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Journal of Advances in Medicine and Pharmaceutical Sciences
Published by Lamintang Education & Training Centre
ISSN : 2964268X     EISSN : 29634253     DOI : https://doi.org/10.36079/lamintang.jamaps-xxxx.xxx
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health
Journal of Advances in Medicine and Pharmaceutical Sciences (JAMAPS) scope are including but not limited to: ☛ Drug ☛ Chemistry ☛ Herbal Medicine ☛ Pharmaceutical Science ☛ General and Internal Medicine ☛ Pathology and Forensic Medicine ☛ Pharmacology, Toxicology and Pharmaceutics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 3 No 1: May 2024" : 5 Documents clear
Cissus quadrangularis in Bone Healing and Oxidative Stress Charoensup, Nathirat; Sangthong, Kittisak; Kongcharoen, Watis
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.585

Abstract

Cissus quadrangularis is a plant known for its traditional use in bone healing, has shown potential in modern pharmacological applications due to its bioactive compounds. This study investigates the therapeutic effects of Cissus quadrangularis extract on bone healing, antioxidant activity, and gastric protection. The primary objective was to evaluate its efficacy in accelerating bone regeneration, mitigating oxidative stress, and protecting the gastric mucosa from NSAID-induced damage. The methodology involved a series of in vivo experiments using rats, with treatment groups receiving the extract and control groups given a placebo. Bone healing was assessed radiographically, antioxidant activity was measured using the DPPH assay and SOD enzyme activity, and gastric protection was evaluated by counting gastric lesions. The findings revealed a 40% improvement in bone healing, a 25% increase in SOD activity, and a 60% reduction in gastric lesions in the treatment group compared to controls. These results suggest that Cissus quadrangularis has significant potential as a natural remedy for bone fractures, oxidative stress, and gastric ulcers. Future research should focus on human clinical trials, molecular mechanisms, and long-term safety to support its broader medical application.
Antihyperglycemic Effect of Gymnema inodorum in Type 2 Diabetes Management Kongcharoen, Watis; Jaturaporn, Ananya; Chavalit, Kittisak; Charoensup, Nathirat
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.686

Abstract

This study investigates the antihyperglycemic effects of Gymnema inodorum (Chiang Da), a traditional medicinal plant from northern Thailand, commonly used for managing blood glucose levels. The goal was to evaluate its pharmacological effects, including the inhibition of alpha-glucosidase and its ability to lower blood glucose levels in Type 2 diabetic rats. Ethanol maceration was used to extract bioactive compounds from Chiang Da leaves, yielding gymnemic acids, saponins, and flavonoids. The in vivo study involved administering Chiang Da tea to diabetic rats for 8 weeks, measuring fasting and postprandial blood glucose levels. Results showed a significant reduction in blood glucose levels in the Chiang Da-treated group, comparable to the synthetic drug metformin. In vitro tests also revealed the extract’s concentration-dependent inhibition of alpha-glucosidase, with an IC50 value of 45 µg/mL, indicating moderate potency in delaying glucose absorption. Descriptive and inferential statistics confirmed that Chiang Da tea significantly reduced blood glucose levels, though its effects were less pronounced than metformin’s. These findings support the potential of Chiang Da as a natural alternative for managing Type 2 diabetes, particularly for individuals seeking plant-based treatments. Future research should focus on clinical trials to further evaluate the efficacy and safety of Chiang Da for diabetes management, as well as explore its potential for combination therapy with conventional drugs to enhance therapeutic outcomes.
Exploring the Anticancer Potential of Ferula assa-foetida Bioactive Compounds and Molecular Mechanisms in Breast Cancer Treatment Marcecal, Korthiby; Hashemi, Ramin Hazemi; Jafari, Niloofar; Karimi, Mohammad Reza; Pouran, Leila
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.695

