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Patricia Wulandari
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Sriwijaya Journal of Otorhinolaryngology
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 2987131X     EISSN : 2987131X     DOI : https://doi.org/10.59345/sjorl
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health
Focus Sriwijaya Journal of Otorhinolaryngology (SJORL) focused on the development of medical sciences especially otorhinolaryngology for human well-being. Scope Sriwijaya Journal of Otorhinolaryngology (SJORL) publishes articles which encompass all aspects of basic research/clinical studies related to the field of otorhinolaryngology and allied science fields, especially all type of original articles, case report, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Otorhinolaryngology
Articles 35 Documents
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Cross-Cohort Transcriptomic Analysis Identifies an ECM–CAF Stromal Program but Does Not Validate a Seven-Gene Prognostic Score in Head and Neck Squamous Cell Carcinoma Reisha Notonegoro; Bjorka Alma; Patricia Wulandari; Muhammad Yoshandi
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 2 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v3i2.307

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is biologically heterogeneous, and many public-data gene signatures lack cross-platform replication and unbiased evaluation. Objective: We sought reproducible tumor–normal expression programs and tested the transportability of a derived seven-gene score. Methods: TCGA-HNSC RNA-sequencing defined differentially expressed genes (DEGs) between 520 tumors and 44 normal tissues using TMM normalization and voom–limma, with paired sensitivity analysis. Concordant genes were replicated in 22 GSE6631 matched pairs and analyzed for GO and KEGG enrichment. A seven-gene overall-survival score was developed in event-stratified TCGA training data (n=361), evaluated in held-out TCGA (n=156), repeated nested resampling, and examined in GSE65858 (n=253). ESTIMATE and marker scores characterized tumor-microenvironment features. Results: Among 5,657 TCGA and 168 GSE6631 DEGs, 151 replicated. Upregulated genes were enriched for extracellular-matrix organization, ECM–receptor interaction, integrin signaling, focal adhesion, and PI3K–Akt signaling. The score was associated with survival in training (HR per SD=1.68; C-index=0.642) but not held-out TCGA (HR=1.02; C-index=0.546) or unadjusted GSE65858 (HR=1.15; C-index=0.548). Median nested C-index was 0.564. HPV adjustment attenuated the GSE65858 association. The score correlated with CAF/fibroblast (ρ=0.269) and stromal scores (ρ=0.228). Conclusion: Replicated expression changes support an ECM–CAF program, but the seven-gene score did not generalize and is not a validated prognostic model.
Genetically Proxied Circulating C-Reactive Protein and Selected Cytokines in Relation to Register-Defined Sensorineural Hearing Loss: A Two-Sample Mendelian Randomization Study Rizky Ayu; Adolfo Rawlings; Aleisha Wulandari; Brenda Jaleel
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 2 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v3i2.308

Abstract

Background: Circulating inflammatory biomarkers are associated with sensorineural hearing loss (SNHL), but observational studies cannot establish causality. Objective: To evaluate whether genetically proxied C-reactive protein (CRP) and eight cytokines are associated with SNHL. Methods: We used European-ancestry GWASs for CRP (N = 575,531) and eight cytokines (maximum N = 74,783), with FinnGen R13 outcomes of 48,388 SNHL cases and 432,132 controls; sudden idiopathic hearing loss (4,082 cases) was secondary. Variants were harmonized and pruned using 1000 Genomes Finnish linkage disequilibrium (r² < 0.001 within 10 Mb). Random-effects inverse-variance weighting or a Wald ratio was primary. Sensitivity analyses included MR-Egger, weighted median and mode, MR-RAPS, RadialMR, Steiger directionality, cis-only estimates, source-assay filters, and false-discovery-rate correction. Results: Of 301 unique exposure rsIDs, 279 were retrieved and 276 exposure rows passed harmonization. Finnish LD pruning left 238 CRP instruments. CRP was compatible with the null (OR per unit increase in ln[CRP mg/L], 1.005; 95% CI, 0.948–1.065; p = 0.868), consistent with weighted median, MR-Egger, weighted mode, and MR-RAPS estimates. No cytokine survived FDR correction (all q ≥ 0.393), source-assay filtering yielded no supported association, and secondary-outcome estimates were null. Steiger analyses favored the exposure-to-outcome direction. Conclusion: Results support no material effect of lifelong genetically proxied circulating CRP on register-defined SNHL. Cytokine evidence remains less definitive because instrument sets were small, predominantly trans acting, heterogeneous, and assay sensitive. The findings neither exclude acute or cochlea-specific inflammation nor evaluate corticosteroid effectiveness. Independent replication and cis-pQTL colocalization are required before therapeutic inference.
Secondary Cross-Platform Transcriptomic Reanalysis of Laryngeal Squamous Cell Carcinoma Identifies Reproducible Tumor-Associated Programs but No Independently Validated Prognostic Biomarker Rachmat Hidayat; Mustafa Mahmud
Sriwijaya Journal of Otorhinolaryngology Vol. 4 No. 1 (2026): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v4i1.314

