cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Evy Yunihastuti
Contact Email
redaksi.jurnalpenyakitdalam@ui.ac.id
Phone
-
Journal Mail Official
redaksi.jurnalpenyakitdalam@ui.ac.id
Editorial Address
Departemen Ilmu Penyakit Dalam, FKUI/RSCM Jln Diponegoro No.71, Jakarta. 10430
Location
Kota depok,
Jawa barat
INDONESIA
Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 414 Documents
 11   12   13   14   15 
Pseudoakalasia sebagai Manifestasi Awal Karsinoma Sel Skuamosa Kepala Leher Loho, Imelda Maria; Syibli, Ahmad; Fauzi, Achmad
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pada kasus-kasus yang langka, sekelompok gejala yang menyerupai akalasia dapat muncul sebagai akibat dari suatu penyebab ekstra esofageal dan disebut sebagai pseudoakalasia. Membedakan akalasia dengan pseudoakalasia merupakan sesuatu yang tidak mudah karena pemeriksaan klinis, radiologis, dan manometris, dapat memberikan hasil yang serupa. Berikut ini kami laporkan sebuah kasus pseudoakalasia yang mucul sebagai manifestasi awal karsinoma sel skuamosa kepala leher.
Evidence-based Medicine dalam Pelayanan Penyakit Dalam Subekti, Imam
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Perkembangan masalah di bidang kedokteran, tidak terkecuali di bidang Penyakit Dalam, mengharuskan seorang dokter yang berkecimpung di pelayanan penyakit dalam untuk terus mengembangkan diri. Ada dua aspek penting yang terkandung di dalam pengertian "mengembangkan diri". Pada satu sisi, seorang dokter harus secara aktif menelaah dan meneliti, diawali dengan membuat pertanyaan untuk masalah kedokteran dari fenomena yang ada di pelayanan kedokteran sehari-hari, membuat hipotesis untuk memberikan jawaban sementara terhadap pertanyaan, dan selanjutnya membuktikan kebenaran yang digagasnya.
Perubahan Kadar Fibrinogen Plasma dan Korelasinya dengan Perubahan Kadar hs-CRP dan Aktivitas Fibrinolisis pada Sindroma Koroner Akut Sudrajat, Dedy G.; Atmakusuma, Djumhana; Alwi, Idrus; Harimurti, Kuntjoro
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan: Peningkatan kadar fibrinogen yang menetap merupakan faktor risiko yang kuat untuk kejadian penyakit jantung koroner (PJK). Di sisi lain peningkatan fibrinogen plasma dapat merupakan respon fase akut. Pada kondisi ini peningkatan fibrinogen plasma bukan merupakan faktor risiko PJK. Penelitian ini bertujuan untuk mengetahui apakah kadar fibrinogen plasma meningkat pada fase akut dan tetap tinggi pada fase pasca akut dan mengetahui korelasi antara perubahan kadar fibrinogen plasma dengan perubahan aktivitas inflamasi dan fibrinolisis. Metode: Desain penelitian adalah studi prospektif dengan metode pengambilan sampel secara konsekutif. Pengambilan sampel fase akut untuk hs-CRP, aktivitas fibrinolisis, dan fibrinogen masing-masing diambil pada hari ke-2, 5, dan 6 pasca awitan sedangkan fase pasca akut diambil pada hari ke-13 pasca awitan. Fibrinogen diperiksa dengan metode Clauss, hs-CRP dengan metode ELISA, dan aktivitas fibrinolisis dengan metode ECLT manual. Analisis beda rerata dilakukan dengan uji t-berpasangan dengan alternatif uji wilcoxon. Analisis korelasi dengan uji Spearman. Hasil: Sampai akhir penelitian didapatkan 38 subyek sesuai kriteria inklusi dan eksklusi. Terdapat penurunan median kadar fibrinogen plasma pada fase pasca akut dibandingkan fase akut (415,5vs380,5mg/dL;p Simpulan: Pada sindroma koroner akut, perubahan aktivitas fibrinolisis dan inflamasi memiliki korelasi positif lemah terhadap perubahan kadar fibrinogen. Pada kelompok dengan hiperfibrinogenemia yang menetap kadar fibrinogen pasca akut masih dominan dipengaruhi aktivitas inflamasi yang masih cukup aktif.
Vaksin Influenza sebagai Modalitas Pencegahan Kejadian Rawat Inap Akibat Penyakit Kardiovaskular Rusdi, Lusiani; Adnan, Nurhayati; Suhardi, Kevin Fernando
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sensitisasi Alergen Makanan pada Pasien Kolitis Eosinofilik: Laporan Kasus Zagoto, Agnes Dina Irene Dorithy; Mulya, Deshinta Putri; Ratnasari, Neneng
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Eosinophilic colitis is a very rare disease that can occur in the bimodal population (neonates and young adults) with a prevalence was 2.1/100,000 in overall population and 2.3/100,000 in adults. However, only about 0.1% of cases were diagnosed from biopsy results obtained during colonoscopy. The lack of precise histological criteria for the quantity of eosinophils in the colon mucosa creates a distinct challenge in diagnosing eosinophilic colitis. Eosinophilia in the gastrointestinal tract can be mediated by IgE and non-IgE, but non-IgE tends to be dominant in adults. This report discusses about a case of a 64-year-old male with bloody diarrhea that has been occur for two years. The anamnesis revealed symptoms suggestive of eosinophilic colitis, including complaints of diarrhea with abdominal pain and weight loss. Laboratory tests revealed an increase in peripheral eosinophil count and elevated levels of IgE. A positive skin prick test supported the presence of food allergen sensitization. The endoscopy revealed signs of ulcerative colitis, but the biopsy showed evidence of eosinophilic colitis. Initially, the patient was treated for ulcerative colitis but did not show improvement. Following treatment for eosinophilic colitis, the patient’s clinical status showed improvement. Since eosinophilic colitis can be chronic and recur, an accurate diagnosis and proper management are crucial for achieving complete remission. Keywords: chronic diarrhea, eosinophilic colitis, food allergen sensitization, IgE, peripheral eosinophilia
Profilaksis Pasca Paparan Virus HIV pada Petugas Kesehatan Karjadi, Teguh Harjono
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Health workers (HCWs) are prone to get infected by HIV infection when carrying out their duties. The injuries can be caused by needle sticks, sharp objects (scalpels, lancets, or other) that have been exposed to body fluids or splashes of body fluids onto the body’s mucosa (eyes, nose, mouth) and non-intact skin have the potential to transmit the HIV infection. Post-exposure transmission due to contamination of body fluids to health workers can be prevented by providing post-exposure prophylaxis therapy. Post-exposure prophylaxis (PEP) is given as soon as possible and no later than 72 hours after exposure. Prophylaxis is given to HCWs who are significantly exposed using three antiretroviral drugs. In Indonesia, for adolescents and adults ≥ 10 years old, the main choice is Tenofovir (TDF) + Lamivudine (3TC) + Dolutegravir (DTG). Simultaneously with the administration of ARV drugs, counseling is also carried out regarding side effects of ARV, medication adherence, drug interactions, the possibility of seroconversion, and if necessary, management of anxiety that may arise. ARVs will be given for 28 days. After being given post-exposure prophylactic therapy, monitoring for side effects of ARV drugs must be carried out which are given in the 2nd and 4th week. Re-examination of HIV testing to see the effectiveness of treatment was carried out at 12 weeks and 6 months after exposure. Keywords: HIV infection, PEP of HIV
