cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
 1   2   3 
Search results for , issue "JPS Volume 9 Nomor 2 (2026)" : 26 Documents clear
Studi In Vivo Efek Nefroprotektif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) terhadap Profil Kreatinin Serum Mencit Khofifah, Dian Nur; Muslihin, A. M.; Hardia, Lukman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1522

Abstract

Background: Nephrotoxicity due to the use of drugs such as gentamicin can cause kidney damage characterized by increased creatinine levels. The use of medicinal plants as nephroprotective agents is a potential alternative; one such plant is yellow rope stem (Anamirta cocculus (L.) Wight & Arn.), known to contain antioxidant compounds. Objective: This study aims to assess the nephroprotective activity of yellow rope stem ethanol extract and determine the optimal dose for reducing gentamicin-induced increases in creatinine levels in mice. Method: The study was conducted experimentally with a pre-test and post-test design using the maceration method with 70% ethanol solvent. Mice were divided into six groups, namely negative control, positive control (vitamin E), healthy control, and three treatment groups with varying extract doses. Creatinine levels were measured using the Jaffe method with a UV-Vis spectrophotometer. Results: The results showed that the yellow rope stem ethanol extract at a dose of 77 mg/kgBW was able to reduce creatinine levels significantly (p<0.05), while lower doses did not show a significant difference. Conclusion: Ethanol extract of yellow rope stems has nephroprotective activity at an optimal dose of 77 mg/kgBW, thus having the potential to be developed as a herbal agent to protect kidney function.
Konsentrasi dan Energi Urbach Nanopartikel ZnO yang Disintesis Menggunakan Enkapsulan Tween 80 Saragih, Horasdia; Yustian , William; Lingga , Ananda E.J.; Simanjuntak , Anggraini O.; Marcia, Brianna D.; Manalu, Dea R.; Oumaro , Gefriella B.; Leo, Jeanet G.R.; Kusminarti , Karin; Silalahi, Ladyos D.; La'lang , Michelle A.; Nurbayanti , Rima S.; Leo , Ruly Y.R.R.; Situmorang , Santika; Siahaan , Widya A.
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1527

Abstract

Excessive exposure to ultraviolet (UV) radiation can cause skin damage, necessitating the development of effective and transparent sunscreen materials. ZnO nanoparticles are a promising candidate; however, they often suffer from agglomeration, which degrades their optical performance. This study aims to investigate the effect of varying concentrations of Tween 80 as an encapsulating agent on the optical and structural characteristics of ZnO nanoparticles. The nanoparticles were synthesized using a rotor–stator homogenization method with Tween 80 concentrations ranging from 2 to 5 mL (each dissolved in 50 mL of ethanol), followed by characterization using UV–Vis spectroscopy. The results indicate that increasing the concentration of Tween 80 enhances the concentration of ZnO nanoparticles without significantly altering the average particle size (~2.44 nm), resulting in a monodisperse system. Urbach energy analysis reveals that crystal order improves up to an optimum at 4 mL of Tween 80, followed by a slight decrease at higher concentrations. Optically, all samples exhibit strong absorption in the UV region and high transmittance in the visible range (95–100%). These findings demonstrate that the synthesized ZnO nanoparticles have strong potential as a sunscreen. It is concluded that Tween 80 plays a crucial role in controlling the growth, crystal structure, and optical properties of ZnO nanoparticles, with the optimum concentration yielding the best performance.
Evaluasi Mutu Fisikokimia dan Aktivitas Antioksidan Minuman Isotonik Ekstrak Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Khasanah, Nadziatul; Muslihin, A.M.; Rossardy, Marzella Dea; Fadli, Justitia Cahyani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1529

Abstract

as having potential as a natural antioxidant agent. One potential way to utilize this plant is by innovating it into an isotonic drink product. Objective: This study aimed to evaluate the physicochemical properties and antioxidant activity of an isotonic drink formulated with yellow rope stem extract. Methods: he extraction process was conducted using the maceration method with 70% ethanol as the solvent. The isotonic drink was developed into three formulas, which were then tested for their physicochemical properties and antioxidant activity using the DPPH method. Results: The results indicated that the best formula was FII, with an overall hedonic score of 4,6 (neutral). All three formulas showed identical pH values (4,0) and Total Soluble Solids (TSS) of 7%, while the total acidity decreased progressively: FI (1,024%), FII (0,896%), and FIII (0,704%). The isotonic drinks from yellow rope stem extract for formulas FI, FII, and FIII produced IC50 values of 35,61, 46,56, and 57,69 μg/mL, respectively. Based on these data, FI and FII were identified as having very strong antioxidant intensity, while the FIII showed activity classified in the strong category. Conclusion:.The test results demonstrate that the isotonic drink made from yellow rope stem extract exhibits antioxidant potential with intensity levels ranging from strong to very strong.
Sistem Penghantaran Obat Mutakhir: Tantangan Formulasi Nano untuk Fitokimia yang Sulit Larut dalam Air Palungan, Juliana; Kamilah , Rona Hawa; Firmansah , Moh.; Putri, Sima Asmara Dewa Marya Mahardika; Rahmah , Winda Wahyu Setya; Thaher , M Iman Tarmizi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1537

