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Patricia Wulandari
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Scientific Journal of Dermatology and Venereology
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 30256208     EISSN : 30256208     DOI : https://doi.org/10.59345/sjdv
Core Subject : Health,
Health Professions
Focus Scientific Journal of Dermatology and Venereology (SJDV) focused on the development of medical sciences especially dermatology, venereology and aesthetics medicine for human well-being. Scope Scientific Journal of Dermatology and Venereology (SJDV) publishes articles which encompass all aspects of basic research/clinical studies related to the field of dermatology and venereology and allied science fields, especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Dematologi
Articles 25 Documents
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Formulation and Effectiveness Test of 96% Ethanol Extract Anti-Acne Serum Cashew Leaves (Anacardium occidentale L.) Mc Seer, Raysha; Rini Dwiastuti; Eka Indra Setyawan
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.99

Abstract

Introduction: Recently, the use of cosmetics to cure acne made from natural ingredients can have a good effect. Cosmetic preparations that are currently developing rapidly are serum preparations because they have better effects, and the moisturizing technology used is based on skin physiology. The natural ingredient in question is cashew leaves, which treat acne caused by Propionibacterium acnes. This research aims to obtain a serum preparation of cashew leaf extract to determine its effectiveness against P. acne and optimize the two ingredients, namely carbopol and triethanolamine (TEA) so that the serum preparation has physical stability that meets predetermined standards. Methods: This research is pure experimental research of a qualitative nature to obtain a serum preparation of cashew leaf extract with effectiveness as an anti-acne and using the factorial design method with the optimization factor for carbopol concentration comparison as a gelling agent and TEA as an alkalizing agent. The physical property parameters observed as a response to the equation are spreadability and viscosity using two-way statistical tests, ANOVA, with IBM SPSS statistics 29.0.1.0 software. Results: The research results obtained indicate the effectiveness of cashew leaf extract serum preparations against bacteria, such as Propionibacterium acnes. Apart from that, there is no significant difference between the formulas in the spreadability parameters, which means there is no influence from variations in carbopol and TEA concentrations on the physical evaluation of spreadability. Meanwhile, there are significant differences between the formulas in the viscosity parameters, there is an influence of variations in the concentration of carbopol and TEA on the physical evaluation of viscosity. Conclusion: Cashew leaf extract serum preparations are effective in treating bacteria Propionibacterium acnes, the cause of acne.
Effectiveness of Topical Treatment of Steroid and Calcineurin Inhibitor Combination Therapy for Atopic Dermatitis in Children at Skopje Hospital, Macedonia Wilson, Maria Margareth
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.130

Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease that often occurs in children. Topical treatments, including steroids and calcineurin inhibitors (CNI), are the main line of AD therapy. This study aimed to evaluate the effectiveness of topical treatment of combination steroid and CNI therapy for AD in children at Skopje Hospital, Macedonia. Methods: This research was a retrospective study involving 60 children with AD who were treated with combination therapy of steroids and CNIs for 8 weeks. Clinical data, including SCORAD (Severity of Atopic Dermatitis) score and extent of eczema, were collected before and after treatment. Results: Steroid and CNI combination therapy showed significant improvement in SCORAD score (p<0.001) and eczema extent (p<0.001) after 8 weeks of treatment. Reported side effects are minimal. Conclusion: Combination therapy of steroids and CNIs is an effective and safe treatment for AD in children.
Effectiveness of Systemic and Topical Combination Therapy for the Treatment of Pustular Psoriasis: A Meta-Analysis Study Muhammad Yusuf
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.131

Abstract

Introduction: Pustular psoriasis is a rare and severe variant of psoriasis, characterized by sterile pustules that appear over erythematous plaques. Treatment is challenging and often requires a combination of systemic and topical therapy. This meta-analysis study aims to evaluate the effectiveness of systemic and topical combination therapy for the treatment of pustular psoriasis. Methods: Relevant publications were identified through electronic searches in PubMed, Scopus, and Web of Science. Studies evaluating the effectiveness of systemic and topical combination therapy for the treatment of pustular psoriasis were included. Data were extracted and analyzed using random effects statistics. Results: A total of 10 studies with a total of 324 patients were included in the analysis. Systemic and topical combination therapy demonstrated significant effectiveness in improving pustular psoriasis plaque improvement (PASI 75: 58% vs. 23%, p<0.001) and time to recurrence (12 months vs. 6 months, p<0.001) compared with systemic therapy or single topical. The most common side effect is skin irritation, which occurs in 15% of patients. Conclusion: Systemic and topical combination therapy is an effective treatment option for pustular psoriasis. The choice of therapy should be based on the individual characteristics of the patient. Further research is needed to optimize the combination of agents and to evaluate long-term effectiveness.
Analysis of Risk Factors that Influence Patient Compliance in Taking Antiretroviral Drugs for HIV/AIDS Treatment in Hanoi Hospital, Vietnam Pham Uyen; Mariette Jackson
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.132

