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INDONESIA
Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 414 Documents
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Vaksinasi pada Lansia Rengganis, Iris
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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The Patterns of Primary Cotrimoxazole Prophylaxis in Adult HIVPatients in HIV Integrated Clinic Cipto Mangunkusumo HospitalJakarta in 2004-2013 Mastini, Ken Ayu; Djoerban, Zubair; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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Introduction. Low rate use of cotrimoxazole which is a standard of primary prevention against toxoplasmosis infection and Pneumocystis jirovecii pneumonia (PCP) in patients with CD4 <200 cell>/mm3 was found. This study aims to describe prescription pattern of cotrimoxazole primary prophylaxis in adult HIV patients in RSCM. Methods. A cohort retrospective study was conducted in HIV Integrated Clinic Cipto Mangunkusumo Hospital patients from 2004 to 2013. Individuals were eligible for this study if they were ≥18 years old and had indication of primary cotrimoxazole prophylaxis. Variable analyzed in this study were initiation, discontinuation, dosage, duration, duration percentage, and adverse events of primary cotrimoxazole prophylaxis. Results. A total of 3.818 patients had indication of primary cotrimoxazole prophylaxis. Initiation of primary cotrimoxazole prophylaxis was performed in 83% patients who met indication. Total od 99,8% patients used appropriate dose of cotrimoxazole. Frequent adverse events were increasing hepatic transaminase (38,1%), leucopenia (16,9%), anemia (16,5%), nausea (15,4%), vomiting (7,8%), thrombocytopenia (7,4%), and hypersensitivity (5,3%). Adverse event causing discontinuation were hypersensitivity (100%), anemia (2,4%), increasing hepatic transaminase (2,1%), vomiting (0,8%), and leucopenia (0,6%). Inappropriate discontinuation of cotrimoxazole was 61,6% with median duration percentage was 87,5% (IQR 39) and median of duration was 20 months (IQR 20). Duration in patients with CD4 ≤100 cell/mm3 and >100 cell/mm3 was 21 months (IQR 22) and 12,5 months (IQR 14,75) p <0,001. Conclusion. Although initiation of primary cotrimoxazole prophylaxis was done in 83% adult HIV patients with appropriate dosage, it was found that 61,6% discontinuation was inappropriate according with guideline.
Antiphospholipid Antibody Profile in HIV/AIDS Patients Pandjaitan, Inolyn; Sukmana, Nanang; Effendy, Shufrie
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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Introduction. Through the process of molecular mimicry, human immunodeficiency virus (HIV) infection can increase the concentration of antiphospholipid antibody (APA) which has possible association with thrombosis. The molecular mimicry in this HIV/AIDS patients is influenced by several factors, such as immunocompromised condition, the use of antitretroviral (ARV) therapy, hepatitis B and C coinfection, use of other drugs, and history of intravenous drug user (IDU). We conducted this study to determine the profile and prevalence of antiphospholipid antibody in patients with HIV/ AIDS in Dr. Cipto Mangunkusumo General Hospital. Further, we explored the relationship between APA in HIV/AIDS patients with the factors mentioned before. Methods. This cross sectional study was done on HIV/AIDS outpatient at AIDS Working Group Clinic at Dr. Cipto Mangunkusumo General Hospital. We assessed the patients by history taking and measured their level of antibody anticardiolipin (ACA) dan Anti β2 glycoprotein I (anti-β2 GP1). Subjects were selected using simple random sampling. Descriptive data regarding the characteristics of the subjects and the proportions of APA were presented in numbers and percentages. The bivariate analysis between APA with the history of injecting drug use, the absolute CD4 lymphocyte count, antiretroviral therapy, and chronic hepatitis coinfection was performed using Chi-Square test and Fisher test. Results. APA examination results showed 27 (29,3%) patients were positive for ACA IgM, 77 (83,7%) patients were positive for ACA IgG, 61 (66,3%) patients were positive for anti β2 GP1 IgM, and 7 (7,6%) pateints were positive for anti β2 GP1 IgG. There is significant association between APA and the history of intravenous drug user (IDU) and ARV therapy. No association was observed between CD4 lymphocyte count and hepatitis coinfection with prevalence of APA in patients with HIV/AIDS patient. Conclusion. Proportion of anticardiolipin antibody IgG is higher than IgM (83,7% vs 29,3%), while the proportion of anti-β2 GP1 IgM is higher than IgG (66,3% vs 7,6%).
