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Acta Medical and Health Sciences (AMHS)
Published by Universitas Jenderal Achmad Yani
ISSN : 28305531     EISSN : 28305426     DOI : https://doi.org/10.35990
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Acta Medical and Health Sciences (AMHS) is a scientific journal that publishes research articles, case reports, literature reviews, and other topics relevant to the field of medicine and health, either clinically or to the biomolecular level. Manuscript under consideration that may be uploaded is a full text of article which has not been published in other national magazines. AMHS is published three times a year (every February, June, and October).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 60 Documents
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Differences in Mediterranean diet adherence on lipid profile and plasma atherogenic index in dyslipidemia patients Dewi R Handayani; Khomaini Hasan; Iis I Rakhmat; Endry Septiadi; Yudith Y Kusmala
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

Dyslipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol, triglycerides, and Low-Density Lipoprotein (LDL), as well as a decrease in High-Density Lipoprotein (HDL). According to the 2018 Basic Health Research (Riset Kesehatan Dasar/RISKESDAS), 12.6% of the Indonesian population aged 55–64 years had high cholesterol levels along with very high LDL and triglyceride levels. The Mediterranean diet is a form of non-pharmacological therapy involving nutritional intervention for patients with dyslipidemia. This study aimed to examine the effect of adherence to the Mediterranean diet on lipid profiles and the Plasma Atherogenic Index (PAI) in dyslipidemic patients at a private clinic in Bandung. This research employed an observational analytic method with a prospective cohort design involving 30 patients with dyslipidemia. Subjects were selected using a systematic random sampling technique and categorized into three groups based on their adherence to the Mediterranean diet: low, medium, and high. At the end of the month, lipid profile parameters and PAI were measured. Data on total cholesterol, LDL, and HDL levels were analyzed using ANOVA and Tukey’s Post Hoc test, while triglycerides and PAI were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed significant differences in total cholesterol (p = 0.007), LDL (p = 0.019), HDL (p = 0.006), triglycerides (p = 0.005), and PAI (p = 0.036) across the adherence groups. These findings suggest that higher adherence to the Mediterranean diet is associated with improvements in lipid profile and PAI. The beneficial effects are likely due to the diet’s rich content of monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), phytosterols, and polyphenols, which positively influence lipid metabolism and reduce atherogenic risk. DOI : 10.35990/amhs.v1n1.p1-9 REFERENCES Jameson JL. Harrison’s Principles of Internal Medicine. Edisi ke-19. Kasper DL, editor. New York: McGraw-Hill; 2015. hlm. 2438. John MF, Adam. Dislipidemia. Dalam: Sudoyo AW, dkk., editor. Buku Ajar Penyakit Dalam. Edisi IV. Jakarta: Balai Penerbit Departemen Ilmu Penyakit Dalam FKUI; 2006. hlm. 2554. Gebreegziabiher G, Belachew T, Mehari K, Tamiru D. Prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City, Northern Ethiopia. PLoS One. 2021;16:1–18. Qi L, Ding X, Tang W, Li Q, Mao D, Wang Y. Prevalence and risk factors associated with dyslipidemia in Chongqing, China. Int J Environ Res Public Health. 2015;12(10):13455–65. Roslaeni R, Sundari R, Baswedan MH. Gambaran Risiko Penyakit Jantung Koroner Berdasarkan Rasio Profil Lipid Pada Usia Dewasa Muda. Med Kartika J Kedokt dan Kesehat. 2019;2(2):110–22. Millán J, Pintó X, Muñoz A, Zúñiga M, Rubiés-Prat J, Pallardo LF, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009;5:757–65. Arsana PM, Rosandi R, Manaf A, Budhiarta A, Permana H. Pedoman Pengelolaan Dislipidemi di Indonesia 2019. PB PERKENI; 2019. hlm. 9. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. Panduan Tatalaksana Dislipidemia. 2017. Van Horn L, Carson JAS, Appel LJ, Burke LE, Economos C, Karmally W, et al. Recommended dietary pattern to achieve adherence to the AHA/ACC Guidelines: A scientific statement from the American Heart Association. Circulation. 2016;134(22):505–29. Liyanage T, Ninomiya T, Wang A, Neal B, Jun M, Wong MG, et al. Effects of the Mediterranean diet on cardiovascular outcomes: A systematic review and meta-analysis. PLoS One. 2016;11(8). Anggraini DI, Labibah Z. Diet Mediterania dan Manfaatnya terhadap Kesehatan Jantung dan Kardiovaskular. J Major. 2016;5(3):1–3. Jacobs S, Harmon BE, Ollberding NJ, Wilkens LR, Monroe KR, Kolonel LN, et al. Among 4 diet quality indexes, only the alternate Mediterranean diet score is associated with better colorectal cancer survival and only in African American women in the Multiethnic Cohort. J Nutr. 2016;146(9):1746–55. Tian HY, Qiu R, Jing LP, Chen ZY, Chen GD, Chen YM. Alternate Mediterranean diet score is positively associated with skeletal muscle mass index in middle-aged adults. Br J Nutr. 2017;117(8):1181–8. Shvetsov YB, Harmon BE, Ettienne R, Wilkens LR, Le Marchand L, Kolonel LN, et al. The influence of energy standardisation on the alternate Mediterranean diet score and its association with mortality in the Multiethnic Cohort. Br J Nutr. 2016;116(9):1592–601. Feng L, Nian S, Tong Z, Zhu Y, Li Y, Zhang C, et al. Age-related trends in lipid levels: A large-scale cross-sectional study of the general Chinese population. BMJ Open. 2020;10(3):e034226. Liu HH, Li JJ. Aging and dyslipidemia: A review of potential mechanisms. Ageing Res Rev. 2015;19:43–52. DG I, Shetty S, Rao AV, Ahmad S. Age-related difference in the lipid profile in normal healthy women. J Health Allied Sci NU. 2014;4(2):94–7. Palmisano BT, Zhu L, Stafford JM. Role of estrogens in the regulation of liver lipid metabolism. In: Advances in Experimental Medicine and Biology. Vol. 1043. 2017. hlm. 227–56. Schwingshackl L, Morze J, Hoffmann G. Mediterranean diet and health status: Active ingredients and pharmacological mechanisms. Br J Pharmacol. 2020;177(6):1241–57. Poli A, Marangoni F, Corsini A, Manzato E, Marrocco W, Martini D, et al. Phytosterols, cholesterol control, and cardiovascular disease. Nutrients. 2021;13(8):1–13. Castro-Barquero S, Lamuela-Raventós RM, Doménech M, Estruch R. Relationship between Mediterranean dietary polyphenol intake and obesity. Nutrients. 2018;10(10):1–13. Ferro Y, Mazza E, Salvati M, Santariga E, Giampà S, Spagnuolo R, et al. Effects of a portfolio-Mediterranean diet and a Mediterranean diet with or without a sterol-enriched yogurt in individuals with hypercholesterolemia. Endocrinol Metab. 2020;35(2):298–307. Hannon BA, Thompson SV, An R, Teran-Garcia M. Clinical outcomes of dietary replacement of saturated fatty acids with unsaturated fat sources in adults with overweight and obesity: A systematic review and meta-analysis of randomized control trials. Ann Nutr Metab. 2017;71:107–17. Hernáez Á, Fernández-Castillejo S, Farràs M, Catalán Ú, Subirana I, Montes R, et al. Olive oil polyphenols enhance high-density lipoprotein function in humans: A randomized controlled trial. Arterioscler Thromb Vasc Biol. 2014;34(9):2115–9. Grao-Cruces E, Varela LM, Martin ME, Bermudez B, Montserrat-De la Paz S. High-density lipoproteins and Mediterranean diet: A systematic review. Nutrients. 2021;13(3):1–11. Alves-Bezerra M, Cohen DE. Triglyceride metabolism in the liver. Compr Physiol. 2018;8(1):1–22. Betaubun AM, Bahrun U, Pakasi R. Indeks Aterogenik Plasma di Penyakit Diabetes Melitus Tipe 2 (Atherogenic Index of Plasma in Type 2 Diabetes Mellitus). Indones J Clin Pathol Med Lab. 2018;22(1):82.
