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Mawaddah Ar Rachmah
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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 299 Documents
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KORELASI KADAR D-DIMER DENGAN JUMLAH SINUS VENA SEREBRAL PADA PASIEN CEREBRAL VENOUS THROMBOSIS Aditya Kurnianto; Yovita Andhitara; Dodik Tugasworo; Retnaningsih Retnaningsih; Rahmi Ardhini; Vivi Kristiani Rumapea; Jethro Budiman
NEURONA Vol 38 No 1 (2020)
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Abstract

Introduction: Cerebral venous thrombosis (CVT) is a rare yet potentially devastating disease. According to the Virchow Triad, one of the predisposing factors is the hypercoagulable state of the blood that can be measured with D-dimer. Aim: To evaluate the correlation of D-dimer level and number of venous sinus in patient with CVT. Methods: A retrospective study including 45 patients with CVT between January 2019-January 2020 in Dr. Kariadi General Hospital, Semarang were conducted. The diagnosis of CVT was confirmed by digital subtraction angiography (DSA). Data on coagulation profile including platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen level, and d-dimer level were collected. The correlation between the D-dimer level and the number of the venous sinus was analyzed by Spearman’s rank correlation test. Results: Most of the sample were female with the mean age of 39.6 years. Multiple venous sinus occurred in 24 patients, and the most location of the CVT was sagittal sinus. The mean platelet count was 296,000cells/mcL, mean fibrinogen 326.9mg/dL, mean APTT 34s, mean PT 12.4s, and the median D-dimer level was 556.5ng/mL. There was a moderate correlation of D-dimer level and number of venous sinus (p=0.000, r=0.529). Discussion: D-Dimer level in CVT patients were elevated. The increased level of D-dimer was associated with multiple cerebral venous sinus in CVT patients because the extension of thrombosis causing an increase in D-dimer level. Keywords: coagulation, CVT, D-dimer, cerebral venous sinus
KORELASI KADAR ASAM URAT DALAM DARAH TERHADAP LUARAN KLINIS STROKE ISKEMIK AKUT Daniel Mahendrakrisna; Aria Chandra Gunawan Triwibowo Soedomo
NEURONA Vol 38 No 1 (2020)
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Abstract

Background: Uric acid is an end metabolism product of purine. It has been known as an important antioxidant in the serum. Correlation between uric acid serum with stroke has been reported controversial finding. However, Uric acid has been proposed to be a stroke risk factor. Aim: To determine the correlation between uric acid serum levels and acute stroke ischemic outcome. Method: This was a cross-sectional study at Surakarta Hospital. All of first experience stroke ischemic patients proven by CT-Scan were included as subjects. Demographic data (age, sex, blood pressure, etc) and laboratory results such as uric acid 24 hours, blood glucose test (random glucose test and fasting glucose test), lipid profile (cholesterol, triglyceride) were obtained from medical records. Data was analysed by software and p<0.05 was statistically accepted. Results: Of 49 acute stroke ischemic patients were include to this study. The mean of uric acid level serum as 5.71±2.64 mg/dL. 30,6% subjects had hyperuricemia and 8,2% subjects had hypouricemia. There were no correlation between uric acids levels with stroke clinical outcome (r= 0.08, p>0.05). Conclusion: There was no correlation between uric acid serum levels and acute stroke ischemic outcome.. Keywords: Ischemic, Modified Rankin Scale,
PENGARUH POLA MAKAN TERHADAP KEJADIAN STROKE HEMORAGIK DI RUANG POLIKLINIK SARAF RSUD TGK CHIK DITIRO SIGLI Teuku Jauhardin; Rachmat Andi Hartanto; Endro Basuki; Ismail Setyopranoto
NEURONA Vol 38 No 1 (2020)
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Abstract