Association between Disease Activity and Depression inRheumatoid Arthritis Patients Mudjaddid, E; Puspitasari, Myra; Setyohadi, Bambang
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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Introduction. Rheumatoid Arthritis (RA) is a chronic, systemic disease that cause synovialinflammation and progressive destruction to cartilages and deformities. Prevalence of depressionin RA patients is 20 to 30%. Disease activity is considered to have association with depression. This study aims to identify the prevalence of depression in RA patients and the associationbetween disease activity index and depression in RA patients. Methods. A cross-sectional study of 145 RA patients that fulfilled the inclusion criteria was conducted in Rheumatology Outpatient Clinic at Cipto Mangunkusumo Hospital Jakarta from January to March 2017.Evaluation of Disease Activity Score - 28 (DAS 28) and Back Depression Inventory (BDI) was done to the patients. Statistical analysis was performed using SPSS version 20. Categorical variables were compared using chi-square test. Results. A total of 145 subjects were included in this study and most of them were female (90.3%). Median age of subjects was 55 years (range 19-83 years). Forty five subject (31%) were identified having psychosocial stressor. The proportion of depression in RA patients was 35.9% (95% CI 30-42%). Based on Disease Severity Score, it was found that subject with mild, moderate, and severe score were 24 (82.8%), 52 (66.7%), and 4 (23.5%), respectively. There was significant association between disease activity with depressionin rheumatoid arthritis patient (p= 0.001).
Diagnosis and Treatment of Pneumocystis Carinii Pneumonia (PCP)/Pneumocystis Jirovecii Pneumonia in HIV patient: A Case Report Agustina, Dewi Rizki; Efiyanti, Christy; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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Pneumocystis carinii pneumonia (PCP) or pneumocystis jirovecii pneumonia is an opportunistic infection that can occur in immunocompromised patients. In patients with HIV, PCP is the most common opportunistic infection especially in patients with CD4 cell counts less than 200 cell /ul. To diagnose a PCP is very difficult because symptoms, blood tests, and thoracic radiography are not pathognomonic for PCP. However, untreated PCP is almost always fatal. Trimethroprimsulfamethoxazole (TMX-SMX) orally or intravenously for 21 days is the drug of choice for managing PCP with or without HIV. This article discusses a case with patients with symptoms of dyspneu, unproductive cough, diagnosed with PCP and finally improvement with TMX-SMX therapy
Cardiotoxicity Complication of Radiotherapy Wisman, Beta Agustia; Nasution, Sally Aman; Panggabean, Marulam M
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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Radiation is an important modality in the management of malignancy. Some cases of malignancy requiring radiotherapy in the chest include breast cancer, Hodgkin's lymphoma, or lung cancer.Cardiotoxicity due to radiotherapy can occur within 3 to 29 years after radiotherapy, mostly in the second or third decade after therapy. Some cardiovascular complications resulting from radiotherapy may affect pericardial, myocardial, vascular, heart valves and conduction disturbances. Symptomatic cardiotoxicity may occurs 10% in patients undergoing radiotherapy in the chest area. It is important for clinicians to understand the cardiotoxicity of radiotherapy for educational purposes, therapeutic and dosing considerations, treatment monitoring and early detection. Early detection and post-radiation monitoring have an important role to reduce morbidity and mortality due to cardiovascular disease after radiotherapy and comprehensive management is necessary
Apakah Hemodialisis Tiga Kali Seminggu Lebih Baik? Nugroho, Pringgodigdo
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3
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Reliability and Validity Test Of Indonesian Version Short Form12 Quality of Life Questionnaire in Rheumatoid Arthritis Patient Falah, Nabil Mubtadi; Putranto, Rudi; Setyohadi, Bambang
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3
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Introduction. Rheumatoid Arthritis is a chronic disease requiring a long-term medication affecting quality of life. Short Form 12 is a generic questionnaire to assess patients quality of life and has been validated in England. This study was designed to test reliability and validity of Indonesian version of SF-12 questionnaire. Methods. Sixty-five patients with clinically diagnosed RA using ACR/EULAR criterion were interviewed using Short Form 36 and Short Form 12 questionnaire. Validity was assessed with construct validity and external validity, while reliability tested with internal consistency and test-retest method. Results. Short-Form 12 (Indonesian Version) did not proved having a good validity, as it have a poor correlation between RE and MH domain in SF-36 and SF-12. Indonesian version of SF-12 shown a poor internal consistency (Cronbach Alpha: 0.561- 0.754) but a good test and retest reliability ( intraclass correlation coefficient: 0.844-0.980, p <0,05) Conclusions. Indonesian version SF-12 is not reliable nor valid to evaluate quality of life in RA patients.