Noise induced hearing loss among furniture factory workers PT Chitose Cimahi Yanti Nurrokhmawati; Desire M Nataliningrum; Dian Anggraeny
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

Noise Induced Hearing Loss (NIHL) merupakan masalah kesehatan yang cukup umum terjadi pada pekerja pabrik, termasuk di industri manufaktur furnitur. Paparan kebisingan yang melebihi ambang batas intensitas dalam waktu yang lama dapat menyebabkan gangguan pendengaran, baik bersifat sementara maupun permanen. Jika tidak ditangani dengan serius, kondisi ini dapat berdampak pada gangguan pendengaran maupun gangguan non-pendengaran. Tujuan dari penelitian ini adalah untuk mengetahui prevalensi gangguan pendengaran akibat kebisingan, karakteristik pekerja, lama kerja, kebiasaan penggunaan alat pelindung telinga (APD), serta gejala auditorik dan non-auditorik pada pekerja di PT Chitose, Cimahi, Jawa Barat. Subjek dalam penelitian ini adalah sebanyak 66 pekerja yang terdiri dari 62 laki-laki dan 4 perempuan, dipilih dengan metode total sampling. Penelitian dilakukan dengan metode deskriptif potong lintang (cross-sectional). Anamnesis dilakukan melalui pengisian kuesioner, pemeriksaan fisik telinga, dan pemeriksaan audiometri nada murni (pure tone audiometry). Hasil penelitian menunjukkan bahwa prevalensi NIHL ditemukan pada 37 orang (56%). Dari pasien dengan NIHL tersebut, rata-rata usia adalah 37,8 tahun, dengan mayoritas berjenis kelamin laki-laki (95%). Sebagian besar berasal dari bagian produksi (73%), dengan rata-rata lama kerja 16,6 tahun. Sebanyak 54% pekerja tidak pernah menggunakan APD. Gejala auditorik yang paling sering dirasakan adalah tinnitus (54%), sedangkan gejala non-auditorik yang paling sering dilaporkan adalah kesulitan tidur (19%). Kesimpulan: Prevalensi NIHL pada pekerja PT Chitose Cimahi tergolong tinggi. Hal ini disebabkan oleh paparan kebisingan dan dipengaruhi oleh berbagai faktor risiko. Oleh karena itu, diperlukan program pencegahan dari pihak perusahaan serta rehabilitasi bagi pekerja yang terdampak. Gangguan pendengaran yang ditemukan pada pekerja pabrik furnitur PT Chitose Cimahi merupakan gangguan pendengaran yang disebabkan oleh kebisingan. DOI : 10.35990/amhs.v1n1.p10-18 REFERENCES Sliwinska-Kowalska, M., & Davis, A. (2012). Noise-induced hearing loss. Noise & Health, 14, 274–280. Mazlan, N., Yahya, K., & Haron, Z. (2018). Characteristic of Noise-induced Hearing Loss among Workers in Construction Industries. E3S Web of Conferences, 34, 02025. Robinson, T., Whittaker, J., Acharya, A., Singh, D., & Smith, M. (2015). Prevalence of noise-induced hearing loss among woodworkers in Nepal: a pilot study. International Journal of Occupational and Environmental Health, 21(1), 14–22. Dement, J., Ringen, K., Welch, L., Bingham, E., & Quinn, P. (2018). Hearing loss among older construction workers: Updated analyses. American Journal of Industrial Medicine, 61(4), 326–335. Nelson, D., Nelson, R., & Barientos, M.C. (2005). The global burden of occupational noise-induced hearing loss. American Journal of Industrial Medicine, 48(6), 446–458. Hong, O.S. (2005). Hearing loss among operating engineers in the American construction industry. International Archives of Occupational and Environmental Health, 78(7), 565–574. Vos, T., Flaxman, A.D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., et al. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380, 2163–2196. Masterson, E.A., Bushnell, P.T., Themann, C.L., & Morata, T.C. (2016). Hearing impairment among noise-exposed workers — United States, 2003–2012. MMWR Morbidity and Mortality Weekly Report, 65, 389–394. Kemenkes RI. (2022). Kemenkes Terus Upayakan Kurangi Masalah Gangguan Pendengaran. Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Retrieved from: http://p2p.kemkes.go.id/kemenkes-terus-upayakan-kurangi-masalah-gangguan-pendengaran/ National Institute of Environmental Health Science. (2010). Hearing protection. NIEHS, Connecticut. Dawes, P., Fortnum, H., Moore, D.R., Emsley, R., Norman, P., Cruickshanks, K., & Munro, K. (2014). Characteristics of Noise-Induced Hearing Loss among workers. Ear and Hearing. Shargorodsky, J., Curhan, S.G., Eavey, R., & Curhan, G.C. (2010). A prospective study of cardiovascular risk factors and incident hearing loss in men. Laryngoscope, 120(9), 1887–1891. Hong, O., Buss, J., & Thomas, E. (2013). Type 2 diabetes and hearing loss. Disease-a-Month, 59(4), 139–146. PT Chitose Internasional Tbk. (2020). Profil Perusahaan. Retrieved from: http://www.chitose-indonesia.com/tentang-kami/ Neitzel, R., Seixas, N., Goldman, B., & Daniell, W. (2008). Comparison of perceived and quantitative measures of occupational noise exposure. Annals of Occupational Hygiene, 53(1), 41–54. Kryter, K.D. (2005). The Effects of Noise on Man (2nd ed., Ch. 2). London: Academic Press. Soetirto, I., & Bashiruddin, J. (2001). Gangguan pendengaran akibat bising. Disampaikan pada Simposium Penyakit THT Akibat Hubungan Kerja & Cacat Akibat Kecelakaan Kerja, Jakarta, 2 Juni. Lintong, F. (2009). Gangguan Pendengaran Akibat Bising. Jurnal Biomedik, 1(2), 81–86. Kandou, L.F., & Mulyono. (2013). Hubungan karakteristik dengan peningkatan ambang pendengaran penerbang. The Indonesian Journal of Occupational Safety and Health, 2(1), 1–9. Suryani, S., Mulyadi, A., & Afandi, D. (2015). Analisis Gangguan Pendengaran Tipe Sensorineural pada Pekerja akibat Kebisingan di Industri Mebel Kayu di Kota Pekanbaru. Jurnal Ilmu Lingkungan, 9(1), 1–11. Wald, P.H., & Stave, G.M. (2012). Physical and Biological Hazards of the Workplace (2nd ed., pp. 279–290). John Wiley & Sons, New York. Fatimah, S. (2008). Pengaruh Kebisingan terhadap Noise-Induced Hearing Loss (NIHL) Karyawan di PT. SCTI Jakarta Timur Tahun 2008. FKM UI. Barbara, A., & Jill, M. (2012). Industrial noise. In Fundamentals of Industrial Hygiene. New York. Hastono, S.P. (2017). Basic Data Analysis for Health Research. Fakultas Kesehatan Masyarakat, Universitas Indonesia. Lewkowski, K., Fritschi, L., Heyworth, J., Liew, D., & Li, I. (2020). Productivity burden of occupational noise-induced hearing loss in Australia: A life table modelling study. International Journal of Environmental Research and Public Health, 17(13), 4667. Mukono, M.S. (2000). Prinsip Dasar Kesehatan Lingkungan. Airlangga University Press, Surabaya. Roestam, A.W. (2004). Program konservasi pendengaran di tempat kerja. Cermin Dunia Kedokteran (CDK). Setiawan, F.E.B. (2021). Prevention of noise-induced hearing loss in worker: A literature review. Jurnal Kedokteran dan Kesehatan Indonesia, 12(2). The International Programme on Chemical Safety (IPCS). (n.d.). Environmental Health Criteria (EHC) 215: Vinyl chloride. Retrieved from: ipcs.com (Accessed on 12 Feb 2022). Centers for Disease Control and Prevention. (2022). Reducing Noise Exposure: Personal Protective Equipment. Retrieved from: https://www.cdc.gov/niosh/topics/noise/reducenoiseexposure/adminppe.html (Accessed on 8 Jan 2022).
