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INDONESIA
Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 414 Documents
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Correlation between Spiritual Aspect and Serum Interleukin-6Level in Chronic Hemodialysis Patients Hanida, Wika; Mudjaddid, E; Nasution, Habibah Hanum; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Introduction. Holistic approach in psychosomatic focus on spirituality factor and spiritual support is expected to improve services and psychological condition of the patients. Inflammatory response during hemodialisis procedure hence increased with the evidence of increasing level of serum interleukin-6 (IL-6). Further research is still needed to see the spiritual factors that can decrease the inflammatory factors. Methods. Cross sectional study on 51 chronic hemodialisis patients at RSUP. H. Adam Malik and RSU dr. Pirngadi Medan between July-August 2014. Serum IL-6 was measured using quantitative enzyme-linked immune sorbent assay (ELISA) methods. Blood samples and spiritual aspect assessment by handing out FACIT Sp-12 questionnaire to patients were taken in the morning, 30 minutes before hemodialisis. Results. Subscale meaning 10.67 (SB 2.66), peace 9.63 (SB 2.19) and faith 11.47 (SB 2.91). Median serum IL-6 level is 5,63 (1,48- 28,88) pg/mL. Median FACIT Sp-12 is 30,00 (18-48). Correlation test between serum IL-6 level and spiritual aspect have shown statistically weak negative correlation (correlation coefficient -0,330, p=0.018). Conclusions: spirituality level in chronic hemodialisis patients are higher. Weak negative correlation between serum IL-6 level and spiritual level on chronic hemodialisis patients was found in this study.
Right Ventricular Systolic and Diastolic Function Profile inPatient with Stable Chronic Obstructive Pulmonary Disease Oktavia, Dina; Nasution, Sally Aman; ZN, Anna Uyainah; Rumende, C Martin
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Introduction. Right ventricular dysfunction is one of the common complication of chronic obstructive pulmonary disease (COPD). Right ventricular assessment is importance, since it related with exercise intolerance and poor prognosis. Methods. Thirty stable COPD men (mean age: 65 ± 6 yr) underwent spirometry. In addition to conventional echocardiographic parameters, TAPSE, right heart chambers, and trans tricuspid inflow were determined. Results. The mean value of FEV1 was 28 ± 8% of the predicted value. There was no subject with mild airflow limitation, 57% subjects were with very severe airflow obstruction. All of pulmonary function test showed mixed restrictive-obstructive pattern. Mean of right chamber was in normal limit. Forty percent of the patients suffered right ventricular diastolic dysfunction. Means of TAPSE was 16.96 ± 96 mm. Sixty percent of the patients suffered right ventricular systolic dysfunction. There was no significant difference in TAPSE between groups with moderate-severe flow obstruction and very severe airflow obstruction. There was no significant correlation between FEV1 % prediction and TAPSE, so the cut-off value between the two variables cannot be determined. Conclusions. The proportion of right ventricular systolic dysfunction was 60% and diastolic dysfunction was 40%. There was no correlation between FEV1 % prediction and TAPSE. The cut-off value between the two variable in stable COPD patients cannot be determined.
Association of Glucose Variability in the First 72 Hours of ICUCare with ICU Mortality in Critically-III Patients Yasmine, Elizabeth; Mansjoer, Arif; Purnamasari, Dyah; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Introduction. Hyperglycemia during hospitalization is a risk factor that can be managed in order to reduce mortality. Inspite of hyperglycemia, glucose variability also brings negative outcome to cells. Studies about glucose variability effect to mortality had been studied using many variables of glucose variability. Methods. Retrospective cohort study is done to 280 critical ill patient in ICU and HCU in Cipto Mangunkusumo Hospital who admitted to critical care between January 2012-August 2013. MAG change and glucose standard deviation are divided into 4 quartiles. Relationship between MAG change and glucose standard deviation are analyzed using Chi Square test. To control the confounders (MSOFA score, Charlson comorbidities index, hypoglycemia, and hyperglycemia), logistic regression is done Results. Median of MAG change is 3.3 mg/dL/hour and median of glucose standard deviation is 37.63 mg/dL. Mortality proportion is higher in upper quartile of MAG change and glucose standard deviation compared to lower quartile. OR of upper quartile MAG change to ICU mortality is OR 4.26 (95% CI 1.98-9.15) and OR of upper quartile glucose standard deviation to ICU mortality is OR 2.78 (95% CI 1.35-5.71). These results are adjusted to MSOFA score, hypoglycemia, and hyperglycemia. In logistic regression test, fully adjusted OR are 3.34 (95% CI 1.08-10.31) and 0.90 (95% CI 0.28-2.88) for MAG change and glucose standard deviation, respectively. Conclusions. Mortality proportion of upper quartile of MAG change (>8.1 mg/dL/hour) is higher than lower quartile (59 mg/dL) is higher than lower quartile(<22.7 mg/dL), but the difference is not statistically significant.
