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INDONESIA
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Published by Politeknik Indonusa Surakarta
ISSN : 25486667     EISSN : 27759032     DOI : 10.46808
Core Subject : Health, Science,
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health
The journal includes various fields of pharmaceuticals sciences such as: Pharmacy, Pharmacokinetics, Community and Clinical Pharmacy, Medical, Alternative medicines, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Microbiology, Tissue Culture, Botany and Animals Related to Pharmaceutical Products, Midwifery, Health Analyst, Nutrition and Public Health, Pharmacology and Toxicology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 162 Documents
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PENGETAHUAN MASYARAKAT RURAL TENTANG DAGUSIBU (DAPATKAN, GUNAKAN, SIMPAN, BUANG) OBAT KAMPUNG BONGAS KABUPATEN GARUT Raden Aldizal Mahendra Rizkio Syamsudin; Dewi Sinta; Risa Susanti; Framesti Frisma Sriarumtias
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.326

Abstract

The DAGUSIBU Program (Get, Use, Store, Dispose) is a program aimed at improving public health and safety in medication use. This study aims to analyze the knowledge of the residents of Bongas Village, Garut, regarding the DAGUSIBU concept. The study used a cross-sectional method with quota sampling and data collection through questionnaires. Results showed that the majority of residents had a moderate level of knowledge (55.4%) while 44.6% had a lower level of understanding of DAGUSIBU. Education level (p 0.04) also influenced knowledge levels. In conclusion, further education on DAGUSIBU is needed in the community.
FORMULASI DAN UJI ANTIOKSIDAN GEL MOISTURIZER EKSTRAK BIJI KOPI HIJAU ROBUSTA (Coffea canephora Pierre ex A. Froehner) DENGAN METODE DPPH Tiara Ramadaini; Muhammad Andry; Cindy Marseli; Rafifah Azzahra; Nurfitriyana; Lilik Septiana; Siti Nurhaliza
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.327

Abstract

Introduction: Robusta green coffee beans (Coffea canephora) are recognized for their abundant chlorogenic acid content, a bioactive compound with significant antioxidant capacity capable of neutralizing free radicals that contribute to dermal damage. The gel dosage form was selected owing to its lightweight consistency, rapid dermal absorption, and combined moisturizing and protective properties. This study aimed to produce a physically and organoleptically stable gel formulation derived from robusta green coffee bean extract, with emphasis on optimizing antioxidant activity as assessed by the DPPH method through IC₅₀ determination. Method: An experimental laboratory approach was employed, utilizing beans obtained from Parapat, Toba region. The study encompassed three sequential stages: plant material extraction, gel preparation, and comprehensive physicochemical stability assessment. Results: Extraction produced an 11.15% yield. Characterization of the crude extract met established quality parameters, with moisture content at 2.5%, water-soluble extract at 13.3%, ethanol-soluble extract at 13.6%, total ash at 3.33%, and acid-insoluble ash at 0.5%. All three gel formulations (F1, F2, F3) exhibited characteristic coffee organoleptic profiles, maintained homogeneity, demonstrated stable pH values ranging from 6.2 to 6.7, displayed satisfactory spreadability, and caused no skin irritation. Moisturization parameters including skin hydration, wrinkle reduction, and pore appearance were improved across all formulations. Formulation F3, containing 9% extract, delivered the highest antioxidant efficacy with an IC₅₀ of 53.157 ppm, placing it in the strong antioxidant category. Conclusion: Robusta green coffee bean extract was successfully incorporated into a stable and safe gel moisturizer with strong antioxidant activity. A direct relationship was observed between extract concentration and both moisturizing performance and free radical scavenging capability.
PERBANDINGAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) DAN KOPI ROBUSTA (Coffea canephora L.) SEMENDE DARAT LAUT SUMATERA SELATAN Indah Indah; Wahyu Wahyu; Yovi Pranata
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.329

Abstract

This research was conducted to determine and compare the antioxidant capacity of 70% ethanolic extracts of Arabica (Coffea arabica L.) and Robusta (Coffea canephora L.) coffee beans collected from Semende Darat Laut, South Sumatra, Indonesia. The coffee beans were extracted by maceration using 70% ethanol, while free-radical scavenging activity was examined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) assay and read at 517 nm using UV-Vis spectrophotometry. The Arabica bean extract produced an IC₅₀ of 38.879 µg/mL and was classified as having very strong antioxidant activity. In comparison, the Robusta extract yielded an IC₅₀ of 52.402 µg/mL, which falls into the strong category. As the positive control, vitamin C showed an IC₅₀ of 29.636 µg/mL. Qualitative phytochemical tests detected phenolic compounds, saponins, and steroids in both extracts. These results suggest that Arabica coffee beans from Semende Darat Laut exhibit stronger antioxidant potential than Robusta beans, presumably due to differences in phenolic constituents, including chlorogenic acid. Thus, both local coffee varieties may be considered prospective natural antioxidant sources for health-related product development.
ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT PENGETAHUAN KESEHATAN REPRODUKSI PADA REMAJA PUTRI DI SMP IT AR-RISALAH SUKOHARJO Wahyu Ratri Sukmaningsih; Nadia Marsha Karinda; Natasya Mutoliah; Wahyu Arcinta Ma’rifatullah; Yuni Tri Utami; Zahra Gita Cahyani; Zalra rahmawati Nuraini
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.330

