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Adinda Juwita Sari
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INDONESIA
Jurnal Kesehatan Metro Sai Wawai
Published by Poltekkes Kemenkes Tanjung Karang
ISSN : 1979469X     EISSN : 26571390     DOI : https://doi.org/10.26630
Core Subject : Health, Social,
Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Kesehatan Metro Sai Wawai E-ISSN 2657-1390 and P-ISSN 19779-469X is published by the Midwifery Department, Poltekkes Kemenkes Tanjung Karang, Metro City, Indonesia. The Jurnal Kesehatan Metro Sai Wawai was first published in December 2008 as print media. Since 2016, the Journal has been published in print and online twice a year (June and December). All manuscripts submitted will go through double-blind peer review and editorial before being given acceptance for publication. The scope is midwifery, public health, nursing, nutrition, complementary and alternative medicine (CAM), and education in health.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 192 Documents
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Molecular Docking Study of Phenolic Compounds from the Ethanolic Extract of Olive Leaves (Olea europaea L.) as Potential Treatment for Preeclampsia Anggraini, Yetti; Yuliawati, Yuliawati
Jurnal Kesehatan Metro Sai Wawai Vol. 18 No. 2 (2025): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsw.v18i2.5519

Abstract

Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria and is closely associated with oxidative stress, inflammation, endothelial dysfunction, and apoptosis. Olive leaves (Olea europaea L.) are rich in phenolic compounds with well-documented antioxidant and anti-inflammatory properties, making them a promising source of natural therapeutic agents. This study aimed to evaluate the potential of phenolic compounds from the ethanolic extract of olive leaves as candidates for treating preeclampsia using a molecular docking approach. The two-dimensional structures of selected phenolic compounds, including kaempferol, luteolin, and oleuropein, were obtained from the PubChem database and prepared as ligands. Target proteins associated with the pathophysiology of preeclampsia were prepared using AutoDock Tools by removing water molecules and separating native ligands. Molecular docking simulations were conducted to analyze binding affinities and interaction patterns between the phenolic compounds and the target proteins. The results demonstrated that all tested compounds exhibited favorable binding energies and formed stable interactions with key amino acid residues at the active sites of the target proteins. Among the compounds evaluated, oleuropein showed the strongest binding affinity, followed by luteolin and kaempferol. These findings suggest that phenolic compounds from the ethanolic extract of olive leaves have potential as therapeutic agents for preeclampsia, possibly through antioxidant and anti-inflammatory mechanisms. However, further in vitro and in vivo studies are required to validate these computational findings and confirm their biological efficacy.
Dynamics and Literature Review of Malaria Cases in Indonesia in the Development of Diagnosis and Management in 2020-2025 Sangging, Putu Ristyaning Ayu; Zahira TS, Shifa Tanjia; Al Ayubi, M. Mahdi; Aurelia, Faizah Zahra; Satria, Rasha Andhika; Putra, Rangga Pratama Wahyuono
Jurnal Kesehatan Metro Sai Wawai Vol. 19 No. 1 (2026): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsw.v19i1.5448

Abstract

Malaria remains a major public health problem in Indonesia, especially in eastern provinces such as Papua and West Papua. The period 2020–2025 is critical because it combines the national malaria elimination program with disruptions to health services during the COVID-19 pandemic. Understanding trends in diagnosis and clinical management is important to strengthen national strategies. This systematic review summarizes evidence on malaria trends in Indonesia from 2020 to 2025, focusing on diagnostic developments and treatment practices. A systematic search was conducted in PubMed, Scopus, Google Scholar, ScienceDirect, SINTA, and Garuda using keywords such as “malaria,” “Indonesia,” “diagnosis,” “management,” “RDT,” “microscopy,” “PCR,” and “ACT.” Articles published between January 2020 and February 2025 were screened using PRISMA guidelines. Studies were included if they reported malaria incidence, diagnostic methods, treatment strategies, or surveillance outcomes in Indonesia. Of 1,182 records identified, five studies met the final inclusion criteria. Data were extracted and analyzed narratively. The findings show that microscopy remains the gold standard for malaria diagnosis. However, its effectiveness is limited by uneven distribution of trained personnel and laboratory capacity. Rapid Diagnostic Tests (RDTs) are increasingly used in remote areas because they are practical and easy to use, although their sensitivity decreases in cases with low parasite levels. Polymerase Chain Reaction (PCR) offers better detection of low-density and mixed infections, but its use is largely restricted to research centers and tertiary laboratories. For treatment, Artemisinin-based Combination Therapy (ACT) remains the main therapy for uncomplicated malaria, while intravenous artesunate is the first-line treatment for severe cases. Across the reviewed studies, early diagnosis, appropriate use of antimalarial drugs, and reduction of mosquito exposure were consistently linked to better outcomes. Screening of students from endemic areas who were studying in non-endemic provinces did not detect asymptomatic malaria cases. Overall, the review shows both progress and ongoing challenges. Diagnostic capacity has improved, but regional disparities remain. Strengthening laboratory skills, better integrating RDT, microscopy, and PCR approaches, and improving surveillance and referral systems are essential to reach the 2030 malaria elimination target. Future research should focus on monitoring treatment response, mapping drug resistance, and evaluating the implementation of diagnostic strategies.

Page 20 of 20 | Total Record : 192

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