Potential of red guava fruitghurt in lowering blood glucose levels in streptozotocin induced rats Ania K P Dewi; Rona J H Dewi; Endry Septiadi
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
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Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose levels due to decreased insulin production, insulin action or both. Red guava fruitghurt contains flavonoid phytochemical compound. This research aims to determine the effect of red guava fruitghurt on reducing blood glucose levels in rats. The study was laboratory experiment. The subjects of this study were white rats (Rattus norvegicus) with wistar lines, where each group needed 5 rats, therefore the total was 25 rats. The sampling technique used is simple random sampling, The experimental animals are grouped into 5 groups, negative control, positive control, treatment 1 (administration of fruitghurt), treatment 2 (administration of glibenclamide), and treatment 3 (combination of fruitghurt and glibenclamide). The data analysis was performed with paired t test, one way anova, pairwise comparison test and post hoc duncan. The study found that red guava fruitghurt can reduce blood glucose levels in rats induced by streptozotocin and show a probability value or p value of 0.000 (p value < 0.05), meaning that there is a significant difference between Treatment 1, 2, and 3. The blood glucose level of rats after administration of fruitghurt was 75.4mg/dl, after administration of glibenclamide was 48.4mg/dl and the combination of fruitghurt and glibenclamide was 44.0mg/dl. From these data, it can be seen that the most influential treatment in reducing blood glucose levels is the combination of fruitghurt and glibenclamide. The significant effect in lowering blood glucose levels is the combination of fruitghurt and glibenclamide. DOI : 10.35990/amhs.v1n1.p19-27 REFERENCES Khairani, R. (2016). Prevalensi diabetes mellitus dan hubungannya dengan kualitas hidup lanjut usia di masyarakat. Universa Med, 26(1). Newman, W. A., & Kamus Saku Kedokteran Dorland. (2011). Kamus Saku Kedokteran Dorland (Ed. 28, Vol. 28). Djojoningrat, D. (2014). Buku Ajar Ilmu Penyakit Dalam (Edisi VI, Jilid I). Amir, S. M. J., Wungouw, H., & Pangemanan, D. (2015). Kadar glukosa darah sewaktu pada pasien diabetes melitus tipe 2 di Puskesmas Bahu Kota Manado. J e-Biomedik, 3(1). https://doi.org/10.35790/ebm.3.1.2015.6505 (2013). Global Status Report. NCD Executive Summary. New Dir Youth Dev, 2013(140). Kementerian Kesehatan Republik Indonesia. (2016). Mari Kita Cegah Diabetik Dengan Cerdik. (April 2015). Putra, J. S., Achmad, A., & Pramestutie, R. H. (2017). Kejadian efek samping potensial terapi obat anti diabetes pada pasien diabetes melitus berdasarkan algoritme Naranjo. Pharm J Indones, 2(2). https://doi.org/10.21776/ub.pji.2017.002.02.38 Rachmaniar, R., & Kartamihardja, H. (2016). Pemanfaatan sari buah jambu biji merah (Psidium guajava) sebagai antioksidan dalam bentuk granul effervescent. Indones J Pharm Sci Technol, 5(1). Labiba, N. M., Marjan, A. Q., & Nasrullah, N. (2020). Pengembangan soyghurt (yoghurt susu kacang kedelai) sebagai minuman probiotik tinggi isoflavon. Amerta Nutr, 4(3). https://doi.org/10.20473/amnt.v4i3.2020.244-249 Salimah, D. M., Lindriati, T., & Purnomo, B. H. (2015). Sifat fisik dan kimia puree jambu biji merah (Psidium guajava) dengan penambahan gum arab dan gum xanthan. J Agroteknologi, 09(02). Dewi, I. P., Septriani, R., Verawaty, V., & Mulyani, D. (2019). Daya antihiperglikemia yoghurt pada mencit putih jantan. J Katalisator, 4(2). https://doi.org/10.22216/jk.v4i2.4607 Shinta, A., & Kusuma, W. (2015). The effect of ethanol extract of soursop leaves (Annona muricata) to decreased levels of malondialdehyde. Vol 4. Nugraheni, A. A., Jaelani, M., Rahayuni, A., & Semedi, P. (2019). Efektifitas pemberian jus tomat dan jambu biji merah terhadap penurunan kolesterol total pada wanita overweight. J Ris GIZI, 7(2). https://doi.org/10.31983/jrg.v7i2.5121 Watanabe, D., Kuranuki, S., Sunto, A., Matsumoto, N., & Nakamura, T. (2018). Daily yogurt consumption improves glucose metabolism and insulin sensitivity in young nondiabetic Japanese subjects with type-2 diabetes risk alleles. Nutrients, 10(12). https://doi.org/10.3390/nu10121834 Arnanda, Q. P., & Nuwarda, R. F. (2019). Penggunaan radiofarmaka teknisium-99M dari senyawa glutation dan senyawa flavonoid sebagai deteksi dini radikal bebas pemicu kanker. Farmaka Suplemen, 14(1). Rezaei, M., Sanagoo, A., Jouybari, L., Behnampoo, N., & Kavosi, A. (2017). The effect of probiotic yogurt on blood glucose and cardiovascular biomarkers in patients with type II diabetes: A randomized controlled trial. Evid Based Care J, 6(4). https://doi.org/10.22038/ebcj.2016.7984 Wallace, B. Y. T. C., Velasco, A., Lay, T., et al. (2016). Pengaruh perbandingan jambu biji (Psidium guajava) dengan rosella (Hibiscus sabdariffa Linn) dan jenis jambu biji terhadap karakteristik jus. Bull Seismol Soc Am, 106(1). Novrial, D., Sulistyo, H., & Setiawati. (2013). Comparison of antidiabetic effects of honey, glibenclamide, metformin and their combination in the streptozotocin-induced diabetics rat. Semin Nas Kesehat Jur Kesehat Masy FKIK UNSOED. Lenzen, S. (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia, 51(2). https://doi.org/10.1007/s00125-007-0886-7 Saputra, N. T., Suartha, I. N., & Dharmayudha, A. A. G. O. (2018). Agen diabetagonik streptozotocin untuk membuat tikus putih jantan diabetes mellitus. Bul Vet Udayana. https://doi.org/10.24843/bulvet.2018.v10.i02.p02 Gomes, A. C., Bueno, A. A., De Souza, R. G. M. H., & Mota, J. F. (2014). Gut microbiota, probiotics and diabetes. Nutr J, 13(1). https://doi.org/10.1186/1475-2891-13-60 Sari, P. M. D. R. (2014). Studi literatur interaksi obat pada peresepan pasien diabetes melitus tipe 2 di instalasi rawat jalan RSUD Panembahan Senopati Bantul Yogyakarta periode Desember 2013. Fakultas Farmasi, Universitas Sanata Dharma Yogyakarta. König, A., Schwarzinger, B., Stadlbauer, V., et al. (2019). Guava (Psidium guajava) fruit extract prepared by supercritical CO₂ extraction inhibits intestinal glucose resorption in a double-blind, randomized clinical study. Nutrients, 11(7). https://doi.org/10.3390/nu11071512 Nilamaya, F. A. (2018). Pengaruh variasi konsentrasi perisa sari jambu biji merah (Psidium guajava) terhadap tingkat kesukaan panelis dan kandungan vitamin C pada yoghurt susu UHT (Ultra High Temperature). [Skripsi]. Rifdiyani, F. A. (2018). Pengaruh pemberian bakteri asam laktat Dangke jenis Lactobacillus plantarum dan Enterococcus faecium terhadap kadar glukosa darah mencit (Mus musculus) ICR jantan. [Skripsi].
