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Acta Medical and Health Sciences (AMHS)
Published by Universitas Jenderal Achmad Yani
ISSN : 28305531     EISSN : 28305426     DOI : https://doi.org/10.35990
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Acta Medical and Health Sciences (AMHS) is a scientific journal that publishes research articles, case reports, literature reviews, and other topics relevant to the field of medicine and health, either clinically or to the biomolecular level. Manuscript under consideration that may be uploaded is a full text of article which has not been published in other national magazines. AMHS is published three times a year (every February, June, and October).
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Hubungan Usia dengan Kejadian Hipotermia pada Pasien Anestesi Umum Sevoflurane Aini, Quratul; Saadah, Hindun; Bisri, Tatang
ACTA Medical Health Sciences Vol. 4 No. 1 (2025): Acta Medical and Health Sciences
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General anesthesia is a procedure to eliminate pain centrally accompanied by reversible loss of consciousness. General anesthesia has several complications, one of which is hypothermia. There are several factors that influence the occurrence of hypothermia during surgery including age. This study aims to determine the relationship between age and the incidence of hypothermia in patients with general anesthesia. This type of research is quantitative research with a cross-sectional research design. The sampling technique used consecutive sampling with a total of 31 respondents with inclusion and exclusion criteria. The instruments in this study were observation sheets and tympanic thermometers for body temperature. Data collection was carried out with observation sheets and data were analyzed using the Spearman rank test. The results of the study showed that almost all respondents were adults (96.8%). The results of the study showed no significant relationship between age and the incidence of hypothermia (p-value 0.375). There was no significant relationship in this study, possibly caused by several other factors that influenced the relationship between age and the incidence of hypothermia. DOI : 10.35990/amhs.v4n1.p1-8 REFERENCES Handayani T, Azizah AN. Hubungan antara usia dengan kejadian hipotermi pasien pasca operasi dengan general anestesi RS PKU Muhammadiyah Bantul. Unisa. 2022;1(1):1–18. Handayani T, Azizah N. Hubungan antara usia dengan kejadian hipotermi pasien pasca operasi dengan general anestesi di RS PKU Muhammadiyah Universitas Aisyiyah Bantul. Yogyakarta. 2022;1. Wulandari R, Wibowo H, Yudono T. Hubungan usia dengan hipotermi pada pasien lanjut usia post general anestesi di ruang pemulihan Rumah Sakit Jatiwinangun Purwokerto. Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan. 2022;15(2):12–19. Ramadhan D, Faizal M, Fitri N. Pengaruh konseling dengan pendekatan thinking, feeling dan acting (TFA) terhadap tekanan darah pada pasien pre operasi. Jurnal Profesional Perawat Penelitian. 2023;5(2):637–41. Fitriani D, Nurohman E, Armanda L. Determinan faktor hipotermi pasca operasi dengan general anestesi di instalasi bedah sentral RSUD Banten. HEME: Health and Medical Journal. 2023;5(1):50–7. Millizia A, Maghfirah P, Rizaldy M. General anestesi pada tindakan esofagogastroduodenoscopy. Galenical: Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh. 2023;2(4):44–52. Firdaus, Suandi M, Adriani P. Hubungan usia dan IMT dengan kejadian hipotermi pasca general anestesi di RS Bhayangkara Bengkulu. Jurnal Inovasi Penelitian. 2022;3(7):6945–8. Sherwood L. Introduction to human physiology. 8th ed. Jakarta: Yolanda Cossio; 2014. Robinson N, Hall G, Fawcett W. How to survive in anaesthesia: a guide for trainees. 4th ed. Oxford: BMJ Books/Wiley-Blackwell; 2012. Caniago A. Hubungan lama operasi dengan hipotermi pasien pasca spinal anestesi di instalasi sentral RSU Permata Madina Panyabungan Kabupaten Mandailing Natal Provinsi Sumatera Utara. Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat (SNPPKM). 