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Contact Name
Mawaddah Ar Rachmah
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neurona.perdossi@gmail.com
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+6282130377088
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SEKRETARIAT PP PERDOSSI Apartemen Menteng Square, Tower A Blok R-19 Jl. Matraman nomor 30E, RT.5/RW.6, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta 10430
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INDONESIA
Neurona
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Articles 299 Documents
Diagnosis dan Tatalaksana Epilepsi pada Subcortical Band Heterotopia: Sebuah Kasus Langka Stella Natadidjaja; Gilbert Tangkudung; Herlyani Khosama
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.202

Abstract

Abstract Subcotical band heterotopia (SBH) is characterized by symmetrical and bilateral bands of heterotopic gray matter, located between the ventricular wall and the cortical mantle, and clearly separated from both. It is caused by genetic mutations. It’s a rare disorder with only a few hundred cases reported in literature till now and most of the patients were females. Clinical symptoms typically include recurrent seizures and intellectual delay. Treatment is mainly symptomatic and may include antiepileptics, although some cases may be refractory to medical therapy. Here we report a rare case of 13-year old girl with SBH in Indonesia with seizures that was responded to anti epileptic medication. Keywords:double cortex syndrome, epilepsy, subcortical band heterotopia
GAMBARAN KONDUKSI SARAF TEPI NEUROPATI ASIMPTOMATIK PADA PENYAKIT GINJAL KRONIS STADIUM 3 DAN 4 4 Tania Sananta
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.205

Abstract

Introduction Neuropathy is the most common neurologic complication in Chronic Kidney Disease (CKD) patients. Uremic neuropathy usually happen when glomerular filtration rate fall below 12 mL/minute (stage 5), but factors contributing development of uremic neuropathy actually can be found in earlier stage of CKD. Previously the nerve conduction studies in asymptomatic neuropathy CKD stage 3 and 4 patients is not known. Aim To identify nerve conduction studies in asymptomatic neuropathy CKD stage 3 and 4 patients Methods This was a cross sectional, observational descriptive study conducted in patients with stage 3 and 4 CKD without symptoms and sign of neuropathy. The study was done in two hospital in Bandung from December 2017 until March 2018. Nerve conduction study was done in eligible subjects. Results There were 16 subjects, age 22–72 (81% men, 19% women) with glomerular filtration rate 32,2±11,6ml/minute. Nerve conduction study showed that 37,5% subject had asymptomatic neuropathy. The most common type were axonal sensory motor polyneuropathy with lower extremities predominance. Stage 4 CKD patients have 57,14% prevalence of neuropathy and stage 3 CKD patients have 22,22%. Discussion Nerve conduction study showed axonal damage ini sensoric and motoric fibers with predominance in the longest axon and the farthest axon from cell body. Neuropathy was more frequent in later stage of CKD. One third of stage 3 and 4 CKD patients had polyneuropathy even without clinical symptoms of neuropathy. . Keywords : Asymptomatic neuropathy, stage 3 and 4 chronic kidney disease
- PENYAKIT HUNTINGTON : SEBUAH LAPORAN KASUS DAN ULASAN SINGKAT: - Richard Suherlim
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.206

Abstract

Huntington's disease is an autosomal dominant hereditary disease that is very rare in Indonesia. This disease is characterized by involuntary movement disorders in the form of chorea that worsens from distal to proximal. Patients with Huntington's disease usually have impaired cognitive function and psychiatric disorders. The diagnosis was obtained from clinical examination, family history, and confirmed by genetic examination where a mutation in the HTT gene that encodes for the CAG trinucleotide repeats more than 35 times resulted in a toxic protein called huntingtin. Huntington's disease does not have a therapeutic regimen that can cure or slow its progression. Patients will only receive symptomatic therapy aimed at maintaining quality of life. Huntington's patients have a poor prognosis, with a median mortality of 17-20 years after symptom onset. This article reports a 76-year-old female patient, an Indonesian citizen, who had symptoms of chorea and impaired cognitive function with onset 10-15 years ago. The patient has a mother, sister, and children who also have similar symptoms. The patient was suspected of having Huntington's disease, but could not be confirmed because no genetic examination was performed. The patient did not receive any form of therapy for his illness.
Revaskularisasi pada Diseksi Arteri Karotis Setelah Pengobatan dengan Novel Oral Anticoagulan (NOAC) pada Stoke Infark Akut Orlando Pikatan
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.207

