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Sanus Medical Journal
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : -     EISSN : 2745868     DOI : https://doi.org/10.22236/sanus
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Sanus Medical Journal is a peer-reviewed medical and health journal published periodically every six months. Sanus Medical Journal publishes descriptive, analytical, and experimental studies, reviews, systematic reviews, case reports, letters, and editorials in the fields of Medicine, Health, Medical and Health Education, and Islamic Medicine. The scope of Sanus Medical Journal goes beyond the boundaries of discussions in the fields of clinical medicine and health in general, by providing new insights into etiologies, determinants, distribution, management and prevention of diseases in individuals and communities. Sanus Medical Journal attempts to meet the demands of rapid developments in information and medical and health research by committing to reduce the range of online publications to around six weeks after the submission of a manuscript. Articles will be published online in advance, and the printed version included in the next scheduled edition. Sanus Medical Journal will continue to strive to improve its scientific reputation by publishing quality articles reviewed by experts who are highly competent in their respective fields. Sanus Medical Journal greatly appreciates the contributions of authors from related disciplines. Manuscripts can be sent via email to: smjournal@uhamka.ac.id or via the website https://journal.uhamka.ac.id/index.php/smj.
Arjuna Subject : Kedokteran - Farmakologi (Medis)
Articles 89 Documents
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Ikan Zebra (Danio rerio) sebagai Binatang Model pada Penelitian Biomedis dan Cara Pemeliharaannya Husnul Khotimah; M. Muljohadi Al
Sanus Medical Journal Vol. 1 No. 1 (2020): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5301

Abstract

Biomedical research requires suitable model organisms to be able to understand the pathogenesis of disease at the cellular and molecular level and the suitability of systems for the development and testing of new therapies. The choice of model organisms for biomedical research depends very much on the research objectives. Basically, the selection of model organisms is based on several aspects, namely: biological, technical and historical aspects. The general criteria for selecting model organisms are: small size, fast reproduction time, low and easy maintenance, easy experimental techniques, complete basic information. The development of research using animal models further leads to the level of genetic functional conservation in the basic processes of cell biology between mammals and invertebrates such as fruit flies (Drosophila melanogaster) and nematode worms (Caenorhabditis elegans). However, there are significant limitations between mammals and invertebrates, among others due to differences in organ systems and their development, so now widely used zebra fish (Danio rerio) as model organisms that bridge between invertebrates and vertebrates. In addition to these reasons there are several other scientific reasons that make zebra fish a superior organism model for biomedical research, namely: having a high homology with humans (75%), transparent embryos, high levels of fecundity, fast embryogenesis, relatively fast life span , procurement and maintenance is relatively inexpensive, complete basic information and genetic information (whole genome sequencing), has a cardiovascular system, nerves, immune system and digestive system similar to mammals, sensitive to environmental changes so that many bio-indicators are used for toxicity testing and testing and development drug.
Comparing Clock Test for Cognitive Screening: Quantitative Analysis of Five Scoring Methods – What Is Optimal? Gea Pandhita; Bambang Sutrisna; Samekto Wibowo
Sanus Medical Journal Vol. 1 No. 1 (2020): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5302

Abstract

Objectives: The clock drawing test (CDT) is a widely used cognitive screening tool that has been well accepted. However, it is still questionable which scoring system is the best. We assessed the correlation of five common scoring methods of the CDT with Mini Mental State Examination (MMSE), and intercorrelations between each different scoring system. Methods: CDT scores of different scoring systems from participants from the geriatric club in Pondok Kopi Jakarta Islamic Hospital, were compared. The CDT was scored according to the methods of Rouleau, Babins, Mendez, Lin, and Shulman. Correlation coefficients between the five scoring methods of the CDT with MMSE were calculated, as well as the intercorrelations between each different scoring system. Results: The study sample consisted of 106 non-demented subjects, aged between 60 and 77 years. The five scoring methods of the CDT correlated significantly with MMSE, but correlation coefficients were moderate (r = 0.43 to r = 0.46). The highest was Lin's method (r = 0.46). Especially, correlation coefficients between the five scoring methods of the CDT with MMSE attention domain were higher (r = 0.42 to r = 0.52). The intercorrelations between each different scoring system were high (r = 0.87 to r = 0.99). The correlation coefficients between Rouleau's method with Mendez's method was the highest (r = 0.99). Conclusions: The correlation of five common scoring methods of the CDT with MMSE were moderate positive. The CDT scored according to the method of Lin was the highest. The intercorrelations between each different scoring system were high.
Deep Vein Thrombosis: How do I Manage in Daily Practice Sidhi Laksono
Sanus Medical Journal Vol. 1 No. 1 (2020): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5352

Abstract

Deep vein thrombosis (DVT) is part of venous thromboembolism disease dan the incidence increases sharply with age. In European countries, DVT incidence is 70-140 cases/100,000 person-year. Patient with DVT, short-term mortality rates were 2-5% and more frequent in proximal than distal DVT. DVT is a common condition for complication such as post phlebitic syndrome, pulmonary embolism and death. An algorithm strategy combining pre-test probability, D-dimer testing and compressible Doppler ultrasound imaging can be applied for suspected lower extremity DVT. Patients with low pre-test probability and a negative D-dimer test result can be excluded from diagnosis of DVT without the need for Doppler ultrasound imaging. Primary treatment of DVT is anticoagulation therapy, intervention using thrombolysis and vena cava filters are for special conditions. The duration of anticoagulation therapy depends on the risk factors.
Peran Sel Punca dalam Pengobatan Regeneratif Silmi Mariya
Sanus Medical Journal Vol. 1 No. 1 (2020): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5353

Abstract

Penggunaan sel punca merupakan hal yang sangat menguntungkan bagi ilmu pengetahuan, bagaimana organisme dapat berkembang dari satu sel dan bagaimana sel yang sehat dapat mengganti kerusakan sel pada mahluk hidup. Hal yang menjanjikan ini membuat para peneliti mengembangkan lebih jauh kemungkinan pengobatan menggunakan sel punca, untuk suatu penyakit yang dikenal dengan pengobatan regeneratif. Sel punca mempunyai dua karakteristik penting, yang membedakan mereka dari jenis sel lainnya.
Stem Cell Therapy for Ischemic Heart Disease: Clinical Use Sidhi Laksono PURWOWIYOTO
Sanus Medical Journal Vol. 1 No. 1 (2020): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5402

Abstract

Ischemic heart disease is still becoming a cause of morbidity and mortality in the world. Regenerative cellular or stem cell therapy is a new and emerging as an alternative option for this disease. There are several stem cell types that used in ischemic heart disease, most used stem cell for this treatment are bone marrow-derived stem cell and mesenchymal stem cell. The mechanism of action for stem cell therapy is depends on transdifferentiation and paracrine effect. It effects the release of cytokines, chemokines and growth factors that inhibits apoptosis and fibrosis, enhance contractility and activate regenerative mechanism. Factors associated with the efficacy of stem cell therapy are delivery route to target myocardium, number of stem cell infusion, injection timing, physical condition of patient and stem cell microenvironment.
Pengaruh Pemberian Diet Restriksi Vitamin B12 Pada Tikus: Kajian Insulin dan Glukosa Plasma Imelda Rosalyn; Dewi Irawati SS; Irena Ujianti; Patwa Amani
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5431

Abstract

Background: Deficiency of vitamin B12 remains a health problem in both developed and developing countries. Many journal studies showed an association between deficiency of vitamin B12 and metabolic disorder, one of which is insulin resistance, one of the most significant metabolic diseases. Resistance to insulin may be assessed by changes in plasma glucose and insulin levels. This study explored a possible relationship between vitamin B12 restriction and glucose metabolism. Materials and Methods: This study used an experimental method of 18 male Sprague Dawley rats (Rattus norvegicus, 300-400 gram, age 7-8 months), divided into three groups: control (G1), four weeks treatment group (G2 ) and 12-week treatment group (G3). In the control group, regular feed, the standard diet was given, while the treatment group was assigned vitamin B12, AIN-93M deficiency feed according to the treatment age. Results: Plasma glucose increased in treatment group after 4 weeks (control vs P1= 104.7 ± 5.04 vs 206.8 ± 4.5 p = 0.000) and 12 weeks (control vs P3 = 99.9±6.3 vs 144.7±6.8 p<0.01). Plasma insulin decreased in treatment group after 4 weeks (control vs P1=63.8 ± 1.5 vs 59.9 ± 0.7 p > 0.05) and 12 weeks (control vs P3 = 61.5±0.64 vs 57.4±1 p>0.05). Conclusion: Increased homocysteine deficiency due to dietary vitamin B12 can cause insulin resistance syndrome. As a result, glucose and plasma insulin levels are disrupted Keywords: Homocysteine, vitamin B12 Deficiency, Glucose, Insulin, Insulin Resistance
Chronic Limb Ischemia: Awareness and Treatment in Primary Care Sidhi Laksono Purwowiyoto; Reynaldo Halomoan
Sanus Medical Journal Vol. 5 No. 1 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.6347

Abstract

Chronic limb ischemia (CLI) is a type of peripheral arterial disease (PAD) that is still underdiagnosed and undertreated despite the increasing incidence, thus becoming a global health burden. The prevalence of PAD is quite high, approximately around 200 million globally in the adult population and increased drastically in older age population. It might be difficult to diagnose at an early stage because around 20-50% patients may be asymptomatic. More than 70% of primary physicians also did not notice that the diagnosis was already established during screening of the PAD patients. All these problems could increase the incidence of PAD in the following year. The untreated conditions will develop into a more severe form of PAD known as chronic limb-threatening ischemia (or critical limb ischemia), and patients are at a higher risk of having limb loss, and also increased morbidity and mortality. The primary physicians in the primary health facilities hold an important role in the early diagnosis and management of patients with CLI symptoms or with risk factors of CLI. Due to the limitation of diagnostic testing modality at primary health facilities, the physician can assess the ankle-brachial index (ABI) to determine the presence of CLI. Management of the disease is different for every patient and is customized based on the other comorbidities. Risk factors should be controlled in order to achieve a better outcome. A good management strategy will improve the condition. This review aims to describe how to give an early diagnosis and management for CLI patients in primary health care.
Telekardiologi dan Aplikasinya: Pendekatan Rumah Sakit selama Pandemi Sidhi Laksono Purwowiyoto; Anhari Achadi; Adik Wibowo
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6519

Abstract

Covid19 has changed how we serve patients in all areas of health, and cardiology is no exception. Telemedicine is an option that hospitals can do during this pandemic. Telecardiology is part of telemedicine. By transmitting clinical data and electrocardiograms, telecardiology allows access to cardiology consultation services (telecardiology) without the need to travel to the practice area for both patients and cardiologists. These services can be in the form of teleconsultation, teleelectrocardiography, telerehabilitation, or teleechocardiography. Telecardiology can be applied in prehospital (teleconsultation, teleelectrocardiography,) if there is a referral for a heart attack patient or consult for chronic heart disease through online media; at the hospital in the form of discussions with peripheral hospitals and referral hospitals (teleechocardiography with other small hospitals); and posthospital treatment can be performed for cardiac telerehabilitation in patients with heart failure or teleconsultation of posttreatment patients.
Analisis Kadar Nrf2 plasma Pada Tikus dengan Defisisensi Vitamin B12 Endin Nokik Stujanna; Irena Ujianti; Etty Farida Mustifah
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6545

Abstract

Background. Vitamin B12 deficiency is a significant problem, particularly in developing countries. The increasing complexity of the Vitamin B12 molecule, the deficiency condition, causes a complex cell level disorder. The clinical manifestation of vitamin B12 deficiency is anemia, but it is believed that due to the complexity of vitamin B12, there are still other molecular disorders. This study aims to establish the pathway of damage caused by vitamin B12 deficiency in the Nrf2 molecule. Methods. An animal experiment involving 12 male Sprague Dawley rats were randomly divided into control and 16-week treatment. There are two research groups, namely the control group and the treatment group. The control group was given a standard diet, while the treatment group was assigned a vitamin B12 deficiency diet. At the end of treatment, The levels of vitamin B12 in the liver tissue and plasma NRF2 were measured. Statistical Analysis. Nrf2 and vitamin B12 levels were statistically analyzed using the Student's T-test, and the correlation between vitamin B12 and Hb was analyzed using the Spearmen test. Data that cannot use by Independent T-test were tested using the Mann Whitney test. Results/Conclusion. There was no significant difference between the control and treatment groups on plasma Nrf2 levels (4.02 ± 0.59 pg/ml vs 3.34 ± 0.55 pg/ml; p = 0.07) and tissue vitamin B12 (0.0035 ± 0.0016 µg/ml vs 0.0030 ± 0.0006 µg/ml ; p = 0.8). Keywords: Nrf2 Plasma, Defisiensi, Vitamin B12
Hipertensi Masa Kini dalam Perspektif Kesehatan Masyarakat Bety Semara Lakhsmi; Annisa Intan Yudyawati
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6606

Abstract

Hipertensi adalah penyakit yang didefinisikan sebagai peningkatan tekanan darah secara menetap. Seseorang dikatakan menderita hipertensi apabila tekanan darah sistol di atas 140 dan diastole di atas 90 mmHg. Hipertensi dibedakan menjadi dua macam, yaitu hipertensi primer (esensial) dan hipertensi sekunder. Hipertensi dipicu oleh beberapa faktor risiko, seperti seperti umur, jenis kelamin, riwayat keluarga, genetik (faktor risiko yang tidak dapat diubah/dikontrol), kebiasaan merokok, konsumsi garam, konsumsi lemak jenuh, penggunaan jelantah, kebiasaan konsumsi minum – minuman beralkohol, obesitas, kurang aktivitas fisik, stres, serta penggunaan estrogen.

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