2022;197–201. Allene M. Postoperative hypothermia and associate factors at Debre Berhan Comprehensive Specialized Hospital 2019: a cross-sectional study. Int J Surg Open. 2020;24:112–6. Xu R, Hu X, Sun Z, Zhu X, Tang Y. Incidence of postoperative hypothermia and shivering and risk factors in patients undergoing malignant tumor surgery: a retrospective study. BMC Anesthesiol. 2023;23(1):2–11. Pratama IMA. Hubungan antara usia dengan hipotermi pada pasien pasca general anestesi di ruang IBS RSUD Buleleng. Itekes. 2021;1(1):35–45. Rahmanto ET, Novitasari D, Sukmaningtyas W. Hubungan lama operasi dengan hipotermi pada pasien pasca spinal anestesi. Jurnal Penelitian Perawat Profesional [Internet]. 2024;6(4):1449–56. Available from: http://jurnal.globalhealthsciencegroup.com/index.php/JPPP Pringgayuda F, Purbianto, Putra A. Faktor-faktor yang berhubungan dengan hipotermi pada pasien pasca general anestesi. Jurnal Kesehatan Panca Bhakti Lampung. 2020;8(1):10–9. Wulandari R, Aprisunadi, Susanti F, Kalsum U. Hubungan lama operasi dengan hipotermi pada pasien pascaoperasi general anestesi di ruang pemulihan kamar operasi RS TK.II Moh Ridwan Meuraksa. Jurnal Bidang Ilmu Kesehatan. 2024;14(2):128–37. Available from: http://ejournal.urindo.ac.id/index.php/kesehatan Widiyono, Suryani, Setiyajati A. Hubungan antara usia dan lama operasi dengan hipotermi pada pasien pasca anestesi spinal di instalasi bedah sentral. J Ilmu Keperawatan Medikal Bedah. 2020;3(1):55–65. Mubarokah PP. Faktor-faktor yang berhubungan dengan hipotermi pasca general anestesi di instalasi bedah sentral RSUD Kota Yogyakarta. Poltekkes Kemenkes. 2017;1(1):44–57. Fajari M, Ernawati D, Azizah A. Faktor-faktor yang mempengaruhi hipotermi pada pasien post general anestesi: literature review. Universitas Aisyiyah Yogyakarta. 2022;1:1–6. Liu M, Qi L. The related factors and countermeasures of hypothermia in patients during the anesthesia recovery period. Am J Transl Res [Internet]. 2021;13(4):3459–65. Available from: www.ajtr.org Panji P, Cindryani M. Anestesiologi dan terapi intensif. 1st ed. Jakarta: PT Gramedia Pustaka Utama; 2019.
Analysis of HbA1c levels in patients with type 2 diabetes: a study at dustira hospital, cimahi Kusmala, Yudith Y; Wirasiti, Deasy; Sihotang, Shareen A
ACTA Medical Health Sciences Vol. 4 No. 1 (2025): Acta Medical and Health Sciences
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Abstract

The HbA1c test has been recommended by the International Committee and the American Diabetes Association to diagnose and monitor the effectiveness of therapy in patients with diabetes mellitus. Pharmacological therapy for controlling blood sugar levels in patients with type 2 diabetes mellitus may include oral medications, insulin, or a combination of both. This study aimed to compare the average HbA1c levels of patients with type 2 diabetes mellitus using oral antidiabetic drugs (OAD), insulin, or a combination of OAD and insulin. This research utilized an observational analytic method with a cross-sectional design and employed a consecutive sampling technique, analyzing patients' medical records from January 2019 to June 2022 at Dustira Hospital. Bivariate analysis was performed using the Kruskal-Wallis test, followed by the Mann-Whitney test. The study concluded that among the 123 data samples, 41 patients using OAD had an average HbA1c of 11.77%, 41 patients undergoing insulin therapy had an average HbA1c of 9.68%, and 41 patients receiving a combination of OAD and insulin had an average HbA1c of 10.73%. The results indicated a significant difference in the average HbA1c levels between the OAD and insulin treatment groups (p=0.002; < 0.05) and no significant difference between the OAD and OAD-insulin combination groups (p=0.092; > 0.05). Although significant differences in average HbA1c levels were observed between the three types of management, the ideal HbA1c target had not been achieved. This suggests that other factors, such as patient adherence to medication, physical activity patterns, nutritional diet, and the duration of diabetes mellitus, may also play a role in influencing treatment outcomes. DOI : 10.35990/amhs.v4n1.p9-16 REFERENCES World Health Organization (WHO). Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus. Diabetes Res Clin Pract. 