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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 322 Documents
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Duchenne Muscular Dystrophy: Dari Kesadaran Genetik Menuju Kualitas Hidup yang Lebih Baik Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 1 (2025): Volume 42, No 1 - Desember 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i1.883

Abstract

Duchenne Muscular Dystrophy (DMD) is one of the most common genetic neuromuscular disorders in boys, despite being a rare disease. Inherited in an X-linked recessive pattern, DMD carries severe consequences not only for the patient but also for their family. A mother who is a carrier is likely to pass the DMD gene mutation to her son, with a real risk of having a generation with progressive muscle weakness from an early age. Awareness of this inheritance pattern is crucial, given that early diagnosis through genetic screening can provide crucial information for families to take appropriate medical and psychosocial measures. DMD is more than just a muscle disease. Its impact is far-reaching on the quality of life of children, who over time can lose the ability to walk, experience cardiopulmonary complications, and become dependent on intensive care. Families face significant physical, emotional, and financial burdens. Therefore, medical intervention and psychosocial support are crucial. The quality of life of patients and their families must be the primary focus of treatment, not only to prolong life but also to ensure a more meaningful childhood and adolescence. In many developed countries, the development of gene therapy has opened a new chapter in the treatment of DMD. This approach targets the underlying cause of the disease—mutations in the dystrophin gene—thus enabling molecular improvements in muscle function. While still facing challenges in terms of cost, access, and long-term evaluation, this therapy has significantly improved survival rates and slowed disease progression. Meanwhile, in Indonesia, DMD treatment is still dominated by conservative therapy. Corticosteroids, physiotherapy, nutritional support, occupational therapy, and cardiopulmonary management are the main pillars. This multidisciplinary care has been proven to slow progression, improve quality of life, and extend life expectancy, which can now reach the third decade of life with good management. While different from gene therapy practices abroad, conservative therapy still offers significant benefits when implemented consistently and comprehensively. Public awareness of genetic diseases like DMD needs to be increased. The label "rare disease" often keeps it out of the public eye, despite the fact that cases are real and not infrequent. Education about the importance of genetic screening, understanding inheritance patterns, and social acceptance of children with DMD will strengthen the support families need. Furthermore, the involvement of policymakers in expanding access to genetic diagnostics and paving the way for innovative therapies in the future will significantly determine the direction of DMD management in Indonesia. DMD teaches us that genetic diseases are not just clinical issues, but also social and humanitarian ones. Children with DMD deserve a better quality of life, with solid medical, family, and community support. The momentum of increasing public awareness about genetic diseases must continue to be encouraged to reduce stigma, increase access to services, and give every child born with DMD the opportunity for a more meaningful life.
HUBUNGAN PARAMETER KEBUGARAN FISIK DENGAN SINDROMA FRAILTY PADA LANSIA DI JAKARTA Rayner Abdiwijaya Hariyanto; Linda Suryakusuma; Yvonne Suzy Handajani; Yuda Turana
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026
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Abstract

Introduction: Frailty is a multifactorial geriatric syndrome resulting from the loss of the body's ability to cope with stressors due to aging. According to a study conducted by Asenso et al., the global prevalence of frailty is 13.6%. Aim: This study is aimed to understand the relationship between physical fitness parameters and frailty syndrome in the elderly. Methods: This study uses a cross-sectional involving 98 respondents aged 60 years and above. ADL was measured using the Barthel Index. Balance was measured using the Berg Balance Scale. Physical activity was measured using the SQUASH questionnaire with cutoffs based on the GPAQ. Frailty status was assessed using the Fried frailty phenotype. Results: From 98 respondents, the majority were female (71.4%), aged 60-74 years (74.5%), with a higher education level (51%). A total of 18.4% of the elderly experienced frailty. Chi-square analysis showed that significant factors were age (p<0.001; OR: 7.408), ADL (p=0.019; OR: 3.944), Balance (p=0.042; OR: 7,800), and physical activity (p=0.014; OR: 3.714). Multiple logistic regression showed that age is the most influential factor in frailty (p=0.002; OR: 6,209) and followed by physical activity (p=0.030; OR: 3.834). Discussion: Age, ADL, balance, and physical activity were found to have a significant relationship with frailty. Among these factors, age was identified as the most influencing factor. Keywords: ADL, age, balance, elderly, frailty, physical activity
Prediksi Hiperlaktatemia Terhadap Sepsis Dan Luaran Buruk Pada Pasien Intracerebral Hemorrhage Retnaningsih; Dodik Tugasworo; Ageng Priatmaja; Supardi
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026
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Abstract

