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Dina Kartika Maharani
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Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia. 60231
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Unesa Journal of Chemistry
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Published by Universitas Negeri Surabaya
ISSN : -     EISSN : 22528180     DOI : https://doi.org/10.26740/ujc.v11n2
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology
UNESA Journal of Chemistry is online Journal covering all aspects of Chemistry. The journal publishes original research paper and review articles.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 103 Documents
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EXPOSURE PATHWAYS AND THE EFFECTS OF TRACE METALS AND POLYCYCLIC AROMATIC HYDROCARBONS (PAHS) ON HUMANS Ogbuewu, Ifeanyi; Nnaji, Jude Chidozie
Unesa Journal of Chemistry Vol. 13 No. 2 (2024): Vol 13 No 2 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

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Abstract

ABSTRACT The various exposure pathways and health impacts of trace metals (TMs) and polycyclic aromatic hydrocarbons (PAHs) on humans were reviewed. They have been confirmed to be toxic and carcinogenic to humans, especially above safe limits. Various forms of industrial and domestic processes lead to the discharge of trace metals, PAHs, and their compounds in different forms such as gases, vapour, particulates, liquid waste, and solid waste into the air, water-bodies, and soil. TMs and PAHs are deposited in food through the combustion of fossil fuels, grilling of food at high temperatures, pan frying, and microwave methods of cooking. Some heavy metals like chromium, cadmium, and arsenic are said to cause cancer and genetic instability. The cancer-causing potential of PAH is a result of the metabolic transformation undergone by PAH in the human body which forms active metabolites that bind to DNA, a genetic material inside the cell. PAHs have been classified by the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO) according to their degree of toxicity and carcinogenicity to humans. Avoiding contact of food with flames and cooking with the heat sources above rather than below food is the recommendation made by the Joint Expert Committee on Food Additives (JECFA) as a measure of PAH reduction.
INVESTIGATION ON THE BIOSORPTION OF MANGANESE USING TEA LEAVES AND TEA FIBERS (camellia sinensis) AS ADSORBENTS Etim, Emmanuel E.; Yakubu, Shedrach; Undie, David Akpanke; Shinggu, John Paul
Unesa Journal of Chemistry Vol. 13 No. 2 (2024): Vol 13 No 2 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

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Abstract

Heavy metal-containing liquid effluents pose a health and environmental risk due to the rapid industrialization of businesses like mining, petrochemicals, fertilizers, and pesticides. The adsorption of manganese from an aqueous solution utilizing biosorbents such as tea leaves and tea fibers is the subject of this study. The adsorption process was studied by varying the initial concentration, adsorption dosage, time, temperature, and pH of the adsorbents. The FTIR results confirmed the presence of -OH, -NH2, C=O providing binding sites in both tea leaves and fibers. The research uses Langmuir and Freundlich adsorption isotherms, with Freundlich the best fitting for tea fiber and Langmuir for tea leaves. Kinetic studies show second-order kinetics is better for both, confirming an endothermic biosorption process.
Eksplorasi Senyawa Alkaloid Carbazole Murraya microphylla sebagai Antikanker Inhibitor SIRT1 dan CDK9: Studi In Silico Raihan, Muhammad
Unesa Journal of Chemistry Vol. 13 No. 2 (2024): Vol 13 No 2 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

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Abstract

Cancer is currently a major health problem due to its significantly increasing number of deaths and prevalence, including breast cancer and cervical cancer. The development of new drugs is a major effort to overcome the risk of cancer. Natural compounds are the main source of medicinal compounds and are believed to have lower toxicity than synthetic drugs. This study aimed to reveal the anticancer activity of Murraya microphylla carbazole alkaloids as SIRT1 and CDK9 inhibitors in silico. Based on the results of molecular docking simulations, isomahanimbine and mahanimbine compounds were obtained as SIRT1 inhibitors, and girinimbine and koenigine compounds were obtained as CDK9 inhibitors with binding energy values lower than those of control inhibitors, indicating that these compounds have potential as anticancer agents. Prediction of the physicochemical properties, drug-likeness, and pharmacokinetics of the four compounds showed good results and fulfilled the criteria for medicinal compounds. Further research is needed to reveal the potential of these compounds as anticancer drugs.
PENGARUH PENAMBAHAN HIDROLISAT TEMPE TERHADAP KUALITAS FISIK DAN KIMIAWI DARI PENYEDAP RASA listyowati; tini, Rudiana Agus
Unesa Journal of Chemistry Vol. 13 No. 2 (2024): Vol 13 No 2 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