2011;93:299–309. Available from: https://doi.org/10.1016/j.diabres.2011.03.012 World Health Organization (WHO). Classification of diabetes mellitus. Geneva: WHO; 2019. Kementerian Kesehatan Republik Indonesia (Kemenkes RI). Cegah, cegah, dan cegah: suara dunia perangi diabetes. Jakarta: Kemenkes RI; 2018. Available from: https://www.kemkes.go.id/article/view/18121200001/prevent-prevent-and-prevent-the-voice-of-the-world-fight-diabetes.html International Diabetes Federation (IDF). Diabetes Atlas. 10th ed. Brussels: IDF; 2021. p.6–9. Available from: www.diabetesatlas.org Kementerian Kesehatan Republik Indonesia. Infodatin: Tetap produktif, cegah, dan atasi diabetes melitus. Jakarta: Pusdatin Kemenkes RI; 2020. p.1–10. Dinas Kesehatan Jawa Barat. Jumlah penderita diabetes melitus berdasarkan kabupaten/kota di Jawa Barat. Bandung: Dinkes Jabar; 2020. Available from: https://opendata.jabarprov.go.id/idk/dataset/jumlah-penderita-diabetes-melitus-berdasarkan-kabupatenkota-di-jawa-barat Lestari R. Kendalikan diabetes melalui program Affordability Project. Bandung: Dinkes Jabar; 2022. Available from: https://diskes.jabarprov.go.id/informasi-publik/detail_berita/dWEwYUlUczBLQjJoaFhHUUU5YkpKZz09 Kim HJ, Choi EY, Park EW, Cheong YS, Lee HY, Kim JH. The utility of HbA1c as a diagnostic criterion of diabetes. Korean J Fam Med. 2011;32(7):383. Available from: http://dx.doi.org/10.4082/kjfm.2011.32.7.383 Rakhmat II, Kusmala YY, Handayani DR, Juliastuti H, Nawangsih EN, Wibowo A, et al. Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus disease 2019 (COVID-19): a systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr Clin Res Rev. 2021;15:777–82. Available from: https://doi.org/10.1016/j.dsx.2021.03.027 Handayani DR, Juliastuti H, Nawangsih EN, Kusmala YY, Rakhmat II, Wibowo A, et al. Prognostic value of fasting hyperglycemia in patients with COVID-19: diagnostic test accuracy meta-analysis. Obes Med. 2021;23:100333. Available from: https://doi.org/10.1016/j.obmed.2021.100333 Widiasari KR, Wijaya IMK, Suputra PA. Diabetes melitus tipe 2: faktor risiko, diagnosis, dan tatalaksana. Ganesha Med. 2021;1(2):114. Available from: https://doi.org/10.23887/gm.v1i2.40006 Hakim A, Ismunandar H, Wahyuni A, Sangging PRA. Manajemen diabetes melitus: an update. Medula. 2022;12(1):160–5. Arini NMA, Dwipayana IMP. Hubungan kadar HbA1c terhadap terapi obat anti diabetes oral dan kombinasi obat anti diabetes oral–insulin pada penderita diabetes melitus tipe 2 di Poliklinik Diabetes RSUP Sanglah Denpasar tahun 2016. J Med Udayana. 2020;9(9):94–9. Available from: https://doi.org/10.24843/MU.2020.V9.i9.P16 Versita R, Handayani D, Adiningsih R, Oktoviani. Hubungan pola penggunaan obat terhadap lama rawat pada pasien. Ilm Kefarmasian. 2022;7(4):781–8. Available from: https://doi.org/10.37874/ms.v7i4.476 Prasetyani D, Sodikin S. Analisis faktor yang mempengaruhi kejadian diabetes melitus tipe 2. J Kesehat Al-Irsyad. 2017;10(2):5–7. Jamaluddin G, Nalapraya WY. Perbandingan efektivitas insulin, obat antidiabetik oral dan kombinasi terhadap kadar gula darah pada pasien rawat jalan dengan DM tipe 2 di RSUD Al-Ihsan. Medika. 2021:511–6. Putra IWMM, Budyono C, Ekawanti A, Anggoro J. Factors affecting controlled blood sugar levels in patients with type 2 diabetes mellitus at the internal medicine polyclinic at the Regional General Hospital of West Nusa Tenggara Province. J Biol Trop. 2023;23(1):65–72. Available from: https://doi.org/10.29303/jbt.v23i1.4509 Mahfudzoh BS, Yunus M, Ratih SP. Hubungan antara faktor risiko diabetes melitus yang dapat diubah dengan kejadian DM tipe 2 di Puskesmas Janti Kota Malang. Sport Sci Heal. 2019;1(1):59–71. Perkumpulan Endokrinologi Indonesia (Perkeni). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia 2021. Jakarta: Perkeni; 2021. Sugandha PU, Lestari AW. Gambaran pengendalian kadar gula darah dan HbA1c pada pasien diabetes melitus tipe 2 yang dirawat di RSUP Sanglah periode Januari–Mei 2014. E-Jurnal Med Udayana. 2015;4(1):1–8. Hirsch IB, Gaudiani LM. Using insulin to treat poorly controlled type 2 diabetes in 2020. JAMA Insight. 2020:5–6. Available from: https://doi.org/10.1001/jama.2020.1303 Udayani NNW, Ratnasari NLAM, Cahyaningsih E, Wardani IGAAK. Evaluasi efek samping penggunaan kombinasi insulin pada pasien rawat jalan diabetes melitus tipe 2 di salah satu rumah sakit kota Denpasar. J Med Udayana. 