Abstract

Background: Public transcriptomes can reveal reproducible laryngeal squamous cell carcinoma (LSCC) programs, but differential expression alone does not establish prognosis. Objective: To evaluate paired tumor-associated expression changes and test whether any gene met independent prognostic criteria. Methods: Depositor-processed GSE127165 RNA-sequencing data from 57 paired LSCC and adjacent-mucosa specimens were analyzed with patient-blocked limma-trend after predefined filtering of log₂(FPKM + 1) values. Differentially expressed features required Benjamini–Hochberg false-discovery rate (FDR) <0.05 and absolute paired mean difference ≥1. Functional over-representation used g:Profiler. Expression replication used 23 paired TCGA larynx-labeled cases. Prognostic associations were assessed continuously in GSE27020 training (n=59) and validation (n=50) cohorts and 116 TCGA larynx-labeled tumors, with progression-free interval primary and overall survival secondary. Results: Of 11,908 tested features, 230 were upregulated and 205 downregulated. Excluding three quality-control-associated pairs retained 418 primary calls; quantile normalization retained 396. Among 327 measurable discovery features in TCGA, 184 replicated at FDR <0.05 with the same direction; directional concordance was 89.0% and effect correlation was ρ=0.774. Keratinization, extracellular-matrix, adhesion, and inflammatory programs were over-represented. No gene satisfied the operational prognostic criterion. SERPINE1 was exploratory: training HR=2.09, validation HR=1.53, and TCGA progression-free interval HR=1.28; the modified Knapp–Hartung pooled inference was non-significant. Conclusion: LSCC showed reproducible bulk-tissue expression programs, but no single differentially expressed gene qualified as an independently validated prognostic biomarker. These findings support biological prioritization, not clinical decision-making.
Incidence, Mortality, Sex Differences, and Demographic Projections for Six Selected Head and Neck Cancer Site Groups in Indonesia: A Secondary Analysis of GLOBOCAN 2024 Modeled Estimates Lisye Tiur Simanjuntak; Ayesh Mahmood
Sriwijaya Journal of Otorhinolaryngology Vol. 4 No. 1 (2026): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v4i1.317

Abstract

Background: Nationally representative data on the heterogeneous malignancies managed in head and neck oncology remain limited in Indonesia. Objective: To estimate incidence, mortality, sex differences, and demographic change for six selected head and neck cancer site groups in Indonesia. Methods: We performed a descriptive secondary analysis of GLOBOCAN 2024 aggregate modeled estimates (version 08 July 2026). The definition included lip and oral cavity (C00–C06), salivary glands (C07–C08), oropharynx (C09–C10), nasopharynx (C11), hypopharynx (C12–C13), and larynx (C32). Counts and age-standardized rates were aggregated across mutually exclusive sites. Indonesia was compared descriptively with four reference populations. Constant-rate Cancer Tomorrow projections and two definitional sensitivity analyses were evaluated. Source uncertainty distributions were unavailable; therefore, confidence intervals were not constructed. Results: An estimated 28,226 cases and 16,025 deaths occurred in 2024; summed ASIR and ASMR were 8.91 and 5.06 per 100,000. Nasopharyngeal cancer contributed 16,064 cases (56.9%) and 8,718 deaths (54.4%). Male rates exceeded female rates: ASIR 13.19 versus 5.18 and ASMR 7.73 versus 2.77. With 2024 rates held constant, annual cases increased to 46,895 (+66.1%) and deaths to 27,900 (+74.1%) by 2050. All 21 validation checks passed. Conclusion: Indonesia's selected head and neck cancer burden is dominated by nasopharyngeal cancer and higher male rates. These modeled estimates support prevention, registry strengthening, and planning hypotheses but do not measure stage, utilization, treatment need, survival, cost, or causal effects.
Otitis Media and Upper Respiratory Infection Health Loss in 11 Current ASEAN Member States, 1990–2023 Imanuel Simbolon; Muhammad Rusli; Moon Kaeun
Sriwijaya Journal of Otorhinolaryngology Vol. 4 No. 1 (2026): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v4i1.321

Abstract

Background: Otitis media and upper respiratory infections (URIs) are distinct Global Burden of Disease (GBD) causes but form a clinically relevant comparative pair for otorhinolaryngology. Objective: To quantify their health loss in 11 current ASEAN member states. Methods: We analysed GBD 2023 estimates for both sexes from 1990 to 2023. Outcomes were all-age disability-adjusted life-year (DALY) numbers, age-standardized DALY rates, and DALY numbers and rates at ages 0–14 years. Country-specific estimated annual percentage changes (EAPCs) used log-linear regression with Newey–West 95% confidence intervals. Analyses were descriptive and non-causal. Results: The sum of 11 national URI DALY point estimates increased from 372,296 in 1990 to 476,741 in 2023 (+28.1%), while the unweighted cross-country median age-standardized rate fell 10.9% to 66.2 per 100,000. Otitis media DALYs increased from 175,399 to 191,971 (+9.4%), while the corresponding median rate fell 19.7% to 29.0 per 100,000. All 22 country-cause EAPC point estimates were negative. Thailand had the highest 2023 URI rate and Cambodia the highest otitis media rate. Ages 0–14 years accounted for 35.8% and 39.1% of summed URI and otitis media DALYs, respectively. Conclusion: Declining standardized rates coexisted with increasing absolute health loss. DALYs provide a planning signal rather than measured clinical workload; translation into otolaryngology services requires local diagnostic, hearing, referral, and capacity data.

Page 4 of 4 | Total Record : 35

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