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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 314 Documents
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Duchenne Muscular Dystrophy: Dari Kesadaran Genetik Menuju Kualitas Hidup yang Lebih Baik Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 1 (2025): Volume 42, No 1 - Desember 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i1.883

Abstract

Duchenne Muscular Dystrophy (DMD) is one of the most common genetic neuromuscular disorders in boys, despite being a rare disease. Inherited in an X-linked recessive pattern, DMD carries severe consequences not only for the patient but also for their family. A mother who is a carrier is likely to pass the DMD gene mutation to her son, with a real risk of having a generation with progressive muscle weakness from an early age. Awareness of this inheritance pattern is crucial, given that early diagnosis through genetic screening can provide crucial information for families to take appropriate medical and psychosocial measures. DMD is more than just a muscle disease. Its impact is far-reaching on the quality of life of children, who over time can lose the ability to walk, experience cardiopulmonary complications, and become dependent on intensive care. Families face significant physical, emotional, and financial burdens. Therefore, medical intervention and psychosocial support are crucial. The quality of life of patients and their families must be the primary focus of treatment, not only to prolong life but also to ensure a more meaningful childhood and adolescence. In many developed countries, the development of gene therapy has opened a new chapter in the treatment of DMD. This approach targets the underlying cause of the disease—mutations in the dystrophin gene—thus enabling molecular improvements in muscle function. While still facing challenges in terms of cost, access, and long-term evaluation, this therapy has significantly improved survival rates and slowed disease progression. Meanwhile, in Indonesia, DMD treatment is still dominated by conservative therapy. Corticosteroids, physiotherapy, nutritional support, occupational therapy, and cardiopulmonary management are the main pillars. This multidisciplinary care has been proven to slow progression, improve quality of life, and extend life expectancy, which can now reach the third decade of life with good management. While different from gene therapy practices abroad, conservative therapy still offers significant benefits when implemented consistently and comprehensively. Public awareness of genetic diseases like DMD needs to be increased. The label "rare disease" often keeps it out of the public eye, despite the fact that cases are real and not infrequent. Education about the importance of genetic screening, understanding inheritance patterns, and social acceptance of children with DMD will strengthen the support families need. Furthermore, the involvement of policymakers in expanding access to genetic diagnostics and paving the way for innovative therapies in the future will significantly determine the direction of DMD management in Indonesia. DMD teaches us that genetic diseases are not just clinical issues, but also social and humanitarian ones. Children with DMD deserve a better quality of life, with solid medical, family, and community support. The momentum of increasing public awareness about genetic diseases must continue to be encouraged to reduce stigma, increase access to services, and give every child born with DMD the opportunity for a more meaningful life.
HUBUNGAN PARAMETER KEBUGARAN FISIK DENGAN SINDROMA FRAILTY PADA LANSIA DI JAKARTA Hariyanto, Rayner Abdiwijaya; Suryakusuma, Linda; Handajani, Yvonne Suzy; Turana, Yuda
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026 (in Press)
Publisher : PERDOSNI

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Abstract

Introduction: Frailty is a multifactorial geriatric syndrome resulting from the loss of the body's ability to cope with stressors due to aging. According to a study conducted by Asenso et al., the global prevalence of frailty is 13.6%. Aim: This study is aimed to understand the relationship between physical fitness parameters and frailty syndrome in the elderly. Methods: This study uses a cross-sectional involving 98 respondents aged 60 years and above. ADL was measured using the Barthel Index. Balance was measured using the Berg Balance Scale. Physical activity was measured using the SQUASH questionnaire with cutoffs based on the GPAQ. Frailty status was assessed using the Fried frailty phenotype. Results: From 98 respondents, the majority were female (71.4%), aged 60-74 years (74.5%), with a higher education level (51%). A total of 18.4% of the elderly experienced frailty. Chi-square analysis showed that significant factors were age (p<0.001; OR: 7.408), ADL (p=0.019; OR: 3.944), Balance (p=0.042; OR: 7,800), and physical activity (p=0.014; OR: 3.714). Multiple logistic regression showed that age is the most influential factor in frailty (p=0.002; OR: 6,209) and followed by physical activity (p=0.030; OR: 3.834). Discussion: Age, ADL, balance, and physical activity were found to have a significant relationship with frailty. Among these factors, age was identified as the most influencing factor. Keywords: ADL, age, balance, elderly, frailty, physical activity
Prediksi Hiperlaktatemia Terhadap Sepsis Dan Luaran Buruk Pada Pasien Intracerebral Hemorrhage Retnaningsih; Tugasworo, Dodik; Priatmaja, Ageng; Supardi
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026 (in Press)
Publisher : PERDOSNI

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Abstract

Introduction: Sepsis is a serious complication and major cause of mortality among intracerebral hemorrhage (ICH) patients in the intensive care unit (ICU). Serum lactate is commonly used as a prognostic biochemical marker for sepsis in critically ill patients. Aims: This study aimed to evaluate the relationship between serum lactate levels, sepsis incidence, and clinical outcomes in ICH patients in ICU of Dr. Kariadi Hospital. Methods: A retrospective observational cohort study was performed on 30 ICH patients hospitalized in the ICU during 2024. Data normality tested using Shapiro-Wilk; non-normal data were analysed by Mann-Whitney U, categorical data by Chi-square test. Results: Among 30 patients (12 males, 18 females), 20 had hyperlactatemia (>2 mmol/L). The hyperlactatemia group had higher sepsis incidence (90% vs. 50%, p=0.014), MODS (70% vs. 30%, p=0.037), high NLR (>8; 80% vs. 40%, p=0.028), longer ventilator (>8 days; 75% vs. 40%, p=0.007), and LOS (>8 days; 75% vs. 40%, p=0.007). Discussion: Routine serum lactate monitoring in ICH ICU patients is recommended for early detection and prognosis of sepsis. Larger prospective studies are needed to validate these findings. Keywords: ICU, intracerebral haemorrhage, lactate, prognosis, sepsis
Sejarah Neurointervensi di Indonesia Prabowo, Fajar
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026 (in Press)
Publisher : PERDOSNI

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Abstract

The history of neurointervention began with Prof. Egas Moniz, a Portuguese Nobel Prize-winning physician who discovered angiography in 1928. It later evolved into a minimally invasive procedure. This procedure is performed on patients with cerebral and spinal cord vascular disorders such as stroke, aneurysm, vascular malformation, and brain tumors. In Indonesia, neurointervention procedures are performed by neurologists, radiologists, and neurosurgeons who have completed additional fellowships in vascular neurointervention, neuroradiology, or vascular neurosurgery. The development of neurointervention in Indonesia is inseparable from the efforts of Dr. Fritz Sumantri Usman, who completed his Egas Moniz Neurointervention and Stroke Fellowship at Sir Ganga Ram Hospital in New Delhi, India, in 2008. The team then grew from one person to 10 in 2011, and by 2025, there were 152 neurointerventionists across Indonesia. Fellowship programs currently being pursued come not only from India, but also from South Korea, Vietnam, China, and Austria. Eight hospitals in Indonesia offer fellowship programs in vascular neurointervention. Various endovascular procedures performed by neurointerventionists, such as mechanical thrombectomy, have become the standard of care in acute stroke management. Other minimally invasive endovascular procedures offer advantages over surgery. Hopefully, Indonesian neurointervention will continue to grow and provide the best healthcare for the Indonesian people. As stated in the neurointervention march, "From the beginning, the goal is to climb and climb, it is not easy, unite your steps, with a strong determination for the sake of the motherland, build Neurointervention. Glory to Neurointervention."

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