2021;7(2):112–7. Available from: https://doi.org/10.36733/medicamento.v7i2.2178 Dujunco MM, Gorriceta JH, Dampil OA, Mirasol R. Initiate study: insulin versus oral hypoglycemic agent as initial therapy for newly diagnosed diabetes mellitus type 2: a systematic review and meta-analysis. J ASEAN Fed Endocr Soc. 2014;29(2):172–8. Available from: http://dx.doi.org/10.15605/jafes.029.02.11 Zulkarnain NF, Adawiyah R. Kepatuhan penggunaan obat oral anti-diabetes pada pasien diabetes melitus tipe 2 di puskesmas wilayah Kota Malang dengan model The Medication Adherence Report Scale-5. Sitawa J Farm Sains Obat Tradis. 2025;4(1):1–8. Hasanah U, Kurniawati D, Mustaqimah M, Yuwindry I. Hubungan kepatuhan pasien diabetes dalam mengkonsumsi obat antidiabetes oral terhadap kadar gula darah puasa di RSUD Ulin Banjarmasin. J Surya Med [Internet]. 2024;10(2):64–8. Available from: https://doi.org/10.33084/jsm.v10i2.7725 Alsaidan AA, Alsaidan OA, Mallhi TH, Khan YH, Alzarea AI, Alanazi AS. Assessment of adherence to insulin injections among diabetic patients on basal-bolus regimen in primary and secondary healthcare centers in Al-Jouf Region of Saudi Arabia: a descriptive analysis. J Clin Med. 2023;12(10):3474. Available from: https://doi.org/10.3390/jcm12103474 Osborn C, Gonzales J. Measuring insulin adherence among adults with type 2 diabetes. J Behav Med [Internet]. 2016;39(4):633–41. Available from: https://doi.org/10.1007/s10865-016-759-1
Characteristics and incidence of scabies among pediatric patients at IMCI clinic of caringin primary health center (2022-2023) Nurlaela, Lutfhi; Rochmah, Elly N; Pradana, Fadhil M; Hidayat, Emma M; Budikusuma, Ludmilla; Indriyana, Sri Q
ACTA Medical Health Sciences Vol. 4 No. 1 (2025): Acta Medical and Health Sciences
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Scabies, a parasitic skin infestation caused by Sarcoptes scabiei, primarily affects children under five, presenting with intense pruritus and sleep disturbances. In Bandung City, scabies ranks among the top 21 most commonly reported diseases, with 11,623 cases recorded. Risk factors include poor hygiene practices and suboptimal environmental conditions. This study aimed to characterize the incidence of scabies among children under five treated at the Integrated Management of Childhood Illness (IMCI) Clinic of Caringin Primary Health Center, Bandung City, during 2022–2023. We conducted a descriptive cross-sectional study utilizing secondary data from medical records of diagnosed scabies cases. Analyzed variables included age, gender, nutritional status, and case classification (new or recurrent). Among 196 identified cases (154 in 2022; 42 in 2023), the incidence rate declined from 13.6 to 4.3 per 1,000 children. Most patients were male (57.1%) and aged 2–3 years (49.49%). In terms of nutritional status, 58.67% had normal nutrition, while 21.43% were undernourished, and 17.86% were severely stunted. Recurrent cases predominated in both years, though new cases proportionally increased in 2023. The observed decline in incidence may reflect the efficacy of treatment interventions and preventive programs(e.g., hygiene promotion and sanitation surveillance). However, the the persistent rise in new cases suggest ongoing community transmission. In conclusion, scabies incidence among toddlers attending the IMCI Clinic showed a downward trend during 2022-2023, with highest prevalence in boys aged 2–3 years and normal nutritional status. DOI : 10.35990/amhs.v4n1.p17-25 REFERENCES Romani L, Whitfeld MJ, Koroivueta J, Kama M, Wand H, Tikoduadua L, et al. Mass drug administration for scabies control in a population with endemic disease. New England Journal of Medicine. 2015;373:2305–13. Stephanie AS, Stephanie A. Scabies in the elderly: A narrative literature review. Bioscientia Medicina: Journal of Biomedicine and Translational Research. 2022;6:2377–83. World Health Organization. Scabies. WHO Factsheets. 2023. Ubaidillah. Faktor-faktor yang berhubungan dengan kejadian scabies di Madrasah Tsanawiyah Yogyakarta. Jurnal Kesehatan Kusuma Husada. 