Differences in mediterranean diet adherence on bmi, waist circumference, fat percentage, muscle mass in obesity Endry Septiadi; Dinar Mutiara; Henny Juliastuti; Iis I Rakhmat; Dewi R Handayani
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

Obesity is a multifactorial disease that occurs when there is an abnormal accumulation of body fat due to an imbalance between energy intake and energy expenditure. The prevalence of Riset Kesehatan Dasar in 2018 showed that 21.8% of the Indonesian population over 18 years is obese. One of the diets recommended by European Association for the Study of Obesity Community for obesity is the Mediterranean diet. This study aims to determine the difference of adherence level in the Mediterranean diet to nutritional status, and muscle mass in obese patients. The method used in this study is analytic observational with prospective cohort observations. Subjects in this study were 37 obese patients who were monitored for diet four times in one month with food frequency questionnaire and checked for BMI, waist circumference, body fat percentage, and muscle mass at the end of the month. BMI and body fat percentage were analyzed using the Anova test while waist circumference and muscle mass data were analyzed using the Kruskal Wallis test. The level of adherence to the Mediterranean diet has been shown to significantly affect BMI (p=0.008), waist circumference (p=0.042), body fat percentage (p=0.014), and muscle mass (p=0.009) in obese patients. This associated with the composition of Mediterranean diet which affects increase in thermogenesis, fat oxidation, anti-inflammatory, and increases satiety for a longer period. The results of this study support the hypothesis that there is the difference of adherence to the Mediterranean diet to nutritional status and muscle mass in obese patients. DOI : 10.35990/amhs.v1n1.p28-37 REFERENCES Sugondo S, Purnamasari D. Obesitas. Dalam: Setiati S, Alwi I, Sudoyo AW, editors. Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: InternaPublishing; 2014. Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:p6–10. Harjatmo TP, Par’i HM, Wiyono S. Penilaian Status Gizi. Kementerian Kesehatan Republik Indonesia; 2017. Preedy VR. Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease. Handb Anthr Phys Meas Hum Form Heal Dis. 2012:p1–3107. Ilman M, Zuhairini Y, Siddiq A. Correlation between Body Mass Index and Body Fat Percentage. Althea Med J. 2015;2(4):p575–8. Tomlinson DJ, Erskine RM, Morse CI, Winwood K, Onambélé-Pearson G. The impact of obesity on skeletal muscle strength and structure through adolescence to old age. Biogerontology. 2016;17(3):p467–83. Perkumpulan Endokrinologi Indonesia (PERKENI). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. 2019. Muscogiuri G, El Ghoch M, Colao A, Hassapidou M, Yumuk V, Busetto L. European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis. Obes Facts. 2021;14(2):p222–45. Eric Zacharias MD. The Mediterranean Diet: A Clinician’s Guide for Patients Care. 2012. Chapter 2: p7-16. Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: Meta-analysis. BMJ. 2008;337(7671):p673–5. Boghossian NS, Yeung EH, Mumford SL, Zhang C, Gaskins AJ, Wactawski-Wende J, et al. Adherence to the Mediterranean diet and body fat distribution in reproductive-aged women. Eur J Clin Nutr. 2013;67(3):p289–94. Jura M, Kozak LP. Obesity and related consequences to ageing. Age (Omaha). 2016;38(1). Batsis JA, Zagaria AB. Addressing Obesity in Aging Patients. John. Physiol Behav. 2019;176(3):p139–48. Hodson L, Banerjee R, Rial B, Arlt W, Adiels M, Boren J, et al. Menopausal status and abdominal obesity are significant determinants of hepatic lipid metabolism in women. J Am Heart Assoc. 2015;4(10):p1–14. Masek J, Osancova K, Slabochova Z, Hejda S, Hatle J. Epidemiology and pathogenesis of obesity. Ceska Gynekol. 1962;16:p223–9. Heymsfield SB, Wadden TA. Mechanisms, Pathophysiology, and Management of Obesity. N Engl J Med. 2017;376(3):p254–66. Gruzdeva O, Borodkina D, Uchasova E, Dyleva Y, Barbarash O. Leptin resistance: Underlying mechanisms and diagnosis. Diabetes, Metab Syndr Obes Targets Ther. 2019;12:p191–8. Poulimeneas D, Anastasiou CA, Santos I, Hill JO, Panagiotakos DB, Yannakoulia M. Exploring the relationship between the Mediterranean diet and weight loss maintenance: The MedWeight study. Br J Nutr. 2020;124(8):p874–80. Foster MT, Pagliassotti MJ. Metabolic alterations following visceral fat removal and expansion. Adipocyte. 2012;1(4):p192–9. Wu H, Ballantyne CM. Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020:p1549–64. Vázquez-Jiménez JG, Roura-Guiberna A, Jiménez-Mena LR, Olivares-Reyes JA. Role of free fatty acids on insulin resistance. Gac Mexico. 2019;153(7):p773–83. Agnoli C, Sieri S, Ricceri F, Giraudo MT, Masala G, Assedi M, et al. Adherence to a Mediterranean diet and long-term changes in weight and waist circumference in the EPIC-Italy cohort. Nutr Diabetes. 2018;8(1). Williamson G, Sheedy K. Effects of polyphenols on insulin resistance. Nutrients. 2020;12(10):p1–19. Bodnaruc AM, Prud’Homme D, Blanchet R, Giroux I. Nutritional modulation of endogenous glucagon-like peptide-1 secretion: A review. Nutr Metab. 2016;13(1):p1–16. Washudi, Hariyanto T. BIOMEDIK DASAR. Kementrian Kesehatan Republik Indonesia. 2016. Sherwood L. Introduction to Human Physiology International Edition. Eight Edition. Brooks/Cole Cengage Learning. Virginia: Yolanda Cossio; 2013. Buchanan A, Villani A. Association of adherence to a Mediterranean diet with excess body mass, muscle strength and physical performance in overweight or obese adults with or without type 2 diabetes: Two cross-sectional studies. Healthc. 2021;9(10). Singh M, Thrimawithana T, Shukla R, Adhikari B. Managing obesity through natural polyphenols: A review. Futur Foods. 2020;100002. Battineni G, Sagaro GG, Chintalapudi N, Amenta F, Tomassoni D, Tayebati SK. Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD). Int J Mol Sci. 2021;22(9). McCarthy HD, Samani-Radia D, Jebb SA, Prentice AM. Skeletal muscle mass reference curves for children and adolescents. Pediatr Obes. 2014;9(4):p249–59. Volpi E, Nazemi R, Fujita S. Muscle tissue changes with aging. Curr Opin Clin Nutr Metab Care. 2014;7(4):p405–10. Nikawa T, Ulla A, Sakakibara I. Polyphenols and their effects on muscle atrophy and muscle health. Molecules. 2021;26(16). Kelaiditi E, Jennings A, Steves CJ, Skinner J, Cassidy A, MacGregor AJ, et al. Measurements of skeletal muscle mass and power are positively related to a Mediterranean dietary pattern in women. Osteoporos Int. 2016;27(11):p3251–60. Salucci S, Falcieri E. Polyphenols and their potential role in preventing skeletal muscle atrophy. Nutr Res. 2020;74:p10–22.
The black rice ethanol extract effect on polymorphonuclear cells proliferation of rats induced by lipopolysaccharide Henny Juliastuti; Maman Djamaludin; Hadi Alwani
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Inflammation is a natural defense response of the body when an infection occurs. However, excessive inflammatory reactions can be triggered by lipopolysaccharides (LPS), which are key immunogenic components of bacterial capsules or cell walls. These reactions can lead to harmful effects on the body. Black rice (Oryza sativa L. indica) is a natural source rich in phenols, flavonoids, and antioxidant anthocyanins, which act as immunomodulators. This study aimed to investigate the effect of black rice ethanol extract as an anti-inflammatory agent on the proliferation of polymorphonuclear cells (PMN) in the spleen of rats induced by lipopolysaccharides. The study involved 27 mice, which were given a 400 mg/kg BW dose of black rice ethanol extract for 14 days. Afterward, the rats were induced with 0.3 mg/kg BW LPS intraperitoneally 24 hours before euthanasia using CO2. The spleens were then collected to measure the size of the germinal center diameter. The results showed that the treatment group had a germinal center diameter of 1.311 ± 0.226 μm (p<0.05) when compared to the positive control group. The LPS administration in the control group resulted in the disorganization of the white pulp and a reduction in lymphocyte cells and PMN in the germinal center. In conclusion, black rice ethanol extract at a dose of 400 mg/kg BW has an effect on PMN proliferation, as indicated by changes in the morphology of the white pulp in the germinal center of the spleen in rats. DOI : 10.35990/amhs.v1n1.p38-44 REFERENCES Wahyuningsih P, UP Nursing. Effect of Tintir Distance Extract (Jathropa Multifida Linn) on the Amount of PMN and Mast Cells on Rat Wound Healing with Acute Need Model. Journal Homepage. 2019;4(1):1-6. Harlim A. Textbook on Skin Health Science and Genital Immunology. Henny Juliastuti, et.al. Inflammatory. 2008. FK UKI; p. 1386. VK's sgiaman. Improved Wound Healing in the Oral Mucosa Through the Administration of Aloe Vera (Linn.) Topically. Maranatha Journal of Medicine and Health. 2011;11(1):70-79. Hannoodee S, Dn N. Acute Inflammatory Response: Issues of Concern and Clinicopathologic Correlations. Acute Inflammatory Response. Published online 2021:7-10. FK Treasure. Evaluation of Phytochemicals, Antioxidant Activity, and Immunomodulators of Black Rice (Oryza Sativa L. Indica). 2016. Wijayanti CRT. Anti-Inflammatory Power of Ethanolic Extract of Tripterygium Rootwilfordii Hook. F. on Female White Squeak. Thesis, Sanata Dharma University. Published online 2008:12-13. Alviyani E. Test the Antioxidant Activity of White Rice Ethanol Extract and Black Rice Using the DPPH Method in Gel Form. Thesis. Published online 2020:1-120. FK Treasure. Anti-inflammatory Activity of Ethanol Extract and Black Rice Water (Oryza Sativa L. Indica) in Male Wistar Rats. Journal of Recapangan. 2016;10(1):9-15. Liu H, Huang L, Pei X. Effects of Sorghum Rice and Black Rice on Genes Associated with Cholesterol Metabolism in Hypercholesterolemic Mice Liver and Intestine. Food Science and Nutrition. 2021;9(1):217-229. Bronte V, Pittet MJ. The Spleen in Local and Systemic Regulation of Immunity. Immunity. 2013;39(5):806-818. Noor Mutsaqof AA, -W, Suryani E. Expert System for Diagnosing Infectious Diseases Using Forward Chaining. ITSmart Journal of Technology & Information. 2016;4(1):43. Abidin Z. Effects of Ethanol Extract of Oryza Sativa L. Indica on Kinase B Protein Activity and Serum CA 15-3 Levels in Female Dawley Sprague Mice. eJournal Medis Indonesia. 2017;4(3):187-190. Mangiri J, Mayulu N, Kawengian SES. An Overview of the Nutritional Content in Black Rice Cultivar Pare Ambon South Sulawesi. Journal of e-Biomedicine. 2016;4(1):2-6. Khan A, Tahir A, SU R, et al. Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain. Frontiers in Pharmacology. 2018;9:1-59. Muhammad Nizar. Probiotic Administration of Gingiva Lymphocyte Cells Count of Wistar Rats Induced by Lipopolysaccharides. Jember: Faculty of Dentistry, University of Jember. 2012. Hermida Md ER, de Melo CVB, Lima I dos S, Oliveira GG de S, dos-Santos WLC. Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis. Frontiers in Cellular and Infection Microbiology. 2018;8. doi:10.3389/fcimb.2018.00394 Maleki SJ, Crespo JF, Cabanillas B. Anti-inflammatory Effects of Flavonoids. Food Chemistry. 2019;299(July). Istanti NW, Nabila RA, Listyawati S. Nutritional Content of Black Rice (Oryza Sativa L.) Resulting from Breeding Plants with Gamma Rays of 60Co. Proceedings of Meetings and Scientific Presentations of Basic Research on Nuclear Science and Technology. Published online 2018:295-298. Maharni M. Potential of White Rice, Black Rice, and Brown Rice as Antioxidants and Inhibitors of Tyrosinase. Thesis of Bogor Agricultural University. Published online 2015:1-31. Zahroh F, Agustini R. Determination of the Total Anthocyanin Content of Black Rice Yeast Using the Differential pH Method. Journal of Chemistry of Neger University Surabaya. 2021;10(2):200-208. Arifa AH, Shamsir E, Budijanto S. Physicochemical Characterization of Black Rice (Oryza Sativa L.) from West Java, Indonesia. agriTECH. 2021;41(1):15. doi:10.22146/agritech.53307 Durga M, Nathiya S, Devasena T. Immunomodulatory and Antioxidant Actions of Dietary Flavonoids. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(2):50-56. Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview. Medicines. 2018;5(3):93. Yu GJ, Choi IW, Kim GY, Kim BW, Park C, Hong SH. Anti-inflammatory Potential of Saponins Derived from Cultured Wild Ginseng Roots in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. International Journal of Molecular Medicine. 2015;35(6):1690-1698. Ahn S, Siddiqi MH, Noh HY, Kim YJ, Jin CG, Yang DC. Anti-inflammatory Activity of Ginsenosides in LPS-Stimulated RAW 264.7 Cells. Science Bulletin. 2015;60(8):773-784. Yang M, Koo S, Song W, Chun O. Food Matrix Affecting Anthocyanin Bioavailability: A Review. Current Medicinal Chemistry. 2011;18:291-300.
Developing self-aware mindfulness to manage mood disorder in the adolescent - A Case Report Kiki Puspitasari
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Major depressive disorder (MDD) with psychotic is a complicated affective disease characterized by abnormal clinical sympotms, including neurovegetative disfunction (appetite or sleep disturbances), cognitive dissonance (inappropriate guilt, feelings of worthlessness), aberrant psychomotor activities (agitation or retardation), and elevated suicide risk with psychotic features such as delusions or nihilistic, non-bizarre delusions, somatic, poverty, worthlessness, or delusional beliefs about guilt and being punished, and sometimes appear hallucination. The prevalence of MDD with psychotic features increases with age. In general population, the point prevalence of MDD is about 2% to 4% and it is increasing about 20% lifetime risk. Depression is a leading cause of burden of disease among young people. Current treatments are not uniformly effective, in part due to the heterogeneous nature of MDD. MDDis caused by many factors. A 22-year-old male presented to the inpatient psychiatric unit with suicide attempt. The patient reported experiencing a lack of energy, difficulty falling asleep, lack of motivation, and feeling overwhelmed about his work and experiencing auditoric hallucination. The insight level was 5. Multiaxial diagnosis are axis I: major depressive episode with psychotic symptoms; axis II and III: currently not found; axis IV: problems with workplace; axis V: GAF 20-11. Patient treated with pharmacotherapy group Selective Serotonin Reuptake Inhibitor (SSRI) and second-generation antipsychotics which combined with supportive psychotherapy such as mindfullness. DOI : 10.35990/amhs.v1n1.p45-53 REFERENCES Brown, K. W., & Ryan, R. M. (2004). Perils and promise in defining and measuring mindfulness: Observations from experience. Clinical Psychology: Science and Practice, 11, 242–248. Ohayon, M. M., & Schatzberg, A. F. (2002). Prevalence of depressive episodes with psychotic features in the general population. American Journal of Psychiatry, 159(11), 1855–1861. Fava, M., & Kenneth, K. S. (2000). Major depressive disorder. Neuron, 28(2), 335–351. Chesney, E., Goodwin, G. M., & Fazel, S. (2014). Risks of all-cause and suicide mortality in mental disorders: A meta-review. World Psychiatry, 13(2), 153–160. Kessing, L. V. (2006). Differences in diagnostic subtypes among patients with late and early onset of a single depressive episode. International Journal of Geriatric Psychiatry, 21(12), 1127–1131. Serretti, A., Lattuada, E., Cusin, C., Gasperini, M., & Smeraldi, E. (1999). Clinical and demographic features of psychotic and nonpsychotic depression. Comprehensive Psychiatry, 40(5), 358–362. Klonsky, E. D., May, A. M., & Saffer, B. Y. (2016). Suicide, suicide attempts, and suicidal ideation. Annual Review of Clinical Psychology, 12, 307–330. Auerbach, R. P., Stanton, C. H., Proudfit, G. H., & Pizzagalli, D. A. (2015). Self-referential processing in depressed adolescents: A high-density event-related potential study. Journal of Abnormal Psychology, 124(1), 233–245. Kiang, M., Farzan, F., Blumberger, D. M., Kutas, M., McKinnon, M. C., Kansal, V., et al. (2017). Abnormal self-schema in semantic memory in major depressive disorder: Evidence from event-related brain potentials. Biological Psychology, 126, 41–47. Li, Y., Li, M., Wei, D., Kong, X., Du, X., Hou, X., et al. (2017). Self-referential processing in unipolar depression: Distinct roles of subregions of the medial prefrontal cortex. Psychiatry Research, 263, 8–14. Smeijers, D., Vrijsen, J. N., van Oostrom, I., Isaac, L., Speckens, A., Becker, E. S., et al. (2017). Implicit and explicit self-esteem in remitted depressed patients. Journal of Behavioral Therapy and Experimental Psychiatry, 54, 301–306. Lemogne, C., le Bastard, G., Mayberg, H., Volle, E., Bergouignan, L., Lehéricy, S., et al. (2009). In search of the depressive self: Extended medial prefrontal network during self-referential processing in major depression. Social Cognitive and Affective Neuroscience, 4(3), 305–312. Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Ueda, K., Suzuki, S., et al. (2010). Rostral anterior cingulate cortex activity mediates the relationship between depressive symptoms and medial prefrontal cortex activity. Journal of Affective Disorders, 122(1–2), 76–85. Maslim, R. (2013). Diagnosis Gangguan Jiwa, Rujukan Ringkas PPDGJ-III dan DSM-V (2nd ed.). Jakarta: PT Nuh Jaya. Bailey, R., & Pico, J. (2022). Defense Mechanisms. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK559106/ Inagaki, M., Ohtsuki, T., Yonemoto, N., Kawashima, Y., Saitoh, A., Oikawa, Y., et al. (2013). Validity of the Patient Health Questionnaire (PHQ)-9 and PHQ-2 in general internal medicine primary care at a Japanese rural hospital: A cross-sectional study. General Hospital Psychiatry, 35(6), 592–597. Bolton, J. M., Gunnell, D., & Turecki, G. (2015). Suicide risk assessment and intervention in people with mental illness. BMJ, 351, h4978. Zalsman, G., Hawton, K., Wasserman, D., van Heeringen, K., Arensman, E., Sarchiapone, M., et al. (2016). Suicide prevention strategies revisited: 10-year systematic review. The Lancet Psychiatry, 3(7), 646–659. Antara, J. (2014). Episode depresif berat dengan gejala psikotik: Sebuah laporan kasus. E-Jurnal Medika Udayana, 4(3). Weickert, T. W., & Goldberg, T. E. (2005). First- and second-generation antipsychotic medication and cognitive processing in schizophrenia. Current Psychiatry Reports, 7(4), 304–310. Bennabi, D., Charpeaud, T., Yrondi, A., Genty, J.-B., Destouches, S., Lancrenon, S., et al. (2019). 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Correlation between presbycusis with quality of life based on hearing handicap inventory for the elderly screening version (HHIE-S) Nazarudin, Nurbaiti; Priasty, Vania Nanda; Ma’mur, Iwan Darmawan
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Presbycusis is an age-related hearing loss caused by a degeneration process which is a cumulative effect of various risk factors. Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S) questionnaire is a questionnaire that can be used to measure the quality of life in patients with hearing loss. This study aimed to determine the relationship between presbycusis with the quality of life. The research uses cross sectional analytical research methods. The data used in form of primary data is the result of filling in the guided questionnaire and the results of the audiogram, while secondary data is in the form of medical records of presbycusis patients at Dustira Hospital in the period January 2017-December 2018. Data were analyzed by Chi-Square and Spearman Correlation Test. The incidence of presbycusis in the period January 2017-December 2018 at Dustira Hospital was 2,6%. The result showed most of the patients were 65-74 years old (61,8%), male (52,7%), married (58,2%), economic were similar between moderate and low economic status (49.1%), had a history of chronic diseases (76, 4%), had a moderate degree of hearing loss (61,8%) and had a mild-moderate degree of quality of life (52,7%). Based on HHIE-S questionnaire the results showed that there was a significant and strong relationship between presbycusis and patients’ quality of life (p <0.001) and r=0,509. In conclusion, degrees of hearing loss in presbycusis patients will correspond to degrees of decrease in quality of life. DOI : 10.35990/amhs.v1n2.p54-63 REFERENCES Kementerian Kesehatan Republik Indonesia. Gambaran kesehatan lanjut usia di Indonesia. Buletin Jendela Data dan Informasi Kesehatan: Kementerian Kesehatan RI; 2013: 27-39. Suhartin P. Teori penuaan, perubahan pada sistem tubuh dan implikasinya pada lansia. Semarang: Fakultas Kedokteran Universitas Diponegoro; 2010. Ballenger JJ, Snow JB. Ballenger’s Otorhinolaryngology Head and Neck Surgery. 16th ed. BC Decker Inc. Spain; 2003: 443-454. Suwento R, Hendarmin H. Gangguan pendengaran pada geriatri. Dalam: Soepardi EA, Iskandar N, Bashiruddin J, Restuti RD, Eds. Buku Ajar Ilmu Kesehatan Telinga Hidung Tenggorok Kepala & Leher. Ed 7. Jakarta: Balai Penerbit FKUI, 2016: 36-38. Ardan, Juliarti. Sinopsis Ilmu Kesehatan Telinga Hidung Tenggorok. Bangka Belitung: Penerbit Buku Kedokteran AFJ; 2008: 15-18. Lalwani AK. Current Diagnosis & Treatment. 3rd ed. LANGE; 2012: 689-967. World Health Organization (WHO). Millions of people in the world have hearing loss that can be treated or prevented. 2013. Kementerian Kesehatan Republik Indonesia. Pendengaran sehat untuk hidup bahagia; 2013. Kementerian Kesehatan Republik Indonesia. Telinga sehat pendengaran baik; 2010. Hoffman HJ, Dobie RA, Losonczy KG, Themann CL, Flamme GA. Declining prevalence of hearing loss in US adults aged 20 to 69 years. JAMA; 2017; 143(3): 274-285. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Riset kesehatan dasar (Riskesdas 2013). Kementerian Kesehatan Republik Indonesia, Jakarta; 2013: 243-245. Dina, L. Prevalensi presbikusis dan faktor risiko yang mempengaruhi lanjut usia di Balai Perlindungan Sosial Provinsi Banten. Jakarta: Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Syarif Hidayatullah; 2013. Astari NL. Uji diagnostik HHIE-S versi Indonesia untuk skrining gangguan pendengaran usia lanjut. [Tesis]. Denpasar: Program Pascasarjana Universitas Udayana; 2014. Muthmainnah D. Hubungan presbikusis dengan depresi pada lansia di Poliklinik THT RSUD Dr. Zainoel Abidin Banda Aceh. [Tesis]. Darussalam Banda Aceh: Fakultas Kedokteran Universitas Syiah Kuala; 2014. Nurbaiti Nazarudin, et al. Kualitas hidup lansia. Jurnal Keperawatan, ISSN 2086-3071; 2012. WHO. Programme on mental health: WHOQOL user manual. Geneva: World Health Organization; 2012. Salim OC, Sudharma NI, Kusumaratna RK, dan Hidayat A. Validitas dan reliabilitas World Health Organization quality of life – Bref untuk mengukur kualitas hidup lanjut usia. Jakarta: Jurnal Universa Medika; 2007; 26(1). Wikanada G. Hubungan kualitas hidup dan faktor risiko pada usia lanjut di wilayah kerja puskesmas Tampaksiring I Kabupaten Gianyar Bali. Intisari Sains Medis; 2017; 8: 41-49. Istiqomah SN, Imanto M. Hubungan gangguan pendengaran dengan kualitas hidup lansia. Majority, 2019; 8(2): 234-239. Aktarabay K. Hubungan fungsi pendengaran dengan kualitas hidup pasien gangguan dengar di Poliklinik THT-KL RSUD ZAB Banda Aceh. Darussalam Banda Aceh: Fakultas Kedokteran Universitas Syiah Kuala; 2018. Nordvik O, Laugen Heggdal PO, et al. Generic quality of life in persons with hearing loss: A systematic literature review. BMC Ear, Nose and Throat Disorders; 2018; 18(1): 1-13. Lazzarotto S, Baumstrack K, Auqueir P. Age-related hearing impairment and impact on quality of life: A review of available questionnaires. Ann Otolaryngol Rhinol. Paris; 2016; 3(5): 1107:1-8. Said EA. Health-related quality of life in elderly hearing aid users vs. non-users. Egyptian Journal of Ear, Nose, Throat and Allied Sciences; 2017; 18: 271-279. Djamin R. Kualitas hidup lansia dengan gangguan pendengaran. Makasar: Laporan penelitian bagian Ilmu Kesehatan Telinga Hidung Tenggorok; 2010. Gondodiputro S, Hidayari AR, Rahmiati L. Gender, age, marital status and education as predictors to quality of life in elderly: WHOQOL-BREF Indonesian version. Department of Public Health, Faculty of Medicine University Padjajaran. Bandung. 2018. Fatmawati R, Dewi YA. Karakteristik penderita presbiakusis di Bagian Ilmu Kesehatan THT-KL RSUP Dr. Hasan Sadikin Bandung periode Januari 2012 - Desember 2014. [Tesis]. Departemen Ilmu Kesehatan Telinga Hidung Tenggorok Bedah Kepala dan Leher, Fakultas Kedokteran, Universitas Padjadjaran / Rumah Sakit Hasan Sadikin Bandung. 2015. Megari, K. Quality of life in chronic disease patients. Health Psychology Research. Italy. 2013: 141-148. Nazarudin N, Kristianti A, Nurrokhmawati Y. Pemeriksaan pendengaran: Pemeriksaan audiometri dan murni. Dalam: Nataliningrum RDM, Pratiwi ST, Djajasasmita D, Kristianti A, Handayani DR, editors. Buku pedoman praktikum (BPP) Blok 20 Kedokteran Kerja. FK Unjani. Cimahi; 2018: 33-38. Purnami N, Mulyaningsih EF, Ahadiah TH, Utomo B, Smith A. Score of hearing handicap inventory for the elderly (HHIE) compared to whisper test on presbycusis. Indian J Otolaryngol Head and Neck Surg; 2020: 1-5. https://doi.org/10.1007/s12070-020-01997-5.
