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Ayyub Harly Nurung
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Editor's Address: 3rd Floor Laboratory Faculty of Pharmacy, 2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia
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INDONESIA
Journal Microbiology Science
Published by Universitas Muslim Indonesia
ISSN : 2808392X     EISSN : 28083911     DOI : https://doi.org/10.56711/jms
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
Journal Microbiology Sciences (J. Mic. Sciences) receives writing in the form of research results, scientific studies and brief descriptions relating to Microbiology, such as Molecular and Microbial Epidemiology Clinical Microbiology Medical Microbiology Pharmaceutical Biotechnology and others related to Microbiology Sciencee
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 75 Documents
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Antifungal Activity of Cosmos caudatus Kunth Leaf Ethanol Extract Against Candida albicans Fitriana, Fitriana; Nuryanti, Siska; Ramadhan, Wahyu Gilang
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1366

Abstract

Ethanol extract of Kenikir leaves (Cosmos caudatus Kunth) is known to contain bioactive compounds such as flavonoids, tannins, saponins, and phenolics, which exhibit potential antibacterial and antifungal properties. This study aimed to evaluate ycandidiasis. Extraction was performed using maceration with 96% ethanol, yielding an extract with a 10.58% recovery rate. Preliminary screening at 0.1% concentration demonstrated fungal growth inhibition. Subsequent testing of Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) employed the solid dilution technique, revealing both MIC and MFC values at 0.1%. Antifungal activity was further assessed using the agar diffusion method at varying concentrations (2.5%, 5%, and 10%), with ketoconazole as a positive control. The largest inhibition zone (9.22 mm diameter) was observed at 10% concentration. Data were analyzed using one-way ANOVA followed by Tukey’s HSD test, revealing statistically significant differences between 2.5% and 10% concentrations, as well as between 5% and 10%. These findings demonstrate that C. caudatus ethanol extract possesses significant antifungal activity against C. albicans.
Antifungal Activity Test of Robusta Coffee (Coffea canephora) Bean Ethanol Extract Against Candida albicans, Malassezia furfur, and Aspergillus oryzae Using the Agar Diffusion Method Fajri, Ainun Nurul
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1307

Abstract

The ethanol extract of robusta coffee beans (Coffea canephora) contains bioactive compounds primarily chlorogenic acid that may exert antifungal effects. This study evaluated the antifungal activity of the extract against Candida albicans, Malassezia furfur, and Aspergillus oryzae using the agar diffusion method. A preliminary screening at 0.1% concentration demonstrated that the extract inhibited the growth of all test fungi. In subsequent assays, extract concentrations ranging from 0.5% to 32% were tested, revealing a dose-dependent increase in inhibition zone diameters. The maximum inhibition was observed at 32%, with zones measuring 19.04 mm for C. albicans, 17.65 mm for M. furfur, and 16.97 mm for A. oryzae. These results, in comparison with the positive control (ketoconazole), suggest that the robusta coffee bean extract has substantial potential as a natural antifungal agent
Antibacterial Activity of N-Hexane and Ethyl Acetate Fractions Of Pandanus Nut (P. Julianettii) Against Oral Pathogens Nur, Wardah Rafidah; Naid, Tadjuddin; Herwin, Herwin
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1333

Abstract

Oral infections caused by Streptococcus mutans and Porphyromonas gingivalis are common health problems. This in vitro study aimed to evaluate the antibacterial activity of Pandanus nut (Pandanus julianettii) with n-hexane and ethyl acetate fractions against these pathogens through agar diffusion assays. The n-hexane and ethyl acetate fractions were subjected to agar diffusion testing, with Minimum Inhibitory Concentration (MIC) values determined at 0.8% and 0.2% respectively against both bacterial strains. Subsequent Minimum Bactericidal Concentration (MBC) testing revealed values of 6.4-12.8% for n-hexane fraction and 3.2-6.4% for ethyl acetate fraction. In agar diffusion assays, the n-hexane fraction at 12.8% concentration produced inhibition zones of 15.54±0,20 mm on S. mutans and 15.46±0,35 mm on P. gingivalis. The ethyl acetate fraction showed significantly larger inhibition zones of 18.76±0,79 mm against S. mutans and 15.59±0,42 mm against P. gingivalis at the same concentration. These findings demonstrate that both n-hexane and ethyl acetate fractions of Pandanus nut possess substantial antibacterial activity against oral pathogens.
Antibacterial Activity of Ethanolic Extract of Pandanus Nut (Pandanus julianettii) Gastrointestinal Bacteria Using The Agar Diffusion Method Monika, Arum; Naid, Tadjuddin; Herwin, Herwin
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1334

Abstract

Gastrointestinal infections are a major global health concern, often caused by pathogenic bacteria. This study aimed to evaluate the antibacterial activity of the ethanolic extract of Pandanus nut (Pandanus julianettii) against gastrointestinal pathogens using the agar diffusion method. The Minimum Inhibitory Concentration (MIC) of the extract was determined to be 6.4% for Shigella dysenteriae, Salmonella typhi, and Escherichia coli, and 3.2% for Vibrio cholerae. The Minimum Bactericidal Concentration (MBC) for all tested bacteria was 12.8%. Antibacterial activity analysis revealed that at the 12.8% concentration, the largest inhibition zones were observed: 22.68 mm for Salmonella typhi, 22.20 mm for Shigella dysenteriae, 21.26 mm for Escherichia coli, and 20.80 mm for Vibrio cholerae. These findings indicate that the ethanolic extract of Pandanus julianettii possesses strong antibacterial properties and holds potential as a natural therapeutic agent for managing gastrointestinal infections.
Potential of Antibacterial Producing Rhizosphere Bacteria from Porang Roots (Amorphophallus muelleri Blume) against Gastrointestinal Pathogens Nuryanti, Siska; Nurung, Ayyub Harly; Akihito mr, Andi Al Kahfi
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1342

Abstract

Increasing antibiotic resistance in gastrointestinal pathogens such as Escherichia coli, Shigella dysenteriae, and Vibrio cholerae encourages the search for new antimicrobial agents. This study aims to evaluate the antibacterial potential of rhizosphere bacteria from porang roots (Amorphophallus muelleri Blume) against the three pathogens through in vitro tests. Isolation was carried out from rhizosphere soil using a serial dilution technique. Eleven isolates were characterized morphologically and tested for antibacterial activity using the agar diffusion method. Two selected isolates (IBRAM-2 and IBRAM-11) were fermented and extracted with ethyl acetate. Antibacterial activity was evaluated using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests with the microdilution and drop plate methods, each with three replications and chloramphenicol as a positive control. The results showed an inhibition zone of 13.2–18.7 mm. The MIC value is 25,000 ppm, while the MBC value ranges from 25,000–50,000 ppm. Although it shows antibacterial activity, the high concentration required indicates weak antibacterial potential.

Page 8 of 8 | Total Record : 75

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