Abstract

Adolescent reproductive health is an important issue in public health because it is closely related to the quality of future generations. This study aimed to analyze the factors associated with the level of reproductive health knowledge among female adolescents at SMP IT Ar-Risalah Sukoharjo. This research employed an observational analytic quantitative study with a cross-sectional design. A total of 65 respondents were selected using purposive sampling technique. The independent variables included age, menarche status, educational exposure, source of information, parental role, and media access, while the dependent variable was the level of reproductive health knowledge. Data were collected using questionnaires that had been tested for validity and reliability. Data analysis was performed using Chi-Square test and Logistic Regression. The results showed that most respondents had a good level of reproductive health knowledge (56,9%). Bivariate analysis indicated that all variables were significantly associated with the level of knowledge (p<0,05). Multivariate analysis showed that educational exposure (p=0,015; OR=3,67) and parental role (p=0,043; OR=2,74) were significant factors influencing reproductive health knowledge. Educational exposure was identified as the most dominant factor. This study highlights the importance of structured reproductive health education and active parental support in improving reproductive health knowledge among female adolescents.
POTENSI INTERAKSI FARMAKOKINETIK OBAT STATIN PADA PASIEN RAWAT INAP: KAJIAN RETROSPEKTIF DI RUMAH SAKIT X PALEMBANG Alinda Tania; Salsabila Gustiharda; Edy Sapada
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.331

Abstract

Drug interaction is defined as an alteration in the effect of a drug caused by the administration of another drug, either given previously or concurrently, which may influence the effectiveness or increase the toxicity of one or more drugs. This study was conducted to analyze the potential drug interactions associated with statin therapy among hospitalized patients at Hospital X in Palembang during the period of January–December 2023. This study uses retrospective data with descriptive analytical research design. Based on the calculation using the Slovin formula, 76 medical records were used as the sample. The results show that the highest patient age group was 56–65 years (36%), the majority were female (64%), and the most common diagnosis was hypertension (26%). The most widely used statin was simvastatin (55%), followed by atorvastatin (45%). The most commonly co-prescribed drug class was antihypertensives (29%). Drug interaction potential was found in 83% of patients, while 17% had no potential interactions. The predominant severity level was moderate (52%), followed by major (47%), and minor (1%). The most common interaction mechanism was pharmacokinetic (91%), followed by pharmacodynamic (9%).
UJI ANTIPIRETIK PATCH TRANSDERMAL EKSTRAK ETANOL HERBA MENIRAN (Phyllanthus niruri L.) TERHADAP TIKUS PUTIH JANTAN Disa Andriani; Yunissa Aurini Sukarno; Eka Wisnu Kusuma
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.332

Abstract

Fever is a physiological response to infection characterized by an increase in body temperature due to prostaglandin production in the hypothalamus. Phyllanthus niruri contains flavonoids and alkaloids with potential antipyretic activity. The development of transdermal patch dosage forms is intended to improve therapeutic effectiveness by avoiding first-pass metabolism. Ethanol extract of meniran at two dose levels, 0.3 g and 0.6 g/200 g body weight of rats. Patch characteristics were evaluated including organoleptic properties, pH, weight uniformity, thickness, folding endurance, and moisture absorption. The antipyretic activity test was conducted on male white rats induced with DPT-HB-Hib vaccine. The ethanol extract of meniran yielded 14.39% and tested positive for flavonoids and alkaloids. All patch formulations met the requirements for transdermal dosage forms. The antipyretic test showed that formula F2 (0.6 g/200 g BW) had higher effectiveness than F1 (0.3 g/200 g BW), with %AAP values of 2.021% and 1.884%. Statistical analysis indicated a significant difference among treatment groups (p < 0.05).
ANALISIS LEAN SERVICE RECOVERY (LSR) DALAM MEDICATION MANAGEMENT DAN PELAYANAN KEFARMASIAN RUMAH SAKIT: A SYSTEMATIC LITERATURE REVIEW Isma Oktadiana
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.333