Introduction: Sepsis is a serious complication and major cause of mortality among intracerebral hemorrhage (ICH) patients in the intensive care unit (ICU). Serum lactate is commonly used as a prognostic biochemical marker for sepsis in critically ill patients. Aims: This study aimed to evaluate the relationship between serum lactate levels, sepsis incidence, and clinical outcomes in ICH patients in ICU of Dr. Kariadi Hospital. Methods: A retrospective observational cohort study was performed on 30 ICH patients hospitalized in the ICU during 2024. Data normality tested using Shapiro-Wilk; non-normal data were analysed by Mann-Whitney U, categorical data by Chi-square test. Results: Among 30 patients (12 males, 18 females), 20 had hyperlactatemia (>2 mmol/L). The hyperlactatemia group had higher sepsis incidence (90% vs. 50%, p=0.014), MODS (70% vs. 30%, p=0.037), high NLR (>8; 80% vs. 40%, p=0.028), longer ventilator (>8 days; 75% vs. 40%, p=0.007), and LOS (>8 days; 75% vs. 40%, p=0.007). Discussion: Routine serum lactate monitoring in ICH ICU patients is recommended for early detection and prognosis of sepsis. Larger prospective studies are needed to validate these findings. Keywords: ICU, intracerebral haemorrhage, lactate, prognosis, sepsis
Sejarah Neurointervensi di Indonesia Fajar Prabowo
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026
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Abstract

The history of neurointervention began with Prof. Egas Moniz, a Portuguese Nobel Prize-winning physician who discovered angiography in 1928. It later evolved into a minimally invasive procedure. This procedure is performed on patients with cerebral and spinal cord vascular disorders such as stroke, aneurysm, vascular malformation, and brain tumors. In Indonesia, neurointervention procedures are performed by neurologists, radiologists, and neurosurgeons who have completed additional fellowships in vascular neurointervention, neuroradiology, or vascular neurosurgery. The development of neurointervention in Indonesia is inseparable from the efforts of Dr. Fritz Sumantri Usman, who completed his Egas Moniz Neurointervention and Stroke Fellowship at Sir Ganga Ram Hospital in New Delhi, India, in 2008. The team then grew from one person to 10 in 2011, and by 2025, there were 152 neurointerventionists across Indonesia. Fellowship programs currently being pursued come not only from India, but also from South Korea, Vietnam, China, and Austria. Eight hospitals in Indonesia offer fellowship programs in vascular neurointervention. Various endovascular procedures performed by neurointerventionists, such as mechanical thrombectomy, have become the standard of care in acute stroke management. Other minimally invasive endovascular procedures offer advantages over surgery. Hopefully, Indonesian neurointervention will continue to grow and provide the best healthcare for the Indonesian people. As stated in the neurointervention march, "From the beginning, the goal is to climb and climb, it is not easy, unite your steps, with a strong determination for the sake of the motherland, build Neurointervention. Glory to Neurointervention."
EFISIENSI DAN KESELAMATAN PERANGKAT EMBOLIZASI PIPA DALAM PENATALAKSANAAN ANEURISMA INTRAKRANIAL: TINJAUAN SISTEMATIS, Nasrul Musadir
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 2 (2026): Volume 42, No 2 - Maret 2026
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i2.910