Introduction: Intracerebral hemorrhage accounts for ~ 10% of all strokes and is associated with high mortality. Aceh province has a prevalence of stroke as much as 6.6 per mile. The diet pattern of Acehnese people tends to be high in fat and protein but low in fiber causes an imbalance in nutrient intake, a risk factor for hemorrhagic stroke. Aim: To determine the effect of eating patterns in the incidence of hemorrhagic stroke in the polyclinic of neurology at RSUD Tgk Chik Ditiro Sigli. Methods: Observational analytic with case control design. Cases were hemorrhagic stroke sufferers, controls were healthy subjects who did not suffer from hemorrhagic strokes and did not have risk factors for hypertension and diabetes mellitus. The number of subjects is 136 subjects.. Eating patterns data is collected using a modified qualitative food frequency form. The results of the study were analyzed using Chi-square, and logistic regression tests. Results: Data obtainained from this research is average age of study subjects was 46.69 years. As many as 73% of subjects were male. The results showed risk factors that were proven to have a significant relationship with the incidence of hemorrhagic stroke were low fiber consumption (OR= 3.61; p= 0.022), obesity (OR= 9.16; p<0,001), smoking (OR= 6,31; p= 0,004), lack of physical activity (OR= 5.53; p= 0,002), LDL-Cholesterol (OR= 8.74; p= 0.003). Discussion: Lack of fiber consumption were proven to increased the incidence of hemorrhagic stroke. Obesity is a risk factor that has the most influence on the incidence of hemorrhagic stroke. Keywords: eating patterns , hemorrhagic stroke, stroke risk factors.
SEBARAN GANGGUAN NEUROPSIKIATRI PADA STAF MEDIK NEUROLOGI SELAMA PANDEMI COVID-19 Rini Nindela; Yunni Diansari; Sri Handayani; Selly Marisdina; Bintang Arroyantri Prananjaya
NEURONA Vol 38 No 1 (2020)
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Introduction: Corona Virus Disease-2019 (COVID-19) is a new disease designated as a global pandemic by WHO after causing a large number of deaths in a short period of time in various parts of the world. The COVID-19 pandemic has not only caused physical impacts, but also mental fatigue on the community, especially health workers as the frontline in handling COVID-19. Aim: To determine the distribution of neuropsychiatric symptoms among neurological medical staff that have occurred since the COVID-19 pandemic. Methods: This research was a descriptive study with a cross-sectional approach, taking place from May to June 2020 and was conducted on neurological medical staff who were members of the PERDOSSI and students participating in the Neurology specialist education program. Data collection was carried out using a questionnaire, namely the Beck Anxiety Inventory to assess anxiety, the Beck Depression Inventory to assess depression, the Insomnia Severity Index to assess insomnia and a checklist of questions to assess headaches that were sent online.. Results: The data obtained in this study indicate that a total of 13.6% of neurological medical staff in this study experienced anxiety, 4.5% experienced depression, 6.1% experienced insomnia, and 24.2% experienced headaches suspected to be related to COVID-19. The severity of neuropsychiatric symptoms in this study ranged from mild to moderate, none of the subjects experienced severe symptoms. Generally the subjects with these complaints were women and they did not feel safe with the personal protective equipment/PPE used. Discussion: The distribution of neuropsychiatric disorders due to the COVID-19 pandemic among neurology medical staff in the PERDOSSI’s working area is still low. Keywords: COVID-19 pandemic, neuropsychiatric disorders, neurology medical staff
PENGARUH PEMBERIAN STIMULUS MUSICAL FRISSON TERHADAP PERFORMA MEMORI JANGKA PENDEK Christopher Alvaro Dharmawan; Yosef Purwoko; Maria Belladonna Rahmawati; Hexanto Muhartomo
NEURONA Vol 38 No 1 (2020)
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Introduction: A person’s intelligence may be determined by the capacity of working and short-term memory. Stimulations restrain the early-onset neurodegenerative process and short-term memory loss. Musical frisson stimulation can increase the production of dopamine, blood flow, and activities of some parts of the brain that have roles in short-term memory process. Aims: To prove that musical frisson stimulation can increase short-term memory performance and association between the duration of frisson and short-term memory performance change. Methods: A quasi-experimental study with one group pre and post-test design was carried out among medical students of Diponegoro University. A total of 25 participants were selected by purposive sampling technique. The stimulation was by listening to mp3 of 5 researcher-selected songs that could induce frisson using an earphone before going to bed. Stimulation would last for 15 minutes in 3 consecutive days. The frisson that was felt measured by using a stopwatch in terms of minutes. Short-term memory was measured before and after the stimulation using Scenery Picture Memory Test (SPMT), so that the difference could be calculated. The collected data was then analyzed using Wilcoxon test and simple linear regression. Results: The pre-test score was 15.763.179, meanwhile the post-test score was 20 (13-23), so there was a significant increase on SPMT score (p < 0.001). Duration of the frisson had positive effect on SPMT score differences (p < 0.001). Discussion: Musical frisson stimulation can increase short-term memory performance. The frisson that lasts longer will have more significant improvement on short-term memory performance. Keywords: Duration, musical frisson, scenery picture memory test, short-term memory
FUNGSI KOGNITIF PADA PASIEN TUMOR OTAK METASTASIS PASCA RADIASI WHOLE BRAIN RADIOTHERAPY DI DUA RS RUJUKAN KANKER INDONESIA Rahmi Ardhini; Tiara Aninditha; Rini Andriani; Henry Riyanto Sofyan
NEURONA Vol 38 No 1 (2020)
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Abstract