2021;89–93. Astanti YOV, Mardiana N, Ardiansyah. Faktor-faktor yang berhubungan dengan kejadian skabies. Jurnal Penelitian Keperawatan. 2025;11:13–22. Akbar KF, Hamsah IA, Darmiati, Mirnawati. Deteksi dini tumbuh kembang balita di posyandu. Jurnal Ilmiah Kesehatan Sandi Husada. 2020;9:2654–63. [Internet]. Available from: https://akper-sandikarsa.e-journal.id/JIKSH Asthiningsih NWW, Wijayanti T. Edukasi personal hygiene pada anak usia dini dengan G3CTPS. Jurnal Untuk Pesut: Pengabdian Kesejahteraan Umat. 2019;1:84–92. Fadlyana E. Pemantauan pertumbuhan anak. Ikatan Dokter Anak Indonesia. 2016. Dinas Kesehatan Kota Bandung. Profil Kesehatan Kota Bandung Tahun 2021. Bandung: Dinas Kesehatan Kota Bandung; 2022. Istiqomah A, Masmur SK, Amali RA, Tiawati S. Peran gizi terhadap pertumbuhan dan perkembangan balita. Antigen: Jurnal Kesehatan Masyarakat dan Ilmu Gizi. 2024;2:67–74. Anggreni PMD, Indira IGAAE. Korelasi faktor predisposisi kejadian skabies pada anak-anak di Desa Songan, Kecamatan Kintamani, Kabupaten Bangli, Provinsi Bali. E-Jurnal Medika. 2019;8. Anwar R. Faktor-faktor yang mempengaruhi status gizi balita di Desa Penggalaman, Kecamatan Martapura Barat. Jurnal Skala Kesehatan. 2022;13. Rosyida IA, Arisandra ML, Noviyanti DA, Aprilian R, Cahyono CB, Abidin KU. Pemantauan status gizi balita dan pentingnya pemberian PMT pada balita di Desa Durikedungjero, Ngimbang, Lamongan. Jurnal Kita Bakti. 2024;5:24–33. Kusuma RM. Antropometri pengukuran status gizi anak usia 24–60 bulan di Kelurahan Bener, Kota Yogyakarta. Jurnal Medika Respati. 2018;13:36–42. Sudirman AA, Ali L. Penerapan manajemen terpadu balita sakit (MTBS) di Puskesmas Kota Gorontalo. Zaitun Jurnal Ilmu Kesehatan. 2015;3. Anggraini R, Yani FF, Rasyid R. Analisis implementasi manajemen terpadu balita sakit (MTBS) terhadap kualitas pelayanan di Puskesmas Kota Padang. JIK Jurnal Ilmu Kesehatan. 2022;6:339–46. Badan Pusat Statistik (BPS) Kota Bandung. Penduduk Kecamatan Babakan Ciparay menurut jenis kelamin dan kelurahan Semester II 2019. Bandung: BPS Kota Bandung; 2020. Setia MS. Methodology series module 3: Cross-sectional studies. Indian Journal of Dermatology. 2016;61. Gunardi KY, Sungkar S, Irawan Y, Widaty S. Level of evidence diagnosis skabies berdasarkan Oxford Centre for Evidence-Based Medicine. eJournal Kedokteran Indonesia. 2022;10:276–83. World Health Organization (WHO). WHO Child Growth Standards: Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: Methods and development. Geneva: WHO Press; 2006. Suryana E, Sopiah M, Agustiawan, Harto S. Early childhood development (physical, intellectual, emotional, social, moral, and religious tasks) implications for education. Indonesian Journal of Early Childhood: Jurnal Dunia Anak Usia Dini. 2022;4:362–73. Hervina. Profil kejadian skabies di RSUD Dr. R.M. Djoelham Binjai Sumatera Utara periode Januari 2017–Desember 2021. JUMANTIK (Jurnal Penelitian Kesehatan). 2023;9:30. Yunita MS, Gustia R, Anas E. Faktor-faktor yang berhubungan dengan kejadian skabies di wilayah kerja Puskesmas Lubuk Buaya Kota Padang Tahun 2015. Jurnal Kesehatan Andalas. 2018;7:51–8.
An analysis of differences in kellgren-lawrence scores between patients with knee osteoarthritis and class II obesity versus those without obesity Ambarukmi, Fransiska; Kusumah, Djoni; Dewi, Herfani H
ACTA Medical Health Sciences Vol. 4 No. 1 (2025): Acta Medical and Health Sciences
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Individuals with overweight or obesity are at a higher risk of developing knee osteoarthritis (OA) compared to those with a normal body mass index (BMI). This increased risk is attributed to metabolic effects and the excessive mechanical load on the joint, which escalates with weight gain. Previous studies have established a correlation between the higher BMI and increased severity of joint damage in patients with knee OA. This analytic, comparative study utilized cross-sectional design to investigate the difference in Kellgren-Lawrence (KL) Score between patients with and without obesity who have knee osteoarthritis (OA) The analysis was conducted using secondary data from medical records and knee X-rays at Cianjur General District Hospital