Abstract

Carotid Arterial Dissection is an emerging disease that frequently lead to stroke. We report a case of a 64-year-old man with weakness on the right side of the body and motor transcortical aphasia. The patient had history of cough and hypertension. Head MRI revealed embolic stroke with left internal carotid arterial dissection. There was a revascularization in arterial dissection after three months therapy with NOAC rivaroxaban.
BANGKITAN SIMTOMATIK AKUT: INSIDENSI, ETIOLOGI, DAN MORTALITAS PASIEN RSUD GUNUNGSITOLI TAHUN 2015–2019 Stefanus Erdana Putra; Berkat Hia; Muhammad Hafizhan; Fauzi Novia; Isnaening Tyas; Astrida Fesky Febrianty
NEURONA Vol 38 No 2 (2021)
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Abstract

Introduction: Acute symptomatic seizures are seizures that occur due to acute disorders of the central nervoussystem due to structural, infectious, inflammatory, and metabolic disorders. Acute symptomatic seizures and unprovokedseizures must be distinguished because they have different prognoses. Aim: To determine the incidence, etiology, and prognosis of acute symptomatic seizure patients treated inGunungsitoli Regional General Hospital during 2015-2019. Methods: This was a cross-sectional study in patients with acute symptomatic seizure in Gunungsitoli RegionalGeneral Hospital Nias District during 2015-2019. Data were obtained from the medical record in Gunungsitoli RegionalGeneral Hospital. Multiple logistic regression analysis was used to calculate odds ratios (ORs) of age for mortality. Results: There were 88 acute symptomatic seizure patients with a proportional comparison between males andfemales (1.1:1). The most prevalent encountered etiology of acute symptomatic seizure patients was metabolic disorders(51.14%) consisting of 25% uremia; 5.68% hyponatremia; 4.54% hyperglycemia; 6.83% hepatic; and 9.09% hypoglycemiawith a case fatality rate of 29.55%. Discussion: Characteristics of acute symptomatic seizures patients treated in Gunungsitoli Regional GeneralHospital were not affected by gender, with the most often encountered etiology was metabolic disorders. Keyword: Acute symptomatic seizure
GAMBARAN ARSITEKTUR TIDUR PADA PASIEN TUMOR OTAK YANG MENGALAMI GANGGUAN TIDUR Yesi Astri; Manfaluthy Hakim; Tiara Aninditha; Renindra Ananda Aman; Astri Budikayanti
NEURONA Vol 38 No 2 (2021)
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Abstract

Introduction: Sleep disorder is commonly found in brain tumor patients (42-46%). It can be detected using thePittsburg Sleep ????uality Inde???? (PS????I) as a screening tool and confirmed by analyzing the sleep architecture obtainedthrough a Polysomnographic (PSG) examination.Aim: To evaluate the sleep architecture in brain tumor patients who experience sleep disorder.Methods: In this descriptive cross-sectional study, patients with primary brain tumor were screened for sleep disorderusing the PSQI. The ‘poor sleepers’ would proceed to PSG examination.Results: Of 40 participants, 14 were males and 26 were females with a mean age of 45.5±11.7 years old. The mostprevalent tumor was meningioma (42.5%), while the most affected regions were the frontal lobe (40%) and the sellarsuprasellarregion (2????.5%). Poor sleep ????uality and difficulty in initiating sleep (????3 times per week) was reported in77.5% and 60% of participants, respectively. All participants experienced reduced sleep duration, the majority of whichdemonstrated low sleep efficiency (8????.5%). An estimate of 60% participants e????perienced headache at night and 50% tooksleeping pills for these complaints. Most of them reported disruption in daytime activities. On PSG analysis, we observedshortening of sleep latency, reduced sleep efficiency, total sleep time, N2, N3, REM, arousal inde????, and increase of N1.There was a statistically significant difference between ????5 hours of sleep duration and decrease of N3 phase (p????0.05).Discussion: Abnormal sleep architecture presents in brain tumor patients with sleep disorder.Keywords: brain tumor, Pittsburgh Sleep Quality Index, polysomnography, sleep architecture
PERBEDAAN KADAR N-TERMINAL PRO BRAIN NATRIURETIC PEPTIDE PLASMA BERDASARKAN LUARAN FUNGSIONAL STROKE ISKEMIK AKUT Gunawan Septa Dinata; Syarif Indra
NEURONA Vol 38 No 2 (2021)
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Abstract

