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Sriwijaya Journal of Otorhinolaryngology
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 2987131X     EISSN : 2987131X     DOI : https://doi.org/10.59345/sjorl
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health
Focus Sriwijaya Journal of Otorhinolaryngology (SJORL) focused on the development of medical sciences especially otorhinolaryngology for human well-being. Scope Sriwijaya Journal of Otorhinolaryngology (SJORL) publishes articles which encompass all aspects of basic research/clinical studies related to the field of otorhinolaryngology and allied science fields, especially all type of original articles, case report, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Otorhinolaryngology
Articles 26 Documents
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Proteomic Analysis of Saliva in Patients with Oral Squamous Cell Carcinoma: Identifying Diagnostic and Prognostic Biomarkers in Indonesia Rachmat Hidayat; Johan Wirahadi Putro; Arsan Saliha
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 2 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.31

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is a significant health problem in Indonesia, characterized by high morbidity and mortality rates. Early detection is critical for improving patient outcomes. Saliva, a readily accessible biofluid, holds promise as a non-invasive source for identifying biomarkers for OSCC diagnosis and prognosis. This study aimed to identify salivary proteomic biomarkers associated with OSCC in an Indonesian population. Methods: Saliva samples were collected from 50 OSCC patients and 50 healthy controls. Proteomic analysis was performed using liquid chromatography-mass spectrometry (LC-MS/MS). Differentially expressed proteins were identified and validated using enzyme-linked immunosorbent assays (ELISA). Bioinformatic analysis was conducted to explore the functional roles and pathways associated with identified biomarkers. Results: LC-MS/MS analysis revealed 100 differentially expressed proteins in the saliva of OSCC patients compared to controls. After validation by ELISA, five proteins consistently showed significant differences: Increased levels of S100A7, MUC5B, and IL-6, and decreased levels of Statherin and Histatin 1 were observed in OSCC patients. Conclusion: This study identified a panel of salivary protein biomarkers with potential for OSCC diagnosis and prognosis in the Indonesian population. Further validation in larger cohorts is needed to assess their clinical utility and develop potential screening tools.
Living with Tinnitus: A Qualitative Exploration of Indonesian Patients' Coping Strategies and Support Needs Venny Meilinda; Michelle Birne; Mariana Alifah; Imanuel Simbolon
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 2 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.32

Abstract

Introduction: Tinnitus, the perception of sound without an external source, affects many people globally. Its causes are varied and often unclear, and it can significantly impact the quality of life, causing distress, sleep problems, and concentration difficulties. This study explored the experiences of Indonesian tinnitus patients, focusing on their coping strategies and support needs. Methods: We conducted semi-structured interviews with 25 Indonesian adults diagnosed with tinnitus. Participants were recruited from otorhinolaryngology clinics in Jakarta and Surabaya. Interviews were audio-recorded, transcribed, and analyzed using thematic analysis. Results: Four main themes emerged: (1) The multifaceted impact of tinnitus: emotional distress, social isolation, and functional limitations; (2) Diverse coping mechanisms: acceptance, sound therapy, and traditional remedies; (3) Perceived support needs: desire for information, counseling, and support groups; and (4) Cultural influences: spiritual beliefs and alternative medicine. Conclusion: This study provides valuable insights into the experiences of Indonesian tinnitus patients. It highlights the need for culturally sensitive and holistic management, including comprehensive support services like information, counseling, and support groups tailored to their needs.
Optimizing Postoperative Pain Management After Endoscopic Sinus Surgery in Indonesia: A Comparative Study of Analgesic Regimens Nabila Saraswati; Made Swastika; Zahra Amir; Husin Sastranagara; Bernadette Wilson
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 2 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.33