The duration of Mediterranean diet affects the levels of the lipid profile in dyslipidemia patients Handayani, Dewi R; Septiadi, Endry; Inayati, Iis; Pratiwi, Siska T; Anugrah, Rifal A; Rohman, Nur M; Prawira, Achmad H; Rais, Muhammad A
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Abstract

Dyslipidemia is a lipid metabolism disorder that indicates abnormal levels of lipid profile in plasma. The most notable lipid profile abnormalities include increased levels of total cholesterol, low-density lipoprotein cholesterol (LDL), triglycerides, and a decrease in high-density lipoprotein cholesterol (HDL). One of the non-pharmacological management for dyslipidemia is diet modification with the Mediterranean diet. This study aims to determine the relationship between the duration of the Mediterranean diet and lipid profile levels in Prolanis patients who experience dyslipidemia in a clinic in Bandung. The research method was analytical with cohort observations. Sampling was done by consecutive sampling. Subjects in this study were 30 dyslipidemic patients who followed a Mediterranean diet and were examined for lipid profile levels in the first and third months. Data on total cholesterol, LDL, HDL, and triglycerides were analyzed using the T-dependent test. Total cholesterol and Triglycerides decreased significantly, and HDL increased significantly in the first and third month. The duration of the Mediterranean diet shows a reduction effect of total cholesterol, LDL, triglycerides and significantly increase HDL in patients with dyslipidemia because the recommended foods are high in monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), which can correct abnormalities in lipid profile levels. DOI : 10.35990/amhs.v1n2.p64-70 REFERENCES Anwar TB. Dislipidemia Sebagai Faktor Resiko Penyakit Jantung Koroner. 2006;1–10. Wahjuni S. Dislipidemia menyebabkan stres oksidatif ditandai oleh meningkatnya malondialdehid. Bali: Universitas Udayana; 2015. hlm. 1–109. Hamam F. Dyslipidemia and related risk factors in a Saudi university community. Food Nutr Sci. 2017;8(1):56–69. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS). Jakarta: Kemenkes RI; 2013. Labibah Z, Anggraini DI. Diet Mediterania dan manfaatnya terhadap kesehatan jantung dan kardiovaskular. J Majority. 2016;5:1–3. Estruch R. Anti-inflammatory effects of the Mediterranean diet: The experience of the PREDIMED study. Proc Nutr Soc. 2010;69:333–340. Sofi F, Macchi C, Abbate R, Gensini GF, Casini A. Mediterranean diet and health. Ann Ist Super Sanita. 2013;39:335–342. Tuttolomondo A, Simonetta I, Handayani DR, Daidone M, Mogavero A, Ortello A, Pinto A. Metabolic and vascular effects of the Mediterranean diet. Int J Mol Sci. 2019;20(19). John MF, Adam. Dislipidemia. Dalam: Sudoyo AW, dkk, editor. Buku Ajar Ilmu Penyakit Dalam. Jilid III, Edisi IV. Jakarta: Balai Penerbit FKUI; 2006. hlm. 2556–2557. Wiyono P. Penatalaksanaan dislipidemia pada diabetes melitus. 2003;1–11. Corradi PF, Agrawal N, Gumaste N, Goldberg IJ. Principles of Diabetes Mellitus. Principles of Diabetes Mellitus. 2016;1–19. Anneke R, Sulistiyaningsih. Review: Terapi herbal sebagai alternatif pengobatan dislipidemia. Farmaka. 2018;16:213–221. Rhee E, Kim HC, Kim JH, Lee EY, Kim BJ, Kim EM, et al. 2018 Guidelines for the management of dyslipidemia and cardiovascular disease in Koreans. Korean J Intern Med. 2019;34(4):723–771. Lestari A, Handini MC, Sinaga TR. Faktor risiko kejadian dislipidemia pada lansia (Studi kasus kontrol pada lansia di Poli Lansia RSUD Bangkinang Kabupaten Kampar Tahun 2016–2017). J Ris Hesti Medan Akper Kesdam I/BB Medan. 2018;3(2):16. Steinberg D, Witztum JL. History of discovery: Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010;30(12):2311–2316. Tautik S. Hubungan antara kadar estradiol dengan profil lipid. 2011;1:47. Nugraheni K. Pengaruh pemberian minyak zaitun ekstra virgin terhadap profil lipid serum tikus putih strain Sprague Dawley hiperkolesterolemia. J Ilmu Gizi. 2012;1:27. Mekki K, Bouzidi BN, Kaddous A, Bouchenak M. Mediterranean diet improves dyslipidemia and biomarkers in chronic renal failure patients. 2010;1:110–115. Pachyrrhizus B, Pada E, No JS. J Nutr College. 2014;3:573–579. Make Each Day Mediterranean. U.S. News and World Report; 2012. hlm. 1–11. Dernini S, Berry EM, La Vecchia C, Capone R. MedDiet4.0: The Mediterranean diet with four sustainable benefits. Public Health Nutr. 2016;20(7):1322–1330. Boucher JL. Mediterranean eating pattern. Diabetes Spectrum. 2017;72–76. American Diabetes Association. Widmer RJ, Flammer AJ, Lerman LO, Lerman A. The Mediterranean diet, its components, and cardiovascular disease. Am J Med. 2015;128(3):229–238. Nutrition Clinics for UW Medical Foundation. Mediterranean Food Guide. UW Health; 2019. hlm. 1–42. Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, et al. Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut. 2020;69(7):1258–1266.
The learning impact of the Online Formative Assessment system (OFAs) for undergraduate medical students Sari, Sylvia M; Saadah, Hindun
ACTA Medical Health Sciences Vol. 1 No. 2 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

Formative assessment is a continuum process of evaluating students’ performance to enhance students’ learning quality. The shift to full-online learning in pandemics reduces student-lecturer attachments during formative assessment. Therefore, we developed the Online Formative Assessment system (OFAs) based on a self-regulatory learning framework. This study aimed to explore the learning impact of OFAs, such as learning preparation, feedback perception, and self-reflection. We used the mixed method with an exploratory approach. We collected quantitative data from 150 students who experienced OFAs, using 26 questions adapted from AEQ (Assessment Experience Questionnaire) and analyzed by pre-post design (paired-T test). To explore a deeper understanding, we conducted 6 FGDs (N=28). Finally, we analyzed the quantitative and qualitative data sequentially. We found the difference in students’ preparation (p<0.5), feedback perception (p<0.5), and no difference in self-reflection (p>0.5). In Qualitative data, we found three themes as follows: (1) OFAs improve student preparation in learning; 2) Students are aware of being assessed during tutorials; 3) Require more specific and individual written feedback; 4) Lack of self-reflection due to unspecific feedback. These findings represent that learning impact is a complex pathway that online assessment systems can drive. It needs externally driven feedback quality and internally driven factors such as self- reflection skills. However, we found the challenges to improving students' quality feedback and self-reflection skills. This study brings further research on student-lecturer engagement in online formative assessment. DOI : 10.35990/amhs.v1n2.p71-78 REFERENCES Preston, R., Gratani, M., Owens, K., Roche, P., Zimanyi, M., & Aduli, B. M. (2020). Exploring the impact of assessment on medical students’ learning. Assessment & Evaluation in Higher Education, 45(1), 109–124. Norcini, J., Anderson, M. B., Bollela, V., et al. (2018). Consensus framework for good assessment. Medical Teacher, 2. https://doi.org/10.1080/0142159X.2018.1500016 Kulasegaram, K., & Rangachari, P. K. (2018). Beyond “formative” assessments to enrich student learning. Advances in Physiology Education, 42(1), 5–14. https://doi.org/10.1152/advan.00122.2017 Wiliam, D. (2011). What is assessment for learning?. Studies in Educational Evaluation, 37, 3–14. https://doi.org/10.1016/j.stueduc.2011.03.001 Schuwirth, L. W. T., & Van der Vleuten, C. P. M. (2011). Programmatic assessment: From assessment of learning to assessment for learning. Medical Teacher, 33, 478–485. Larsen, D. P., Butler, A. W., & Roediger, H. L. (2008). Test-enhanced learning in medical education. Medical Education, 42, 959–966. https://doi.org/10.1111/j.1365-2923.2008.03124.x Green, M. L., Moeller, J. J., & Spak, J. M. (2018). Test-enhanced learning in health professions education: A systematic review (BEME Guide No. 48). Medical Teacher, 40(4), 337–350. https://doi.org/10.1080/0142159X.2018.1430354 Ten Cate, T. J., Kusurkar, R. A., & Williams, G. C. (2011). How self-determination theory can