Validity and Reability Test of Indonesian Version of World HealthOrganization Quality of Life-HIV BREF Questionnaire to MeasureThe Quality of Life Patients with HIV/AIDS Muhammad, Nanda N.; Shatri, Hamzah; Djoerban, Zubairi
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3
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Introduction. Health-related quality of life among HIV patients can be used as one of several indicators of successful therapy. WHOQOL-HIV BREF questionnaire is one of the instruments used to assess the patients’ quality of life that has been used in many countries, but never been tested for its validity and reliability in Indonesia. This study aims to determine the validity and reliability of the questionnaire WHOQOL-HIV BREF in bahasa Indonesia as a tool for measuring the quality of life of HIV patients. Methods. A cross-sectional study was conducted in HIV Integrated Service Unit Cipto Mangunkusumo General Hospital (RSCM) Jakarta in November 2016 with consecutive sampling method. The study was conducted in two phases: first phase for the language and cultural adaptation process and second phase to test the validity and reliability of the questionnaire. Results. Fifty six respondents filled the questionnaire, 69.6% of them were male. Using a multi-trait scaling analysis, correlation coefficient value had a high correlation with the total score domain. This meant that it had a good validation. Correlation between questionnaire domain WHOQOL-HIV BREF and SF-36 questionnaire domain obtained 6 significant domains that shown strong correlation coefficient (r = 0.60 to 0.79; p <0.005). Reliability of the questionnaire was assessed by intraclass correlation coefficient of each domain, which was range from 0.401 to 0.484 with Cronbach Alpha 0.513 to 0.798 . Conclusions. The questionnaire WHOQOL-HIV BREF in the Indonesian language is valid and reliable.
Prevalence of Noncompliance of Control Visits in HypertensivePatients Treated at Primary Referral Hospitals and Related Factors Darnindro, Nikko; Sarwono, Johannes
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3
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Introduction. According to WHO, hypertension is associated with 7.5 million deaths worldwide or 12.8% of all deaths. Meanwhile, based on Riskesdas 2013 in Indonesia, hypertension is still a major health problem with a prevalence of 26.5%. Noncompliance is a major cause of treatment failure of hypertension and risk factors for cardiovascular comorbidity. No previous research has been found that examines patient control compliance in the suburban community. This study aims to analyze the prevalence of patients who did not control after hypertension treatment in primary referral hospitals Methods. This study was a retrospective study, by tracking medical records in patients treated between October and December 2015. Results. A total of 80 hypertensive patients participated in the study (55 were females). The mean age was 57.5 ± 11 years, and 22,5% had diabetes mellitus. Mean systolic pressure was 161± 19 mmHg, diastolic pressure was 96 ± 10 mmHg. The majority of the patients had 2nd degree hypertension according to ESC 2013. Sixty percent of patient was given monotherapy and the most frequently prescribed drugs were calcium channel blockers (CCB) (70.0%). The prevalence of loss-to-follow up patient was 63,8% (51/80). Respondents with mono-therapy, without comorbidities, and admission from emergency department were more often loss-to-follow up than those with combination therapy (OR 10.3; 95%CI 3.5 – 30.1), with comorbidities (OR 4,3; 95%CI 1.6 – 11.4), and admission from outpatient clinic (OR 14.6; 95%CI 4.8 – 44.6) although the comorbidities variable was not significant in multivariate analysis. Conclusion. The prevalence of noncompliance of control is still high. Further research is needed to determine other etiological factors.

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