Abstract

Introduction: Endoscopic sinus surgery (ESS) is a frequently performed procedure for chronic rhinosinusitis in Indonesia. Effective postoperative pain management is vital for patient comfort, early recovery, and minimizing healthcare expenses. This study compared the efficacy of different analgesic regimens in managing postoperative pain after ESS in an Indonesian population. Methods: This prospective, randomized controlled trial involved 120 patients undergoing ESS at a tertiary hospital in Indonesia. Patients were randomly allocated to one of three groups: Group A received intravenous patient-controlled analgesia (PCA) with morphine, Group B received a combination of intravenous ketorolac and oral paracetamol, and Group C received oral paracetamol alone. Pain intensity was evaluated using the Visual Analog Scale (VAS) at 2, 6, 12, and 24 hours postoperatively. The requirement for rescue analgesia and the occurrence of adverse effects were also documented. Results: Group A (PCA with morphine) exhibited significantly lower VAS scores at all time points compared to Group B (ketorolac and paracetamol) and Group C (paracetamol alone) (p<0.001). Group B showed lower VAS scores than Group C at 2 and 6 hours postoperatively (p<0.05). The need for rescue analgesia was significantly higher in Group C compared to the other groups (p<0.001). The incidence of nausea and vomiting was higher in Group A, while constipation was more frequent in Group B. Conclusion: Intravenous PCA with morphine provided superior postoperative pain control after ESS compared to other analgesic regimens. However, the increased incidence of nausea and vomiting should be taken into account. A combination of intravenous ketorolac and oral paracetamol presented a suitable alternative with a more favorable side effect profile. Further investigation is necessary to optimize pain management protocols for ESS in the Indonesian population.
Prognostic Factors for Hearing Recovery Following Sudden Sensorineural Hearing Loss in Singapore: A Multivariate Analysis Nazimah Syarif; Vita Amanda; Shina Abdulkadir
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 2 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.34

Abstract

Introduction: Sudden sensorineural hearing loss (SSNHL) is an otologic emergency characterized by an unexplained, rapid loss of hearing, usually in one ear. Identifying prognostic factors for hearing recovery is crucial for guiding treatment strategies and patient counseling. This study aimed to determine the prognostic factors associated with hearing recovery in a cohort of SSNHL patients in Singapore. Methods: A retrospective cohort study was conducted involving 150 patients diagnosed with SSNHL at three tertiary referral hospitals in Singapore between January 2019 and December 2022. Data on demographics, clinical characteristics (degree and configuration of hearing loss, presence of vertigo and tinnitus), treatment modalities (corticosteroids, hyperbaric oxygen therapy), and hearing outcomes at 1, 3, and 6 months following diagnosis were collected. Hearing recovery was defined as an improvement of at least 15 dB in pure-tone average (PTA) across frequencies 0.5, 1, 2, and 4 kHz. Multivariate logistic regression analysis was performed to identify independent predictors of hearing recovery. Results: The mean age of the participants was 47.5 ± 12.8 years. Complete hearing recovery was observed in 48% of patients at 6 months. Multivariate analysis revealed that younger age (OR = 0.95, 95% CI: 0.92-0.98, p=0.003), absence of vertigo (OR = 3.15, 95% CI: 1.52-6.53, p=0.002), and prompt initiation of corticosteroid therapy (OR = 2.87, 95% CI: 1.38-5.97, p=0.005) were independent predictors of favorable hearing recovery. The degree of initial hearing loss and the presence of tinnitus were not significantly associated with hearing outcomes. Conclusion: Younger age, absence of vertigo, and early initiation of corticosteroid therapy are associated with better hearing outcomes in Singapore patients with SSNHL. These findings underscore the importance of prompt diagnosis and treatment to maximize the chances of hearing recovery.
The Role of Vestibular Rehabilitation in the Treatment of Benign Paroxysmal Positional Vertigo in Brazil: A Randomized Controlled Trial Juan Pablo Fernando Rodriguez; Sarah Fernandez
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 2 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.35

Abstract

Introduction: Benign paroxysmal positional vertigo (BPPV) is a prevalent vestibular disorder causing recurrent episodes of vertigo. Vestibular rehabilitation (VR) is a recognized treatment for BPPV, but its effectiveness in the Brazilian population remains to be fully elucidated. This randomized controlled trial aimed to investigate the impact of VR on BPPV outcomes in Brazil. Methods: 120 participants diagnosed with BPPV were randomly assigned to either a VR group (n=60) or a standard medical care (SMC) group (n=60). The VR group received a personalized program comprising canalith repositioning maneuvers (CRM) and vestibular exercises, while the SMC group received medication and lifestyle advice. The primary outcome was the Dizziness Handicap Inventory (DHI) score at 4 weeks. Secondary outcomes included vertigo frequency and intensity (assessed via a Vertigo Diary) and balance function (measured using the Timed Up and Go (TUG) test). Assessments were conducted at baseline, 2 weeks, and 4 weeks. Results: Both groups showed improvement in DHI scores over time. However, the VR group demonstrated significantly greater improvement in DHI scores at 4 weeks compared to the SMC group (p<0.05). Vertigo frequency and intensity also decreased significantly in both groups, with the VR group exhibiting a more pronounced reduction (p<0.05). Similarly, TUG test performance improved in both groups, but the VR group showed significantly better improvement at 4 weeks (p<0.05). Conclusion: This study provides evidence supporting the effectiveness of VR in treating BPPV in the Brazilian population. VR, incorporating CRM and vestibular exercises, resulted in significant improvements in dizziness-related handicap, vertigo symptoms, and balance function compared to SMC alone. These findings underscore the importance of integrating VR into BPPV management in Brazil.
Characterizing the Biofilm-Forming Capacity of Bacterial Isolates from Chronic Suppurative Otitis Media in Bhutan Tan Kiew Lee; Hasrita Soleiman
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.79