systemic vascular system when ischemic stroke occur. BNP is secreted by myocardial and causes vasodilatation, natriuresisand diuresis. Increase myocardial wall pressure triggers pre-proBNP synthesis in myocardial. Pre-proBNP then wasdivided into an active form (BNP1-32) and inactive amino-terminal fragmen (NT-proBNP).Objective: To evaluate the differences of plasma N-terminal pro brain natriuretic peptide (NT-proBNP) levels inacute stroke ischemic based on functional outcome of acute ishemic stroke patient.Methods: This is an observational study that was conducted at neurology ward of M. Djamil Padang Hospitalfor acute stroke ischemic patients. The sample was selected by consecutive sampling method. Functional outcome wasassessed by Modified Rankin Scale (mRS). Plasma NT-proBNP levels were analyzed by enzyme-linked immunosorbentassay (ELISA).Results: The mean level of plasma NT-proBNP of acute ischemic stroke patient was 287.8±84.2 pg/mL. Data wasanalyzed using ????ruskal ????allis and the result showed that there is a significant differences in plasma NT-proBNP (????????2hours) levels based on functional outcome of acute ischemic stroke, p value ????0.05 (p????0.018).Discussion: There is an differences in acute phase of NTproBNP plasma level with functional outcome ischaemicstroke.Keywords: BNP, functional outcome, NT-proBNP
KOMPLIKASI VENTRIKULOPERITONEAL SHUNT PADA PASIEN PEDIATRIK USIA 0-2 TAHUN DI RUMAH SAKIT UMUM PUSAT NASIONAL DR CIPTOMANGUNKUSUMO Samsul Ashari; Bhayu Rizallinoor; Hilman Mahyudin; Moh. Saekhu; Renindra Ananda Aman; David Tandian; Abdi Reza; Setyo Widi Nugroho
NEURONA Vol 38 No 2 (2021)
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Introduction: Ventriculoperitoneal shunt is the procedure of choice in the management of hydrocephalus. However,the ventriculoperitoneal shunt procedure also carries a risk of complications. In Indonesia, data on the incidence andprevalence of ventriculoperitoneal shunt complications have not been obtained.Aim: In this study, we examined the complications of shunts and the factors associated with the duration of timeMethods: This study is a retrospective study of pediatric patients aged 0-2 years with hydrocephalus who underwentventriculoperitoneal shunt surgery for the first time at Cipto Mangunkusumo Hospital in 2015-2020 and e????periencedcomplications. The duration of time the complications occurred was divided into before and after six months. Demographicdata, clinical data, and types of complications were analyzed descriptively.Result: From ????anuary 2015 to March 2020 at Cipto Mangunkusumo Hospital, 168 ventriculoperitoneal shuntoperations were performed at 0-2 years. It was found that 20 patients (12%) e????perienced complications with a duration offewer than si???? months by ????.8% and more than si???? months by 4.2%. The total complications that occurred were mechanicalcomplications (????.2%), infection (3.6%), and over drainage (1.2%).Discussion: The percentage of complications of ventriculoperitoneal shunt in patients aged 0-2 years at CiptoMangunkusumo Hospital, in the first si???? months was ????.8%, with the highest incidence was infection (3.6%) which waslower than the literature, while the percentage of complications of ventriculoperitoneal shunts which more than six monthswere 4.2% and caused mainly by distal malfunction (3%).Keywords: aged 0-2 years, complications, pediatric, ventriculoperitoneal shunt
HUBUNGAN ANTARA ANEMIA DEFISIENSI BESI DENGAN FUNGSI KOGNITIF PADA ANAK SEKOLAH DASAR USIA 09-11 TAHUN Hening Widjayanti; Hexanto Muhartomo; M. I. Widiastuti; Amin Husni; Dani Rahmawati; Trianggoro Budisulistyo
NEURONA Vol 38 No 2 (2021)
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Introduction: Iron deficiency anemia is the most common form of anemia found in children. In iron deficiency anemia, levels of hemoglobin and ferritin must be considered. Hence, anemia can cause in impairment of cognitive function in children. Aim: To analyze the correlation between iron deficiency anemia and cognitive function in primary school children aged 9-11 years. Methods: This was an observational study with cross sectional design. The subjects of this study were students at Taqwiyatul Waton Primary School, Semarang and Tanjung Mas Primary School, Semarang, who met the inclusion and exclusion criteria. This study was conducted from March to June 2019. Laboratory tests for hemoglobin levels and ferritin levels were carried out at Paramitha Laboratory, Semarang. The data were obtained either from the study subjects and their parents. The assessment of cognitive function used modified Mini Mental State Examination (MMSE). Data analysis used Spearman's bivariate correlation test and partial correlation. The result was considered significant if the p value <0.05. Results: This study was carried out 70 students from Taqwiyatul Waton Primary School, Semarang and Tanjung Mas Primary School, Semarang. A moderate correlation was found between iron deficiency anemia and cognitive function (r = -0.505; p <0.001). Discussion: Their was a moderate relationship between iron deficiency anemia and cognitive function. Keyword : Cognitive function, iron deficiency anemia, nutritional status
MANIFESTASI NEUROLOGI PADA PASIEN COVID-19 DI RUMAH SAKIT UMUM DAERAH KOTA TANGERANG SEBAGAI PUSAT RUJUKAN COVID-19 PROVINSI BANTEN Hananto Pratignyo; Paulina Thiomas; Hesti Setiastuti; Usynara Usynara; Fitrie Rahayu; Virginia Nuriah
NEURONA Vol 38 No 2 (2021)
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Abstract