The Difference in Prevalence of Helicobacter pylori Infectionbetween Chinese and Dayak Ethnics with Dyspepsia Syndrome Uwan, Willy Brodus; Syam, Ari Fahrial; Lesmana, C. Rinaldi A.; Rumende, C Martin
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Introduction. Helicobacter pylori (H. pylori) infection risk is associated with many factors related to host-agent-environment. Ethnicity is one of the host factors which was the most studied factor overseas. The prevalence of H. pylori infection was found higher in certain ethnic such among Chinese. Based on migration and transmission theory, it was suspected that H. pylori infection was transmitted by people migrating from areas with a high prevalence of infection to the destination area. Chinese in West Borneo are originated from South China region where the prevalence of H. pylori infection is high. It is estimated that there are differences in the prevalence of H. pylori infection among Chinese compared to the native people of West Borneo, the Dayaknese. Methods. This was a cross-sectional study to determine the differences in the prevalence of H. pylori infection. The study was conducted at St. Antonius General Hospital Pontianak from December 2014 to June 2015 with consecutive sampling method. H. pylori infection prevalence is presented in percentage numbers, while the epidemiological characteristics and endoscopic finding differences among Chinese and Dayaknese were analyzed by bivariate analysis using the chi-square with significance value (p) = 0.05. Results. From a total of 203 subjects in this study, consisted of 102 Chinese subjects and 101 Dayaknese subjects, the prevalence of H. pylori infection was 40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0% and 33.7%, respectively. There is no difference in the epidemiological characteristics and endoscopic findings in both ethnic groups. Conclusions. The prevalence of H. pylori infection among the Chinese (48.0%) is higher than among Dayaknese (33.7%). There is no difference in the epidemiological characteristics and endoscopic findings among both ethnic groups.
Gastrointestinal Bleeding as a Manifestation of IntestinalTuberculosis in Leprosy Patients with Reversal Reaction andHistory of Long-Term Steroid Therapy Gebrina, Meutia; Nursyirwan, Saskia Aziza; Soewondo, Pradana; Fauzi, Achmad; Renaldi, Kaka
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Intestinal tuberculosis is difficult to be diagnosed. Signs and symptoms usually are not specific, and the results of diagnostic tools are frequently negative. One of the unusual symptoms of intestinal tuberculosis is gastrointestinal bleeding, which should increase the awareness of clinical practitioners.
Elderly Mistreatment: Risk Factors and Therapy Madina, Ummi Ulfah; Dwimartutie, Noto
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Elderly mistreatment is a preventable serious health problem that lowering older adults quality of life. Elderly mistreatment can be done by the caregiver or even the patient himself, regardless the intention. Meanwhile, defining an elderly mistreatment is still a challenge due to varied risk factors and cultural differences in each country. Those conditions result in challenges in identifying and managing elderly mistreatment. This review will also discuss screening modalities to identify elderly who is at risk or currently abused to prevent and manage elderly mistreatment properly.
Immunohistochemistry Profile of Breast Cancer Patients that Get Anthracyclin–Based Chemotherapy in RSUD Kota Bogor Robinson, Marthino; Atmakusumah, Tubagus Djumhana; Irawan, Cosphiadi; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 4
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Introduction. Breast cancer is the most prominent cancer and causing death in women. Treatment of breast cancer requires immunohistochemistry (IHC) to determine prognostic and predictive and imaging tests to determine staging. However, currently in Indonesia only 17 hospital can conduct IHC test. RSUD Kota Bogor like other Type B Hospital have no IHC test facilities. To fullfil that test, its important to refer patient to referal hospital. Because of limitation there are patients who did not do IHC test and continued get anthracycline chemotherapy. The objective of this research is to find out immunohistochemistry profile of breast cancer patients who received anthracycline-based chemotherapy in RSUD Kota Bogor. Methods. A descriptive retrospective study by collecting the breast cancer patients medical records was done since January 2014 to December 2017 in RSUD Kota Bogor. Results. Total of 174 subjects were include in this study which consist of 84 subjects (48%) with IHC test and 90 subjects (52%) without IHC test. The immunohistochemistry profile of breast cancer patients who received anthracycline-based chemotherapy since January 2014 to December 2017 in RSUD Kota Bogor were luminal type (64%), HER2-enriched (18%), and TNBC (18%). Conclusion. Luminal type is the most molecular subtypes in breast cancer patients who received anthracycline-based chemotherapy in RSUD Kota Bogor. However, because of limitation, since January 2014 to December 2017 only 48% of breast cancer patient that get anthracyclin chemotherapy who got IHC test in RSUD Kota Bogor.