Abstract

Introduction: Chronic suppurative otitis media (CSOM) is a persistent middle ear infection characterized by recurrent ear discharge and hearing loss, significantly impacting the quality of life. Biofilm formation by bacteria plays a crucial role in the chronicity and recalcitrance of CSOM to conventional antibiotic treatments. This study aimed to characterize the biofilm-forming capacity of bacterial isolates from CSOM patients in Bhutan and assess their antibiotic susceptibility. Methods: Ear swab samples were collected from 100 patients diagnosed with CSOM at a tertiary hospital in Bhutan. Bacterial isolates were identified using standard microbiological techniques, including Gram staining, culture on selective media, and biochemical tests. Biofilm formation was quantitatively assessed using the crystal violet assay, and the biofilm architecture was visualized using confocal laser scanning microscopy (CLSM). The antibiotic susceptibility of biofilm-forming isolates was determined using the minimum biofilm eradication concentration (MBEC) assay. Results: The most prevalent bacterial isolates were Pseudomonas aeruginosa (35%), Staphylococcus aureus (25%), and Escherichia coli (15%). A significant proportion of these isolates (70%) exhibited strong biofilm-forming capacity. CLSM revealed a complex three-dimensional structure of the biofilms with channels and water passages, facilitating nutrient transport and waste removal. Biofilm-forming isolates demonstrated significantly higher MBEC values compared to their planktonic counterparts, indicating enhanced antibiotic resistance. Conclusion: This study highlights the significant prevalence of biofilm-forming bacteria in CSOM cases in Bhutan. The enhanced antibiotic resistance of these biofilms emphasizes the urgent need for alternative treatment strategies, such as biofilm-disrupting agents or targeted drug delivery systems, to effectively manage CSOM and prevent associated complications like hearing loss and intracranial infections.
Early Detection of Hearing Loss in Neonates in Mexico: Comparing the Accuracy of Auditory Brainstem Response and Otoacoustic Emissions Sophia Lucille Rodriguez; Made Swastika; Theresia Putri Sinaga
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.80

Abstract

Introduction: Early detection of hearing loss in neonates is critical for timely intervention and optimal speech and language development. This study aimed to compare the accuracy of Auditory Brainstem Response (ABR) and Otoacoustic Emissions (OAEs), two commonly used hearing screening methods, in identifying hearing loss in newborns in Mexico City. Methods: A prospective cross-sectional study was conducted at a tertiary care hospital in Mexico City. Newborns were screened with both ABR and OAEs within the first 48 hours of life. Infants who failed either screening test underwent diagnostic audiological evaluation by three months of age. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ABR and OAEs were calculated using the diagnostic evaluation as the gold standard. Results: A total of 500 newborns were included in the study. The prevalence of hearing loss was 3%. ABR had a sensitivity of 95%, specificity of 92%, PPV of 60%, and NPV of 99%. OAEs had a sensitivity of 85%, specificity of 90%, PPV of 45%, and NPV of 98%. ABR demonstrated significantly higher sensitivity compared to OAEs (p<0.05). Conclusion: ABR exhibited higher sensitivity in detecting hearing loss in neonates compared to OAEs. However, both methods demonstrated high NPV, suggesting their suitability for universal newborn hearing screening programs. The choice between ABR and OAEs may depend on available resources and the specific needs of the healthcare setting.
A Comparative Study of Intranasal Corticosteroids versus Antihistamines in the Management of Persistent Allergic Rhinitis in Indonesia Mariana Alifah; Abhimanyu Putra; Zainal Abidin Hasan; Aisyah Andina Rasyid; Sari Sulistyoningsih
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.92