Abstract

Edisi Suplemen Neurona Bekerjasama dengan PIN PERDOSNI 2026 PIN PERDOSNI
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia 2026
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Abstract

NEURONA sebagai jurnal ilmiah resmi milik Perhimpunan Dokter Spesialis Neurologi Indonesia (PERDOSNI) yang telah terbit secara berkesinambungan sejak tahun 2007, kembali menghadirkan edisi suplemen sebagai bagian dari komitmen dalam mendukung pengembangan ilmu pengetahuan dan publikasi ilmiah di bidang neurologi. Bekerja sama dengan Pertemuan Ilmiah Nasional (PIN) PERDOSNI 2026, edisi suplemen ini memuat seluruh abstrak ilmiah yang dipresentasikan pada kegiatan tersebut.Berbagai karya ilmiah yang tersaji dalam edisi suplemen ini mencerminkan perkembangan terkini di bidang neurologi, meliputi stroke, neurointervensi, neuroimaging, epilepsi, gangguan gerak, neuroinfeksi, neuroimunologi, neurootologi dan neurooftalmologi, neurorestorasi dan neuroengineering, neurologi perilaku dan kognitif, neurologi anak, neurologi komunitas, neuroepidemiologi, serta aspek etik dan hukum dalam praktik neurologi.Kami berharap edisi suplemen ini dapat menjadi sarana diseminasi hasil penelitian, laporan kasus, dan inovasi ilmiah yang bermanfaat bagi para neurolog, peserta didik, peneliti, serta tenaga kesehatan lainnya. Selain itu, publikasi ini diharapkan dapat mendorong lahirnya kolaborasi penelitian dan pengembangan publikasi ilmiah yang lebih luas di masa mendatang.Kerja sama antara NEURONA dan PIN PERDOSNI merupakan wujud sinergi yang penting dalam memperkuat budaya akademik dan meningkatkan kualitas publikasi ilmiah neurologi di Indonesia. Dukungan dan partisipasi seluruh pihak dalam kegiatan ilmiah maupun publikasi ini menjadi modal berharga bagi keberlanjutan dan kemajuan jurnal yang menjadi kebanggaan seluruh anggota PERDOSNI.Atas kontribusi para penulis, reviewer, panitia PIN PERDOSNI 2026, serta seluruh pihak yang telah mendukung terbitnya edisi suplemen ini, kami menyampaikan penghargaan dan terima kasih yang sebesar-besarnya.
PENGARUH STIMULASI MAGNETIK TRANSKRANIAL BERULANG UNTUK MENGURANGI SKALA NYERI PASIEN STROKE DENGAN GANGGUAN KECEMASAN : Case Report Jumraini Tammasse; Kurnia Bintang; Amanda Tiksnadi; Ahmad Zaki
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 3 (2026): Juni 2026
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i3.201

Abstract

Introduction : Central post stroke pain (CPSP) is a chronic central neuropathic pain syndrome associated with somatosensory abnormalities caused by stroke lesion in central nervous system (CNS). Pain which occurs either with a stimulus or spontaneous, usually exist 1-6 months after ischemic or hemorrhagic stroke. CPSP can cause anxiety, depression, sleeping disorder that lead to decrease quality of life in patient due to chronic pain. Transcranial Magnetic Stimulation (TMS) is a non-pharmacological, as well a non-invasive intervention therapy used to relieve chronic pain and anxiety disorders by using a magnetic field converted by electricity through a coild placed on the skull bone, which useful for reorganizing intracranial structures and functions disturbed by stroke lesion. Case : A 49 year-old patient came to clinic with pain in the left arm and leg, suffered since 5 months before admission, occurred with or without stimulus, reduced with analgetic drug but it came again soon after drug consumption. She felt a continuous stabbing and burning sensation with neurological pain rating scale (NPRS) : 6-7. Stroke history 3 years ago and routinely control to neurologist for medication. She felt difficult to sleep and anxiety because this pain. Hamilton Anxiety Rating Scale (HARS) was measured before and after rTMS. Discussion : Improvement in HARS and NPRS score was noted after rTMS, thought to occur due to reorganization of neurotransmitters involved in chronic pain pathophysiology. Conclusion : rTMS helped to improve quality of life in patient with CPSP. Keyword : Central Post Stroke Pain, Repetitive Transcranial Magnetic Stimulation, Anxiety Disorder, Hamilton Anxiety Rating Scale, Neurological Pain Rating Scale.
LAPORAN KASUS PERDARAHAN INTRASEREBRAL DISERTAI HIPERTENSI Puspa Dewanti
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 3 (2026): Juni 2026
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i3.853