Pemberian Antibiotik Dini Berpengaruh terhadap Mortalitas COVID-19? Sofro, Muchlis Achsan Udji
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coronavirus disease 2019 (COVID-19) merupakan infeksi saluran napas yang diakibatkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data di seluruh dunia sampai akhir Juni 2022 menunjukkan bahwa COVID-19 telah menyebabkan 6,2 juta kematian dengan jumlah 530 juta kasus.
Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients Chen, Lie Khie; Nathanael, Jason; Shakinah, Sharifah; Pasaribu, Adeline; Sinto, Robert; Nainggolan, Leonard; Susilo, Adityo
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Patients with moderate and severe COVID-19 generally receive antibiotic therapy with consideration of the possibility of co-infection or secondary bacterial infection which clinically is difficult to distinguish from COVID-19 symptoms. Overuse of antibiotics can lead to an increased risk of bacterial resistance to antibiotics which is associated with poor outcomes in COVID-19 patients. This study aimed to assess the effect of early antibiotic administration on mortality in moderate and severe COVID-19 patients. Methods. An observational study with a retrospective cohort design was conducted at Dr. Cipto Mangunkusumo Hospital. Data were obtained from medical records of patients admitted from March to September 2020. Patients who received early antibiotics were defined as patients who received antibiotics hospital, 108 subjects were included in this study, 74 (68.5%) with moderate degrees and 34 (31.5%) with severe degrees. Early antibiotics were administered to 79 (73.1%) subjects with a median start time of one day. The results of the bivariate analysis did not find a significant effect of early antibiotic administration on mortality in moderate or severe COVID-19 patients (p=0.42). Subgroup analysis based on the degree of disease also found no significant results. Conclusion. There is no relationship between early antibiotic administration and mortality of moderate and severe COVID-19 patients.
Determinant Factors of Cognitive Frailty in Elderly Patients Santoso, Valencia; Rensa, Rensa
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Physical frailty and cognitive impairment have a strong relationship and there are differences in factors associated with cognitive frailty. This research aimed to determine the prevalence of cognitive frailty and identify factors associated with cognitive frailty in the elderly population in hospital polyclinic. Methods. A cross-sectional study with secondary data on patients aged ≥60 years in the Internal Medicine Polyclinic of Atma Jaya Hospital, Jakarta, from May 2020 to May 2021. The independent variables of this study were age, cardiovascular disease, type 2 diabetes mellitus, dyslipidemia, risk of malnutrition, risk of depression, and functional status. The alternative criteria by Won et al. were used to classify cognitive frailt. Bivariate analysis (chi-square test) and multivariate analysis (logistic regression) were performed using SPSS program. Results. There were 343 subjects with a median age of 66 years, 35% had cardiovascular disease, 5.2% had a high risk of malnutrition, 9.3% had depressive symptoms, 20.4% had a low functional status (ADL-Barthel index), 55.7% were diagnosed with type 2 diabetes mellitus, and 36.4% were diagnosed with dyslipidemia. The prevalence of subjects with cognitive frailty is 1.2% and 98.8% without cognitive frailty. The determinant factor of cognitive frailty is the presence of cardiovascular disease [OR 10.17 (95% CI 0.97-106.54); p=0.05]. Conclusions. Prevalence of cognitive frailty in elderly outpatients is 1.2%. The determinant factor of cognitive frailty is cardiovascular disease.
Effectiveness of Garlic Extract (Allium sativum) to Reduce Level of Malondialdehyde Serum and Improve Quality of Life in Patients with Chronic Hemodialysis: A Randomized Double-Blind Placebo-Controlled Trial Istiqomah, Amelia; Ali, Zulkhair; Saleh, Irsan
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Study reported that malondialdehyde (MDA) levels as an in vivo marker of oxidative stress were increased in patients undergoing hemodialysis. Antioxidants allicin compounds contained in garlic (Allium sativum) are known to have antioxidant activity by inducing antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and inhibiting prooxidant enzymes (nitric oxide synthase, xanthine, NADPH oxidase, and cyclooxygenase). This study aimed to investigate the effectiveness of Allium sativum to reduce level of MDA serum and improve quality of life in patients with chronic hemodialysis. Methods. This study was a crossover randomized double-blind placebo-controlled trial. The subjects were 40 chronic kidney disease (CKD) stage 5 patients with chronic hemodialysis (HD). Subjects were randomly divided into 2 groups, namely the group that received 1,000 mg of garlic extract per day (2 x 500 mg) for 6 weeks and the group that received a placebo, which was then carried out during a washing period for 2 weeks and then the two groups were crossover. Each group measured the levels of serum MDA before and after treatment, also fill in kidney disease quality of life (KDQOL) SF-36 questionnaire. Results. Out of 40 subjects, most of them were male (57.5%) with median of age of 48.6 (range 26-59) years. It was found that serum MDA levels before and after garlic extract administration were 2.423 (SD 0.236) nmol/l and 1.649 (SD 0.26) nmol/l (p<0,001) with a mean change of -0.782 (SD 0.735) nmol/l. Statistical analysis showed a significance difference of MDA serum between the two groups. There was significant improvement in quality of life before and after garlic extract administration from 57.81 (SD 16.95) to 67.62 (SD 13.61) with a mean change of 9.81 (SD 3.34). But there was no significant difference between quality of life and MDA serum. Conclusion. There is effectiveness of garlic extract to decrease serum MDA and improve the quality of life in patients with CKD stage 5 using chronic HD at Mohammad Hoesin Hospital, Palembang.

