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Adinda Juwita Sari
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Jurnal Kesehatan Metro Sai Wawai
Published by Poltekkes Kemenkes Tanjung Karang
ISSN : 1979469X     EISSN : 26571390     DOI : https://doi.org/10.26630
Core Subject : Health, Social,
Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Kesehatan Metro Sai Wawai E-ISSN 2657-1390 and P-ISSN 19779-469X is published by the Midwifery Department, Poltekkes Kemenkes Tanjung Karang, Metro City, Indonesia. The Jurnal Kesehatan Metro Sai Wawai was first published in December 2008 as print media. Since 2016, the Journal has been published in print and online twice a year (June and December). All manuscripts submitted will go through double-blind peer review and editorial before being given acceptance for publication. The scope is midwifery, public health, nursing, nutrition, complementary and alternative medicine (CAM), and education in health.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 191 Documents
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Molecular Docking Study of Phenolic Compounds from the Ethanolic Extract of Olive Leaves (Olea europaea L.) as Potential Treatment for Preeclampsia Anggraini, Yetti; Yuliawati, Yuliawati
Jurnal Kesehatan Metro Sai Wawai Vol. 18 No. 2 (2025): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsw.v18i2.5519

Abstract

Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria and is closely associated with oxidative stress, inflammation, endothelial dysfunction, and apoptosis. Olive leaves (Olea europaea L.) are rich in phenolic compounds with well-documented antioxidant and anti-inflammatory properties, making them a promising source of natural therapeutic agents. This study aimed to evaluate the potential of phenolic compounds from the ethanolic extract of olive leaves as candidates for treating preeclampsia using a molecular docking approach. The two-dimensional structures of selected phenolic compounds, including kaempferol, luteolin, and oleuropein, were obtained from the PubChem database and prepared as ligands. Target proteins associated with the pathophysiology of preeclampsia were prepared using AutoDock Tools by removing water molecules and separating native ligands. Molecular docking simulations were conducted to analyze binding affinities and interaction patterns between the phenolic compounds and the target proteins. The results demonstrated that all tested compounds exhibited favorable binding energies and formed stable interactions with key amino acid residues at the active sites of the target proteins. Among the compounds evaluated, oleuropein showed the strongest binding affinity, followed by luteolin and kaempferol. These findings suggest that phenolic compounds from the ethanolic extract of olive leaves have potential as therapeutic agents for preeclampsia, possibly through antioxidant and anti-inflammatory mechanisms. However, further in vitro and in vivo studies are required to validate these computational findings and confirm their biological efficacy.

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