Abstract

This study aims to analyze the implementation of Lean Service Recovery (LSR) in medication management and hospital pharmaceutical services through a Systematic Literature Review (SLR) approach. The research was conducted using the PRISMA framework by systematically reviewing scientific articles retrieved from Scopus, ScienceDirect, SpringerLink, PubMed, and Google Scholar databases. The literature selection process yielded 22 relevant studies focusing on lean management, service recovery, medication management, patient safety, and pharmaceutical care in hospital settings. The findings indicate that Lean Service Recovery significantly contributes to improving both the efficiency and quality of pharmaceutical services. This is achieved through the optimization of prescription workflows, reduction of waiting times, prevention of medication errors, improvement in drug distribution accuracy, and enhancement of patient safety and patient satisfaction. Furthermore, the integration of smart pharmacy systems and digital healthcare technologies enhances service effectiveness and accelerates service recovery processes. However, several challenges were identified, including organizational resistance to change, limited human resources, insufficient lean management training, and suboptimal pharmaceutical information systems. Therefore, Lean Service Recovery can be considered a strategic approach that integrates operational efficiency, service recovery, continuous improvement, and patient-centered care to support more responsive, safe, and sustainable hospital pharmaceutical services.
TINGKAT PENGETAHUAN PENGGUNAAN ANTIBIOTIK DI FKTP dr. WENY MAYRENDA BAGAN PETE KOTA JAMBI Anggun Mutiara; Najwa Salsabila; Septa Pratama
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.334

Abstract

The high use of antibiotics may occur because of increased the antibiotics consumption. A low level of knowledge regarding antibiotic use is known to contribute to antibiotic resistance. The objective of this study was to asses the level of knowledge related to antibiotic use among patients at FKTP dr. Weny Mayrenda Bagan Pete, Jambi City. The research design used a descriptive quantitative method with a cross-sectional design. The findings revealed that among 110 respondents, the majority were early adult (60%) and female (60%). Based on the educational background, most respondents had secondary education (46.4%), and a substantial number of respondents were unemployed (33.6%). The findings of the study showed that most respondents possessed a high level of knowledge regarding antibiotics, with a total of 52 respondents (47,3%), followed by a moderate level of knowledge with 31 respondents (28.2%), and a low level of knowledge with 27 respondents (24.5%). No meaningful relationship was observed between the level of knowledge and respondents’ age or gender (p-value > 0.05). However, educational level and employment status were significantly related to the level of  knowledge (p-value < 0.05).
POTENSI GEL SARANG BURUNG WALET PUTIH (Aerodramus fuciphagus) DALAM PENYEMBUHAN LUAS LUKA INSISI PADA MENCIT (Mus musculus) Mirna Mualim; Sry Almarahma; Farah Diba ‘Izzati; Amani Aldiyanti; Muhammad Rizki Fadillah; Fadhil Muharram
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.336

Abstract

The white edible bird’s nest (Aerodramus fuchipagus) is formed from the secretion of bird saliva that is woven into a nest and is known to have various benefits, particularly in accelerating wound healing due to its high protein content. This study aimed to evaluate the effect of white edible bird’s nest gel on incision wound healing in mice (Mus musculus). The observed parameters included the time required for complete wound closure and morphological changes of the wound compared to the control group. This study employed a laboratory experimental method using 24 male mice, which were divided into six groups: four treatment groups (white edible bird’s nest gel at concentrations of 10%, 15%, and 30%, and a gel base group) and two control groups (a positive control using povidone iodine and a negative control with natural healing without treatment). Prior to treatment, the mice were anesthetized and the dorsal area was shaved. A square-shaped incision wound measuring 1.0–1.2 cm was then created down to the fascia. The gel was applied to the wound area twice daily for 14 days, and wound size was measured daily. The results showed a significant difference between the treatment groups and the control groups. The groups treated with white edible bird’s nest gel exhibited faster wound healing compared to the control groups. Specifically, the 10% concentration of the gel demonstrated the most optimal healing effect compared to other treatments and controls.
ANALISIS KESESUAIAN BIAYA RIIL TERHADAP TARIF INA- CBG`s PADA PENGOBATAN PASIEN RAWAT INAP DIARE DI RUMAH SAKIT SUMBER HURIP CIREBON Trisna Lestari; Denmas Teo Bimantara; Nur Rahmi Hidayati; Aan Kunaedi; Giska Amelia
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 10 No. 1 (2026): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v10i1.337

Abstract

The management of hospitalized patients with diarrhea incurs significant costs, particularly for JKN participants under the INA-CBG’s package payment system. Discrepancies between actual hospital costs and INA-CBG’s rates can result in financial losses for healthcare facilities. This study analyzes the alignment of actual treatment costs with INA-CBG’s rates for inpatients with diarrhea at Sumber Hurip Hospital in Cirebon, and evaluates patient characteristics and treatment profiles. The study employs a quantitative, observational approach with a retrospective design. A total of 213 medical records of inpatients with diarrhea from January to December 2024 were collected using random sampling. Data analysis was performed using SPSS with descriptive and bivariate correlation tests. The majority of patients were aged 18–59 years (100%), female (63.8%), admitted to Class III (64.7%), had a length of stay of 3–5 days (86.39%), and had mild cases (91.55%). Treatment was dominated by Diagit (52.95%) and New Diatab (43.01%). The average INA-CBG rate was Rp434,257,800, while the average actual cost reached Rp568,133,904, resulting in a shortfall of Rp133,876,104. Factors with a significant influence (p<0.05) were age, length of hospital stay, secondary diagnosis, severity level, and care class, while gender had no effect.

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