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Journal of Pharmaceutical and Sciences.

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Published by Universitas Tjut Nyak Dhien

ISSN : - EISSN : 26563088 DOI : https://doi.org/10.36490/journal-jps.com

Core Subject : Health, Science, Agriculture, Engineering,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 68 Documents

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Search results for , issue "JPS Volume 6 Nomor 2 (2023)" : 68 Documents clear

Formulasi sediaan garam mandi dengan penambahan pewarna alami kopigmentasi kesumba keling (Bixa orellana L.) dan angkak merah Salman Salman; Agustina Magdalena; Sudewi Sudewi; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Annato seeds and red yeast rice contain carotenoids and anthocyanins as natural dyes so that they can replace synthetic dyes. This study aims to determine the copigmentation of annatto seeds and red yeast rice in the form of ethanol extract which can be formulated as a natural dye into salt bath preparations. Methods; Annatto seeds and red yeast rice were macerated using 96% ethanol. Making formulations in concentrations of 3%, 6% and 9%. Then the preparation evaluation test was carried out which included the pH test, water content test, dissolution time test, moisture test and irritation test. Result; The yield of annatto seeds and red yeast rice was 8.65% and 11.19%, respectively. The preparation of copigmented bath salts of annatto seeds ethanol extract with red yeast rice is a preparation that has a pH range of 7.4-7.5, with a dissolving time of under 5 minutes. The preparation of copigmented bath salts with the ethanol extract of annatto seeds and red yeast rice with a concentration of 6% (F2) is a preparation containing a water content of 13.5% and a humidity of 58.8% including the "moist" category. the results of testing on volunteers showed that salt bath from copigmentation of annatto seeds and red yeast rice did not cause irritation

Formulasi Dan Uji Efektivitas Sediaan Salep Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) Terhadap Penyembuhan Luka Bakar Pada Marmut Jantan (Cavia porcellus) Muharni Saputri; Yessi Febriani; Olyvia putri Olyvia putri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Scar tissue formation due to infectious burns causes delayed maturation of the epidermis. Sintrong contains flavonoids, alkaloids, glycosides, saponins, tannins, and steroids which have anti-inflammatory and antioxidant functions and can protect the body from the harmful effects of free radicals. Preparations with good titration and long exposure times are needed to treat burn problems. This study aims to determine the process of making sintrong leaf ointment (Crassocephalum crepidiodes (Benth.) S.Moore) and the effect of treating burns from sintrong leaf extract in an ointment preparation that has been tested on male guinea pigs (Cavia porcellus). Methods; In this study, test methods were used by means of simplicia preparation, characterization, test phytochemical screening, extraction, formulation and adjustment of ointment preparations to concentrations of 0.5%, 1% and 1.5%, as well as evaluation of ointment tests which included stability tests, sensory tests, homogeneity tests,adhesion, spreadability, pH test, irritation test and efficacy test of ointment preparations. The results obtained from the characteristic examination indicate that the simplicia of the sintrong leaf has fulfilled the requirements of the characteristic test for simplicia. Result; The results of the phytochemical test showed that the positive sintrong leaves contained alkaloids, flavonoids, glycosides, saponins, tannins and triterpenes or steroids. The results of the evaluation of the ethanol extract of sintrong leaf ointment for stable results. The best formulation is formula 3 with a concentration of 1.5% with a wound healing diameter of 0.13 cm on the 21st day

Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S. Moore) Terhadap Tikus Putih Jantan Yang Diinduksi Aloksan Muharni Saputri; Debi Sanura Boru perangin angin; Salmah Handayani Lubis
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Diabetes is a disease that occurs over a long period of time caused by the pancreas not being able to produce insulin optimally or the body not using insulin effectively. The administration of antidiabetic drugs in the form of insulin and oral is the treatment for diabetes. However, because the price is expensive for the middle to lower class, the treatment of sintrong leaf medicinal plants (Crasocephalum crepidioides (Benth.) S. Moore m mm) was developed. The purpose of this study was to determine the effectiveness of ethanol extract of sintrong leaves as an antidiabetic and able to reduce blood sugar levels (BSL) from fasting male white rats induced by alloxan. Methods; The stages of this study include plant identification, preparation of dry powder simplisia, characterization of simplisia, screening of secondary metabolite compounds (phytochemistry), extraction of dry simplisia powder of sintrong leaves, and testing of antidiabetic activity using 25 rats divided into 5 groups, the negative control group (CMC-Na), the positive control group (metformin), the test group of ethanol extract of sintrong leaves at a dose of 75 mg / kgbw, 150 mg / kgbw, and 300 mg / kgbw. As a test group, the administration of extracts to rats was given orally and then the BSL was measured. Blood sugar was determined at the beginning of fasting, day 3, 6, 9, 12, 15. Blood sugar of each group was statistically analyzed by one-way ANOVA method. Results; Based on the test results from each test group, the ethanol extract of sintrong leaves showed that the ethanol extract of sintrong leaves as antidiabetic activity that can reduce fasting BSL in male rats with an effective dose of 150 mg/kgbb with BSL obtained 89.40 mg/dL on day 15

Formulasi Sediaan Lipstik Menggunakan Pewarna Alami Kopigmentasi Biji Kesumba Keling (Bixa orellana L.) Dengan Angkak Merah Sebagai Pewarna Salman Salman; Muhammad Iskandar; Sudewi Sudewi; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; appearance is the most common thing to pay attention to, especially among women. Cosmetics are preparations that can improve appearance, one of which is lipstick. Lipstick has the main components, namely wax, oil and dye. One of the natural dyes that can be used as cosmetic dyes are annatto (Bixa orellana L.) and red yeast rice seeds. However, the use of natural dyes in cosmetics has an unstable color. The purpose of this study was to stabilize the dye from annatto (Bixa orellana L.) with red yeast rice seeds using the copigmentation method. Methods; in this study, a maceration process was carried out to obtain extracts from annatto (Bixa orellana L.) and red yeast rice seeds with a ratio of 1:10 (w/v). Then mixed with the thick extract of annatto (Bixa orellana L.) with red yeast rice as a coloring agent, formulated in a ratio of 1:1, 1:2, 2:1 and 2:2. Then the physical quality test of the lipstick preparation was carried out which included homogeneity test, melting point test, lipstick strength test, stability test, smear test, and irritation test. Result; the results showed that the Annatto (Bixa orellana L.) with red yeast rice in the form of copigmentation can be formulated into lipstick preparations with poor homogeneity results. All lipstick preparations meet the requirements of the melting point test, strength test, stability test, smear test, irritation test. The formula with a ratio of 1:2 (F2) is the most preferred preparation by volunteers because it has a good color, smell and texture.

Formulasi dan Uji Stabilitas Emulgel Ekstrak Etanol Bunga Telang (Clitoria ternatea L) Sebagai Lotion Annisa Fatmawati; Geby Ariskha; Anggraini Putri Rusdiana Dewi; Ika Ristia Rahman; Tri Yanuarto
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cosmetic preparations derived from natural ingredients have the potential to become self-sufficient active raw materials with antioxidant activity. Natural ingredients provide a source of antioxidants, which can capture free radicals and prevent premature aging. Butterfly pea flower extract (Clitorea ternatea L) has antioxidant, antibacterial, and anti-fungal activity. Making Emulgel preparations with the active ingredient of butterfly pea flower extract aims to increase the comfort and effectiveness of topical use as a cosmetic. Butterfly pea flower extraction was carried out by soaking the butterfly pea powder using 70% ethanol (1:5). Determination of total flavonoid content using AlCl3 and potassium acetate reagents with the Visible Spectrophotometry method. Emulgel extract of butterfly pea flower was prepared by varying the concentration of the extract (0.5%, 1.0%, and 2.0% w/w) and then mixed in an emulgel base using ultra turrax for 10 minutes. Furthermore, the Emulgel was tested to evaluate its physical properties and storage stability at room temperature on day 0 and day 28. Evaluation includes organoleptic observations and pH. The total content of total flavonoids in the ethanol extract of butterfly pea flowers was 5.74 ± 0.32 mgEQ. Formula III (2% EEBT) is the best formula based on organoleptic, pH, adhesion, spreadability, and room temperature stability tests

Angka Lempeng Total Dan Cemaran Bakteri Pada Daging Domba di pasar Tradisional Kampung Lalang Erika Triayu; Kurniawan Sinaga; Alfath Rusdhi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Meat is an important food ingredient in meeting nutritional needs. The purpose of this study was to detect total plate count and bacterial contamination in lamb meat. The research method used in this research is descriptive method, because this research describes the characteristics of a population or a phenomenon that is the object of research that is experimental. Observational data were analyzed using a descriptive method of 6 samples of lamb meat obtained from the traditional market in Kampung Lalang and found Escherichia coli and Salmonella sp. The highest TPC analysis values were found in traders 2 and 3 samples 2, namely 6.45x106 cfu/g and 7.05x106 cfu/g and the lowest amount of contamination was found in traders 1 sample 2, namely 4.5x105 cfu/g. In accordance with the limit for Escherichia coli 1x 101 colonies/gram and the limit for Salmonella sp negative/25 gram. The results showed that 95% of the lamb meat samples were contaminated with Escherichia coli and Salmonella sp. This shows that the lamb meat sold in Kampung Lalalang traditional markets does not meet the Indonesian National Standard (SNI) or is unfit for consumption.

Deteksi Bakteri Patogen Pada Daging Ayam Di Pasar Tradisional Hamparan Perak Nuraini Sihotang; Kurniawan Sinaga; Alfath Rusdhi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Chicken meat is a source of animal protein for humans. The aim of this study was to detect pathogenic bacteria in chicken meat sold at the Silver Plain traditional market. The method used in this study is descriptive because research that describes the characteristics of a population or a phenomenon that is the object of research is trial and error. From the observational data analyzed descriptively as many as 10 samples from 10 traders obtained from the silver overlay market found the presence of Salmonella sp and Escherichia coli bacteria. The results showed that the highest number of colonies was found in trader 10, namely 3.8x106 cfu/g and the lowest in trader 5, namely 3.9x104 cfu/g, this was not in accordance with the maximum limit of microbial contamination in foodstuffs (fresh chicken meat) according to the National Standard. Indonesia (SNI) 7388:2009 namely TPC 1 x 106 colonies/gram. The results also showed that 70% of the chicken meat samples were contaminated with Salmonella sp bacteria, and 60% of the samples were contaminated with Escherichia coli bacteria. This shows that the quality of chicken meat sold in the Silver Plain traditional market does not meet the Indonesian National Standard (SNI) 7388:2009 Escherichia coli 1 x 101 colonies/gram, and Salmonella sp negative/25gram

Faktor Yang Mempengaruhi Penggunaan Obat Kategori Over The Counter Pada Mahasiswa UNSIKA Mally Ghinan Sholih; Indah Laily Hilmi; Rahmi Indian
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Survey conducted by the Statistics Indonesia in 2020 regarding self-medication, it was recorded that 88,28% people of West Java carried out self-medication, one of which was with over the counter drugs. The high use of this Over The Counter (OTC) category of drugs increases the possibility of abuse in terms of use. The purpose of this study is to identify the factors that influence the use of drugs in the OTC category and to test it againts Singaperbangsa Karawang University (UNSIKA) students. This research was conducted from January to March 2022 using a descriptive analytic design with a cross sectional approach. The instrument used is a questionnaire. The sampling technique used is the accidental sampling method with a sample consisting of 392 UNSIKA students who entered the inclusion criteria. The results of the univariate analysis shows that the majority of respondents have good knowledge, are influenced by product effectiveness and efficiency, have adequate information availability, believe in manufacturers, are influenced by usage preferences, and use drugs well. The results of the bivariate analysis using the Chi square method indicates that there is a relationship between knowledge, trust in manufacturers, and usage preferences for the use of drugs in the OTC category with a significance value of 0.001 (p <0.05) and there is no relationship between product effectiveness and efficiency and the availability of information on the use of drugs in the over the counter category with a significance value of 0.911 and 0.973, respectively (p > 0.05).

Sintesis Senyawa Asetil Vanilat melalui Vanilin dan Peranannya Sebagai Komponen Senyawa Analgesik Salman Salman; Elvira Julia Ariyanto; Shafira Intan Anggraini; Siti Nafisa; Welly Windari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

People in Indonesia are inseparable from pain such as pain. This pain disease is treated with analgesic drugs such as aspirin. Where in aspirin, the salicylate group is most widely used as an analgesic. Aspirin differs from other salicylic acid derivatives in that it has an acetyl group. It is this acetyl group that can inactivate cyclooxygenase, so this drug is called an NSAID. In the synthesis of acetyl vanillate from aspirin via vanillin, the aim is to obtain the synthesis of acetyl vanillic compounds. Vanillin oxidation was carried out using Tollens reagent (AgNO3). The results of the FTIR spectrum showed that there were differences in acetyl vanillic and vanillic acid compounds. Synthesis of acetyl vanillic is carried out by oxidizing vanillin to produce vanillic acid which is then carried out by acetylation of vanillic acid to form acetyl vanillic compounds. The resulting compounds were characterized using the FTIR spectrum and compared to their identification using HNMR. Identification using FTIR is better than HNMR because the carboxylic acid group appears compared to HNMR. HNMR is covered with a large peak of carboxylic groups in the proton environment.

Uji Kualitatif Dan Penetapan Kadar Flavonoid Total Ekstrak Etanol Herba Pegagan (Centella asiatica) Dengan Variasi Konsentrasi Pelarut Wahyu Yuliana Solikah; Annisa Fatmawati; Adhi Gunawan; Astri Yeni Defri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Gotu Kola (Centella asiatica) has been known as a medicinal plant that has pharmacological activity in various diseases. One of the many bioactive compounds found is flavonoids. This study aims to determine the effect of concentration on total levels of flavonoids in the ethanol extract of Centella asiatica herb (EEHP). The method of measuring total flavonoid content was UV-Visible spectrophotometry with a maximum lambda of 412 nm and using quercetin as a reference standard. The results of total flavonoid levels in EEHP 50%, EEHP 70%, EEHP 80%, and EEHP 96% were 5.58 mgQE/g; 5.24 mgQE/g; 6.67 mgQE/g; 11.92 mgQE/g. The ANNOVA test showed a significant difference in the results of 96% EEHP flavonoid levels with a sig value of 0.001 (<0.5). Trigger concentration is proven to affect the levels of flavonoids contained in the extract. The highest levels of flavonoids were obtained at 96% EEHP, which is 11.92 mgQE/g.

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Editorial Address Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

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Contact Name
Salman

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salman.kimia@gmail.com

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+6285277011177

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admin@journal-jps.com

Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location
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Sumatera utara

INDONESIA