during 2020. A total of 50 patients were included, with 25 patients in each group (OA with obesity and OA without obesity). The majority of participants were female (80%), aged 56-65 years old (52%), and had a BMI classified as class II obesity (50%). KL Score ranged from grade 1 to 3. Data analysis using the non-parametric Mann- Whitney U test revealed a statistically significant difference in KL Score between the two groups (pvalue=0.000). The increased mechanical stress associated with obesity is hypothesized to be a causative agent that aggravates joint damage, as evidenced by the more severe degree of the Kellgren- Lawrence Score in the obese population. In conclusion, a significant difference in the severity of OA Genu degree, based on the Kellgren-Lawrence scoring system, was found between obese and non-obese patients. DOI : 10.35990/amhs.v4n1.p26-34 REFERENCES Kulkarni K, Karssiens T, Kumar V, Pandit H. Obesity and osteoarthritis. Maturitas [Internet]. 2016;89:22–8. Available from: http://dx.doi.org/10.1016/j.maturitas.2016.04.006 Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72(2):220–33. National Public Health Agenda. Osteoarthritis: 2020 update. 2020. Widjayanti Y. Gambaran keluhan akibat penurunan kadar hormon estrogen pada masa menopause. Adi Husada Nursing Journal [Internet]. 2016;2(1):96–101. Available from: https://adihusada.ac.id/jurnal/index.php/AHNJ/article/view/41/121 Loeser RF. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage [Internet]. 2009;17(8):971–9. Available from: http://dx.doi.org/10.1016/j.joca.2009.03.002 Dewi S, Kalim H, Alwi I. Rekomendasi IRA untuk diagnosis dan penatalaksanaan osteoartritis. Divisi Reumatologi Departemen Ilmu Penyakit Dalam FKUI/RSCM. 2014. p.1–3. Jameson J, Fauci A, Kasper D, Hauser S, Longo D, Loscalzo J. Harrison’s Principles of Internal Medicine. 20th ed. New York: McGraw Hill Education; 2018. Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al. Obesity in adults: a clinical practice guideline. CMAJ. 2020;192(31):E875–91. World Health Organization. Obesity and overweight. WHO; 2020. Zheng H, Chen C. Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies. BMJ Open. 2015;5(12). Raud B, Gay C, Guiguet-Auclair C, Bonnin A, Gerbaud L, Pereira B, et al. Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis. Sci Rep. 2020;10(1):1–7. Hardiyanti V, Devi M, Setiawan IMB, Wungou HPL. Correlation of body mass index and Kellgren-Lawrence degrees in genu osteoarthritis. Scr SCORE Sci Med J. 2020;2(1):1–5. Tiulpin A, Saarakkala S. Automatic grading of individual knee osteoarthritis features in plain radiographs using deep convolutional neural networks. arXiv. 2019;1–12. Kohn MD, Sassoon AA, Fernando ND. Classifications in brief: Kellgren–Lawrence classification of osteoarthritis. Clin Orthop Relat Res. 2016;474(8):1886–93. Mutiwara E, Najirman N, Afriwardi A. Hubungan indeks massa tubuh dengan derajat kerusakan sendi pada pasien osteoartritis lutut di RSUP Dr. M. Djamil Padang. J Kesehat Andalas. 2016;5(2):376–80. Widhiyanto L, Desnantyo AT, Djuari L, Kharismansha M. Correlation between knee osteoarthritis grade and body mass index in outpatients of Orthopaedic and Traumatology Department RSUD Dr. Soetomo. J Orthop Traumatol Surabaya. 2019;6(2):71. Reyfar K. Hubungan antara IMT dengan derajat keparahan radiologis Kellgren–Lawrence pada penderita OA lutut lansia di KPKM Reni Jaya Pamulang Tahun 2017. 2018. Ibrahim A, Alang AHM. Metodologi Penelitian [Internet]. Makassar: Gunadarma Ilmu; 2018. p.166. Available from: http://repositori.uin-alauddin.ac.id/12366/1/BUKUMETOLOGI.pdf Mulyatiningsih E. Terapan Riset. 2011. p.1–254. Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, et al. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol. 2016. Widhiyanto L, Desnantyo AT, Djuari L, Kharismansha M. Correlation between knee osteoarthritis grade and body mass index in outpatients of Orthopaedic and Traumatology Department RSUD Dr. Soetomo. J Orthop Traumatol Surabaya. 2014;2:2–31. Chu IJH, Lim AYT, Ng CLW. Effects of meaningful weight loss beyond symptomatic relief in adults with knee osteoarthritis and obesity: a systematic review and meta-analysis. Obes Rev. 2018;19(11):1597–607.
