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Patricia Wulandari
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Scientific Journal of Dermatology and Venereology
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 30256208     EISSN : 30256208     DOI : https://doi.org/10.59345/sjdv
Core Subject : Health,
Health Professions
Focus Scientific Journal of Dermatology and Venereology (SJDV) focused on the development of medical sciences especially dermatology, venereology and aesthetics medicine for human well-being. Scope Scientific Journal of Dermatology and Venereology (SJDV) publishes articles which encompass all aspects of basic research/clinical studies related to the field of dermatology and venereology and allied science fields, especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Dematologi
Articles 25 Documents
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Comparative Genomics of Monkeypox Virus Isolates from Sudan and Other Endemic Regions: Insights into Viral Evolution and Spread Shina Abdulkadir
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.2

Abstract

Introduction: Monkeypox, a zoonotic viral disease endemic to Central and West Africa, has recently gained global attention due to outbreaks beyond its traditional range. Understanding the genomic diversity of monkeypox virus (MPXV) isolates, particularly those from Sudan, is crucial for effective public health surveillance and vaccine development. Methods: In this study, we employed comparative genomics to analyze MPXV isolates from Sudan and other endemic regions. We utilized publicly available genomic sequences from NCBI's GenBank database. Phylogenetic analysis, sequence alignment, and identification of single nucleotide polymorphisms (SNPs) were performed to assess genetic diversity and identify potential geographic or temporal clustering. Results: Our analysis revealed distinct genetic lineages of MPXV circulating in Sudan compared to other endemic regions. Specific SNPs and genomic signatures were identified that could serve as potential markers for differentiating Sudanese isolates. Notably, some Sudanese isolates exhibited closer genetic relatedness to isolates from recent outbreaks outside of Africa, suggesting potential transmission pathways. Conclusion: This study provides valuable insights into the genomic diversity of MPXV in Sudan and other endemic regions. The identification of Sudan-specific genomic signatures highlights the importance of considering regional variations in public health surveillance and vaccine development efforts. Continued genomic surveillance is essential for monitoring the evolution of MPXV and detecting potential emerging variants with altered virulence or transmissibility.
The Role of Moisturizers in Maintaining Skin Barrier Function in a Desert Climate: A Comparative Study in Dubai and a Temperate Region Franklin Shane
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.3

Abstract

Introduction: Desert climates present unique challenges to skin health due to low humidity, high temperatures, and intense sun exposure, potentially compromising the skin barrier. Moisturizers play a crucial role in mitigating these effects. This study investigates the impact of moisturizers on skin barrier function in individuals residing in Dubai (desert climate) and a temperate region. Methods: A cross-sectional study was conducted involving 100 participants (50 from Dubai, 50 from a temperate region). Skin barrier function was assessed using transepidermal water loss (TEWL) measurements and stratum corneum hydration levels. Participants' moisturizer usage patterns and perceived skin dryness were recorded. Results: Dubai residents exhibited significantly higher TEWL values and lower stratum corneum hydration levels compared to those in the temperate region, indicating a compromised skin barrier. Regular moisturizer use was associated with significantly improved skin barrier function in both groups, with a more pronounced effect observed in Dubai residents. Conclusion: This study highlights the vulnerability of skin barrier function in desert climates. Regular moisturizer use effectively improves skin barrier function, particularly in arid environments. These findings underscore the importance of moisturizers as a cornerstone of skincare in desert climates.
Occupational and Environmental Risk Factors for Contact Dermatitis among Industrial Workers in Karawang, Indonesia: A Cross-Sectional Study Suryani, Febria; Iting Shofwati
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.4

Abstract

Introduction: Contact dermatitis is a prevalent occupational skin disease, particularly among industrial workers exposed to various irritants and allergens. This study aimed to investigate the prevalence of contact dermatitis and identify occupational and environmental risk factors among industrial workers in Karawang, Indonesia. Methods: A cross-sectional study was conducted among 450 industrial workers in Karawang, Indonesia. Data were collected using a structured questionnaire, including demographics, occupational history, and environmental exposures. Dermatological examinations were performed to diagnose contact dermatitis. Descriptive statistics, chi-square tests, and logistic regression analysis were used to analyze the data. Results: The prevalence of contact dermatitis among the industrial workers was 22.4%. The most common type was irritant contact dermatitis (75%). Significant risk factors identified included exposure to solvents (OR = 3.2, 95% CI: 1.8-5.7), detergents (OR = 2.5, 95% CI: 1.4-4.5), and metalworking fluids (OR = 2.1, 95% CI: 1.2-3.7). Longer duration of employment (OR = 1.2, 95% CI: 1.1-1.4) and poor personal protective equipment (PPE) use (OR = 2.8, 95% CI: 1.6-4.9) were also associated with increased risk. Conclusion: Contact dermatitis is a significant occupational health problem among industrial workers in Karawang, Indonesia. Exposure to specific chemicals, longer duration of employment, and inadequate PPE use contribute to the increased risk. Implementing preventive measures, including proper PPE use, workplace hygiene, and health education programs, is crucial to reducing the burden of contact dermatitis in this population.
Molecular Epidemiology of Tinea Pedis Among Palm Oil Plantation Workers in Labuhan Batu Utara Regency, Indonesia: Identification of Causative Fungal Pathogens Haryani, Sela; Riri Arisanty Syafrin Lubis; Rinna Azrida
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.5

