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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 86 Documents
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Search results for , issue "JPS Volume 8 Nomor 4 (2025)" : 86 Documents clear
Analisis Faktor Faktor Yang Berhubungan Dengan Kejadian Wasting Pada Bayi 6-24 Bulan Utami, Febi Aidha; Fanaetu, Emnalia; Ndruru, Usniar; Sitio, Dormianti; Amarliana, Dea; Nababan, Tiarnida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1217

Abstract

Background: Wasting, a form of acute malnutrition characterized by low weight-for-height, remains a critical public health problem in Indonesia. This condition increases the risk of child mortality and reflects short-term nutritional deficiencies. The prevalence of wasting in Indonesia continues to exceed the World Health Organization (WHO) threshold, underscoring the need for targeted interventions. Objective: This study aimed to analyze factors associated with wasting among children aged 6–24 months. Methods: A cross-sectional study was conducted at the UPT Puskesmas Bestari, Medan. The sample comprised 35 children aged 6–24 months selected using total sampling. Data were collected through interviews, nutritional status assessment (weight-for-height), and questionnaires. Data analysis included univariate analysis, bivariate analysis (Chi-square test), and multivariate analysis (logistic regression). Results: The prevalence of wasting was 71.4% (25 of 35 children). Bivariate analysis showed significant associations between wasting and inadequate dietary intake (p = 0.004), low maternal knowledge (p = 0.000), and low household income (p = 0.004). No significant associations were found between wasting and child sex (p = 0.421) or family size (p = 0.134). Multivariate analysis identified low maternal knowledge as the most dominant factor associated with wasting. Conclusion: Wasting among children aged 6–24 months is significantly influenced by inadequate dietary intake, low maternal knowledge, and low household income. Comprehensive interventions focusing on maternal nutrition education, strengthening household food security, and improving family economic capacity are essential to prevent wasting in this vulnerable age group.
Hubungan Kerasionalan Obat Antihipertensi Dengan Kontrol Tekanan Darah Pada Pasien Stroke Non-Hemoragik di Instalasi Rawat Inap RS X Surakarta Tahun 2024 Locita , Zana Sahya; Mutmainah, Nurul
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1261

Abstract

Background: Non-hemorrhagic stroke or ischemic stroke is the most common type of stroke and remains one of the leading causes of mortality and long-term disability. Blood pressure management through antihypertensive therapy is a key component of secondary prevention; however, variations in clinical practice indicate that the rational use of these medications still requires evaluation. Objective: This study aims to determine the relationship between the rationality of antihypertensive therapy and blood pressure control in non-hemorrhagic stroke patients based on clinical parameters in the inpatient ward of Hospital X, Surakarta. Methods: This research employed an analytical observational design with a retrospective cross-sectional approach. Data on antihypertensive use were collected from medical records of patients hospitalized in 2024, and a total of 100 patients met the inclusion criteria. Data analysis was performed using the Chi-square test. Results: Among non-hemorrhagic stroke patients in the inpatient ward of Hospital X Surakarta in 2024, 90 patients received rational antihypertensive therapy. Antihypertensive treatment was predominantly from the dihydropyridine CCB class, particularly amlodipine, either as monotherapy or in combination. Fisher’s exact test analysis showed a p-value < 0.05, indicating a significant association between the rationality of antihypertensive therapy and blood pressure control. Conclusion: There is a significant relationship between the rationality of antihypertensive therapy and blood pressure control in non-hemorrhagic stroke patients, highlighting the importance of rational drug selection as a crucial aspect of secondary prevention strategies.
Determinan Kepatuhan Pasien Tuberkulosis Paru Dalam Menjalani Pengobatan di UPT. Puskesmas Simalingkar Tahun 2024 Barus , Nanda Isabel; Manurung, Kesaktian; Hutajulu , Johansen; Wandra , Toni; Girsang , Vierto Irennius
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1386

Abstract

Background: Pulmonary tuberculosis (TB) is a chronic infectious disease that remains a major global and national public health problem, with Indonesia ranking second among countries with the highest TB burden worldwide. Non-adherence to treatment is one of the main barriers to successful TB control, as it may lead to treatment failure, drug resistance, and increased morbidity and mortality. At the Simalingkar Community Health Center (UPT Puskesmas Simalingkar), the specific factors determining treatment adherence among pulmonary TB patients have not been extensively studied. Objective: This study aimed to analyze the determinants of treatment adherence among pulmonary tuberculosis patients at the Simalingkar Community Health Center in 2024. Methods: This study employed an analytical cross-sectional design. The study population consisted of all pulmonary TB patients undergoing treatment at the Simalingkar Community Health Center, with a total sample of 90 respondents selected using a total sampling technique. Data were collected through questionnaires and medical records, and analyzed using univariate, bivariate (Chi-square test), and multivariate (logistic regression) analyses, with a significance level of p < 0.05. Results: A total of 77.8% of patients were adherent to treatment. Bivariate analysis showed significant associations between education (p < 0.001), employment status (p = 0.004), knowledge (p = 0.006), and health care services (p = 0.011) with treatment adherence. Age, sex, and family support were not significantly associated with adherence. Multivariate analysis indicated that the most dominant factor associated with treatment adherence was educational level (OR = 9.004; 95% CI: 2.58–31.49), followed by employment status (OR = 5.59; 95% CI: 1.48–21.12), and health care service support (OR = 3.99; 95% CI: 1.09–14.56). Conclusion: The significant determinants of treatment adherence among pulmonary TB patients at the Simalingkar Community Health Center were educational level, employment status, and health care service support, with education being the most dominant factor. It is recommended that TB control programs place greater emphasis on interventions aimed at improving health literacy, socio-economic support, and the quality and accessibility of health care services to enhance treatment adherence.
Analisis Metanil Yellow Pada Minuman Sinom Di Surabaya Menggunakan Metode Spektrofotometri UV-Vis Pramushinta , IAK; Fitriyati , Irenia Ida; Ambawarwati , Nadya
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1131

Abstract

Background: Metanil yellow in food is very dangerous to human health. This is because this dye contains heavy metal residues that have been proven to cause cancer. Indonesian Minister of Health Regulation No. 239/Menkes/Per/V/85 prohibits the use of metanil yellow as a food dye, but this dye is often found in various markets. Objective: This study analyzed metanil yellow in sinom drinks circulating in the city of Surabaya. Methods: The analysis of metanil yellow dye included method validation using UV-Vis spectrophotometry on five samples of sinom drinks. Research Results: Theresults of the metanil yellow analysis in sinom drinks showed linearity with a regression of y = 0.0191x – 0.1774, an r2 value of 0.9961, an LOD of 1.30833 ppm, and an LOQ value of 4.36108 ppm. The precision value was RSD 1.19%. Accuracy values with average % recovery of 94.26% (80%), 94.66% (100%), and 92.91% (120%). In the analysis of metanil yellow from 5 samples circulating in the southern part of Surabaya, code C 0.001854%, west code A 0.002475%, center code C 0.001725%, east code B 0.001249%, and north code A 0.002823%. Conclusion: The UV-Vis spectrophotometry method has been validated and meets the requirements for preliminary screening analysis of metanil yellow. Preliminary screening results of five samples of sinom drinks circulating in the city of Surabaya showed indications of metanil yellow in all samples with concentrations ranging from 12.41 to 28.28 ppm. Due to the limited specificity of the UV-Vis spectrophotometry method, this study needs to be confirmed with more specific techniques such as HPLC or TLC to ensure the identity of the metanil yellow compound.
Aktivitas Antibakteri Kombucha Daun Sirsak (Anonna muricata L.) Terhadap Bakteri Escherichia coli Rahmasari, Nadia; Rahmawati , Ismi; Saptarini , Opstaria
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.996

Abstract

Infectious diseases caused by pathogenic bacteria such as Escherichia coli are increasing, especially due to antibiotic resistance. One potential alternative treatment is the use of natural antibacterial compounds, such as those found in soursop leaves (Annona muricata L.). Soursop leaves contain various bioactive compounds, such as flavonoid polyphenols, acetogenins, and tannins, which have antibacterial activity. This study aims to of soursop leaf-based probiotic kombucha fermentation in inhibiting the growth of Escherichia coli. In this study, probiotic kombucha was produced through a fermentation process using Symbiotic Culture of Bacteria and Yeast (SCOBY) with variations in temperature, time, and soursop leaf extract concentration parameters. Activity testing was carried out using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods to assess its antibacterial effectiveness. The results showed that soursop leaf kombucha fermentation had significant antibacterial activity against Escherichia coli. The disc diffusion activity test obtained in this study was 9.1 mm (15% concentration); 5.10 mm (10% concentration); and 2.3 mm (5% concentration) with different concentration variations on the 7th day of fermentation. The resulting inhibition zone diameter for E. coli bacteria indicates that kombucha's antibacterial activity is in the moderate category, as it produced the highest inhibition zone of 9.1 mm. This study demonstrates that soursop leaf kombucha has the potential to be developed as a functional probiotic beverage with effective and natural antibacterial effects.
Analisis Perbandingan Kualitas Hidup Pasien Gangguan Kecemasan Yang Mendapatkan Zolpidem dan Escitalopram di RSUD Goeteng Taroenadibrata Menggunakan Instrumen EQ-5D-5L Ubay, Saskia Nur; Kurniasih, Khamdiyah Indah; Fauziah, Fauziah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1083

Abstract

Anxiety disorders are among the most common mental health problems in society and can affect patients’ quality of life. This study provides a comparative overview of the quality of life of patients with anxiety disorders at Goeteng Taroenadibrata Regional General Hospital who received Zolpidem or Escitalopram therapy. The purpose of this study was to determine whether there was a significant difference in the quality of life between patients using Zolpidem and those using Escitalopram. This study was a descriptive quantitative study using a cross-sectional approach. The study population consisted of patients with anxiety disorders at Goeteng Taroenadibrata Regional General Hospital, with a sample of 60 patients divided into two groups based on the therapy received, namely Zolpidem (30 patients) and Escitalopram (30 patients). Quality of life was measured using the EQ-5D-5L instrument. The results showed that 53.3% of patients in the Zolpidem group were male, while 66.7% of those in the Escitalopram group were female. In terms of age, most patients were over 60 years old, both in the Zolpidem group (83.3%) and the Escitalopram group (80.0%). In addition, the majority of patients in both groups had been undergoing treatment for more than six months (66.7%), with 20 patients in each therapy group. Statistical analysis using the Mann-Whitney test showed no significant difference in the quality of life between patients receiving Zolpidem and those receiving Escitalopram, with a p-value greater than 0.05.

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