Abstract

Intracerebral hemorrhage, a subtype of stroke, is a very serious condition in which a hematoma forms within the brain parenchyma with or without blood expanding into the ventricles. Non-traumatic intracerebral hemorrhage accounts for 10-15% of all strokes and is associated with high morbidity and mortality.1 A 37-year-old woman came to the emergency room of Dr. Haryoto Lumajang on September 8, 2025 at 20.24 with complaints of decreased consciousness since 2 hours ago with weakness of the right limbs when the patient was in the bathroom and then fell to the floor, CT scan results showed ICH, treatment was given Nacl 0.9% infusion 1000cc / 24 hours, syringe pump nicardipine 11.25cc / hour, ranitidine injection 2x1, citicoline 2x500mcg, mecobalamin 1x500mg, mannitol loading 200cc followed by mannitol maintenance 6x100cc tapering off daily, nootropic drugs, neuroprotectants, and antihypertensives as well as rehabilitation and physiotherapy. Keywords: Intracerebral hemorrhage, weakness, mannitol.
GAMBARAN RADIOLOGIS GLIOBLASTOMA : LAPORAN KASUS yudhisman imran
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 3 (2026): Juni 2026
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Abstract

ABSTRACT Background : Space Occupying Lesions (SOL) are pathological abnormalities within the intracranial space that can cause progressive neurological disorders. Intracranial SOL include cerebral contusions, hematomas, infarctions, abscesses, and tumors that grow in the intracranial space. According to the World Health Organization (WHO) 2021, glioblastoma is defined as a wild type isocitrate dehydrogenase (IDH) astrocytic tumor or grade 4 glioma, as determined by histological features and molecular markers. Glioblastoma is commonly found in the frontal, temporal, and parietal lobes. Patients with brain tumors often present as neuroemergencies due to increased intracranial pressure. Glioblastoma can be detected using a CT (Computed Tomography) scan or atau MRI (Magnetic Resonance Imaging) as the initial imaging modality. Case Description : A 43 year old man presented to the Emergency Department complaining of headaches that had persisted more than two weeks. The headaches had been persistent throughout the day and were progressively worsening. A neurological examination revealed compos mentis consciousness with left hemiparesis. A non-contrast head CT scan was performed, suggesting a cerebral abscess (DD)/cystic glioma. A contrast-enhanced CT scan revealed a diagnosis of glioblastoma multiforme. A craniotomy was performed, and the post-operative tissue section underwent pathologic examination, which concluded epithelioid glioblastoma and metastatic poorly differentiated carcinoma. Conclusions: Although brain imaging suggests glioblastoma, a definitive diagnosis cannot be made on the basis of radiographs due to their limitations in assessing the tumor's histological and molecular characteristics. In the latest WHO classification, the diagnosis of glioblastoma encompasses both histological features and molecular. These findings cannot be assessed solely on radiographs, necessitating tissue examination. Keywords: Brain Tumor, Glioblastoma,CT Scan
KERENTANAN STATUS GIZI PADA STROKE ISKEMIK AKUT: DAMPAK GABUNGAN DISFAGIA DAN GANGGUAN KOGNITIF Amriani Amriani; Ika Marlia; Nasrul Musadir
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 3 (2026): Juni 2026
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i3.911

Abstract

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