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Abstract

Flavoring is a food product additive that is used in food with the aim of adding flavor. The addition of flavorings can produce an umami taste in a dish. This research aims to make flavorings from shiitake mushrooms, beef and tempeh hydrolyzate. Tempeh protein is hydrolyzed with protease enzymes to produce tempeh hydrolyzate. The flavoring was tested proximately and the resulting water content was 7.3% - 11.53%, ash content 4.6 - 6.1% and protein content 33.44% - 43.55%. The research results indicated that formula 3 with the ratio (50 grams of shiitake mushrooms: 50 grams of beef: 20 grams of tempeh hydrolyzate) was preferred by respondents. Based on research, it shows that flavor enhancer from shiitake mushrooms, beef and tempeh hydrolyzate can be used as alternatives to synthetic flavorings.
Optimasi Respon Elektrokimia Gliserol Berbagai Tingkat pH Studi Voltametri Siklik Dengan Elektroda Kerja Amalgam (Cu/Hg) Rohman, Mohammad Chabibur; Pirim Setiarso
Unesa Journal of Chemistry Vol. 13 No. 3 (2024): Vol 13 No 3 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v13n3.p89-94

Abstract

Effect of pH on glycerol measurement using Cu/Hg amalgam working electrode by cyclic voltammetry method. The Cu/Hg amalgam electrode was chosen for its good conductivity and ease of surface cleaning, which prevents passivation due to compound buildup on the surface. In this study, the working electrode, comparison electrode, and auxiliary electrode were dipped into a glycerol solution with a pH variation between 5 and 8. The results show that the optimum pH for glycerol measurement is pH 7, with the highest reduction current response of -0.0142 A, indicating optimal glycerol ionization conditions. The decrease in current response above pH 7 is due to the interaction of glycerol with phosphate buffer which shifts the reaction equilibrium towards the formation of a by-product, hydroxypropenal. Therefore, the Cu/Hg amalgam electrode is effectively used as a working electrode for glycerol analysis, with the optimum pH at 7 for maximum results
Potensi Minuman Fermentasi Sari Kulit Singkong (Manihot esculenta) Dengan Kultur Starter Lactobacillus plantarum B1765 Sebagai Minuman Probiotik Maulah, Ismatul; Wikandari, Prima Retno
Unesa Journal of Chemistry Vol. 13 No. 2 (2024): Vol 13 No 2 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

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Abstract

This study aims to determine the effect of fermentation time on the microbiological (total lactic acid bacteria), chemical (pH, total titratable acid), and organoleptic (color, taste, and aroma) quality of probiotic beverage products from cassava peel juice (Manihot esculenta) with Lactobacillus plantarum B1765 starter culture which has been known to have potential as a probiotic candidate. Fermentation was carried out for 0, 12, 24, 36, 48, and 60 hours with 5% (v/v) L. plantarum B1765 starter culture at 37ºC. Total LAB count was determined using Total Plate Count method, Total Titratable Acid was determined using acid-base titration, and pH was determined using pH meter, organoleptic was tested using hedonic scale method. The results showed that the length of fermentation can increase the total lactic acid bacteria (LAB), Total Titrated Acid (TAT), and Total Flavonoids. in addition, it also affects the decrease in pH value. The results showed that 24 hours of fermentation had optimal results with total LAB reaching 3.33×107 CFU/mL CFU/mL, pH value 3.84±0.030, TAT value 0.202±0.007 and the average value of color liking 3.29; taste 3.55; and aroma 3.42 which showed liking criteria. Based on total LAB, pH and TAT, the quality of this product has met the Indonesian National Standard (SNI) for probiotic drinks, so it can be used as a probiotic drink.
ARTIKEL REVIEW : MANFAAT KANDUNGAN ALFA-MANGOSTIN DALAM KULIT BUAH MANGGIS Hidayanti, Restu
Unesa Journal of Chemistry Vol. 13 No. 3 (2024): Vol 13 No 3 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v13n3.p95-100

Abstract

Mangosteen, as one of the most popular tropical fruits in Indonesia, has many chemical compounds in its rind that are beneficial for treatment. Alpha-mangostin which is a major component has various activities such as antibacterial, anticancer, and antitumor. Mangosteen peel has the main compound, xanthone. Where there is an important content in inhibiting the growth of cancer cells, and anti-inflammation. In addition, mangosteen peel also has anti-inflammatory compounds such as flavonoids, vitamins B1, B2, C, saponins and tannins which have properties in accelerating healing. In fact, mangosteen peels are used medicinally by Asian populations in the treatment of skin infections and cholera since ancient times. The main and most abundant constituent found in Garcinia mangostana L, the xanthone class is α- mangostin. One of the main compounds in mangosteen pericarp is α- Mangostin. α- Mangostin shows good pharmacological activity as well as from in vivo or in vitro models. α- Mangostin shows strong potential to be used as a drug in the future. However, the application of α-Mangostin in the clinical field is still lacking.
Sintesis dan Karakterisasi Nanoenkapsulasi Sambiloto (Andrographis paniculata) Berbasis Karboksimetil Kitosan 'Aisy, Khulud Rihadatul; Cahyaningrum, Sari Edi
Unesa Journal of Chemistry Vol. 13 No. 3 (2024): Vol 13 No 3 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v13n3.p108-112

Abstract

This study aims to synthesize and characterize the nanoencapsulation of sambiloto (Andrographis paniculata) extract based on carboxymethyl chitosan to improve the bioavailability of bioactive compounds. The sambiloto extract was obtained by maceration using methanol and subsequently encapsulated with carboxymethyl chitosan using ultrasonication method. Characterization results using a Particle Size Analyzer showed a particle size of 492.19 nm with a polydispersity index (PDI) of 0.3464, thus meeting the criteria for good nanoparticles in drug delivery systems. The pH stability test showed that the encapsulated sambiloto had relatively good stability. This suggests that carboxymethyl chitosan-based nanoencapsulation has the potential to protect bioactive compounds in the digestive system.
Sintesis Enkapsulasi Ekstrak Kunyit (Cursuma longa. L) Berbasis Karboksimetil Kitosan sebagai Penghantaran Obat: indonesia Wahyudi, Ainaia Deaqiila; Cahyaningrum, Sari Edi
Unesa Journal of Chemistry Vol. 13 No. 3 (2024): Vol 13 No 3 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v13n3.p101-107

Abstract

Curcumin is the main bioactive compound in turmeric (Curcuma longa L.) with high antioxidant activity, yet its application is limited due to poor solubility and low stability under physiological conditions. This study aimed to synthesize and characterize curcumin-encapsulated nanoparticles based on carboxymethyl chitosan (Cur-NPs) as a more stable drug delivery system. The synthesis was performed using the sonication method, while characterization included particle size and polydispersity index (PDI) analysis via PSA dan pH stability testing. The results showed that Cur-NPs had a particle size of 281.3 nm and a PDI of 0.3897, indicating a uniform particle distribution. Cur-NPs exhibited greater stability than turmeric extract across various pH conditions (2-10). These findings demonstrate that curcumin encapsulation using CMC can enhance the stability and release efficiency of curcumin in biological systems.
PENGGUNAAN KITOSAN-POLIVINIL ALKOHOL (PVA)-KALSIUM KARBONAT SEBAGAI MATRIKS UREA SLOW-RELEASE FERTILIZER (SRF) Nanda Onky Stefani; Sari Edi Cahyaningrum
Unesa Journal of Chemistry Vol. 14 No. 1 (2025): Vol 14 No 1 (2025)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v14n1.p1-7

Abstract

Slow-release fertilizer (SRF) is a method used to improve the efficiency of nutrient absorption, particularly urea, which is essential for plants during the early growth stages. This study aims to develop and characterize SRF urea modified with chitosan–polyvinyl alcohol (PVA) incorporating various concentrations of calcium carbonate. The SRF urea was prepared in membrane form and characterized through swelling and porosity tests, as well as urea release analysis over 30 days using UV-Vis spectrophotometry. The results showed that increasing calcium carbonate concentration affected the SRF’s physical properties and urea release rate. The SRF urea formulation labeled C1 exhibited optimal characteristics, with a swelling capacity of 202,5% and porosity of 15,6%, indicating its ability to regulate water diffusion effectively. SRF urea C1 released 72% of its urea content over 30 days, which was higher than that of formulations C2 and C3, yet still maintained controlled-release behavior. Therefore, a calcium carbonate concentration of 0.01% is considered optimal for producing an SRF urea formulation with both high and controlled urea release, suitable for application as a chitosan–PVA-based slow-release fertilizer.

Page 9 of 11 | Total Record : 103

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