assist our understanding of the teaching and learning processes in medical education. Medical Teacher, 33(12), 961–973. https://doi.org/10.3109/0142159X.2011.595435 Kusurkar, R. A., Croiset, G., Mann, K. V., Custers, E., & Ten Cate, O. (2012). Have motivation theories guided the development and reform of medical education curricula? A review of the literature. Academic Medicine, 87(6), 735–743. https://doi.org/10.1097/ACM.0b013e318253cc0e Evans, D. J., Zeun, P., & Stanier, R. A. (2014). Motivating student learning using a formative assessment journey. Journal of Anatomy, 224(3), 296–303. https://doi.org/10.1111/joa.12117 Sari, S. M., Inayati, I., & Sidiqa, A. (2021). Towards paradigm change of formative assessment in the undergraduate curriculum: The participatory action research (PAR). ICME Conference Book. https://doi.org/10.2991/assehr.k.210930.049 Pressentin, V. (2016). Towards tailored teaching: Using participatory action research to enhance the learning experience of Longitudinal Integrated Clerkship students in a South African rural district hospital. BMC Medical Education, 16, 82. Gibbs, G., & Simpson, C. (2005). Conditions under which assessment supports students’ learning. Learning and Teaching in Higher Education, 12, 3–31. Nagandla, K., Sulaiha, S., & Nalliah, S. (2018). Online formative assessments: Exploring their educational value. Journal of Advances in Medical Education & Professionalism, 6(2), 51–57. PMCID: PMC5856905 Marden, N. Y., Ulman, L. G., Wilson, F. S., & Velan, G. M. (2013). Online feedback assessments in physiology: Effects on students' learning experiences and outcomes. Advances in Physiology Education, 37(2), 192–200. https://doi.org/10.1152/advan.00092.2012 Creswell, J. W., & Creswell, D. J. (2018). Research design: Qualitative, quantitative, and mixed methods approaches (5th ed.). Thousand Oaks, CA: SAGE Publications. Rust, C., O’Donovan, B., & Price, M. (2005). A social constructivist assessment process model: How the research literature shows us this could be best practice. Assessment & Evaluation in Higher Education, 30(3), 231–240. Yardley, S., Teunissen, P. W., & Dornan, T. (2012). Experiential learning: AMEE guide No. 63. Medical Teacher. https://doi.org/10.3109/0142159X.2012.650741 Al-Kadri, H. M. A., Al-Moamary, M. S., & Magzoub, M. E., et al. (2011). Students’ perceptions of the impact of assessment on approaches to learning: A comparison between two medical schools with similar curricula. International Journal of Medical Education, 2, 44–52. Al-Kadri, H. M. A., Roberts, C., Al-Moamary, M. S., & Van der Vleuten, C. P. M. (2012). Exploring assessment factors contributing to students' study strategies: Literature review. Medical Teacher. https://doi.org/10.3109/0142159X.2012.656756 Mogali, S. R., Rotgans, J. I., Rosby, L., Ferenczi, M. A., & Low Beer, N. (2020). Summative and formative style anatomy practical examinations: Do they have impact on students' performance and drive for learning? Anatomical Sciences Education, 13(5), 581–590. https://doi.org/10.1002/ase.1931 Palmer, E., & Devitt, P. (2014). The assessment of a structured online formative assessment program: A randomized controlled trial. BMC Medical Education, 14, 8. https://doi.org/10.1186/1472-6920-14-8
Characteristics of Health Protocols and Incidence of COVID-19 in Young Doctors Complete Vaccinated Kristianti, Asti; Indriyana, Sri Q; Fiddiyanti, Ilma
ACTA Medical Health Sciences Vol. 1 No. 2 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

COVID-19 is a respiratory disease that has currently become a pandemic in the world. West Java is one of the provinces with the most cases of COVID-19 in Indonesia. Health workers including young doctors are a group that has a very high risk of getting infected with COVID- 19. The purpose of this study was to determine the characteristics of health protocols and COVID-19 cases in young doctors at Faculty of Medicine, General Achmad Yani University (FK UNJANI) who were fully vaccinated against COVID-19. This study was designed as a descriptive study with a cross-sectional approach. The characteristics assesses in this study were: age, gender, and a confirmed history of COVID-19. Data was collected in June 2021- September 2022 using google form to fill out a questionnaire. The questionnaire was filled out by 105 eligible respondents. Respondents have received at least 2 doses of the COVID-19 vaccine and are aged between 22-23 years. The characteristics of respondents were 71 females (68.57%) and 33 males (31.43%). A total of 78.1% had confirmed COVID-19 and 21.9% had never been infected. A total of 52,4% respondents had good health protocols and 47.6% had poor health protocols. DOI : 10.35990/amhs.v1n2.p79-87 REFERENCES World Health Organization (WHO). (2020). Health topics: coronavirus. Retrieved April 2021 from https://www.who.int/health-topics/coronavirus Burhan, E., Susanto, A. D., Nasution, S. A., Ginanjar, E., Pitoyo, C. W., Susilo, A., et al. (2020). Pedoman tatalaksana COVID-19 (Edisi ke-3). PDPI, PERKI, PAPDI, PERDATIN, IDAI. Jakarta. Handayani, D., Hadi, D. W., Isbaniah, F., Burhan, E., & Agustin, H. (2020). Penyakit Virus Corona 2019. Jurnal Respirologi Indonesia, 40, 119–284. Badan Nasional Penanggulangan Bencana (BNPB). (2020). Situasi Virus Corona. Retrieved October 2022 from https://www.covid19.go.id/situasi-virus-corona/ Lovato, A., de Filippis, C., & Marioni, G. (2020). Upper airway symptoms in coronavirus disease 2019 (COVID-19). American Journal of Otolaryngology, 10, 24–37. Maskari, Z. A., Blushi, A. A., Khamis, F., Tai, A. A., Salmi, I. A., Harthi, H. A., et al. (2020). Characteristics of health care workers infected with COVID-19: A cross-sectional observational study. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2020.10.009 Syafruddin, A., Findyartini, A., Budu, Aras, I., Leatemia, L. D., Wiyanto, M., et al. (2020). Pedoman pelaksanaan pendidikan tahap akademik dan profesi program pendidikan dokter dalam masa pandemi. AIPKI. Jakarta. Kristianti, A., Sutrisno, Kumala, Y. Y., Ratwita, W., Irawan, J., Quintina, S., et al. (2021). Pedoman standar pelaksanaan pendidikan tahap profesi FK UNJANI dalam masa pandemi COVID-19. FK UNJANI. Cimahi. Kementerian Kesehatan Republik Indonesia. (2020). Pedoman pencegahan dan pengendalian Coronavirus Disease (COVID-19). Jakarta. Kementerian Kesehatan Republik Indonesia. (2021). Keputusan Menteri Kesehatan No. HK.01.07/MENKES/4638/2021 tentang Petunjuk Teknis Pelaksanaan Vaksinasi dalam Rangka Penanggulangan Pandemi COVID-19. Kementerian Kesehatan Republik Indonesia. (n.d.). Peraturan Menteri Kesehatan RI. Retrieved from https://hukor.kemkes.go.id Kementerian Kesehatan Republik Indonesia. (2020). Keputusan Menteri Kesehatan RI Nomor HK.01.07/MENKES/382/2020 tentang Protokol Kesehatan bagi Masyarakat di Tempat dan Fasilitas Umum dalam Rangka Pencegahan dan Pengendalian COVID-19. Jakarta. Centers for Disease Control and Prevention (CDC). (n.d.). Your guide to mask. Retrieved from https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/about-face-coverings.html Milani, G. P., Macchi, M., & Mark, A. G. (2021). Vitamin C in the treatment of COVID-19. Nutrients, 13(4), 1172. https://doi.org/10.3390/nu13041172 Ilie, P. C., Stefanescu, S., & Smith, L. (2020). The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality. Aging Clinical and Experimental Research, 32, 1195–1198. World Health Organization (WHO). (2009). Hand hygiene: Why, how & when?. Geneva. Kementerian Kesehatan Republik Indonesia. (2020). Panduan Cuci Tangan Pakai Sabun. Jakarta. Centers for Disease Control and Prevention (CDC). (2021, May 20). Events and gatherings. Kraemer, M. U. G., et al. (2020). The effect of human mobility and control measures on the COVID-19 epidemic in China. Science, 368, 493–497. Isbaniah, F., Kusumowardhani, D., Sitompul, P. A., Susilo, A., Wihastuti, R., Setyawaty, R., et al. (2021). Pedoman pencegahan dan pengendalian Coronavirus Disease (COVID-19) Revisi Keempat. Retrieved June 12, 2021, from https://infeksiemerging.kemkes.go.id/ Xiong, Y., Zang, X., Sun, D., & Zhu, W. (2020). Clinical and CT characteristics of healthcare workers with COVID-19. Medical Journal, 99(30), 1–7.

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