antibacterial Screening Test, MIC Test And KBM Test With Varying Concentrations Of 0.05%, 0.1%, 0.2%, 0.4%, 0.8%, 1.6%, 3.2%, And 6.4%. As Well As Antibacterial Activity Tests With Varying Concentrations Of 1.6%, 3.2% And 6.4%. The Results Obtained In The Screening Test With A Concentration Of 0.1% Showed No Growth In All The Test Bacteria Used, For The MIC Values, Namely Eschericia Coli 0.2%, Salmonella Typhi 0.8%, And Vibrio Cholerae 0.4%, For The KBM Values Eschericia Coli 0.4%, Salmonella Typhi 1.6%, And Vibrio Cholerae 0.8%. As Well As The Results Of Antibacterial Activity Testing, The Largest Inhibitory Zone Diameter Was Obtained For Escherichia Coli Bacteria At A Concentration Of 4.8%, Namely (18.26mm), For Salmonella Typhi Bacteria At A Concentration Of 4.8%, Namely (15.36mm), And For Vibrio Cholerae Bacteria At A Concentration Of 4.8 % Which Is (15.74mm). The Ethanol Extract Of Matoa (Pometia Pinnata) Leaves Has Antibacterial Activity
Antibacterial Activity of Endophytic Fungi Isolate from Bidara Plant (Ziziphus mauritiana Lam.) Against Bacteria That Cause Digestive Infections by Agar Diffusion Method Rahmadhani, Paramita; Fitriana, Fitriana; Nurung, Ayyub Harly
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1145

Abstract

Isolates of endophytic fungi coded IFAZ-6 derived from bidara plants (Ziziphus mauritiana Lam) has antibacterial abilities. This study determine whether those isolates has antibacterial activity against bacteria Escherichia coli. Isolates of endophytic fungi were purified and fermented for 21 days and the fermentation results were extracted using ethyl acetate solvent. The ethyl acetate extract obtained was carried out with a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) as well as activity tests with the agar diffusion method. From the test results, statistical tests were carried out, the highest concentration IFAZ-6 isolate extracts that has highest inhibitory zone was 300,000 ppm in E. coli bacteria but only significantly different to 200.000 ppm.
Antibacterial Activity of Ethanol Extract Red (Jatropha gossypifolia) Leaves Against Bacterial Skin Infections by Agar Diffusion Imada, Nurul
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1125

Abstract

Red Jatropha gossypifolia plant is a type of Jatropha with purplish red leaves which the chemical compounds are found are calcium oxalate, jatroidene, interquinones, flavonoids, flobatin and phenolics, and these compounds can be used as an anticoagulant, anti-inflammatory, analgesic and antibacterial. The aim of this research is to determine the antibacterial activity of red Jatropha leaves ethanol extract against bacteria causes skin infections by Agar Diffusion. The result of screening antibacterial test of red Jatropha leaves ethanol extract with a concentration of 0,1% active against bacteria Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acne and Pseudomonas aeruginosa. The result of analysis Minimum Inhibitor Concentration (MIC) and Minimum Bactericidal Concentration (MBC) ethanol extract obtained MIC value = 0.1% to bacteria acid, MBC value = 0.05% to bacteria acid, and the result of antibacterial activity of ethanol extract obtained the largest inhibitory zone diameter at a concentration of 12.8% was 13.577 mm against Staphylococcus aureus.
Antibacterial Potential of Ethanol Extract from White Pidada (Sonneratia alba) Leaves Against Gastrointestinal Pathogens Rudiah, Sukhriatun
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1123

Abstract

The antibacterial properties of the ethanol extract of White Pidada leaves (Sonneratia alba), a mangrove plant rich in bioactive compounds such as phenols, flavonoids, steroids, saponins, triterpenoids, tannins, and alkaloids, were evaluated in this study. The research focused on determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against gastrointestinal infection-causing bacteria, including Salmonella typhii, Shigella dysenteriae, Escherichia coli, and Vibrio cholerae. The MIC results showed effective inhibition at concentrations as low as 0.025% for Shigella dysenteriae, 0.05% for Salmonella typhii and Vibrio cholerae, and 0.5% for Escherichia coli. The MBC analysis indicated bactericidal activity at higher concentrations, with significant effects observed at 1% for Salmonella typhii, 0.05% for Shigella dysenteriae and Vibrio cholerae, and 0.1% for Escherichia coli. Agar diffusion tests confirmed that increasing extract concentrations correlated positively with the inhibition zone diameter, highlighting the potential of White Pidada leaves as a natural antibacterial agent.
Antibacterial Activity of N-Hexan and Ethyl Acetate Fractions of Gaharu Leaves (Aquilaria malaccensis) Against Bacteria Causing Skin Infection Sompa, Putri Tenri; Herwin, Herwin; Fitriana, Fitriana
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1147