Abstract

Breast cancer is a major global health issue, with limited treatment options that often come with adverse side effects. Ferula assa-foetida, a medicinal plant known for its anti-inflammatory, antioxidant, and antimicrobial properties, has shown potential as an anticancer agent. This study investigates the anticancer effects of Ferula assa-foetida extracts on breast cancer cell lines (MCF-7 and T47D). The research identifies key bioactive compounds, such as ferulic acid and flavonoids, and explores their molecular mechanisms. In vitro assays, including cytotoxicity assays (MTT and Alamar Blue) and apoptosis detection (Annexin V/PI staining), were conducted to measure cell proliferation and apoptosis induction. Furthermore, PCR and Western blot analyses were used to examine the expression of apoptosis-related genes (p53, Bcl-2, and caspase-3). The results indicate that Ferula assa-foetida extracts significantly inhibit cell growth and induce apoptosis in breast cancer cells. This study provides insights into the potential of Ferula assa-foetida as a complementary treatment for breast cancer and supports further research to evaluate its clinical applicability.
Pharmacological Evaluation of Sambong Blumea balsamifera on Diuretic and Kidney Stone Dissolution Effects Jose, Stefhene; Garcia, Maria; Lopez, Juan; Reyes, Ana; Cruz, Luis
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.734

Abstract

This study investigates the pharmacological effects of Blumea balsamifera (Sambong), a plant traditionally used in Filipino medicine for its diuretic and kidney stone-dissolving properties. Using Soxhlet and maceration extraction methods, Sambong extracts were obtained from the leaves and roots of the plant with ethanol as the solvent. Phytochemical analysis revealed bioactive compounds including flavonoids (luteolin, quercetin) and terpenoids (β-caryophyllene), known for their anti-inflammatory, antioxidant, and diuretic effects. The diuretic activity was tested in rats, where Sambong extracts (50 mg/mL and 100 mg/mL) were administered and the urine output was measured over 24 hours. The results showed a dose-dependent increase in urine output, with the 100 mg/mL dose producing a significant increase compared to the control group treated with furosemide. In addition to its diuretic effects, Sambong’s potential to dissolve kidney stones was evaluated by treating rats with calcium oxalate stones. The results indicated a significant reduction in stone size, with the 100 mg/mL dose achieving a 38% reduction. The comparative analysis with furosemide demonstrated that Sambong is a promising natural alternative for managing conditions such as hypertension, kidney stones, and urinary disorders, particularly in areas with limited access to pharmaceutical treatments. These findings validate Sambong’s traditional uses and highlight its therapeutic potential in modern healthcare. Future research should focus on clinical trials to assess its safety, optimal dosage, and efficacy in humans. Further investigation into its pharmacological mechanisms, including its anti-inflammatory and antimicrobial properties, could expand its use in treating various conditions, integrating Sambong into contemporary healthcare systems, especially in underserved areas.
Pharmaceutical Innovations and Stewardship Programs in Combating Antimicrobial Resistance Merddy, Ousu; Rahul, Amit; Gupta, Sharma; Martin, James; Taylor, Sarah; Wilson, Matthew
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.736

Abstract

This study evaluates the effectiveness of the UK’s AMR Strategy 2019-2024 in combating antimicrobial resistance (AMR), focusing on pharmaceutical innovations. By analyzing trends in human and veterinary antibiotic use alongside resistance rates, the research identifies improvements in reducing antibiotic consumption and resistance, with MRSA resistance declining from 10% in 2016 to 6% in 2023. Despite these positive trends, the research highlights ongoing challenges in the development and implementation of new antibiotics and alternative therapies. Semi-structured interviews with stakeholders, including policymakers and pharmaceutical experts, reveal barriers such as regulatory issues, slow innovation, and insufficient funding for new drug development. The study also examines case studies of pharmaceutical innovations, including β-lactamase inhibitors, bacteriophage therapies, and antimicrobial peptides, noting progress in some areas, but significant gaps in others. The research concludes that while the UK’s AMR Strategy has led to some positive outcomes, further efforts are needed to accelerate the development of novel therapies and address structural barriers in the pharmaceutical sector. Future research should focus on enhancing international collaboration, improving regulatory frameworks, and incentivizing innovation to combat AMR more effectively. Comparative analysis with other countries' strategies could also provide valuable insights for improving the UK’s response to the AMR crisis.

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