Brain metastases represent one of the most common neurological complications of systemic cancer, with an incidence was about 40%. Whole brain radiotherapy (WBRT) is a standard treatment to reduce tumor volume and increasing patient’s survival, but WBRT has a side effects due to radiation exposure to the brain parenchyma, including cognitive impairment. This was case series of 8 brain metastases patients, consist of 4 male and 4 female who have undergone radiation on April until June 2018. Cognitive function was assessed using Montreal Cognitive Assessment-Indonesian Version (MoCA-Ina) before and after WBRT. Collected data were age, sex, educational status, number of lesions, tumor site, clinical symptoms, Karnofsky Performance Status (KPS) score, extracranial metastases, radiation dose, primary cancer, hypertension, and diabetes mellitus. Most are multiple lesions and located in parietal lobe. The most common symptom was cognitive impairment. Seven patients already experienced cognitive impairment before WBRT and mostly have improved cognitive function after WBRT. Memory function was impaired in all subjects before WBRT that did not improved afterwards, but other domains including attention, language, executive function, and visuospatial were improved after WBRT. Key word: brain metastases, cognitive function, whole brain radiotherapy.
ABSES TUBERKULOSA OTAK PADA REMAJA DENGAN HIV NEGATIF Mayo Djitro; Yanto Budiman; Ronny Ronny
NEURONA Vol 38 No 1 (2020)
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Abstract

Tuberculosis is highly prevalent in developing countries. It is most commonly seen infecting the lungs but can also be found as extrapulmonary tuberculosis (EPTB). Central nervous system (CNS) tuberculosis represented about 10% of EPTB. The primary form of CNS TB is meningitis TB. There are however, other rarer forms, such as tuberculous brain abscess (TBA). Abscesses are more commonly seen in immunocompromised patients. A 19 year old female came with a complaint of headache for 1 week accompanied with recurrent fever, nausea, and vomiting. Physical examination shows nuchal rigidity in the patient. Blood workup revealed that the patient was HIV negative. Primary lung tuberculosis was found in the patient on chest x-ray. On brain MRI abscesses were found. The patient was given anti-tuberculous drug regiment. Follow up brain MRI was performed 2 months after treatment with oral anti-tuberculous therapy 1x3 4 FDC (fixed drug combination). Before treatment, brain MRI with contrast showed two ring enhanced lesions with irregular border on the right cerebellum hemisphere with approximate size 2.8x2.6x1.8 cm (AP x transversal x height) with some satellite nodules and enhancements on right tentorium cerebelli. There’s also another ring enhanced lesion with irregular border on right frontal lobe pre central gyrus with approximate size 1.4x2x1.1 cm (AP x transversal x height) with perifocal oedema. Follow up MRI after oral anti-tuberculous therapy showed decreased in size for both lesions. We documented one case of brain tuberculosis in non HIV patient, which showed significant improvement after given oral anti-tuberculous drugs. Keywords: extrapulmonary tuberculosis, tuberculosis, tuberculous brain abscess
EFEK HIPOTERMIA SEBAGAI NEUROPROTEKTIF PADA STROKE ISKEMIK Chandra Wirawan; Shierly Shierly
NEURONA Vol 38 No 1 (2020)
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Abstract