Abstract

Gaharu (Aquilaria malaccensis) leaves are plants that are useful in the treatment of infectious diseases. This study aims to obtain n-hexane and ethyl acetate fractions of Gaharu leaves that have antibacterial activity against skin infection bacteria by agar diffusion. The results of antibacterial activity screening of the n-hexane fraction and ethyl acetate fraction at a concentration of 0.1% is bacteriostatic. The test results of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using concentrations of 0.1%, 0.2%, 0.4%, 0.8%, 1.6%, 3.2%, 6.4% and 12.8% obtained MIC value of n-hexane fraction at 0.2% against P. acnes, P. aeurogynes bacteria and 0.4% against S. aureus, S. epidermidis bacteria, MIC value of ethyl acetate fraction was 0.2% against P. aeuroginosa, S. aureus bacteria and 0.4% against P. acnes, S. epidermidis bacteria. MBC value of n-hexan fraction was 0.4% against P. acnes, P. aeuroginosa bacteria, 0.8% against S. aureus bacteria, 1.6% against S. epidermidis bacteria, MBC value of ethyl acetate fraction was 0.4% against P. acnes, P. aeuroginosa, S. aureus bacteria, 0.8% against S. epidermidis bacteria. The results of the antibacterial activity using concentrations of 1.56%, 3.12%, 6.25%, 12.5% and 25% obtained the largest inhibition zone diameter of the n-hexane fraction was 13,99 mm and the ethyl acetate fraction was 27,68 mm against S. epidermidis bacteria at a concentration of 25%. Based on the results, it can be concluded that the antibacterial activity of the ethyl acetate fraction against all test bacteria is stronger than the n-hexane fraction
Antibacterial Evaluation of Agarwood (Aquilaria malaccensis) Leaf Ethanol Extract Against Pathogenic Bacteria Using TLC-Bioautography Marsaoly, Rivaldy
Journal Microbiology Science Vol 4, No 2 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i2.1128

Abstract

Pathogenic bacteria are microorganisms that live in the human body that cause disease, such as the bacteria bacillus subtilis, Pseudomonas aeruginosa, and Eschericia coli. compounds such as flavanoid compounds, alcolloids, saponins, tannins, and terpenoids that has antibacterial properties The purpose of this research was to determine the antibacterial activity of agarwood leaf ethanol extract (Aquilaria malaccensis) against pathogenic bacteria by TLC - bioautography. The results shown that agarwood leaf ethanol extract (Aquilaria malaccensis) has potential as antibacterial against, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli, with three active spots identified in the bioautogram profiles an Rf value of 0.20 demonstrated inhibition against Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli Additionally, Rf values of 0.50 and 0.36 exhibited inhibitory effects against Pseudomonas aeruginosa and Escherichia coli, highlighting the potential of agarwood leaf ethanol extract in combating pathogenic bacteria
Antibacterial Activity Test of Ceremai Leaf Ethanol Extract (Phyllanthus acidus (L.) Skeels) Against Bacteria Causing Skin Infections by KLT-Bioautography and Agar Diffusion Naid, Tadjuddin; Herwin, Herwin; Muldin, Nurul Insani
Journal Microbiology Science Vol 5, No 1 (2025)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i1.1204

Abstract

Ceremai leaves (Phyllanthus acidus) are known for their medicinal properties, including the treatment of infectious diseases. This study aims to evaluate the antibacterial activity of ethanol extract from Ceremai leaves against skin infection-causing bacteria using Thin Layer Chromatography-Bioautography (TLC-Bioautography) and agar diffusion methods. The study began with an antibacterial screening test, followed by TLC-Bioautography, and then determination of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) at various concentrations (0.125% to 16%). The agar diffusion method was used to further assess antibacterial activity. Screening results showed antibacterial activity at a concentration of 1%. TLC-Bioautography with a chloroform: methanol: water (20:2:0.5) eluent revealed active spots with Rf values of 0.8, 0.54, 0.36, and 0.29. The MIC values were 0.25% for P. acnes and S. aureus, and 0.5% for P. aeruginosa and S. epidermidis. The MBC values were 0.5% for P. acnes and S. aureus, and 1% for P. aeruginosa and S. epidermidis. The largest inhibition zone in the agar diffusion test was observed at a 32% concentration against S. aureus, measuring 20.11 mm. These findings suggest that Ceremai leaf extract has significant antibacterial potential and could be considered for developing alternative treatments for skin infections.
Antibacterial Activity of Ethanol Extract of Krokot Herb (Portulaca oleracea L.) against Skin Infection Pathogens: Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes Annisa, Andi Adria
Journal Microbiology Science Vol 5, No 1 (2025)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i1.1163

Abstract

Purslane (Portulaca oleracea L.), a traditional herb, is rich in various secondary metabolites like flavonoids, phenolics, tannins, and saponins, known for their antibacterial properties. This study evaluates the antibacterial efficacy of ethanol extract of purslane against skin-infecting bacteria. Using the Agar diffusion method, the study tested the extract's activity against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes. The results indicate significant antibacterial activity, with the highest inhibition observed at a 32% concentration, producing inhibition zones of 10.29 mm, 9.05 mm, and 8.59 mm against S. aureus, S. epidermidis, and P. acnes, respectively. These findings suggest that purslane extract could be an effective antibacterial agent for treating skin infections. This study contributes to the understanding of the potential applications of purslane in medical treatments, emphasizing the need for further investigation into its bioactive compounds.

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