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Patricia Wulandari
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Scientific Journal of Dermatology and Venereology
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 30256208     EISSN : 30256208     DOI : https://doi.org/10.59345/sjdv
Core Subject : Health,
Health Professions
Focus Scientific Journal of Dermatology and Venereology (SJDV) focused on the development of medical sciences especially dermatology, venereology and aesthetics medicine for human well-being. Scope Scientific Journal of Dermatology and Venereology (SJDV) publishes articles which encompass all aspects of basic research/clinical studies related to the field of dermatology and venereology and allied science fields, especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Dematologi
Articles 34 Documents
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Afatinib-Induced Acneiform Eruption in EGFR Exon 21 L858R-Mutant Stage IVA Lung Adenosquamous Carcinoma: Dermoscopy-Supported Diagnosis and Complete Resolution Fifteen Days After Drug Withdrawal Firdausul Ma'rifah; Triasari Oktavriana; Muhammad Ilham Maulana
Scientific Journal of Dermatology and Venereology Vol. 4 No. 1 (2026): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v4i1.313

Abstract

Background: Acneiform eruption is a monomorphic inflammatory disorder of the pilosebaceous unit that resembles acne vulgaris but characteristically lacks comedones; drug reactions, particularly to epidermal growth factor receptor (EGFR) inhibitors, are its commonest trigger. Objective: To describe the clinical course, bedside diagnostic reasoning and outcome of an afatinib-induced acneiform eruption documented by serial photography, dermoscopy and potassium hydroxide microscopy. Case Presentation: A 59-year-old man with stage IVA adenosquamous carcinoma of the left lung harbouring an EGFR exon 21 leucine 858 to arginine (L858R) mutation developed erythematous papules and pustules on the face, neck, chest and back three days after his first dose of oral afatinib 40 mg daily, and was referred on day 21 with intense pruritus, burning and adherent nasal crusting. Examination showed discrete follicular papules and pustules with crusting and no comedones at any site. Dermoscopy demonstrated folliculocentric papules without comedonal plugging, and 10% potassium hydroxide microscopy showed no hyphae, mites or lice, excluding Malassezia folliculitis and demodicosis. Naranjo scoring yielded 7 points, indicating a probable adverse drug reaction. Afatinib was withdrawn and oral doxycycline 100 mg twice daily for two weeks, as-required cetirizine, saline compresses followed by clindamycin 1% lotion, hydrocortisone 2.5% cream, emollient and photoprotection were given. Pustules and crusts cleared by day nine and the eruption resolved completely fifteen days after withdrawal, leaving post-inflammatory hyperpigmentation. Conclusion: Recognising the monomorphic, comedone-free morphology and its temporal link to the drug permits accurate bedside diagnosis, while prophylaxis begun with the inhibitor may avert withdrawal of effective targeted therapy.
One-Stage Earlobe-Based Transposition Flap After Full-Thickness Excision of a Congenital Verrucous Epidermal Naevus Spanning the Right Earlobe and Lateral Neck in a 3-Year-Old Boy: A Case Report With Dermoscopic and Histopathological Correlation Rizki Audita; Ennesta Asri; Indah Indria Sari
Scientific Journal of Dermatology and Venereology Vol. 4 No. 1 (2026): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v4i1.320

Abstract

Background: Verrucous epidermal naevus is a benign keratinocytic hamartoma that arises from post-zygotic somatic mutation and follows the lines of Blaschko. Lesions crossing the auricular and cervical units are uncommon and difficult to treat, because ablative and topical modalities clear the surface but leave the mutant keratinocyte clone. Objective: To describe the diagnosis, reconstructive decision and outcome of a one-stage earlobe-based transposition flap after full-thickness excision of such a lesion in a preschool child. Case Presentation: A 3-year-old boy was referred with a brown linear verrucous plaque measuring 7 × 0.75 × 0.1 cm, present on the right earlobe since birth and extending along the right lateral neck, thickening and becoming painful over three months. Dermoscopy showed cobblestone verrucous and papillomatous structures with brown to bluish-grey pigmentation and no melanocytic network. Absent pruritus and inflammation, and a normal systemic evaluation, excluded inflammatory linear verrucous epidermal naevus and epidermal naevus syndrome. Full-thickness excision under general anaesthesia with tumescent infiltration removed auricular and cervical specimens of 3.5 × 0.8 cm and 7 × 0.3 cm, and the defect was closed in one stage with an earlobe-based transposition flap. Histopathology showed hyperkeratosis, acanthosis and papillomatosis with focal hypergranulosis and vacuolated granular and spinous cells. Healing was uneventful; a hypertrophic scar confined to the cervical limb appeared by postoperative day 73. Conclusion: Complete excision with a one-stage earlobe-based transposition flap achieved definitive clearance and preserved auricular contour. Suprabasal vacuolation in a keratinocytic naevus should prompt keratin gene sequencing and reproductive counselling.
Multiple Giant Molluscum Contagiosum Arising on Antiretroviral Therapy: A Visible Marker of Unrecognized Immunological Failure in Advanced HIV Disease Aulia Yasmin; Endra Yustin Ellistasari; Ammarilis Murastami; Prasetyadi Mawardi
Scientific Journal of Dermatology and Venereology Vol. 4 No. 1 (2026): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v4i1.325