Post-Anesthesia recovery time in children undergoing hypospadias correction with general anesthesia in bandung Siagian, Alexander; Rochmah, Elly N; Seciora, Raiza D
ACTA Medical Health Sciences Vol. 4 No. 1 (2025): Acta Medical and Health Sciences
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Abstract

Anesthesia is defined as the loss of pain sensation, with or without the loss of consciousness. After the anesthetic is discontinued and surgery is completed, the patient is routinely managed in the recovery room, also known as the Post Anesthesia Care Unit (PACU). One of the primary goals of PACU is to monitor and document the recovery time before the patient is transferred to a general ward or an intensive care unit. One of the post-operative complications in pediatric patients is delayed emergence from anesthesia. This is defined as the failure to regain consciousness within 30–60 minutes after discontinuation of anesthesia. Delayed emergence is often a residual effect of anesthetic, sedative, and analgesic drugs. Hypospadias is one of the various surgical conditions among pediatric patients. Indonesia reports a relatively high incidence of hypospadias. This study aimed to determine the postoperative anesthesia recovery time following hypospadias correction in children with ASA physical status I and II at Bandung City Hospital from 2017 to 2020. This cross-sectional study utilized secondary data from medical records, with a sample of 69 people meeting the inclusion criteria. The results showed a mean recovery time of 59.70 minutes, with the shortest recovery time being 45 minutes and the longest 135 minutes. Regarding operative duration, 89.9% of cases (62 people) were completed within ≤ 75 minutes, while 10.1% (7 people) required > 75 minutes. DOI : 10.35990/amhs.v4n1.p35-40 REFERENCES Elysabeth ZD. Central nervous system drugs. In: Gunawan S, Setiabudy R, Nafrialdi E, editors. 5th ed. Jakarta: Balai Penerbit FKUI; 2009. p. 122–37. Tanra ARN. Chapter 19: Anesthesia. In: Sjamsuhidayat R, Karnadiharja W, Prasetyono T, Rudiman R, editors. Textbook of surgery. 3rd ed. Jakarta: ECG; 2013. p. 314–30. Neal MJ. At-a-glance medical pharmacology. 5th ed. Jakarta: Erlangga; 2013. p. 52. Latief SA, Suryadi KA, Dachlan MR. Practical guide to anesthesiology. 4th ed. Jakarta: Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia; 2009. p. 29–33, 97, 105, 107–8, 112–3, 117. Sommeng F. Relationship between pre-general anesthesia physical status and recovery time in post-mastectomy patients at RS Ibnu Sina, February–March 2017. UMI Med J. 2019;3(1):47–58. Staroverov D, Ismailova R. Recovery room: Safety island in the operating theatre. Med J Zambia. 2010;36(3):132–5. Krisna DM, AM. Hypospadias: What are its characteristics in Indonesia? Sci Med J Duta Wacana. 2017;2(2):325. Lu W, Tao Y, Wisniewski AB, Frimberger D, Kropp BP. Different outcomes of hypospadias surgery between North America, Europe and China: Is patient age a factor? Nephrourol Mon. 2012;4(4):609–12. Indonesian Urological Association. Pediatric urology in Indonesia. Jakarta: Indonesian Urological Association; 2016. p. 1–74. Dinata DA, Fuadi I, Redjeki IS. Recovery time in pediatric patients undergoing general anesthesia at Dr. Hasan Sadikin Hospital, Bandung. J Anestesi Perioper. 2015;3(2):100–9. Indonesia DKR. Age categories [Internet]. 2009 [cited 2025 Sep 4]. Available from: http://kategori-umur-menurut-depkes.html Fenny AS. Description of recovery time post-general anesthesia with ASA II physical status in minor surgery at RS Dustira, 2017 [Undergraduate thesis]. Cimahi: Universitas Jenderal Achmad Yani; 2017.
Immunomodulatory Effect of Red Guava Yogurt on Escherichia coli-Infected Mice Kurniawati PD, Ania; Shavilla, Evy; Rachman, Hidayatul; Rachmat, Iqmal D; Pebrian, Noval Y
ACTA Medical Health Sciences Vol. 4 No. 1 (2025): Acta Medical and Health Sciences
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Antibodies are a component of the adaptive immune system that plays a crucial role in preventing foreign pathogens that cause various infections. One effective way to enhance the immune response is through the consumption of probiotic-based fruit yogurt (fruitghurt). The purpose of this study is to determine the effect of administering red guava juice-based fruitghurt on the immune response of mice induced by Escherichia coli bacteria. This research used is a laboratory experimental design. The subjects consisted of Mus musculus mice, which were divided into 3 groups: positive control group, negative control group, and treatment group. Data were analyzed using one-way analysis of variance (ANOVA), and post hoc comparisons conducted via Tukey’s test to determine specific intergroup differences. The results demonstrate a statistically significant rise in antibody titers among mice receiving fruit yogurt treatment compared to control groups. The observed increase in antibody titers may be attributed to the immunomodulatory effects of Lactobacillus acidophilus, the micronutrient content of red guava, and immune stimulation induced by Escherichia coli exposure. Furthermore, Lactobacillus acidophilus enhances macrophage activity and antigenic presentation, thereby stimulating B lymphocytes to produce antibodies. Concurently, the micronutrients in red guava promotes the proliferation and differentiation of B lymphocytes, further enhancing antibody synthesis. Collectively, these findings demonstrate that yogurt fermented with Lactobacillus acidophilus and enriched with red guava juice exerts significant immunomodulatory effects. This functional food intervention enhances antibody titers, lymphocyte counts, and macrophage activity in Escherichia coli-infected mice, underscoring its potential as a dietary strategy to bolster immune responses against bacterial infections. DOI : 10.35990/amhs.v4n1.p41-50 REFERENCES Masud Parvez GM, Uzzaman S, Miah Akanda K, Mehjabin S. A short review on a nutritional fruit: guava. Open Access Toxicol Res. 2018;1(1):1–8. Yang Y, Greenleaf Z, Kann W, Sha M. Microaerobic fermentation of Lactobacillus acidophilus within gut microbiome physiological conditions by BioFlo® bioprocess control stations. Appl Eppend Note. 2019;(412):1–8. Yousefi B, Eslami M, Ghasemian A, Kokhaei P, Salek-Farrokhi A, Darabi N. Probiotics importance and their immunomodulatory properties. J Cell Physiol. 2019;234(6):8008–18. Rusli, Amalia F, Dwyana Z. Potential of Lactobacillus acidophilus bacteria as antidiare and immunomodulator. J Biol Makassar. 2018;3(2):25–30. Creswell JW. Research design. 4th ed. Thousand Oaks (CA): SAGE Publications; 2014. 342 p. Dewi AKP, Nawangsih EN. Pengaruh penambahan sukrosa dalam media jambu biji merah terhadap TPC Lactobacillus acidophilus pada penyimpanan suhu refrigerator. Fak Kedokt Univ Jenderal Achmad Yani. 2015;55–8. Tejada-Simon MV, Lee JH, Ustunol Z, Pestka JJ. Ingestion of yogurt containing Lactobacillus acidophilus and Bifidobacterium potentiates immunoglobulin A responses to cholera toxin in mice. J Dairy Sci. 1999;82(4):649–60. Widianingsih M, Kurniawati PDA, et al. Efektifitas probiotik single dan multi strain terhadap Escherichia coli secara in vitro. J Sains Teknol. 2018;71(6):885–94. Aattouri N, Bouras M, Tome D, Marcos A, Lemonnier D. Oral ingestion of lactic acid bacteria by rats increases lymphocyte proliferation and interferon-γ production. Br J Nutr. 2002;87(4):367–73. Gutiérrez RMP, Mitchell S, Solis RV. Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2008 Apr 17;117(1):1–27. Subowo. Imunobiologi. 4th ed. Jakarta: Sagung Seto; 2021. Hall JE, Guyton AC. Guyton dan Hall buku ajar fisiologi kedokteran. Philadelphia: Saunders Elsevier; 2011. 1091 p. Marcos A. Editorial: A review of micronutrients and the immune system—working in harmony to reduce the risk of infection. Nutrients. 2021;13(11). Erkelens MN, Mebius RE. Retinoic acid and immune homeostasis: a balancing act. Trends Immunol. 2017 Mar 1;38(3):168–80. World Health Organization, Food and Agriculture Organization. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria [Internet]. 2001 [cited 2023 Feb 4]. Available from: https://www.fao.org/3/a0512e/a0512e.pdf Nanjundaiah YS, Wright DA, Baydoun AR, Khaled Z, Ali Z, Dean P, et al. Modulation of macrophage function by Lactobacillus-conditioned medium. Front Cell Dev Biol [Internet]. 2020 Jul 30 [cited 2023 Feb 4];8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406691/ Todar K. Lactobacillus acidophilus [Internet]. University of Wisconsin; 2020 [cited 2022 Jul 30]. Available from: https://textbookofbacteriology.net/index.html Artanti D, Sari YES, Azizah F, Puwaningsih NV, Rohmayani V, Nasrullah D. Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus. Iran J Microbiol. 2021 Jun;13(3):381–8. Rocha-Ramírez LM, Pérez-Solano RA, Castañón-Alonso SL, Moreno Guerrero SS, Ramírez Pacheco A, García Garibay M, et al. Probiotic Lactobacillus strains stimulate the inflammatory response and activate human macrophages. J Immunol Res. 2017;2017:1–9. Dewi AKP, Pratiwi ST, Hasan K, Sasongko S, Hanif Y, Pardosi DV. Uji organoleptik dan karakteristik fisikokimia fruitghurt sari jambu biji merah (organoleptic test and physicochemical characteristics of fruitghurt red guava). Medika Kartika J Kedokt Kesehat. 2018;4:1–7. Agnesa OS, Susilo H, Lestari SR. Aktivitas imunostimulan ekstrak bawang putih tunggal pada mencit yang diinduksi Escherichia coli. Pharmaciana. 2017 May 8;7(1):105–12. Kopp-Hoolihan L. Prophylactic and therapeutic uses of probiotics: a review. J Am Diet Assoc. 2001 Feb;101(2):229–38. Van Gorkom GNY, Klein Wolterink RGJ, van Elssen CHMJ, Wieten L, Germeraad WTV, Bos GMJ. Influence of vitamin C on lymphocytes: an overview. Antioxidants. 2018;7(3):1–15. Sathawane P, Kamal MM, Deotale PR, Mankar H. Nuances of the Papanicolaou stain. Cytojournal. 2022;19:43. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Lymphocytes and the cellular basis of adaptive immunity. In: Molecular biology of the cell. 4th ed. New York: Garland Science; 2002. p. 1201–55.

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