Abstract

Introduction: Allergic rhinitis (AR) is a prevalent chronic inflammatory disease in Indonesia. Intranasal corticosteroids (INCS) and antihistamines are commonly prescribed treatments, but their comparative effectiveness in the Indonesian context remains unclear. This study aimed to compare the efficacy and safety of INCS versus antihistamines in managing persistent AR in Indonesia. Methods: A randomized controlled trial was conducted involving 120 patients diagnosed with persistent AR according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Participants were randomly assigned to receive either INCS (fluticasone propionate) or oral antihistamines (cetirizine) for eight weeks. The primary outcome was the change in the Total Nasal Symptom Score (TNSS), and secondary outcomes included the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score and adverse events. Results: Both INCS and antihistamines significantly improved TNSS and RQLQ scores from baseline. However, the INCS group demonstrated a significantly greater reduction in TNSS scores compared to the antihistamine group (p<0.05) at weeks 4 and 8. No significant difference was found between the two groups in terms of RQLQ score improvement. Both treatments were well-tolerated, with mild and transient adverse events reported in both groups. Conclusion: INCS are more effective than antihistamines in controlling nasal symptoms in patients with persistent AR in Indonesia. Both treatments improve quality of life, with comparable safety profiles. These findings support the preferential use of INCS as first-line therapy for persistent AR in the Indonesian population.
Evaluating Voice Quality and Pharyngeal Function in Professional Singers: A Cross-Sectional Study in Indonesia Indri Yani Septiana; Nur Diana; Eva Naritawati; Maximillian Wilson; Made Swastika
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.93

Abstract

Introduction: Professional singers heavily rely on their vocal capabilities, necessitating a thorough understanding of the interplay between voice quality and pharyngeal function to maintain vocal health and prevent disorders. This study aimed to evaluate these aspects in professional singers in Indonesia. Methods: This cross-sectional study involved 30 professional singers (15 males, 15 females) aged 20-40 years from Jakarta, Indonesia. Voice quality was assessed using the GRBAS scale (Grade, Roughness, Breathiness, Asthenia, Strain) and acoustic analysis (fundamental frequency, jitter, shimmer, harmonics-to-noise ratio). Pharyngeal function was evaluated via videofluoroscopy, measuring pharyngeal constriction ratio (PCR) during swallowing and vowel phonation. Results: Most singers exhibited normal voice quality per the GRBAS scale. Acoustic analysis revealed significantly higher fundamental frequency in females (p<0.05). Jitter, shimmer, and harmonics-to-noise ratio were within the normal range for both genders. PCR values were significantly higher during vowel phonation than swallowing in both genders (p<0.05), indicating increased pharyngeal constriction during singing. Conclusion: Professional singers in this study demonstrated good voice quality and adapted pharyngeal function to meet singing demands. Higher PCR during phonation suggests specific pharyngeal muscle activation patterns for vocal production. Further research is needed to explore the long-term effects of singing on pharyngeal function and identify potential risk factors for voice disorders in Indonesian singers.
The Impact of Gastroesophageal Reflux Disease (GERD) on Pharyngeal Mucosal Changes: A Case-Control Study in Indonesia Dedi Sucipto; Nurul Hanifah; Vidhya Sathyakirti; Louisa Istarini; Syaifudin Syaifudin
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.94

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is a prevalent digestive disorder with potential extra-esophageal manifestations, including laryngopharyngeal reflux (LPR). LPR can lead to various pharyngeal mucosal changes, impacting voice quality and overall well-being. This study aimed to investigate the association between GERD and pharyngeal mucosal changes in a population in Indonesia. Methods: A case-control study was conducted at a tertiary hospital in Indonesia, involving 100 participants diagnosed with GERD (cases) and 100 participants without GERD (controls). All participants underwent a comprehensive ear, nose, and throat (ENT) examination, including flexible nasopharyngoscopy, to assess pharyngeal mucosal changes. The Reflux Symptom Index (RSI) questionnaire was used to evaluate the severity of reflux symptoms. Data were analyzed using SPSS software, employing chi-square and logistic regression analyses to determine the association between GERD and pharyngeal mucosal changes. Results: The study found a significantly higher prevalence of pharyngeal mucosal changes in the GERD group compared to the control group (78% vs. 22%, p<0.001). Erythema, edema, and posterior pharyngeal wall cobblestoning were the most common findings in GERD patients. The severity of reflux symptoms, as measured by the RSI, was positively correlated with the presence and severity of pharyngeal mucosal changes. Conclusion: GERD is significantly associated with pharyngeal mucosal changes in the Indonesian population studied. These findings underscore the importance of recognizing and managing LPR in patients with GERD to prevent potential complications and improve quality of life.

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