Characteristics of the Indonesian Pilgrims Mortality due to Cardiovascular Disease Sakti, Ali; Alwi, Idrus; Muhadi, Muhadi; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 4
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Introduction. Cardiovascular disease is one of the health problems in Indonesian pilgrims and has become the main cause of death for pilgrims in the past 3 years. Most of them are considered high risk for cardiovascular disease. Some of those risk factors are predicted to have strong association with the pilgrims mortality rate. This study is meant to seek for risk factor associated with the pilgrims mortality rate. Methods. Observational study method of the Indonesian pilgrims in 2017 was conducted to assess the characteristics of Indonesian pilgrims who follow the hajj in 2017 as well as the characteristics of pilgrims who died from cardiovascular disease. Result. The proportion of mortality from cardiovascular disease was 49.2% of all deaths in the Indonesian hajj pilgrims in 2017. Generally, pilgrims are in the category of high risk. Pilgrims who died from cardiovascular disease are mostly aged over 60 years (76.7%) with cardiovascular risk factors including hypertension (53.4%) and obesity (37.3%), and pilgrims with the final wave departure time (53%). Conclusios. The proportion of deaths from cardiovascular disease in the Indonesian pilgrims in 2017 is 49.2%. The characteristics of pilgrims who died with the cause of cardiovascular disease are generally age more than 60 years, pilgrims with hypertension, obesity, and final departure time.
The Role of Paternal History of Type 2 Diabetes Mellitus on Prediabetes Status among The Offspring of Type 2 Diabetes Mellitus Patients Ekaputri, Maulidia; Citrawijaya, Henrico; Sudirman, Adrian Reynaldo; Jonathan, Kevin; Murti, Radityo Alu; Balqis, Ayu Putri; Purnamasari, Dyah
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 4
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Association of Comprehensive Geriatric Assessments Component and Sarcopenia in Elderly Wardhana, Diar Meitha; Widajanti, Novira; Ichwani, Jusri
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 4
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Introduction. Sarcopenia is defined as a declined in skeletal muscle mass and strength along with its function may causes an increase in hospitalization, mortality, and health burden. Multi-factorial conditions of the aging process may cause sarcopenia. To assess those multi-factorial conditions in the elderly, a comprehensive geriatric assessment (CGA) method should be used, in which comprises of socio-demographic, medical, psychological, and functional domains. This research aims to analyze the components of CGA, including age, gender, nutritional status, mental status, and functional status as factors associated to sarcopenia in the elderly community in Surabaya. Methods. This community research was a cross sectional designed analytic observational study. The subjects were all elderly people visiting five chosen Posyandu, an integrated health service post, that meet the inclusion and exclusion criteria. A total of 308 data were collected and then bivariate and multivariate analyzes were performed to determine the components related to sarcopenia. Bivariate analysis was performed on components of age, sex, nutritional status, comorbidities, cognitive status, mental status, and functional status. Variables included in multivariate analysis were age, sex, nutritional status, comorbidities, cognitive status, and functional status. Results. The subjects were dominated by elderly females (74.7%). The median of age were 63 years (range 60-100 years). After performing multivariate analysis, three variables had the association to sarcopenia which were nutritional status assessed by MNA score ≤23.5 (OR 3.61, 95% CI 2.11–6.19), age ≥70 years old (OR 2.82, 95% CI 1.58–5.04), and male (OR 1,83, 95% CI 1,04–3,24). An area under curve (AUC) of 66.2% was obtained from the prediction model. Conclusion. The method of CGA has the power to predict sarcopenia of the elderly in the community as much as 66.2%

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