Introduction: Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, first reported in Wuhan by December 2019, spreading rapidly to various countries. World Health Organization (WHO) has designated COVID-19 as a global pandemic. Although the main clinical manifestation is the respiratory system, neurological symptoms have been reported. There are little data on neurological manifestations in COVID-19 patients, especially in Indonesia. Aim: To determine the neurological manifestations in COVID-19 patients. Methods: This is a retrospective observational study. Data were collected from medical records of hospitalized COVID-19 patients at Tangerang City General Hospital in the period April-August 2020. Data collection based on age, sex, comorbidity, general symptoms, neurological symptoms, laboratory and radiological findings. Neurological examinations were done by two neurologists. Results: Of 492 COVID-19 patients, there were 25 (5%) who had neurological manifestations, the proportion was male (52%) and aged over 60 years (44%). Of the 25 patients, 13 (52%) were confirmed COVID-19. Twenty patients (80%) have comorbidities such as hypertension, diabetes mellitus, vascular disease, tuberculosis, and chronic kidney disease. The neurological manifestations that were found were cerebrovascular disease (50%), meningoencephalitis (7.7%), vertigo (23%), anosmia (15.4%), and myalgia (3.8%). Seven patients (28%) died and 18 patients (72%) had clinical improvement. Discussion: COVID-19 can be accompanied by a variety of neurological symptoms. The neurological manifestations can be found in the central nervous system, peripheral nerves, and musculoskeletal. During a pandemic, COVID-19 is considered a differential diagnosis in patients with neurological symptoms to increase awareness and prevent further transmission. Keywords: Cerebrovascular, COVID-19, manifestation, neurology