Abstract

Introduction: Tinea pedis, commonly known as athlete's foot, is a prevalent fungal infection affecting the feet. Palm oil plantation workers, often exposed to humid and warm conditions, are at an increased risk of contracting this condition. This study aimed to investigate the molecular epidemiology of tinea pedis among palm oil plantation workers in Labuhan Batu Utara Regency, Indonesia, and identify the causative fungal pathogens. Methods: A cross-sectional study was conducted among palm oil plantation workers in Labuhan Batu Utara Regency. Demographic data and clinical information were collected through questionnaires. Skin scrapings were obtained from the affected areas of the feet and subjected to microscopic examination and fungal culture. Molecular identification of the isolated fungi was performed using DNA sequencing of the internal transcribed spacer (ITS) region. Results: A total of 250 palm oil plantation workers participated in the study. The prevalence of tinea pedis was found to be 42.8%. The most common clinical presentations were interdigital scaling and maceration (65.2%), followed by vesicular lesions (23.1%) and hyperkeratosis (11.7%). The predominant fungal pathogens identified were Trichophyton rubrum (58.3%), Trichophyton mentagrophytes (27.8%), and Epidermophyton floccosum (13.9%). Conclusion: Tinea pedis is a significant health problem among palm oil plantation workers in Labuhan Batu Utara Regency. The identification of the causative fungal pathogens is crucial for implementing effective preventive and therapeutic measures to control the spread of this infection.
A Randomized Controlled Trial Evaluating the Impact of Dietary Supplementation with Polyphenols on Disease Severity and Quality of Life in Adults with Moderate to Severe Atopic Dermatitis in Beijing, China Zhou, Suyong; Jinfang Zhang
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.41

Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition that significantly affects quality of life. Polyphenols, with their anti-inflammatory and antioxidant properties, offer a potential therapeutic avenue for AD management. Methods: This randomized, double-blind, placebo-controlled trial enrolled adults with moderate to severe AD in Beijing. Participants were randomized to receive either a polyphenol-rich dietary supplement or a placebo for 12 weeks. The primary outcome was the change in Scoring Atopic Dermatitis (SCORAD) index. Secondary outcomes included quality of life assessment using the Dermatology Life Quality Index (DLQI), and serum inflammatory markers. Results: A total of 120 participants completed the trial. The polyphenol group showed a significantly greater reduction in SCORAD index compared to the placebo group (p < 0.001). DLQI scores also improved significantly in the polyphenol group (p < 0.01). Furthermore, serum levels of inflammatory markers, including C-reactive protein and interleukin-6, decreased significantly in the polyphenol group. Conclusion: Dietary supplementation with polyphenols may offer a safe and effective adjunctive therapy for improving disease severity and quality of life in adults with moderate to severe AD.
Characteristics of Sexually Transmitted Infection (STI) Patients at the Tanggul Health Center in Jember Regency in the January-June 2023 Period Krizdiana, Usqi
Scientific Journal of Dermatology and Venereology Vol. 2 No. 1 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i2.45

Abstract

Introduction: The incidence of sexually transmitted infections (STIs) can expand as the risk factors increase that increase the transmission of STIs, including having unprotected sexual contact with multiple partners, having a history of STIs, having a history of sexual violence, alcohol use, prostitution, having sexual partners who have sexual contact. additional and concomitant or have a history of previous STIs, drug use, and use of intravenous drugs. This study aimed to present the characteristics of sexually transmitted infections in Tanggul Health Center, Jember Regency, Indonesia. Methods: This study is a descriptive observational study. A total of 52 research subjects participated in this study. Analysis of variable characteristics was carried out univariately with SPSS version 25. Results: The highest prevalence of STIs was gonorrhea, namely 20 people (38.46%), the age group with the most STIs, namely 25-49 years, as many as 36 people (69.23%), sex of STI sufferers the most were men, 37 people (71.15%) and the risk factors for experiencing STIs that were most common were customers of sex workers, 31 people (59.61%). Conclusion: This study revealed the characteristics of STI patients at Tanggul Health Center. Gonorrhea was the highest prevalence STI and most of patients were male and had sexual contact history with prostitutes.
The Role of Innate Immunity against Mycobacterium Leprae: A Systematic Literature Review Putra, Reza Agustiantwo
Scientific Journal of Dermatology and Venereology Vol. 2 No. 1 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i2.47