Abstract

Introduction: HIV/AIDS infection remains a global public health problem, with antiretroviral therapy (ARV) being key in its management. Patient adherence to ARV treatment is critical to achieving viral suppression and preventing drug resistance. This study aims to analyze the risk factors that influence patient compliance in taking ARV drugs at Hanoi Hospital, Vietnam. Methods: This study used a cross-sectional analytical observational design involving 300 HIV/AIDS patients undergoing ARV therapy at Hanoi Hospital. Data was collected through structured interviews and patient medical records. Data analysis used logistic regression to identify risk factors associated with patient compliance. Results: The research results showed that the level of patient compliance with ARV treatment was 72%. Risk factors that are significantly associated with patient compliance are: Low social support (OR=2.3; p=0.02), Limited knowledge about HIV/AIDS and ARV treatment (OR=1.8; p=0.04), Stigma and discrimination related to HIV/ AIDS (OR=1.7; p=0.03), Severe side effects of ARV drugs (OR=1.6; p=0.03), Complexity of ARV treatment regimens (OR=1.5; p=0.04). Conclusion: This study found that patient adherence to ARV treatment at Hanoi Hospital was influenced by various factors, including social support, knowledge about HIV/AIDS and ARVs, stigma and discrimination, drug side effects, and the complexity of the treatment regimen. Interventions targeting these risk factors may help improve patient compliance and achieve more optimal treatment outcomes.
Analysis of the Role of Cosmetic Dermatology in Improving the Quality of Life of Patients with Vitiligo: Observational Study at Busan Hospital, South Korea Kim Soohyuk; Moon Kaeun
Scientific Journal of Dermatology and Venereology Vol. 2 No. 2 (2024): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i1.133

Abstract

Introduction: Vitiligo is an autoimmune disease that causes skin depigmentation. This can have a significant impact on the patient's quality of life. Dermatological cosmetics can be used to cover depigmented areas and improve the patient's quality of life. Methods: This observational study was conducted on vitiligo patients treated at Busan Hospital, South Korea. Patients were given a questionnaire to assess their quality of life before and after using dermatology cosmetics. A total of 250 research subjects took part in this study. Data were analyzed using appropriate statistical tests. Results: The results showed that the use of dermatological cosmetics significantly improved the quality of life of vitiligo patients. Patients report improvements in self-satisfaction, self-image, and social interactions. Conclusion: Cosmetic dermatology is a safe and effective therapeutic option to improve the quality of life of vitiligo patients.
Antibacterial Activity of Ethanol Extract of Srikaya Leaves (Annona squamosa Linn) Against the Growth of Acne Vulgaris-Causing Bacteria Staphylococcus epidermidis Amalia, Annora Rizky; Zulaika Febru Zalsabila; Yunita Dian Permata Sari
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.143

Abstract

Introduction: Acne vulgaris, a prevalent skin condition, is primarily triggered by the proliferation of Cutibacterium acnes within pilosebaceous units. However, Staphylococcus epidermidis, a commensal skin bacterium, can exacerbate acne inflammation upon follicular invasion. This study investigates the antibacterial potential of ethanol extract derived from srikaya leaves (Annona squamosa Linn) against S. epidermidis. Methods: Srikaya leaves underwent ethanol extraction via maceration. The extract's antibacterial efficacy was assessed using the agar well diffusion method against S. epidermidis at varying concentrations (25%, 50%, 75%). Zones of inhibition were measured, and minimum inhibitory concentrations (MICs) were determined. Phytochemical screening of the extract was conducted to identify potential bioactive compounds. Results: The ethanol extract of srikaya leaves exhibited significant antibacterial activity against S. epidermidis. Increasing extract concentrations led to larger zones of inhibition, indicating a dose-dependent effect. The MIC of the extract against S. epidermidis was determined to be 50%. Phytochemical analysis revealed the presence of flavonoids, phenols, and alkaloids, which are known for their antimicrobial properties. Conclusion: Ethanol extract of srikaya leaves demonstrates promising antibacterial activity against S. epidermidis, suggesting its potential as a natural therapeutic agent for managing acne vulgaris. Further research is warranted to elucidate the mechanisms of action and evaluate the extract's efficacy in clinical settings.
Exploring the Role of the Microbiome in Atopic Dermatitis: A Longitudinal Metagenomic Analysis in India Ramakhrisnand, Ramakhrisnand
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.155

Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition with a complex etiology, influenced by both genetic and environmental factors. The skin microbiome plays a crucial role in maintaining skin health, and dysbiosis is frequently observed in AD. This longitudinal metagenomic study aimed to investigate the dynamics of the skin microbiome in Indian AD patients and explore its association with disease severity and clinical outcomes. Methods: A cohort of 50 AD patients and 30 healthy controls from diverse regions in India were enrolled. Skin microbiome samples were collected at baseline, 3 months, and 6 months. Metagenomic sequencing was performed to characterize the microbial communities. Clinical assessments, including SCORAD (Scoring Atopic Dermatitis) and patient-reported outcomes, were recorded. Results: Significant differences in microbial diversity and composition were observed between AD patients and healthy controls. AD patients exhibited reduced diversity and an overabundance of Staphylococcus aureus compared to controls. Longitudinal analysis revealed fluctuations in the microbiome associated with disease flares. Specific microbial taxa, such as Streptococcus and Corynebacterium, showed inverse correlations with disease severity. Conclusion: This study provides valuable insights into the skin microbiome dynamics in Indian AD patients. The findings highlight the potential role of the microbiome as a biomarker for disease severity and therapeutic targets. Further research is warranted to explore the functional implications of these microbial shifts and develop microbiome-based interventions for AD management.
Unraveling the Genetic Landscape of Psoriasis: A Genome-Wide Association Study in Egypt Abd El Nasser; Nazeera Hamid
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.157

Abstract

Introduction: Psoriasis is a chronic inflammatory skin disease with a complex genetic basis. While Genome-Wide Association Studies (GWAS) have identified numerous susceptibility loci in European populations, the genetic landscape of psoriasis in Egyptians remains largely unexplored. Methods: The study conducted a GWAS in a cohort of 1,200 Egyptian individuals (600 cases and 600 controls) using the Illumina Infinium Global Screening Array-24 v3.0 BeadChip. After stringent quality control, association analyses were performed using logistic regression, adjusting for age, sex, and principal components. Replication of top signals was attempted in an independent cohort of 500 Egyptian individuals (250 cases and 250 controls). Functional annotation and pathway enrichment analyses were performed to gain insights into the biological relevance of associated loci. Results: We identified novel genome-wide significant associations in the HLA region (rs10484554: p = 1.2 x 10^-15, OR = 2.3) and near the IL23R gene (rs11209026: p = 3.5 x 10^-9, OR = 1.7). These associations were replicated in the independent cohort. Additionally, we observed suggestive associations near several genes previously implicated in psoriasis, including IL12B, TRAF3IP2, and CARD14. Pathway enrichment analyses highlighted the involvement of immune response, cytokine signaling, and keratinocyte differentiation pathways. Conclusion: This GWAS in Egyptians has revealed novel psoriasis susceptibility loci and replicated previously reported associations, contributing to a better understanding of the genetic architecture of psoriasis in this population. These findings may have implications for the development of personalized treatment strategies.
The Rising Incidence of Skin Cancers in Young Adults: A Population-Based Study in Brazil Joseph Jose Flavio; Sarah Fernandez
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.158

Abstract

Introduction: Skin cancers, historically associated with older populations, are increasingly affecting young adults. This study investigates the incidence trends of skin cancers among young adults (18-39 years) in Brazil, a country with high UV exposure and diverse skin types. Methods: A population-based retrospective study was conducted using data from Brazil's National Cancer Registry (INCA) between 2010 and 2023. Incidence rates were calculated for melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) among young adults, stratified by age, sex, and region. Joinpoint regression analysis was used to assess temporal trends. Results: A total of 12,560 skin cancer cases were identified in young adults. BCC was the most common (55%), followed by SCC (30%) and melanoma (15%). Overall incidence rates increased significantly for all skin cancer types, with an average annual percentage change (AAPC) of 3.2% for BCC, 2.8% for SCC, and 4.5% for melanoma. The highest incidence rates were observed in the Southern region, followed by the Southeast. Females had a higher incidence of melanoma, while males had a higher incidence of BCC and SCC. Conclusion: This study demonstrates a concerning rise in skin cancer incidence among young adults in Brazil. The findings highlight the need for targeted prevention efforts, including sun protection education and early detection programs, to address this growing public health issue.
The Rising Incidence of Acne Vulgaris in Adolescents: Lifestyle Factors and Preventive Strategies in Bangladesh Prakesh, Utter; Mahmood Abbas
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.160

Abstract

Introduction: Acne vulgaris, a common skin condition, significantly impacts adolescents' quality of life. In Bangladesh, the prevalence of acne vulgaris has been increasing, particularly among urban adolescents. This study aims to investigate the lifestyle factors associated with acne vulgaris and explore potential preventive strategies. Methods: A cross-sectional study was conducted among 400 adolescents (aged 12-18 years) in Dhaka, Bangladesh. Data were collected using a structured questionnaire, including sociodemographic information, dietary habits, sleep patterns, stress levels, and skincare practices. Acne severity was assessed using the Global Acne Grading System (GAGS). Statistical analyses were performed to identify associations between lifestyle factors and acne severity. Results: The prevalence of acne vulgaris was 68.5%. A significant association was found between acne severity and high glycemic index (GI) diets (p<0.01), irregular sleep patterns (p<0.05), and high stress levels (p<0.001). Inadequate skincare practices, such as infrequent face washing and the use of comedogenic cosmetics, were also associated with increased acne severity (p<0.05). Conclusion: This study highlights the significant impact of lifestyle factors on acne vulgaris in Bangladeshi adolescents. Interventions targeting dietary habits, sleep patterns, stress management, and skincare practices may be effective in preventing and managing acne vulgaris in this population.

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