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Sanus Medical Journal
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : -     EISSN : 2745868     DOI : https://doi.org/10.22236/sanus
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Sanus Medical Journal is a peer-reviewed medical and health journal published periodically every six months. Sanus Medical Journal publishes descriptive, analytical, and experimental studies, reviews, systematic reviews, case reports, letters, and editorials in the fields of Medicine, Health, Medical and Health Education, and Islamic Medicine. The scope of Sanus Medical Journal goes beyond the boundaries of discussions in the fields of clinical medicine and health in general, by providing new insights into etiologies, determinants, distribution, management and prevention of diseases in individuals and communities. Sanus Medical Journal attempts to meet the demands of rapid developments in information and medical and health research by committing to reduce the range of online publications to around six weeks after the submission of a manuscript. Articles will be published online in advance, and the printed version included in the next scheduled edition. Sanus Medical Journal will continue to strive to improve its scientific reputation by publishing quality articles reviewed by experts who are highly competent in their respective fields. Sanus Medical Journal greatly appreciates the contributions of authors from related disciplines. Manuscripts can be sent via email to: smjournal@uhamka.ac.id or via the website https://journal.uhamka.ac.id/index.php/smj.
Arjuna Subject : Kedokteran - Farmakologi (Medis)
Articles 89 Documents
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Pengaruh Nyeri Kronik dalam Penurunan Fungsi kognitif Fahreza Arraisyi; Yudhisman Imran
Sanus Medical Journal Vol. 3 No. 1 (2022): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v3i1.8525

Abstract

Nyeri merupakan gejala yang sering dikeluhkan masyarakat, Di Indonesia sendiri nyeri kronik adalah alasan paling umum pasien untuk berkunjung ke klinik rawat jalan. Nyeri kronik merujuk pada nyeri yang berkelanjutan lebih dari tiga bulan. Penyebab nyeri kronik tersering adalah nyeri punggung bawah kronik, diikuti oleh nyeri leher kronik, migrain, osteoartritis, gangguan muskuloskeletal lainnya, nyeri kepala akibat penggunaan obat yang berlebihan, dan polineuropati diabetikum Prevalensi nyeri kronik meningkat seiring dengan bertambahnya usia. Nyeri kronik merupakan masalah kesehatan di seluruh dunia, mempengaruhi 19% orang dewasa Eropa dan 20,4% di Amerika Serikat. Keluhan subjektif pasien nyeri kronik dari berbagai penelitian menunjukkan bahwa nyeri kronik dikaitkan dengan defisit kognitif. Pada pasien nyeri kronik terjadi interaksi antara nyeri dan fungsi kognitif secara lebih kompleks. Hal ini menyebabkan gangguan fungsi otak yang berkembang mengikuti progresi dari nyeri kronik. Pada nyeri kronik dijumpai aktifitas neuron yang berlebihan, disfungsi jaringan dan pengurangan volume grey matter. Kehilangan grey matter dijumpai dalam amigdala, korteks entorinal girus hipokampus, girus singulata anterior, thalamus dan insula. Hubungan antara nyeri kronik dan penurunan fungsi kognitif selayaknya diperhatikan lebih lanjut dikarenakan memiliki implikasi terhadap fungsi dan kualitas hidup individu. Berbagai penelitian menunjukkan hasil hubungan signifikan terbalik penurunan dari atensi, memori, proses informasi dan fungsi eksekutif pada pasien dengan nyeri kronik.
Narrow distance inter-pregnancies increase the incidence of Post-Partum hemorrhage Nadhira Farah Puspitasaria; Irmiya Rachmiyani
Sanus Medical Journal Vol. 3 No. 1 (2022): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v3i1.8569

Abstract

Background and Aims. Maternal Mortality Rate (MMR) is the parameters of women's health status in community. The single most common cause of maternal mortality is obstetric haemorrhage, generally occurring postpartum. Most postpartum haemorrhage cases are caused by uterus atony, myometrium tonus loss, placenta retention, and clotting disorders. Short pregnancy intervals can cause threefolds of anaemia than normal pregnancy intervals. Pregnant women who suffer from anaemia has the possibility experiencing a postpartum bleeding caused by atonia uteri. This research aims to acknowledge the effect of narrow distance interpregnancy on a postpartum haemorrhage. Methods. This study uses an observational analytic study with a cross"‘sectional design. The data used is secondary data of pregnant women based on medical record to calculate the distance of interpregnancy with the incidence of postpartum bleeding during childbirth at Budhi Asih General Hospital of East Jakarta. The inclusion criteria are women who underwent childbirth during 2017"‘2018, multiparity, and postpartum women between 20"‘35 years old. The exclusion criteria are women with a history of postpartum haemorrhages caused by placental retention, tear of the reproductive tract or blood coagulation), gemelli parturition, macrosomia, assisted childbirth, grande multiparity, induction childbirth, and dystocia. Results. The number of samples used in this study amounted to 111 people. Postpartum haemorrhage are significantly associated with short interpregnancy intervals (p=0,000). Conclusion. Narrower pregnancy interval will leads to postpartum haemorrhage. To prevent this, it is important to consider contraception utilization, to improve iron consumption for pregnant women, and to provide decent antenatal care.
Korelasi Lama Menjalani Hemodialisis Dengan Kualitas Hidup Pada Penderita Nefropati Diabetik Di RS Dinda Tangerang Dalam Periode 3 Tahun Dhiki Nugraha; Fahad Hasan; Dedy Gunawandjati; Sidhi Laksono Purwowiyoto; Endin Nokik Stujana; Ahmad Hidayat
Sanus Medical Journal Vol. 5 No. 1 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.9601

Abstract

Pendahuluan: Salah satu komplikasi mikrovaskular dari diabetes yaitu nefropati diabetik. Penderita nefropati diabetik yang menjalani hemodialisis membutuhkan waktu yang lama dan membutuhkan kepatuhan dalam mengobati komorbid yang mendasarinya. Hal ini akan memberikan stresor baik fisiologis maupun psikologis penderita yang akan mempengaruhi kualitas hidup. Tujuan penelitian ini menentukan korelasi antara lamanya menjalani terapi hemodialisis pada penderita nefropatik diabetik dengan kualitas hidup di RS Dinda Tangerang. Metode: metode penelitian menggunakan analisis parametrik dengan metode pendekatan non parametrik. sampel penelitian ini menggunakan consecutive sampling yang melibatkan 40 penderita nefropati diabetik. data di analisis menggunakan korelasi spearman. Teknik pengumpulan data menggunakan kuesioner KDQOL SF 1.3. Hasil: berdasarkan hasil penelitian didapatkan 23 penderita 57.5% yang menjalani hemodialisis 1- 3 tahun  dan 6 di antara nya penderita yang memiliki kualitas hidup kurang sebanyak 2 orang, dan yang memiliki kualitas hidup cukup  sebanyak 2 orang serta sebanyak  15 orang lainya memiliki kualitas hidup baik. Simpulan: kesimpulan penelitian ini terdapat korelasi yang bermakna p=0,043 antara lama menjalani hemodialisis dengan kualitas hidup dengan nilai (r): 0.309 yang mana mengarah ke arah positif sehingga ketika penderita telah lama melakukan terapi hemodialisis maka semakin baik kualitas hidup dari penderita.
Acute Abdominal Case Report: Ruptured Ovarian Endometriotic Cyst Concurrent with Acute Appendicitis Gupita Nareswari
Sanus Medical Journal Vol. 4 No. 2 (2022): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.9939

Abstract

Acute pain of pelvic origin is a common symptom necessitating emergent medical evaluation. Acute pelvic pain in young women can present as a unique diagnostic dilemma. Differential diagnosis in acute pelvis pain can vary according to risk. Possible causes span a gamut from functional ovarian cysts that require routine follow-up to adnexal torsion and ectopic pregnancy requiring urgent surgical management. This case report illustrates how concomitant gynecologic disorders can occur in patients with acute appendicitis. The laparoscopic operation revealed a ruptured ovarian endometriotic cyst concurrent with acute appendicitis and was proven by histopathology. This serves as a reminder that even though a rare case is contemporary, two different entities can occur.
D-Dimer Sebagai Salah Satu Parameter Perbaikan Klinis pada Kasus Covid-19 Gejala Berat Antin Trilaksmi; Martin
Sanus Medical Journal Vol. 4 No. 2 (2022): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.10039

Abstract

Background. Coronavirus Disease 2019 (COVID-19) has been a global pandemic since March 2020. The number of patients is massive and clinical symptoms vary from mild to severe symptoms. Several laboratory results showed abnormal values in Covid-19 patients, including an increase in the value of D-dimer. Elevated levels of D-dimer in COVID-19 patients are strongly associated with severity and increased mortality. We report a case of a severe symptomatic COVID-19 patient with high D dimer levels at the start of treatment and showing clinical improvement according to a decrease in D dimer levels. Methods. We treat and follow the clinical and laboratory developments of COVID-19 patients with severe symptoms from the time they enter the Intensive Care Unit (ICU) until they move to a regular ward. Results. A 53-year-old male patient diagnosed with viral pneumonia et causa covid-19 was admitted to the ICU with severe symptoms and high initial d-dimer levels (1,413 ug/ml). The patient received ventilator assistance and standard therapy according to the Covid 19 management protocol of the Ministry of Health of the Republic of Indonesia. Anticoagulation using heparin intravenously with a dose adjusted to the level of d dimer, aPTT, and clinical condition of the patient who is monitored regularly. The trend of d dimers decreased parallel to the decrease in C reactive protein (CRP) levels, increased lung gas exchange function was evaluated from the PaO2/Fio2 ratio (PF ratio) and the clinical improvement of the patients. Conclusion. D-dimer is closely related to the severity of covid 19 patients. D dimer can be used as one of the parameters of patient clinical improvement.
Pengaruh Pemakaian Masker Bedah dan Masker Kain pada Wajah Hans Sutanto; Ade Saroso; Dyah Setyaningrum; Florinda Ilona
Sanus Medical Journal Vol. 4 No. 2 (2022): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.10040

Abstract

Background. Face masks are indispensable in preventing the spread of COVID-19 transmission. Face mask use can have beneficial and detrimental effects on a person. In this study, participants' faces were observed before and after wearing surgical and cloth masks for 4 hours per day for five consecutive days. Methods. The research design is experimental. Results. Thirty-two Trisakti University Faculty of Medicine employees aged 26 to 46 years and 18 men and 14 women, participated in this study. Sociodemographic data and facial examination were assessed at the start and end of the study. The research data obtained the results of p = 0.392. Conclusion. There is no significant difference between surgical and cloth masks in terms of acne, skin irritation, and redness.
Emfisema Subkutis sebagai Komplikasi pada Pasien Covid-19 dengan Penggunaan Ventilasi Mekanik Lira Panduwaty; Antin Trilaksmi; Ferdy Cipta
Sanus Medical Journal Vol. 4 No. 2 (2022): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.10388

Abstract

Background. The incidence of subcutaneous emphysema in patients with severe pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection has been in the spotlight recently. Subcutaneous emphysema is a rare complication. With the increasing prevalence of subcutaneous emphysema in patients with confirmed coronavirus disease (COVID-19), it is necessary to know what factors can cause this and how to treat it. Case Description. Two patients, a man and a woman aged 50 and 70 years, diagnosed with COVID-19, came to the Emergency Room (IGD) of Bunda Menteng General Hospital, Jakarta, with symptoms of acute respiratory distress syndrome (ARDS). Both patients experienced severe shortness of breath with a respiratory rate above 30 times per minute. Then the two patients were treated in the intensive care Unit (ICU) isolation room and required mechanical ventilation assistance. After 3-4 days of mechanical ventilation treatment, subcutaneous emphysema develops, characterized by subcutaneous crepitus. After chest x-rays were carried out in both patients, the results were subcutaneous emphysema and pneumomediastinum. Several invasive procedures have been performed, such as subcutaneous insertion of an intravenous cannula, mediastinoscopy, and chest tube insertion. Conclusion. Complications of subcutaneous emphysema in COVID-19 patients are rare and require further research to determine the cause, where the infection is still the focus. With this case report, it is hoped that clinicians will pay more attention to the initial clinical findings of subcutaneous emphysema to reduce even more severe complications such as pneumothorax.
Hubungan Tingginya Nilai ANC (Absolute Neutrophil Count) dengan Kejadian Apendisitis Akut dan Perforasi di RS Islam Jakarta Pondok Kopi Pada Tahun 2018-2020 Amirah Amalia; Fahad Hasan; Ira Wahyuni; Mohamad Riza El Anshori; Zahra Nurusshofa
Sanus Medical Journal Vol. 5 No. 1 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.10715

Abstract

Apendisitis adalah kejadian peradangan pada apendiks vermiformis. Penelitian ini melihat hubungan antara tingginya nilai Absolute Neutrophil Count (ANC) dengan kejadian apendisitis akut dan perforasi. Penelitian ini dilakukan menggunakan desain analitik observasional dengan pendekatan cross sectional. Hasil penelitian menyatakan bahwa terdapat hubungan yang signifikan antara tingginya nilai ANC dengan kejadian apendisitis akut dan perforasi dengan nilai p value sebesar 0.000. Juga ditemukan cut off nilai ANC antara apendisitis akut dan perforasi sebesar 9053 sel/µL dengan sensitivitas sebesar 100% dan spesifisitas sebesar 72,6%. Hasil penelitian menyarankan bahwa penghitungan nilai ANC dapat digunakan sebagai pemeriksaan alternatif untuk penegakan diagnosis apendisitis, namun tidak dapat dijadikan sebagai satu-satunya tolak ukur untuk membedakan antara diagnosis apendisitis akut dan perforasi.
Uji Antibakterial dari Ekstrak Etanol Biji Mangga (Mangifera indica L) Terhadap Bakteri Salmonella typphimurium Adinda Octaviani; Muhammad Zaim; Rizkyana Avissa
Sanus Medical Journal Vol. 5 No. 1 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.10719

Abstract

Abstrak Bakteri Salmonella sp. adalah bakteri gram negatif yang dapat menyebabkan penyakit demam tifoid. Terapi demam tifoid adalah antibiotik seperti kotrimoksazol, kloramfenikol, dan ampisilin. Namun, menurut Badan Litbang Kesehatan, didapatkan Salmonella sp. menunjukkan resistensi sebesar 71% terhadap kotrimoksazol, 57% terhadap kloramfenikol, dan 42% terhadap ampisilin. Oleh karena itu, dibutuhkan bahan alami alternatif untuk memperoleh senyawa antibakteri baru. Salah satu bahan alam yang dapat digunakan adalah biji mangga. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri terhadap bakteri Salmonella sp dari ekstrak biji mangga (Mangifera indica L). Ekstraksi biji mangga menggunakan metode maserasi dengan pelarut etanol 96% yang dilanjutkan dengan pengujian kandungan fitokimia. Hasil uji fitokimia menunjukkan bahwa ekstrak biji mangga mengandung senyawa alkaloid, saponin, tanin, fenolik, flavonoid, tritepernoid, steroid, dan glikosida. Pada penelitian ini dilakukan uji coba perendaman cakram dengan variasi waktu perendaman cakram di ekstrak selama 5 menit, 15 menit, 6 jam, 12 jam, dan 24 jam. Kemudian dilanjutkan dengan peletakan cakram di medium yang mengandung bakteri Salmonella typhimurium sesuai dengan metode difusi cakram. Dari hasil yang didapat, zona hambat muncul secara optimal pada perendaman cakram selama 24 jam. Oleh karena itu, dilakukan perendaman cakram selama 24 jam pada ujicoba antibakteri dengan konsentrasi ekstrak 2.000 ppm, 10.000 ppm, 50.000 ppm, dan 100.000 ppm. Hasil dari penelitian ini adalah ekstrak biji mangga memiliki aktivitas antibakteri terhadap bakteri Salmonella typhimurium yang dapat terlihat mulai dari konsentrasi ekstrak 50.000 ppm dan 100.000 ppm.
Monosodium Glutamat (MSG) dan Gambaran Histologis Otak: Implikasi terhadap Pembentukan Otak Mencit Suriyani Tan; Machrumnizar Machrumnizar; Muhamad Andanu Yunus Slamet
Sanus Medical Journal Vol. 5 No. 1 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.11335

Abstract

Abstract BACKGROUND The sodium salt of glutamic acid, monosodium glutamate (MSG), is a white crystalline compound (glutamic acid). MSG was first produced in large quantities in early 1963 by Korea and Japan which then spread to other countries, including Indonesia. The medical profession is concerned about the detrimental consequences of MSG because of its widespread and uncontrolled consumption. The histological differences between the cerebellum of MSG-treated and MSG-free rats are of interest to researchers. METHOD The Post Test-Only Control Group design was used in this study and used data collected for 14 days. This study used 30 male mice of the Swiss Webster type (Mus Musculus) which were reared as pure strains through inbreeding. Mice taken were 8 weeks old weighing 20 – 40 grams and divided into three groups, each consisting of nine mice with one tail in reserve for each group. One group as a control and two groups will receive MSG orally, each at a dose of 3 mg and 8 mg. Termination of mice was carried out by means of dislocation of the cervical vertebrae and continued with preparation of mice brain tissue preparations. Data analysis, which was obtained from observing the histological appearance of the mouse brain, used the Paired-Sample T test in the SPSS (Statistical Product and Service Solutions) version 20.0 for Windows with a significance level of 0.05. RESULTS In this study, there was no difference in the histological appearance of the brain cerebellum of mice in the control group and the administration of 3 mg and 8 mg of MSG. However, there was a greater increase in body weight in mice given 3 mg of MSG compared to the group given 8 mg of MSG and controls, the average weight gain was 2.87 mg. CONCLUSION After observing through a microscope on the brain preparations of control mice, MSG 3 mg and MSG 8 mg, no difference in histological appearance was found. But giving MSG to mice affects weight gain.   Abstrak LATAR BELAKANG Garam natrium dari asam glutamat, monosodium glutamat (MSG), adalah senyawa kristal putih (asam glutamat). MSG pertama kali diproduksi dalam jumlah besar pada awal tahun 1963 oleh Korea dan Jepang yang kemudian menyebar ke negara lain, termasuk Indonesia. Profesi medis prihatin dengan konsekuensi merugikan dari MSG karena konsumsinya yang meluas dan tidak terkendali. Perbedaan histologis antara otak kecil tikus yang diberi MSG dan bebas MSG adalah hal yang menarik untuk diketahui. METODE Desain Post Test-Only Control Group digunakan dalam penelitian ini dan menggunakan data yang terkumpul selama 14 hari. Penelitian ini menggunakan 30 ekor mencit jantan jenis Swiss Webster (Mus Musculus) yang dipelihara sebagai galur murni melalui perkawinan sedarah. Mencit yang diambil berumur 8 minggu dengan berat 20 – 40gram dan dibagi menjadi tiga kelompok, masing-masing terdiri atas sembilan ekor mencit dengan cadangan satu ekor untuk setiap kelompok. Satu kelompok sebagai kontrol dan dua kelompok akan menerima MSG secara oral, masing-masing dengan dosis 3 mg dan 8 mg. Terminasi mencit dilakukan dengan cara dislokasi vertebra servikal dan dilanjutkan pembuatan preparat jaringan otak mencit. Analisis data, yang diperoleh dari pengamatan gambaran histologis otak mencit, menggunakan Paired-Sample T test pada program SPSS (Statistical Product and Service Solutions) versi 20.0 for Windows dengan tingkat kemaknaan 0,05. HASIL Pada penelitan ini tidak ditemukan adanya perbedaan pada gambaran histologis cerebellum otak mencit pada kelompok kontrol dan pemberian MSG 3 mg dan 8 mg. Namun, terdapat peningkatan berat badan lebih banyak pada mencit yang diberikan MSG 3 mg dibandingkan dengan kelompok yang diberikan MSG 8 mg dan kontrol, rata-rata kenaikan berat badan sebesar 2,87 mg. KESIMPULAN Setelah dilakukan pengamatan melalui mikroskop pada preparat otak mencit kontrol, MSG 3 mg dan MSG 8 mg, belum ditemukan perbedaan gambaran histologis. Tetapi pemberian MSG pada mencit mempengaruhi pertambahan berat badan.

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