Abstract

Introduction: Innate immunity is the body's defense system that exists from birth and is the body's first defense against infection. This system involves multiple defense mechanisms that work together to recognize, deter, and respond to pathogens such as bacteria, viruses, and fungi. In the context of Mycobacterium leprae, the role of the innate immune system is very important because this bacterium has unique pathogenic properties and is capable of infecting human body cells in complex ways. Methods: The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the role of innate immunity against Mycobacterium leprae. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Results: One of the main aspects of the role of the innate immune system against Mycobacterium leprae is the recognition of this pathogen by phagocytic cells, such as macrophages. Mycobacterium leprae evades recognition and destruction by these cells in a number of ways, including cell surface modification of the immune response. Conclusion: The innate immunity response plays a significant role in the response to Mycobacterium leprae infection. Innate immunity acts as an initial and fast response to mitigate the Mycobacterium leprae infection from getting more massive.
The Role of Innate and Adaptive Immunity in Staphylococcal Scalded Skin Syndrome: A Systematic Literature Review Isramilda; Andi Ipaljri
Scientific Journal of Dermatology and Venereology Vol. 2 No. 1 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i2.50

Abstract

Introduction: The innate immune system provides immediate protection in the event of an infection, while the adapted immune system provides a more specific response and has the ability to remember specific pathogens, thereby protecting the body from similar infections in the future. This study aimed to present the role of innate and adaptive immunity in staphylococcal scalded skin syndrome (SSSS). Methods: The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the role of innate and adaptive immunity in staphylococcal scalded skin syndrome. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Results: Five studies were included in this study. A combination of innate and adapted immune systems work together to overcome SSSS infections. Conclusion: The innate immune system provides a rapid initial defense, while the ad apted immune system provides a more specific response and the ability to form immune memory.
MicroRNA Expression Profiling in Syphilis Patients: A Potential Diagnostic and Prognostic Biomarker Discovery Study in Manila, Philippines Helsey, Bryan
Scientific Journal of Dermatology and Venereology Vol. 2 No. 1 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i2.56

Abstract

Introduction: Syphilis remains a significant public health concern in the Philippines, with challenges in early diagnosis and prognostic assessment. MicroRNAs (miRNAs) are emerging as promising biomarkers due to their role in gene expression regulation and stability in body fluids. This study aimed to identify differentially expressed miRNAs in syphilis patients, explore their potential as diagnostic and prognostic markers, and contribute to the development of improved management strategies. Methods: A case-control study was conducted involving syphilis patients and healthy controls in Manila. Blood samples were collected, and miRNA expression profiling was performed using high-throughput sequencing. Differential expression analysis, target gene prediction, pathway enrichment analysis, and receiver operating characteristic (ROC) curve analysis were employed to identify candidate miRNA biomarkers. Results: A panel of differentially expressed miRNAs was identified in syphilis patients compared to controls. These miRNAs were associated with immune response, inflammation, and tissue remodeling pathways. Selected miRNAs exhibited promising diagnostic potential, with high sensitivity and specificity. Additionally, certain miRNAs were correlated with disease severity and treatment response, suggesting their prognostic value. Conclusion: This study provides valuable insights into miRNA dysregulation in syphilis and identifies potential miRNA biomarkers for diagnosis and prognosis. Further validation and functional studies are warranted to establish their clinical utility and contribute to the development of improved syphilis management strategies in the Philippines.
Genetic Predisposition to Malignant Melanoma in the Population of Batam, Indonesia: A Case-Control Study Simanjuntak, Lisye Tiur
Scientific Journal of Dermatology and Venereology Vol. 2 No. 1 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i2.57

Abstract

Introduction: Malignant melanoma, an aggressive skin cancer, poses a significant global health challenge. Genetic predisposition plays a pivotal role in its development. This study investigates the prevalence of high-risk melanoma susceptibility genes (CDKN2A, MC1R, and others) in the population of Batam, Indonesia, aiming to contribute to risk assessment, early detection strategies, and targeted interventions. Methods: A cross-sectional study involving 300 participants from Batam was conducted. Genetic analysis of CDKN2A, MC1R, and additional melanoma-associated genes was performed using next-generation sequencing (NGS). Demographic and clinical data were collected through questionnaires and medical record reviews. Statistical analysis assessed the association between genetic variants and melanoma risk. Results: The prevalence of CDKN2A pathogenic variants was 2.3%, and MC1R high-risk variants were found in 15.7% of the participants. Significant associations were observed between the presence of these variants and personal/family history of melanoma. Multiple logistic regression analysis identified specific variants conferring a higher risk of melanoma development. Conclusion: This study provides insights into the genetic landscape of melanoma susceptibility in Batam. The identified prevalence of high-risk variants underscores the importance of genetic testing and personalized risk assessment.

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