Page 13 of 42 | Total Record : 414

 11   12   13   14   15 

Filter by Year

2014 2025


Reset
Filter By Issues
All Issue Vol. 11, No. 2 Vol. 11, No. 1 Vol. 10, No. 4 Vol. 10, No. 3 Vol. 10, No. 2 Vol. 10, No. 1 Vol. 9, No. 4 Vol. 9, No. 3 Vol. 9, No. 2 Vol. 9, No. 1 Vol. 8, No. 4 Vol. 8, No. 3 Vol. 8, No. 2 Vol. 8, No. 1 Vol. 7, No. 4 Vol. 7, No. 3 Vol. 7, No. 2 Vol. 7, No. 1 Vol. 6, No. 4 Vol. 6, No. 3 Vol. 6, No. 2 Vol. 6, No. 1 Vol. 5, No. 4 Vol. 5, No. 3 Vol. 5, No. 2 Vol. 5, No. 1 Vol. 4, No. 4 Vol. 4, No. 3 Vol. 4, No. 2 Vol. 4, No. 1 Vol. 3, No. 4 Vol. 3, No. 3 Vol. 3, No. 2 Vol. 3, No. 1 Vol. 2, No. 4 Vol. 2, No. 3 Vol. 2, No. 2 Vol. 2, No. 1 Vol. 1, No. 2 Vol. 1, No. 1 More Issue