The incidence of stroke has been increasing continuously. It is found that a higher prevalence of ischemic stroke than the prevalence of hemorrhagic stroke and the disability of stroke is the highest of all other diseases. Many methods of therapeutic hypothermia can be done locally (in body surface or lesion) and systemically (endovascular). Based on various randomized controlled trial (RCT) studies, therapeutic hypothermia can provide neuroprotective effect by reducing brain metabolism, decreasing free radical, inhibiting inflammatory response and preventing neuron cell apoptosis so that the level of the disability can be lower. Key Words: Ischemic stroke, neuroprotective, reperfusion, therapeutic hypothermia
PENDEKATAN DIAGNOSIS DAN TATA LAKSANA MULTIDISIPLIN JANGKA PANJANG PADA NEUROPATI HEREDITER: CHARCOT MARIE TOOTH Putri Widya Andini; Manfaluthy Hakim; Fitri Octaviana; Luh Ari Indrawati; Winnugroho Wiratman; Triana Ayuningtyas; Ahmad Yanuar Safri
NEURONA Vol 38 No 1 (2020)
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Hereditary neuropathy is the most common inherited neuromuscular diseases, with Charcot Marie Tooth being the most common form. It is characterised by degeneration of peripheral sensory and motor nerves due to axonal degeneration or demyelination. The diagnosis of hereditary neuropathy requires comprehensive history taking including family history to determine the mode of inheritance, clinical and neurophysiological examination, and genetic testing. This review provides a diagnostic approach and long-term multidisciplinary management in patients with suspected hereditary neuropathy. Keywords: Charcot Marie Tooth, genetics, neuropathy
MOTOR IMAGERY, ACTION OBSERVATION, DAN GRADED MOTOR IMAGERY PADA REHABILITASI STROKE : MI, AO, DAN GMI PADA REHABILITASI STROKE Made Hendra Satria Nugraha
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.199

Abstract

Stroke merupakan salah satu penyebab utama kecacatan pada orang dewasa. Mirror neuron system (MNS) dianggap sebagai terobosan besar untuk ilmu saraf dan merupakan salah satu fitur penting pada evolusi otak manusia. Penelitian ini merupakan tinjauan pustaka dengan sumber data sekunder berupa kumpulan artikel ilmiah yang diakses melalui journal database, seperti: PubMed Central (PMC) NCBI dan google scholar. Kajian pustaka ini bertujuan untuk: (1) mengetahui efektivitas MI, AO, dan GMI dalam memperbaiki gerak dan fungsi tubuh pada pasien stroke serta (2) memahami protokol penatalaksanaan MI, AO, dan GMI dalam memperbaiki gerak dan fungsi tubuh pada pasien stroke. Hasil kajian pustaka menunjukkan bahwa intervensi MI, AO, dan GMI efektif dalam memperbaiki fungsi dan gerak tubuh saat rehabilitasi stroke. Protokol penatalaksanaan MI, AO, dan GMI memiliki variasi dilihat dari segi frekuensi, intensitas, dan durasi terapi, dimana sebagian besar pemberian intervensi ini dapat menunjukkan manfaat yang lebih baik jika dikombinasikan dengan intervensi konvensional fisioterapi lainnya.

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