Abstract

Background: Molluscum contagiosum is ordinarily self-limiting, but in profound immunosuppression it becomes extensive, giant and atypical. Published reports almost uniformly describe such lesions as revealing previously undiagnosed HIV; lesions arising in a patient already established on antiretroviral therapy are far less often described and carry a more urgent meaning. Objective: To describe a fatal case of giant molluscum contagiosum arising on antiretroviral therapy, to show that the eruption marked unrecognized immunological failure, and to specify the measurements the dermatological consultation should have triggered. Case Presentation: A 39-year-old man presented with one year of enlarging papules and nodules on the eyelids, face, neck, hand and penis, the largest 3.5 × 2.5 × 1.5 cm, and 18 months of pruritic hyperpigmented limb papules, after 24 months of fixed-dose efavirenz, lamivudine and tenofovir disoproxil. Dermoscopy, Giemsa cytology and histopathology confirmed molluscum contagiosum; the limb eruption was pruritic papular eruption. CD4 was 31 cells/µL and CD8 1624 cells/µL, a CD4/CD8 ratio of 0.02; syphilis serology was non-reactive. Serial excision and enucleation, with weekly 90% trichloroacetic acid to the penile lesions, cleared the facial disease by month 3; he died at month 7. No viral load, resistance genotype, cryptococcal antigen or tuberculosis screen was performed. Conclusion: Giant molluscum contagiosum arising after two years of antiretroviral therapy marks therapy that is not working, not merely advanced HIV disease. An audit identified five indicated measurements never obtained. Dermatologists recognizing this eruption should treat the skin and, at the same visit, trigger a viral load and the advanced HIV disease package of care.
Subacute Cutaneous Lupus Erythematosus in an 11-Year-Old Girl with Childhood-Onset Systemic Lupus Erythematosus: Adult Reference Intervals, Unscored Instruments and the Findings the Record Did Not Contain Indira Dharmasamitha; Putu Ayu Gadis Laksmitha Ksata Yadnya; Reika Ravenski Novsa
Scientific Journal of Dermatology and Venereology Vol. 4 No. 1 (2026): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v4i1.338

Abstract

Background: Subacute cutaneous lupus erythematosus is an uncommon cutaneous expression of childhood-onset systemic lupus erythematosus, and paediatric reports usually describe morphology and treatment rather than the measurements on which severity is judged. Objective: To describe paediatric subacute cutaneous lupus in skin of colour and to recompute, from the record alone, the classification, renal, nutritional and drug-exposure quantities it never derived. Methods: One child's record over three assessments and 56 days was reviewed retrospectively and reported following the CARE guideline. Values were reproduced as printed; body surface area, estimated glomerular filtration rate, two nutritional indices, transaminase ratios, per-kilogram drug exposures, the 2019 EULAR/ACR score and the cutaneous activity and damage index were computed from them. Results: An 11-year-old premenarchal Javanese girl presented with a seven-month photodistributed eruption of erythematous and hyperpigmented macules, papules and plaques on the face, neck, thorax, limbs and palms, with fever and weight loss. Antinuclear antibody was 1:10,000 fine-speckled and the erythrocyte sedimentation rate 124 mm/hour; nuchal biopsy showed interface dermatitis with vacuolar degeneration, Civatte bodies and pigment incontinence. A line immunoassay was positive for anti-Sm, anti-SSA/Ro, anti-SSB/La and anti-RNP/Sm. On topical treatment and photoprotection alone the cutaneous activity index fell from 18 to 4 by day 28. A creatinine of 0.84 mg/dL reported as normal corresponds to 69.2 mL/min/1.73 m2 by the bedside Schwartz equation; the 2019 criteria total 10 points, never computed; the nutritional indices disagreed. No urinalysis, creatine kinase or complement was done. Conclusion: Paediatric cutaneous lupus should be reported with its instruments scored and its reference intervals age-appropriate.

Page 4 of 4 | Total Record : 34

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