Abstract

The poor water solubility and low oral bioavailability of various phytochemical compounds (BCS Classes II and IV) continue to be major obstacles in the development of modern therapeutics, despite their remarkable therapeutic potential. This narrative review critically evaluates the use of nanoscale drug delivery systems to overcome the biopharmaceutical limitations of hydrophobic phytochemicals and pinpoints key challenges in clinical translation and industrial-scale production. The review provides a comprehensive analysis of the latest literature on the effectiveness of nanotechnology-based physicochemical modifications, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, polymeric micelles, liposomes, and phytosomes. The review's results indicate that nano-carrier engineering significantly enhances solubility, avoids first-pass metabolic degradation, and enables targeted delivery. Specifically, nanoformulations have proven effective at penetrating the dense matrix of the tumor microenvironment (TME) in cancer therapy, crossing the blood-brain barrier (BBB) in neurodegenerative diseases, and protecting drugs from stomach acid in infectious and metabolic conditions. However, the transition toward commercialization is hindered by issues of long-term physicochemical stability (e.g., lipid polymorphic transitions) and challenges in standardizing botanical raw materials. These issues affect the reproducibility of large-scale production, ultimately delaying the availability of these promising therapies to patients in need. In conclusion, while nanoformulations offer transformative solutions for overcoming phytochemical biological barriers, standardizing protocols, innovating green synthesis, and fostering interdisciplinary collaboration are essential for overcoming scalability barriers and preparing these innovations for clinical application.
Aktivitas Antioksidan dan Karakteristik Body Lotion dengan Perbedaan Konsentrasi Ekstrak Daun Jeruju ( Acanthus ilicifolius ). Mulya, Almaida; Aditia , Rifki Prayoga; Hasanah , Afifah Nurazizatul
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1551

Abstract

This study aimed to determine the effect of different concentrations of Acanthus ilicifolius leaf extract on antioxidant activity and physical characteristics of body lotion. The formulations were prepared with extract concentrations of 0, 2, 4, and 6 g. Antioxidant activity was tested using the DPPH method, while physical evaluations included pH, homogeneity, emulsion type, organoleptic properties, and skin moisture. The results showed that increasing extract concentration increased antioxidant activity, with the highest inhibition value found in P3 (76.19%). All formulations were homogeneous and had oil-in-water emulsion type. The pH values ranged from 6.92 to 7.93 and were within acceptable limits. Organoleptic test showed decreased panelist preference at higher extract concentrations. Moisture test showed no signific ant difference, but all formulations increased skin hydration.
Pengaruh Menopause Terhadap Kardiovaskular Wiriadinata, Guadelupe Maria Melisa; Laksemi, Dewa Ayu Agus Sri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1556

Abstract

Menopause is the permanent cessation of menstruation for 12 consecutive months without any underlying pathological cause. This occurs due to ovarian follicular atresia, which leads to the cessation of estrogen production. The menopausal transition begins 5 to 10 years before menstruation ceases. During menopause, estrogen levels decline, leading to biological changes in the body, such as an increase in total cholesterol, low-density lipoproteins (LDL), triglycerides, and apolipoprotein B, as well as a decrease in high-density lipoprotein (HDL), an increase in visceral fat, and the development of metabolic syndrome. Various characteristics of menopause have been evaluated in relation to cardiovascular disease (CVD) risk, including age at menopause onset, type and stage of menopause, endogenous estradiol levels, and menopause-related symptoms. These factors have been found to be associated with CVD risk, with the highest risk occurring in women with ovarian failure and relatively early menopause. Women with early menopause (aged 40–44 years) have a hazard ratio of 1.55 (95% CI: 1.38–1.73) for coronary artery disease events compared to women with menopause at age 50–54 years. Women with premature ovarian failure tend to have a shorter life expectancy compared to those who experience late menopause, primarily due to an increased risk of cardiovascular disease.

Page 3 of 3 | Total Record : 26

 1   2   3 

Filter by Year

2026 2026


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 2 (2026) JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue